Medical Science Monitor最新文献

{"title":"Current Status of Cellular and Gene-Based Therapies for Congenital Metabolic Disorders: A Review.","authors":"Angelika Masiarz, Pola Kosteczko, Magdalena Mazur, Patrycja Pelczar, Żaneta Kimber-Trojnar, Bożena Leszczyńska-Gorzelak","doi":"10.12659/MSM.954145","DOIUrl":"10.12659/MSM.954145","url":null,"abstract":"<p><p>Congenital metabolic disorders often lead to irreversible organ damage beginning during fetal life or shortly after birth. Advances in prenatal diagnostics have enabled earlier identification of these conditions, creating opportunities for prenatal therapeutic intervention. Preclinical studies have demonstrated that prenatal cell therapies can result in donor cell engraftment, enzyme production, and partial correction of metabolic defects in several disease models. The fetal environment may support immune tolerance and enhance treatment effectiveness. Limited clinical experience suggests that these approaches are feasible and may be beneficial in selected conditions, including lysosomal storage diseases and infantile-onset Pompe disease. In utero gene therapy has also shown long-term metabolic correction in animal models. However, important challenges remain, including limited engraftment, immune responses, vector safety, ethical concerns, and regulatory barriers. Prenatal cellular and gene-based therapies are promising but remain experimental. Current evidence is strongest for biological rationale and preclinical proof of concept; clinical benefit has not yet been established for most disorders. Further clinical studies are needed to determine their safety, efficacy, and future role in the treatment of congenital metabolic disorders. This article reviews the current status of prenatal fetal cellular and gene‑based therapeutic approaches for inborn errors of metabolism.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"32 ","pages":"e954145"},"PeriodicalIF":2.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Errate: Nasal Mucociliary Clearance and Its Relationship With Disease Severity in Patients With Multiple Sclerosis.","authors":"Caner Baydar, Abdulaziz Yalınkılıç, Yaser Said Çetin","doi":"10.12659/MSM.955360","DOIUrl":"10.12659/MSM.955360","url":null,"abstract":"<p><p>In the published version of Figure 2, the bars representing the Ocrelizumab and Fingolimod treatment groups were inadvertently interchanged. The data presented in Table 2 and described in the Results section are correct. The corrected Figure 2 is provided to replace the originally published figure. Reference: Caner Baydar, Abdulaziz Yalınkılıç, Yaser Said Çetin. Nasal Mucociliary Clearance and Its Relationship With Disease Severity in Patients With Multiple Sclerosis. Med Sci Monit. 2026; 32:e952850. DOI: 10.12659/MSM.952850.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"32 ","pages":"e955360"},"PeriodicalIF":2.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Preoperative and Postoperative Serum 25-Hydroxyvitamin D Levels and Vitamin K-Dependent Blood Coagulation Factor Profiles in Patients Undergoing Cholecystectomy.","authors":"Nedim Akgul, Burak Sakar, Mehmet Ilker Turan, Kemal Eyvaz, Onur Ilkay Dincer, Erhan Aydemir","doi":"10.12659/MSM.953264","DOIUrl":"10.12659/MSM.953264","url":null,"abstract":"<p><p>BACKGROUND Cholecystectomy alters enterohepatic bile circulation, impairing fat-soluble vitamin absorption and reducing bioavailability of vitamin D and vitamin K, required for hepatic synthesis of coagulation factors II, VII, IX, and X. Despite the high global frequency of this procedure, evidence regarding clinically significant postoperative changes in fat-soluble vitamin status remains inconsistent. This retrospective single-center study compared preoperative and postoperative serum 25-hydroxyvitamin D (25[OH]D) levels and vitamin K-dependent coagulation profiles in patients undergoing cholecystectomy. MATERIAL AND METHODS All data were retrieved from electronic medical records of patients who underwent cholecystectomy between January 2020 and January 2025. Two distinct cohorts were formed: the vitamin K cohort (n=101), in which prothrombin time (PT), activated partial thromboplastin time (aPTT), and international normalized ratio (INR) were evaluated at ≥7 days postoperatively; and the 25(OH)D cohort (n=78), in which serum 25(OH)D levels were