Medical Science Monitor最新文献

Impact of BMI on Recovery and Quality of Life Post-Revascularization in Peripheral Arterial Disease Patients.

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-12-20 DOI: 10.12659/MSM.946793

Anna Nowaczyk, Justyna Cwajda-Białasik, Maria T Szewczyk

{"title":"Impact of BMI on Recovery and Quality of Life Post-Revascularization in Peripheral Arterial Disease Patients.","authors":"Anna Nowaczyk, Justyna Cwajda-Białasik, Maria T Szewczyk","doi":"10.12659/MSM.946793","DOIUrl":"https://doi.org/10.12659/MSM.946793","url":null,"abstract":"This study included 107 patients with peripheral arterial disease (PAD) undergoing revascularization and aimed to evaluate the effects of body mass index (BMI) on outcomes of quality of life (intermittent claudication questionnaire - ICQ), pain-free walking distance (PFWD), and maximum claudication distance (MCD). The study included 107 patients aged 18-80 years with PAD undergoing revascularization (average age 66±6.7 years; 82% men and 18% women, average BMI 28.02±4.35). The diagnosis of PAD was made based on medical opinion and an ankle-brachial index (ABI) value of <0.9. Methods used were BMI assessment, PFWD and MCD distances assessment (treadmill test using the Gardner-Skinner protocol), and quality of life assessment (ICQ). The examination was performed twice - at 1-5 days before the planned revascularization (classical surgery, angioplasty, or hybrid) and 3 months after the procedure. A statistically significant correlation was demonstrated between the improvement of PFWD, MCD, ICQ, and patients' BMI (P<0.01). The worst results were achieved by patients with II-degree obesity (PFWD improvement by an average 10.33±0.87, MCD of 21.67±3.25, ICQ of 14.01±0.60), while the best results were obtained by those with normal body weight (PFWD improvement by an average of 52.57±2.42, MCD of 137.20±22.30, ICQ of 21.18±0.54). Patients with a higher BMI have worse PFWD and MCD distances and quality of life 3 months after revascularization, which indicates the need to consider obesity when planning therapy. Further studies are needed to better understand the impact of BMI on the effectiveness of treatment and rehabilitation of patients with PAD.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"30 ","pages":"e946793"},"PeriodicalIF":3.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Dual Antithrombotic Therapy with Aspirin and Rivaroxaban on Secondary Cardiovascular Outcomes.

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-12-19 DOI: 10.12659/MSM.945457

Wei Li, Yi Li, Chen Liu, Jinghao Yuan, Weize Fan, Qing Miao, Xinshun Gu

{"title":"Impact of Dual Antithrombotic Therapy with Aspirin and Rivaroxaban on Secondary Cardiovascular Outcomes.","authors":"Wei Li, Yi Li, Chen Liu, Jinghao Yuan, Weize Fan, Qing Miao, Xinshun Gu","doi":"10.12659/MSM.945457","DOIUrl":"https://doi.org/10.12659/MSM.945457","url":null,"abstract":"BACKGROUND Dual antiplatelet therapy is the main treatment for cardiovascular diseases (CADs). In this study, we evaluated the efficacy and safety of aspirin combined with low-dose rivaroxaban in the secondary prevention of high-risk ischemic cardiovascular diseases. MATERIAL AND METHODS In total, 168 patients who were diagnosed with acute myocardial infarction or multiple vessel disease 1 year after percutaneous coronary intervention were divided into 2 groups: the aspirin group (aspirin as acetylsalicylic acid: 100 mg once daily) and the aspirin + rivaroxaban group (aspirin: 100 mg once daily, rivaroxaban: 2.5 mg twice daily). The patients were followed up for 2 years to assess the clinical efficacy and safety of a new dual-channel antithrombotic treatment strategy. RESULTS The occurrence of MACE (recurrent myocardial infarction, in-stent restenosis, coronary target vessel revascularization, stent thrombosis, heart failure, rehospitalization, and all-cause mortality) in the rivaroxaban + aspirin group was lower than that in the aspirin group (3.57% of patients received aspirin + rivaroxaban treatment vs 13.10% of patients received aspirin treatment). There were not more adverse events in the rivaroxaban + aspirin group than in the aspirin group. Compared with patients administered aspirin, the coagulation function of patients taking aspirin + rivaroxaban was significantly changed. No heart failure occurred in either group of patients with CADs. CONCLUSIONS Aspirin + rivaroxaban had better primary outcome and secondary outcomes in patients with a high risk of ischemia. Our results provide a basis for evaluating the efficacy and safety of drugs used in secondary prevention among patients with high risk of ischemia.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"30 ","pages":"e945457"},"PeriodicalIF":3.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Body Mass Index and Survival in Patients with De Novo Metastatic Non-Small Cell Lung Cancer. 新发转移性非小细胞肺癌患者的体重指数与生存期之间的关系

