Medical Science Monitor最新文献

{"title":"Effect of Irrigation Solution Temperature on Bioceramic Sealer Bond Strength.","authors":"Hasret Kilivan, İbrahim Uysal","doi":"10.12659/MSM.946772","DOIUrl":"https://doi.org/10.12659/MSM.946772","url":null,"abstract":"<p><p>BACKGROUND Different temperature conditions can affect the efficiency of irrigation solutions and consequently the ability of canal sealers to bond to root canal walls. The aim of this endodontic study was to evaluate the effect of irrigation solutions at different temperatures on the bond strength of a bioceramic-based root canal sealer. MATERIAL AND METHODS Root canal preparations were completed through irrigation with the following solutions: Group 1 was irrigated with 5 ml NaOCl (sodium hypochlorite) +5 ml EDTA (Ethylenediamine tetra-acetic acid) (22°C); Group 2 was irrigated with 5 ml NaOCl +5 ml EDTA (37°C); Group 3 was irrigated with 5 ml NaOCl +5 ml GA (Glycolic acid) (22°C); Group 4 was irrigated with 5 ml NaOCl +5 ml GA (37°C), Group 5 was irrigated with 20 ml Dual Rinse® HEDP (Etidronate) - NaOCl mixture (22°C); and Group 6 was irrigated with 20 ml of Dual Rinse® HEDP mixture (37°C). Obtained test specimens were subjected to the push-out test. Three-way ANOVA was used to compare bond strength values. RESULTS The main effect of temperature (P<0.05), the main effect of the solution (P<0.05), and the main effect of the section (P<0.05) were significantly associated with the mean values of the bond strength. Heating irrigation solutions increased the bond strength of bioceramic-based canal sealers. CONCLUSIONS The bond strengths of the solutions increased as the temperature increased. EDTA solution significantly increased the bond strength compared to Dual Rinse® HEDP solution. Meanwhile, the bond strengths in the apical region were lower than those in the middle region.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e946772"},"PeriodicalIF":3.1,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143056136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying Gait Asymmetry in Stroke Patients: A Statistical Parametric Mapping (SPM) Approach.","authors":"Jinwoo Park, Kihoon Han","doi":"10.12659/MSM.946754","DOIUrl":"10.12659/MSM.946754","url":null,"abstract":"<p><p>BACKGROUND The VICON Toolkit enables three-dimensional (3D) motion capture for gait analysis. Statistical parametric mapping (SPM) is a voxel-based neuroimaging approach used to identify region-specific effects. This study aimed to apply SPM to analyze the joint angles of the hip, knee, and ankle during gait in 20 post-stroke patients using the VICON motion capture system. MATERIAL AND METHODS A total of 20 post-stroke patients participated in the study. A 10-camera VICON motion capture system (250 Hz) was used to record 3D kinematic data. Joint angles were assessed in the sagittal, frontal, and transverse planes using SPM. The data were normalized to 100% of the gait cycle, and a paired t test was performed to assess asymmetry between affected (AS) and unaffected sides (UAS), with P<0.05 considered statistically significant. RESULTS Significant asymmetry was observed in the hip and knee joint angles in the sagittal plane. The hip joint showed differences during 0-39% of the stance phase and 40-100% of the swing phase. The knee joint exhibited differences during 98-100% of the stance phase and 0-79% of the swing phase (P<0.05). CONCLUSIONS The study highlights the importance of addressing asymmetry in the hip and knee joints in post-stroke rehabilitation programs. The findings indicate the need for improving hip and knee joint mobility to enhance functional gait outcomes. The use of SPM provides a more comprehensive analysis of gait asymmetry, offering insights that go beyond traditional spatiotemporal methods.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e946754"},"PeriodicalIF":3.