evaluated at ≥3 months postoperatively. Patients with comorbidities or medications affecting these parameters were excluded. RESULTS In the 25(OH)D cohort, no significant difference was found between preoperative and postoperative median levels (19.76 vs 19.13 µg/L, P=0.248). In the vitamin K cohort, no significant changes were detected in PT (11.80 vs 11.67 s, P=0.301), aPTT (29.83 vs 30.40 s, P=0.131), or INR (1.03 vs 1.03, P=0.859). Sex-stratified analyses revealed no significant differences. CONCLUSIONS Cholecystectomy was not associated with a clinically significant decline in serum 25(OH)D or alterations in vitamin K-dependent coagulation profiles. Postoperative insufficiencies appear driven by pre-existing metabolic risk profiles. Clinical management should prioritize preoperative metabolic optimization over routine post-surgical supplementation.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"32 ","pages":"e953264"},"PeriodicalIF":2.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Celecoxib Combined With Jintiange Capsules for the Treatment of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.","authors":"Jiaxin Zhao, Yongwei Li, Yulin Wang, Shuo Wang, Jidong Song, Wei Wang","doi":"10.12659/MSM.951501","DOIUrl":"10.12659/MSM.951501","url":null,"abstract":"<p><p>BACKGROUND Knee osteoarthritis (KOA) poses a substantial global health burden, and conventional nonsteroidal anti-inflammatory drug (NSAID) therapy with celecoxib is hindered by adverse effects. This study evaluated the efficacy and safety of combining celecoxib with Jintiange capsules, a synthetic tiger bone formulation used in traditional Chinese medicine (TCM), to manage symptomatic KOA. MATERIAL AND METHODS This 12-week, randomized, double-blind, placebo-controlled trial enrolled 120 patients with KOA (age 40 years; visual analog scale [VAS] score 4-7). Participants received celecoxib (200 mg/day tapered to 100 mg/day) combined with either Jintiange capsules (3.6 g/day) or placebo. The primary outcome was the change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score. Secondary outcomes included WOMAC subscale scores (pain, function, and stiffness), VAS scores, and adverse drug reaction reports. RESULTS The experimental group demonstrated a 23.5-point (37.8%) reduction in WOMAC total score from baseline (P<0.001); the control group showed a 13.2-point (21.6%) reduction (P<0.001). The experimental group achieved 51.6% improvement in the WOMAC pain subscale (P<0.001), whereas the control group showed 33.3% improvement (P<0.001). Relative to the control group, the experimental group demonstrated a greater reduction in VAS score (P<0.001). Combined TCM-NSAID therapy produced significantly greater pain relief and functional improvement than NSAID monotherapy. CONCLUSIONS Celecoxib combined with Jintiange capsules provided clinically meaningful improvements in pain relief and functional outcomes relative to celecoxib monotherapy in patients with KOA. These findings support integration of TCM with conventional pharmacotherapy for osteoarthritis management.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"32 ","pages":"e951501"},"PeriodicalIF":2.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Glucocorticoid Receptor Modulators (SEGRAMs): Can They Improve the Therapeutic Index of Steroid Therapy?","authors":"Michał Pruc, Basar Cander, Iwona Jannasz, Zbigniew Siudak, Konrad Kubiński, Karol Momot, Artur Mamcarz, Queran Lin, Łukasz Szarpak","doi":"10.12659/MSM.953742","DOIUrl":"10.12659/MSM.953742","url":null,"abstract":"<p><p>Glucocorticoids remain indispensable anti-inflammatory drugs across a wide range of inflammatory and immune-mediated diseases, but their long-term use is limited by cumulative toxicity. Attempts to develop safer steroids gave rise to selective glucocorticoid receptor agonists and modulators (SEGRAMs), initially based on the premise that anti-inflammatory efficacy might be preserved while signaling linked to adverse effects was reduced. Current glucocorticoid receptor biology no longer supports such a simple binary model. Glucocorticoid receptor output is shaped by ligand-induced conformation, DNA sequence, chromatin accessibility, cofactor recruitment, and cell-specific transcriptional context, making selective modulation a context-dependent pharmacologic phenomenon rather than