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-12-18 DOI: 10.12659/MSM.946751

Muslih Ürün, Gürkan Güner, Yasin Sezgin, Abdullah Sakin, Saadettin Kılıçkap

{"title":"Association Between Body Mass Index and Survival in Patients with De Novo Metastatic Non-Small Cell Lung Cancer.","authors":"Muslih Ürün, Gürkan Güner, Yasin Sezgin, Abdullah Sakin, Saadettin Kılıçkap","doi":"10.12659/MSM.946751","DOIUrl":"https://doi.org/10.12659/MSM.946751","url":null,"abstract":"BACKGROUND This retrospective study from a single center included 289 patients diagnosed with advanced non-small cell lung cancer (NSCLC) between 2010 to 2017 and aimed to evaluate the effects of body mass index (BMI) on overall survival. MATERIAL AND METHODS This retrospective study involved 289 patients diagnosed with metastatic-stage NSCLC at a single institution between January 2010 and December 2017. Patients were categorized into 2 groups based on their BMI at diagnosis: those with a BMI <25 kg/m² and those with a BMI ≥25 kg/m². Univariate and multivariate Cox regression analyses were conducted to identify factors associated with overall survival. RESULTS A total of 289 patients (241 men, 48 women) were included in the study, with a mean age of 60.1±11.1 years. Among them, 175 patients (60.6%) had a BMI less than 25 kg/m². Multivariate analysis revealed that BMI, pathological diagnosis, and complete response after first-line treatment were independently associated with survival in patients with lung cancer. Predicted survival time was significantly shorter in the BMI <25 group than in the BMI ≥25 group (9.3 months vs 13.0 months, P<0.05). CONCLUSIONS The study demonstrated that a higher BMI at the time of diagnosis is associated with improved overall survival in patients with de novo metastatic NSCLC. BMI may serve as an important prognostic factor in this patient population. Future prospective, multi-center studies are necessary to further validate the role of BMI in predicting survival outcomes in NSCLC patients across different treatment modalities.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"30 ","pages":"e946751"},"PeriodicalIF":3.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Perceived Stress and Its Association with Dental Caries in 290 Undergraduate Medical Students.

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-12-17 DOI: 10.12659/MSM.946528

Saeed Awod Bin Hassan, Lakshya Kumar, Aditi Verma, Prakhar Mittal, Akanksha Yadav, Ahmed Abdullah Al Malwi, Abdulelah Sameer Sindi, Syed M Yassin, Shabina Shafi, Mohamed S M Morsy, Khurshid Mattoo

{"title":"Evaluation of Perceived Stress and Its Association with Dental Caries in 290 Undergraduate Medical Students.","authors":"Saeed Awod Bin Hassan, Lakshya Kumar, Aditi Verma, Prakhar Mittal, Akanksha Yadav, Ahmed Abdullah Al Malwi, Abdulelah Sameer Sindi, Syed M Yassin, Shabina Shafi, Mohamed S M Morsy, Khurshid Mattoo","doi":"10.12659/MSM.946528","DOIUrl":"https://doi.org/10.12659/MSM.946528","url":null,"abstract":"BACKGROUND Stress-induced health disorders are related to an unhealthy lifestyle. This study aimed to investigate the prevalence of perceived stress among medical students and to correlate their respective stress levels with the caries index: decayed, missing, filled surfaces (DMFS). MATERIAL AND METHODS This study included 290 undergraduate medical students (140 men, 150 women) from 4 different grades. Demographic characteristics and perceived stress scale (PSS) were measured using a pre-validated scaled questionnaire. The DMFS for each individual was measured intraorally. Continuous variables were expressed as means, and categorical variables as frequencies. Using Pearson correlation, the types and strengths of the relationships between stress levels and DMFS scores were determined (positive, negative, linear, nonlinear). All differences were considered significant at a P value of less than 0.01 (P<0.01). RESULTS A higher percentage of participants had moderate stress (73.8%), with higher PSS scores among female participants (m=21.52) than male participants (m=20.43). Participants with higher stress scores (27 to 40) had very high DMFS scores (4.5 to 6.5). Age had a negative association with stress (r=-0.072, P=0.219) and DMFS (r=-0.023, P=0.695) scores. No significant differences in scores indicated no significant linear link between the variables. A significantly positive linear correlation was observed between stress and DMFS scores (r=0.41, P=0.000), although the correlation was weak. CONCLUSIONS Undergraduate medical students perceive stress during their training. Level of stress was associated with severity of dental caries.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"30 ","pages":"e946528"},"PeriodicalIF":3.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotional Labor of Caregivers of Elderly Patients with Dementia and Disabilities in a Psychiatric Hospital in China. 中国精神病医院老年痴呆症和残疾患者护理人员的情感劳动。