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COL3A1 Gene Polymorphism and Its Impact on Female Pelvic Organ Prolapse.","authors":"Eighty Mardiyan Kurniawati, Nur Anisah Rahmawati, Anis Widyasari","doi":"10.12659/MSM.946367","DOIUrl":"10.12659/MSM.946367","url":null,"abstract":"<p><p>Pelvic organ prolapse (POP) is a women's health problem in both developed and developing countries. Various studies have found that the occurrence of POP is related to the supporting structures of the pelvic floor, including type III collagen levels. Most studies reported no correlation between collagen 3 alpha 1 (COL3A1) rs1800255 gene polymorphism and the occurrence of POP. However, the studies carried out still need to be clarified in terms of the type of research, the involvement of women of various ages, the method of diagnosing POP, and differences in the measurement of COL3A1 rs1800255 gene polymorphism. Prospectively, as the outcomes of the trials are still inconsistent, more research is required to determine which patients are at risk of pelvic organ prolapse and would benefit from preventive interventions, particularly those using collagen. This article aims to review the relationship between COL3A1 rs1800255 gene polymorphism and female pelvic organ prolapse.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e946367"},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ankle-Brachial Index as a Predictor of Acute Ischemic Cerebrovascular Event After Central Retinal Artery Occlusion.","authors":"Dong-Bo Liu, Bing-Xian Zhang, Yao Zhou, Jian-Hua Zhao, Jie-Wen Zhang","doi":"10.12659/MSM.945937","DOIUrl":"10.12659/MSM.945937","url":null,"abstract":"<p><p>BACKGROUND Identifying patients at higher risk of acute ischemic cerebrovascular events (AICE) following central retinal artery occlusion (CRAO) is crucial for secondary prevention of stroke. This study aimed to investigate whether a low ankle-brachial index value is associated with an increased risk of AICE after CRAO. MATERIAL AND METHODS We prospectively analyzed patients who were admitted to our hospital because of CRAO between February 2019 and March 2023 and whose ankle-brachial index was no greater than 1.40. We explored the potential association between the index and risk of AICE (defined as ischemic stroke or transient ischemic attack) within 1 year after occlusion. Patients were classified into 2 groups according to whether their index was low (≤0.90) or normal (0.91-1.40). RESULTS Of the 335 patients in the final analysis, 110 (32.8%) had an ankle-brachial index of ≤0.90 and 89 (26.6%) experienced AICE during 1-year follow-up. In univariable analysis, patients with a low index had a significantly higher AICE incidence than those with a normal index (36.4% vs 21.8%, P<0.01). Multivariable logistic regression analysis, adjusting for variables associated with low index, identified low index as an independent predictor of AICE after CRAO (OR 1.864, 95% CI 1.095-3.174, P=0.022). CONCLUSIONS Low values of the ankle-brachial index may independently predict higher risk of AICE after CRAO. This index may serve as a non-invasive screening tool for patients with CRAO who require intensified secondary stroke prevention.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e945937"},"PeriodicalIF":3.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of the Dimensional Accuracy of Silicone-Based Putty Reline Impressions with Different Spacer Acquisition Techniques in Fixed Partial Dentures.","authors":"Abdulelah Sameer Sindi, Hanan Salem A Otudi, Asma Ahmed A Muslihi, Roaa Abdu Althurwi, Mohammed E Sayed, Bandar M A Al-Makramani, Fuad A Al-Sanabani, Mohammad Abker Ahmed Ageel, Sultan A Y Jawbahi, Lakshya Kumar, Saeed Awod Bin Hassan, Ahmed Abdullah Al Malwi, Sultan Mohammed Kaleem, Khurshid Mattoo","doi":"10.12659/MSM.946537","DOIUrl":"10.12659/MSM.946537","url":null,"abstract":"<p><p>BACKGROUND A tooth preparation's clinical requirements and geometric configurations should take precedence over material characteristics when advocating for putty reline impression techniques for permanent restorations, since they require a technically sensitive spacer for light body elastomer. We evaluated the linear dimensional accuracy of vinyl polysiloxane-based putty reline impressions with different spacer acquisition techniques in short-span and long-span fixed partial dentures (FPD). MATERIAL AND METHODS A typodont tooth set simulated a 3-unit (short-span) and a 5-unit (long-span) FPD. Between respective prepared abutments, 31 coordinates were identified and