a fixed molecular property. In this clinically oriented narrative review, we reassess the SEGRAMs concept from receptor biology to translational and early clinical evidence, with explicit distinction between mechanistic dissociation, translational separation of efficacy from selected toxicities, and clinically meaningful improvement in the therapeutic index. Representative compounds have shown that selective glucocorticoid receptor modulation is pharmacologically feasible and, in some settings, may separate anti-inflammatory activity from selected steroid-related liabilities. However, the available evidence also indicates that any potential advantage is disease-specific, toxicity-specific, and exposure-dependent, and that mechanistic dissociation does not by itself justify therapeutic claims, particularly in the absence of long-term comparative outcome data. The most credible future for SEGRAMs lies not in universal replacement of conventional glucocorticoids, but in their potential to improve the therapeutic index in diseases for which prolonged or repeated glucocorticoid exposure remains necessary, but in which cumulative harm from toxicity is a major treatment burden.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"32 ","pages":"e953742"},"PeriodicalIF":2.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i) on Liver Function: Results From MELD Analysis in Surgical Revascularization-A Preliminary Study.","authors":"Tomasz Urbanowicz, Monika Bajsert, Monika Łucja Kowalczyk, Zuzanna Marcinkowska, Oksana Wiśniewska, Aleksandra Krasińska-Płachta, Beata Krasińska, Eugeniusz Spasenenko, Zbigniew Krasinski, Krzysztof J Filipiak, Paulina Mertowska, Ewelina Grywalska, Krzysztof Bartus, Marek Jemielity","doi":"10.12659/MSM.953130","DOIUrl":"10.12659/MSM.953130","url":null,"abstract":"<p><p>BACKGROUND Coronary artery disease is associated with long-term systemic inflammation and perioperative multiorgan vulnerability, including transient hepato-renal dysfunction after cardiac surgery. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) provide cardiorenal protection beyond glucose lowering via anti-inflammatory, metabolic, and endothelial effects, but their effect on perioperative liver-related risk markers, including the Model for End-Stage Liver Disease (MELD) score, in off-pump coronary artery bypass grafting (OPCAB) remains uncertain. MATERIAL AND METHODS We retrospectively studied 111 consecutive patients undergoing elective OPCAB in 2024 (chronic hepatic or renal disease excluded). Patients were stratified by long-term preoperative SGLT2i therapy (≥3 months): no SGLT2i (n = 85) vs SGLT2i (n = 26). MELD score, bilirubin, international normalized ratio , and creatinine were assessed preoperatively and on postoperative days 1 and 6. Between-group comparisons used the Mann-Whitney U test; within-group changes were analyzed using the Friedman test, Kendall's W, and Bonferroni post hoc testing RESULTS Baseline MELD and components were comparable. On postoperative day 1, SGLT2i group exhibited lower bilirubin (P < 0.001), INR (P = 0.04), and MELD score (P = 0.03), but higher creatinine (P = 0.002). By day 6, differences attenuated. Within-group analysis showed significant time effects for MELD, INR, and creatinine in both groups, with large effect sizes (W = 0.48-0.88). Total bilirubin changed over time in the control but not the SGLT2i group. CONCLUSIONS Long-term preoperative SGLT2i therapy was associated with distinct perioperative MELD dynamics in OPCAB, with relative preservation of bilirubin and INR despite creatinine changes, suggesting the potential modulation of hepatic function during perioperative stress. Given the observational design and possible confounding, results are hypothesis-generating and warrant prospective confirmation..