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-12-16 DOI: 10.12659/MSM.945722

Shuo Zhong, Xianfei Chen, Jihong Li

{"title":"Emotional Labor of Caregivers of Elderly Patients with Dementia and Disabilities in a Psychiatric Hospital in China.","authors":"Shuo Zhong, Xianfei Chen, Jihong Li","doi":"10.12659/MSM.945722","DOIUrl":"https://doi.org/10.12659/MSM.945722","url":null,"abstract":"BACKGROUND Studies on the emotional labor of caregivers of elderly people with dementia and disabilities are rare. This study aimed to investigate the emotional labor of caregivers of elderly patients with dementia and disabilities in a psychiatric hospital in China and to propose measures to improve emotional labor of the caregivers. MATERIAL AND METHODS Convenience sampling was used in this study. A questionnaire survey was conducted with the caregivers from the Department of Geriatrics, Chengdu Psychiatric Hospital in May 2021. A total of 73 questionnaires were distributed, and 69 valid questionnaires were returned. Descriptive analysis was performed on the frequency and intensity of emotional labor, using minimum value, maximum value, mean, and standard deviation. An independent-sample t test and one-way analysis of variance were performed on the frequency and intensity of emotional labor between different individuals and groups. RESULTS Statistically significant differences (P<0.05) were identified in surface acting among caregivers by sex, age, educational attainment, and monthly income. A statistically significant difference (P<0.05) was identified between deep acting and emotional expression by marital status. A statistically significant difference (P<0.05) was identified between surface acting and deep acting by the number of elderly patients the respondent was taking care of. No statistically significant differences were identified by the form of contract and job position (P>0.05). CONCLUSIONS Heavy emotional labor and negative emotions widely existed among caregivers of the elderly patients with dementia and disabilities in the psychiatric hospital. More training on emotional labor shall be provided for the caregivers.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"30 ","pages":"e945722"},"PeriodicalIF":3.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Pre-Pregnancy Body Mass Index and Labor Induction Success Rates: A Case Control Study. 孕前体重指数与引产成功率的关系：病例对照研究。

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-12-15 DOI: 10.12659/MSM.946357

Dina Marlina, Aditya Utomo, Budi Handono, Dewi Rani Pelitawati, Putri Nadhira Adinda Adriansyah, Muhammad Alamsyah Aziz, Aditiyono Aditiyono

{"title":"Association Between Pre-Pregnancy Body Mass Index and Labor Induction Success Rates: A Case Control Study.","authors":"Dina Marlina, Aditya Utomo, Budi Handono, Dewi Rani Pelitawati, Putri Nadhira Adinda Adriansyah, Muhammad Alamsyah Aziz, Aditiyono Aditiyono","doi":"10.12659/MSM.946357","DOIUrl":"https://doi.org/10.12659/MSM.946357","url":null,"abstract":"BACKGROUND Obesity is described as excessive fat accumulation. Almost 47% of pregnant women gain more weight than recommended. The prevalence of obesity doubled from 2007 to 2018 (10.5% to 21.8%) in Indonesia. An increase in body mass index (BMI) before pregnancy is associated with delayed labor and vaginal delivery failure. Women with overweight or obesity in pregnancy are at increased risk of developing gestational hypertension and gestational diabetes, resulting in the induction of labor or elective cesarean section. This study aimed to investigate the correlation between pre-pregnancy BMI and outcomes from induction of labor in 248 women during 1 year at a hospital in Purwokerto, Indonesia. MATERIAL AND METHODS The study was conducted at Margono Soekarjo General Hospital and involved all pregnant women delivered between 2023 and 2024. Inclusion and exclusion criteria were applied. Total number of pregnant women was 248, BMI used Asian parameters, induction of labor was performed with oxytocin or misoprostol, and outcomes were according to the International Federation of Gynecology and Obstetrics. The design was a case-control study. Statistical analysis performed using IBM SPSS Statistics version 29.0.1.0 was used to analyze odds ratio and chi-square test. RESULTS This research study revealed pregnant women with obesity had statistically significant higher odds, with an odds ratio of 3.78 (95% CI 1.53-9.31, P=0.002), of labor induction failure than did those without obesity. CONCLUSIONS The findings from this study showed that increased BMI in pre-pregnancy significantly increased the risk of failure of labor induction.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"30 ","pages":"e946357"},"PeriodicalIF":3.1,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Efficacy of Unilateral Biportal Endoscopy vs Traditional Surgery in Lumbar Degenerative Disorders. 腰椎退行性病变单侧双ortal 内窥镜与传统手术的疗效比较