measured based on angles (line/point) and surfaces (curved/flat). Sixty impressions (dual stage 2-step putty reline technique) were divided into 5 groups (n=12/group): group PP (pre-preparation putty), group GP (gouging putty), group PS (polythene spacer), group CT (conventional temporary), and group MT (modified temporary), depending on spacer acquisition method. Coordinates measurements were conducted using a measuring microscope. Descriptive and inferential statistical tests (ANOVA, post hoc Tukey) determined between-group and within-group differences, at P≤0.05 significance level. RESULTS In short-span FPD, compared with control, the number of significantly different coordinates group-wise were GP (4 coordinates), PP (2 coordinates), and PS, CT, and MT (1 each). In long-span FPD, compared with control, the number of significantly different coordinates group-wise were group GP (12 coordinates), group PP (10 coordinates), group PS (5 coordinates), and group CT and group MT (4 each). CONCLUSIONS Different spacer acquisition methods produce varied thickness of spacers for relining of putty. CT and MT, when used as spacers, provided maximum accurate coordinates for angles (line/point) and surfaces (curved/flat).</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e946537"},"PeriodicalIF":3.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the Dorsal Cortex of the Inferior Colliculus in the Precedence Effect.","authors":"Jin-Sheng Dai, Xin-Ying Ge, Mo Zhou, Zhi-Qing David Xu, Zi-Hui Zhao, Juan Zhang, Ning-Yu Wang","doi":"10.12659/MSM.945605","DOIUrl":"10.12659/MSM.945605","url":null,"abstract":"<p><p>BACKGROUND The precedence effect (PE) is a physiological phenomenon for accurate sound localization in a reverberant environment. Physiological studies of PE have mostly focused on the central nucleus of the inferior colliculus (CNIC), which receives ascending and descending projections, as well as projections from the shell of the inferior colliculus (IC) and contralateral IC. However, the role of the dorsal cortex of the IC (DCIC), which receives ascending and descending projections to ensure sound information processing and conduction on PE formation, remains unclear. Therefore, this study aimed to understand the role, if any, of the DCIC on PE formation in male Sprague Dawley rats. MATERIAL AND METHODS In vivo, 16-channel electrophysiological recordings were performed in anesthetized rats to investigate neuronal responses in the CNIC, after inducing electrolytic lesions in the DCIC. In vitro, the expression of inhibitory gamma-aminobutyric acid (GABA)ergic receptors in the CNIC was analyzed by Western blot. RESULTS After inducing electrolytic lesions in the DCIC, normalized neural responses of the CNIC to lagging stimuli were significantly increased (P<0.05), half-maximal inter-stimuli delays were shortened (P<0.05), and the expression of GABA A receptor a1 and GABA B receptor 2 decreased (P<0.05). Furthermore, neurons in the CNIC showed a contralateral preference when paired sounds in the free field were presented. CONCLUSIONS Our study suggests that the DCIC could modulate PE formation in the CNIC, potentially involving inhibitory GABAergic mechanisms. This study showed the role of the DCIC on PE formation and proposed a potential structure for identifying likely mechanisms of the PE in the IC.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e945605"},"PeriodicalIF":3.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiari Malformation Type I and Syringomyelia: Outcomes of Arachnoid-Preserving Surgical Technique.","authors":"Okan Turk, Nail Demirel, Muhammet Teoman Karakurt, Revna Cetiner, Omer Faruk Sahin, Adil Can Karaoglu, Ozgur Baran, Mehmet Akif Ambarcioglu, Huseyin Demir, Cumhur Kaan Yaltirik","doi":"10.12659/MSM.946978","DOIUrl":"https://doi.org/10.12659/MSM.946978","url":null,"abstract":"<p><p>BACKGROUND Chiari malformation type 1 occurs when the cerebellar tonsils are pushed into the spinal canal, which can result in syringomyelia. This retrospective study from a single center evaluated outcomes in 89 patients with Chiari malformation type-I (CM-I) and syringomyelia treated with an arachnoid-preserving technique between 2016 and 