</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"32 ","pages":"e953130"},"PeriodicalIF":2.5,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13584803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance and Imaging Features of Dual-Phase Contrast-Enhanced CT in Peripheral Lung Cancer: A Prospective Study With Pathological Correlation.","authors":"Yongzhe Shao, Qingqing Dong, Pinglin Fan","doi":"10.12659/MSM.952575","DOIUrl":"10.12659/MSM.952575","url":null,"abstract":"<p><p>BACKGROUND Peripheral lung cancer is characterized by an insidious onset and nonspecific early symptoms, resulting in delayed diagnosis and poor prognosis. Dual-phase contrast-enhanced computed tomography (CT) has potential advantages in visualizing tumor morphology and vascular characteristics; its diagnostic performance concerning pathological findings has not been fully elucidated. MATERIAL AND METHODS This prospective study included 120 patients with suspected peripheral lung cancer. All patients underwent dual-phase contrast-enhanced CT scanning; histopathological examination of biopsy or surgically resected specimens served as the reference standard. Patients were divided into 2 groups: lung cancer (n=81) and control (n=39). CT imaging features were compared between groups. The diagnostic performance of dual-phase contrast-enhanced CT was evaluated by calculating sensitivity, specificity, accuracy, positive likelihood ratio (PLR), and negative likelihood ratio (NLR), along with 95% confidence intervals. RESULTS Dual-phase contrast-enhanced CT demonstrated a sensitivity of 82.72%, specificity of 74.36%, accuracy of 80.00%, PLR of 3.23, and NLR of 0.23 for diagnosis of peripheral lung cancer. Histopathological examination confirmed 81 cases of peripheral lung cancer and 39 benign lesions. Peripheral lung cancer lesions-more frequently located in the right lung-were characterized by irregular shape, blurred margins, and spiculated margins. The incidences of vacuoles, contrast enhancement, vascular invasion, and lymph node metastasis were significantly higher in the lung cancer group than in the control group. CONCLUSIONS Dual-phase contrast-enhanced CT clearly demonstrated the malignant morphological and vascular characteristics of peripheral lung cancer, supporting use as a complementary noninvasive imaging modality for differential diagnosis of suspected peripheral lung cancer.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"32 ","pages":"e952575"},"PeriodicalIF":2.5,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Platelet Transfusion and ICU Mortality Within 28 Days Among Patients With Intracranial Hemorrhage Complicated by Thrombocytopenia: A Propensity Score-Matched Cohort Study.","authors":"Dachang Qiu, Ze Wang, Xianchao Hu, Lin Wang, Shenhui Jiang, Shiyao Zhang, Yongfei Dong","doi":"10.12659/MSM.953547","DOIUrl":"10.12659/MSM.953547","url":null,"abstract":"<p><p>BACKGROUND Thrombocytopenia is common among patients with traumatic or non-traumatic intracranial hemorrhage admitted to the neuro-intensive care unit (neuro-ICU). The association between platelet transfusion and short-term outcomes in this population remains unclear. This study evaluated the association between platelet transfusion and ICU mortality within 28 days. MATERIAL AND METHODS We analyzed 936 neuro-ICU patients with intracranial hemorrhage complicated by thrombocytopenia, including 173 who received platelet transfusions and 763 who did not. After propensity score matching (PSM), 113 matched pairs were obtained. Cox proportional hazards models, Kaplan-Meier analysis, restricted cubic spline analysis, and exploratory subgroup analyses were used to assess the associations of platelet transfusion status and transfusion volume with ICU mortality within 28 days. RESULTS After PSM, ICU mortality within 28 days did not significantly differ between the transfusion and non-transfusion groups (P=0.292), nor did survival time (P=0.576). Cox regression and Kaplan-Meier analyses showed no significant association between platelet transfusion status and mortality (all P>0.05). Exploratory subgroup analyses suggested heterogeneity among patients with pneumonia (P=0.007, interaction P=0.010) and heart failure (P=0.074, interaction P=0.043). Higher transfusion volume was associated with higher mortality in unadjusted analyses; this association was not significant after multivariable adjustment. CONCLUSIONS Platelet transfusion was not independently associated with ICU mortality within 28 days among neuro-ICU patients with intracranial hemorrhage complicated by thrombocytopenia. Exploratory subgroup findings in patients with pneumonia or heart failure should be interpreted cautiously and require further validation.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"32 ","pages":"e953547"},"PeriodicalIF":2.