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-12-14 DOI: 10.12659/MSM.946468

Zi-Kun Liao, Shu-Yang Xia, Qun Li, Wei Zhou, Ping Zhang

{"title":"Comparative Efficacy of Unilateral Biportal Endoscopy vs Traditional Surgery in Lumbar Degenerative Disorders.","authors":"Zi-Kun Liao, Shu-Yang Xia, Qun Li, Wei Zhou, Ping Zhang","doi":"10.12659/MSM.946468","DOIUrl":"https://doi.org/10.12659/MSM.946468","url":null,"abstract":"BACKGROUND Lumbar degenerative diseases, such as lumbar disc herniation, cause significant pain and neurological deficits. Traditional surgeries like posteriior lumbar interbody fusion (PLIF) have drawbacks, including extensive tissue damage. We sought to evaluate the efficacy of unilateral biportal endoscopy (UBE) compared with PLIF, with a focus on clinical outcomes and complication rates. MATERIAL AND METHODS This retrospective study (January 2020 to January 2023) included 109 patients with lumbar degenerative diseases; 53 treated with UBE and 56 with PLIF. We followed Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines with ethical approval. The statistical analyses used t-tests and Chi-square tests (P<0.05). RESULTS The UBE group showed significantly shorter surgery times (107.3±11.2 minutes) and less intraoperative blood loss (50.2±5.7 mL) compared with the PLIF group (113.5±15.7 minutes; 91.3±9.0 mL). Postoperative pain reduction was greater in the UBE group, with a mean Visual Analogue Scale (VAS) score of 3.50±0.85 vs 4.10±0.95 in the PLIF group (P<0.001). The UBE group also had better lumbar function recovery, with higher Japanese Orthopaedic Association scores (19.80±2.30 vs 17.20±2.05; P<0.001). The incidence of postoperative complications was lower in the UBE group (5.67%) compared with the PLIF group (14.29%), although this difference was not statistically significant (P=0.14). CONCLUSIONS UBE could offer significant clinical efficacy in treating lumbar degenerative diseases. It may improve surgical outcomes, reduce postoperative pain, and present a favorable safety profile. These findings suggest UBE might be a viable, minimally invasive option, promoting better recovery and fewer complications.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"30 ","pages":"e946468"},"PeriodicalIF":3.1,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches.

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-12-13 DOI: 10.12659/MSM.945336

Yuanyuan Deng, Feifei Wang, Li He

{"title":"Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches.","authors":"Yuanyuan Deng, Feifei Wang, Li He","doi":"10.12659/MSM.945336","DOIUrl":"https://doi.org/10.12659/MSM.945336","url":null,"abstract":"Acne vulgaris is a chronic inflammatory disease of the hair follicle-sebaceous gland unit and is the most common skin disorder worldwide. Although it can occur at any age, it predominantly affects young individuals, manifesting as comedones, papules, pustules, cysts, and nodules, primarily in the sebaceous-rich areas of the face, often in a symmetrical distribution. The development of acne vulgaris is believed to result from a combination of genetic and environmental factors, including sun exposure, skincare habits, diet, sleep patterns, and psychological stress, all of which can induce or exacerbate the condition. The pathogenesis of acne vulgaris involves androgen-induced sebaceous gland hyperplasia, excessive sebum production, abnormal follicular duct keratinization, microbial colonization, and immune-inflammatory responses. Historically, treatment has focused on regulating sebum production, improving follicular keratinization, and providing antibacterial and anti-inflammatory therapies, with less attention given to repairing the skin barrier. Treatment outcomes have often been suboptimal, with frequent recurrences, high incidence of skin sensitivity, and significant economic and psychological burdens on patients. This review explores the mechanisms of skin barrier impairment in acne vulgaris and discusses strategies for its repair, offering new perspectives for the clinical management of acne.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"30 ","pages":"e945336"},"PeriodicalIF":3.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability of Extraoral Scanners in Capturing 3D Geometry for Dental Prostheses: A Systematic Review.