2023. MATERIAL AND METHODS A retrospective analysis was conducted at a tertiary referral center, involving 88 adult patients and 1 adolescent patient aged 14 to 61 years, with diagnosis by MRI and treated for CM-I with syringomyelia between 2016 and 2023, using the arachnoid-preserving technique. Patients' demographics, clinical presentations, radiological findings, surgical details, and postoperative outcomes were analyzed. Primary outcomes were postoperative complications, while secondary outcomes included neurological improvement (measured by the visual analog scale) and patient satisfaction. RESULTS The study included 89 patients, with 69 female (77.5%) and 20 male (22.5%) patients. A significant reduction in syrinx size was observed in 83.3% of patients, with complete resolution in 16.7%. Mean surgery duration was 90 min, and average hospitalization duration was 2.75 days. All patients experienced significant improvements in neurological symptoms, such as headache, neck pain, numbness, and weakness. High levels of patient satisfaction were reported, with 100% of patients satisfied with their surgical outcomes. The incidence of complications, such as cerebrospinal fluid leakage and arachnoiditis, was notably lower than those by traditional methods. CONCLUSIONS The linear, arachnoid-preserving suboccipital decompression technique offers a safe, effective, and rapid alternative for managing CM-I with syringomyelia, demonstrating a notable reduction in postoperative complications and significant improvements in neurological outcomes.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e946978"},"PeriodicalIF":3.1,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Caries Removal Efficacy and Pain Perception in Children, Using Smart Bur Versus Carbide Bur: A Randomized Clinical Study.","authors":"Satish Vishwanathaiah, Prabhadevi C Maganur, Shahad Mohammed Maafa, Asayil Mohammed Tulays, May Mohammed Hakami, Nassreen H Albar, Noura Alessa, Khalid Alhakami, Ali Ahmed Assiry, Amjad Ismail Alfaqih, Ather Ahmed Syed","doi":"10.12659/MSM.946802","DOIUrl":"10.12659/MSM.946802","url":null,"abstract":"<p><p>BACKGROUND Dental caries removal is conventionally done using carbide burs, but non-metallic polymer burs have recently been developed with the aim of being more selective and causing less pain. The objective of the study is to evaluate and compare the effectiveness of caries removal, time taken, and patient compliance during restorations using smart bur and carbide burs in pediatric patients. MATERIAL AND METHODS A clinical study was designed and conducted at the Pedodontics Outpatient Department, with a focus on 40 children between 6 and 12 years old, who were split into 2 groups consisting of 20 children each: group 1, using a carbide conventional rotary bur, and group 2, using a smart bur. Efficiency of caries removal was assessed using the Ericson scale. The Face Leg Activity Cry Consolability (FLACC) and Wong-Baker FACES pain rating scale (WBS) were used to assess the intensity of pain, and the behavior of children was assessed using the Frankel behavior rating scale (FBRS). RESULTS A statistically significant difference (P<0.001) was noted in the time taken for caries excavation and Ericson scale (P=0.04), with higher scores observed in the smart bur group. The smart bur group generally reported lower WBS and FLACC scores than the carbide bur group, during caries excavation, restoration and local anesthesia administration, and this difference was very highly significant (P<0.001). CONCLUSIONS Pain perception among children was lesser and overall satisfaction was higher in smart bur group whereas caries removal efficiency was higher in conventional carbide bur group.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e946802"},"PeriodicalIF":3.