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative Values of Femoral Inclination Angle and Medial Proximal Femoral Angle: An MRI-Based Study.","authors":"Kemal Bugra Memis, Volkan Kızılgöz, Sonay Aydın, Mukadder Sunar, Mehmet Burak Gökgöz, Önder Durmaz, Ali Osman Gülmez, Berna Hatun Özkan, Mecit Kantarci","doi":"10.12659/MSM.953394","DOIUrl":"10.12659/MSM.953394","url":null,"abstract":"<p><p>BACKGROUND This study aimed to establish normative values for the femoral inclination angle (FIA) and medial proximal femoral angle (MPFA) using magnetic resonance imaging (MRI), which minimizes projectional and rotational errors, in a large cohort. Sex-based and side-to-side comparisons, as well as correlations with age, were also investigated for these proximal femoral angle measurements. MATERIAL AND METHODS After exclusion of patients with trauma, infection, prior surgery, advanced osteoarthritis, femoroacetabular impingement, avascular necrosis, coxa vara, coxa valga, and low-quality magnetic resonance images, 631 pairs of proximal femurs were retrospectively evaluated for FIA and MPFA measurements. All measurements were performed by consensus between 2 radiologists, then analyzed regarding sex and side differences and correlations with age. RESULTS The mean FIA was 128.53±4.62°, whereas the mean MPFA was 86.62±3.40°. No significant differences were observed between men and women (FIA: P=0.057, MPFA: P=0.050) or between right and left sides (FIA: P=0.178, MPFA: P=0.853). Age was not significantly correlated with either proximal femoral angle measurement. No significant association was found between age and FIA (right: P=0.554, left: P=0.321) or MPFA (right: P=0.954, left: P=0.935). CONCLUSIONS This large MRI-based study provides normative reference values for FIA and MPFA. Neither angle was significantly influenced by sex, side, or age, suggesting that these parameters remain relatively stable across adult populations. These findings may serve as useful reference values for assessment of proximal femoral morphology and preoperative orthopedic planning.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"32 ","pages":"e953394"},"PeriodicalIF":2.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Analysis of Plant-Derived Irrigants, Intracanal Medicaments, and Natural Compounds Against Enterococcus faecalis in Endodontics.","authors":"Hazal Faiz Arslanparcasi, Mehmet Ali Arslanparcasi","doi":"10.12659/MSM.953778","DOIUrl":"10.12659/MSM.953778","url":null,"abstract":"<p><p>BACKGROUND The aim of this study was to bibliometrically map the Web of Science Core Collection-indexed literature related to plant-derived irrigants, intracanal medicaments, and natural compounds investigated against Enterococcus faecalis in endodontics. MATERIAL AND METHODS The literature search was conducted in the Web of Science Core Collection database on March 31, 2026; it included English-language articles and reviews indexed from 2010 through March 31, 2026. Descriptive bibliometric analyses were performed using Web of Science tools. Author keyword co-occurrence and author co-citation analyses were conducted using VOSviewer. RESULTS In total, 144 publications were evaluated. Scientific output greatly increased after 2020, and the highest number of publications was recorded in 2024; data for 2026 represented partial-year coverage through the search date. The total number of citations was 1311, whereas citations excluding self-citations totaled 1179. The average number of citations per publication was 9.1, and the H-index was 22. The leading journal was Cureus Journal of Medical Science. The most prolific authors were Bottino MC and Carvalho CAT. Based on full counting, India, Brazil, and Egypt were the leading countries. The most productive institutions were Egyptian Knowledge Bank, Egypt; The Institute for Medicinal Plant Research \"Dr. Josif Pančić,\" Serbia; and King Khalid University, Saudi Arabia. Keyword co-occurrence analysis showed thematic clustering around antibacterial efficacy, biofilm control, and comparisons with conventional endodontic agents. CONCLUSIONS This bibliometric map characterizes publication output, citation structure, leading contributors, and thematic clustering within the defined indexed literature subset.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"32 ","pages":"e953778"},"PeriodicalIF":2.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}