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-12-12 DOI: 10.12659/MSM.946470

Nasser M Alqahtani

{"title":"Reliability of Extraoral Scanners in Capturing 3D Geometry for Dental Prostheses: A Systematic Review.","authors":"Nasser M Alqahtani","doi":"10.12659/MSM.946470","DOIUrl":"https://doi.org/10.12659/MSM.946470","url":null,"abstract":"BACKGROUND This systematic review aimed to evaluate literature on the use and reliability of extraoral facial scanning/extraoral scanning in capturing 3D geometry in association with intraoral evaluation for dental prostheses fabrication. MATERIAL AND METHODS Two independent reviewers performed a systematic database search of PubMed-Medline, Web of Science, Embase, and Scopus with MeSH terms (keywords), including \"extraoral Scanner\", \"facial scanner\", \"intraoral scanner\", and \"dental prosthesis\" to identify studies on extraoral facial scanning/extraoral scanning reliability in association with intraoral evaluation measurements (from January 1, 2012 to June 1, 2024). The study was registered with International Prospective Register of Systematic Reviews (PROSPERO CRD42024544106) and followed the PRISMA statement. The focused question was \"Does data obtained from extraoral facial scanning/extraoral scanning provide a reliable guideline in association with intraoral evaluation for dental prostheses fabrication?\" The main measure used to assess reliability was the intraclass correlation coefficient (ICC). Risk of bias was assessed using Consolidated Standards of Reporting Trials (CONSORT). RESULTS Out of 1066 studies, 8 studies were included based on eligibility criteria. The studies showed that extraoral facial scanning/extraoral scanning captured 3D geometry of tissues with a high ICC, indicating excellent consistency and accuracy. Elevated ICC values (ICC >0.75; range 0.75-0.99) indicated that these systems possess the ability to consistently reproduce facial geometries, which is a critical factor in fabricating precise and comfortable prostheses using intraoral scanners. CONCLUSIONS The study findings support that extraoral facial scanning/extraoral scanning can be combined with intraoral evaluation and digitized workflow to provide high-quality dental prosthetics.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"30 ","pages":"e946470"},"PeriodicalIF":3.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review.

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-12-11 DOI: 10.12659/MSM.945147

Jing Zhao, He Liang, Yanrong Li, Zimeng Xu, Xueqin Li, Lulu Zhao, Mengqian Zhang, Xuehui Duan

{"title":"Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review.","authors":"Jing Zhao, He Liang, Yanrong Li, Zimeng Xu, Xueqin Li, Lulu Zhao, Mengqian Zhang, Xuehui Duan","doi":"10.12659/MSM.945147","DOIUrl":"https://doi.org/10.12659/MSM.945147","url":null,"abstract":"The liver serves as a crucial organ for detoxification and exhibits a robust regenerative capacity. The improper administration of pharmaceuticals frequently results in drug-induced liver injury (DILI), a condition closely associated with the overproduction of reactive oxygen species (ROS). In addressing DILI, Traditional Chinese Medicine (TCM) often employs plant-based remedies, which have demonstrated favorable therapeutic outcomes. These plant-based treatments are typically rich in antioxidants capable of neutralizing ROS. However, there is a notable lack of comprehensive reviews that synthesize the therapeutic effects of antioxidants derived from medicinal plants on DILI. The present review starts by exploring ROS generation and clearance in human health, then outlines DILI characteristics and treatments, emphasizing its strong link to oxidative stress. Furthermore, we discuss the properties and classification of antioxidants found in plant-based pharmaceuticals, with a particular emphasis on the synergistic effects of these antioxidants and their mechanisms for repairing DILI. Finally, we provide a summary of commonly utilized medicinal plants from TCM for the treatment of DILI. In conclusion, this article explores the future prospects and potential solutions for treating DILI using antioxidants found in plant-based drugs derived from TCM. The objective of this review is to examine the role of antioxidants in TCM and their impact on DILI.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"30 ","pages":"e945147"},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0