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of rTMS and iTBS on Cerebral Hemodynamics and Swallowing in Unilateral Stroke: Insights from fNIRS.","authors":"Qian Zhang, Yangmei Shi, Jiawen Cheng, Yan Chen, Jia Wang, Xianbin Wang, Luoyi Deng, Shuang Wu","doi":"10.12659/MSM.944521","DOIUrl":"10.12659/MSM.944521","url":null,"abstract":"<p><p>BACKGROUND Swallowing is a complex behavior involving the musculoskeletal system and higher-order brain functions. We investigated the effects of different modalities of repetitive transcranial magnetic stimulation (rTMS) on the unaffected hemisphere and observed correlation between suprahyoid muscle activity and cortical activation in unilateral stroke patients when swallowing saliva, based on functional near-infrared spectroscopy (fNIRS). MATERIAL AND METHODS From November 2022 to March 2023, twenty-five patients with unilateral stroke were screened using computed tomography or magnetic resonance imaging and identified via a video fluoroscopic swallow study. Finally, patients were divided into rTMS (n=10) and iTBS (n=10) groups. Both groups received 2 weeks of stimulation on unaffected suprahyoid motor cortex. Surface electromyographic measured peak amplitude and swallowing time of bilateral suprahyoid muscles, and penetration-aspiration scale was assessed at baseline and after treatment. fNIRS monitored oxyhemoglobin beta values (OBV) in the primary motor, sensory, and bilateral prefrontal cortex (PFC). RESULTS Both groups showed significant improvements in penetration-aspiration scale, peak amplitude, and swallowing time, compared with baseline (P<0.001), and increased OBV in unaffected regions (P<0.05), especially PFC (P<0.001). No significant OBV increases were seen in affected regions (P>0.05). After treatment, OBV in the unaffected PFC was significantly higher than in the unaffected primary sensory and motor cortex regions for both groups (P<0.05). No significant differences were observed between groups in outcome measures (P>0.05). CONCLUSIONS rTMS and iTBS significantly improved swallowing function in unilateral stroke, relying on compensation by the unaffected cortex, particularly the PFC. iTBS may outperform rTMS by shortening treatment sessions and improving efficiency.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e944521"},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior and Posterior Ocular Changes in Patients with Active and Inactive Ankylosing Spondylitis.","authors":"Yücel Karakurt, Nurdagül Aktaş, Ahmet Mehmet Somuncu, Adem Uğurlu, İbrahim Çiçek","doi":"10.12659/MSM.946834","DOIUrl":"10.12659/MSM.946834","url":null,"abstract":"<p><p>BACKGROUND The 6-item Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is a method for evaluating disease activity in ankylosing spondylitis (AS). This study included 78 patients with active and inactive AS and aimed to evaluate anterior and posterior segment ocular changes. MATERIAL AND METHODS Seventy-eight patients and 70 control subjects were enrolled in this study. All participants underwent a complete ophthalmic evaluation. The patients were subdivided into 2 groups according to their BASDAI scores: the active group (BASDAI³4) (n: 38) and the inactive group (BASDAI<4) (n: 40). RESULTS Endothelial cell density (ECD) and hexagonality (HEX) decreased, while coefficient of variation (CV) and average cell size (AVG) increased significantly in AS patients compared with the control cases (P 0.001). However, there was no statistically significant difference between active and inactive groups related to these parameters. Central corneal thickness (CCT) and corneal volume were significantly lower in AS patients (P 0.001, P 0.04), without any statistically significant difference between active and inactive groups. Tear break-up time (TBUT) and Schirmer test results were lower and the findings of corneal fluorescein staining and ocular surface disease index scores (OSDI) were higher in AS patients compared with the control cases, without any significant differences between the active and inactive groups (P 0.001). Choroidal thickness was significantly higher in all 5 points investigated - subfoveal (P 0.018), 1000 Nasal (N) (P 0.003), 2000 N (P 0.001), 1000 Temporal (T) (P 0.007), and 2000 T (P 0.013)  in AS patients compared with the control group. CONCLUSIONS AS can cause anterior and posterior changes, even in the absence of uveitis. Therefore, more attention should be paid to ocular surgery and follow-up of ocular diseases in AS patients.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e946834"},"PeriodicalIF":3.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}