Medical Science Monitor最新文献_第10页

Retracted: The Effects of Hesperidin on Neuronal Apoptosis and Cognitive Impairment in the Sevoflurane Anesthetized Rat are Mediated Through the PI3/Akt/PTEN and Nuclear Factor-κB (NF-κB) Signaling Pathways. 撤回：橙皮甙通过PI3/Akt/PTEN和核因子κB（NF-κB）信号通路对七氟醚麻醉大鼠神经元凋亡和认知障碍的影响

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-05-29 DOI: 10.12659/MSM.945269

Haijin Huang, Cuicui Hu, Lin Xu, Xiaoping Zhu, Lili Zhao, Jia Min

引用次数: 0

Maxillary Canine Impaction: Assessing the Influence of Maxillary Anatomy Using Cone Beam Computed Tomography. 上颌犬牙嵌塞：使用锥形束计算机断层扫描评估上颌骨解剖的影响。

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-05-28 DOI: 10.12659/MSM.944306

Mujgan Firincioglulari, Doga Kurt, Sevgi Koral, Kaan Orhan

{"title":"Maxillary Canine Impaction: Assessing the Influence of Maxillary Anatomy Using Cone Beam Computed Tomography.","authors":"Mujgan Firincioglulari, Doga Kurt, Sevgi Koral, Kaan Orhan","doi":"10.12659/MSM.944306","DOIUrl":"10.12659/MSM.944306","url":null,"abstract":"BACKGROUND The purpose of this study was to evaluate the anatomical characteristics of patients with unilateral impacted canine teeth compared to a control group. Cone beam computed tomography (CBCT) records were retrospectively analyzed. MATERIAL AND METHODS CBCT records of 64 patients with unilateral impacted canine teeth (57.8% female and 42.2% male) and 64 controls (59.4% female and 40.6% male) were retrospectively analyzed. On the CBCT images, intermolar width, arch length, arch perimeter, palatal width in the molar region at cementoenamel junction, palatal width in the molar region at the crest, palatal width in the molar region measured from mid-root level, nasal cavity width, and palatal depth were evaluated. RESULTS In the palatal width measurement from the mid-root variable, the measurement of labially positioned canines was significantly lower than the control group (P<0.05). In terms of intermolar width, the labial positioned impacted canines' values were lower than in the control group. There was a significant difference in terms of the perimeter variable and both palatinally and labially positioned impacted canines were significantly lower than in the control group (P<0.05). All parameters were compared according to sex, and measurements of male patients were significantly higher than in female patients (P<0.05). CONCLUSIONS A labially impacted canine was strongly linked to a decrease in mid-root palatal and intermolar widths. Additionally, impacted canines positioned both palatally and labially were found to result in a reduced arch perimeter. Moreover, male patients with impacted canines exhibited notably greater anatomical measurements compared to female patients.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Recovery of Local Anesthesia in Pediatric Patients: The Impact of Photobiomodulation on Reversing Anesthesia Effects. 增强小儿患者局部麻醉的恢复：光生物调节对逆转麻醉效果的影响。

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-05-24 DOI: 10.12659/MSM.941928

Aneta Olszewska, Jacek Matys, Kinga Grzech-Leśniak, Agata Czajka-Jakubowska

{"title":"Enhanced Recovery of Local Anesthesia in Pediatric Patients: The Impact of Photobiomodulation on Reversing Anesthesia Effects.","authors":"Aneta Olszewska, Jacek Matys, Kinga Grzech-Leśniak, Agata Czajka-Jakubowska","doi":"10.12659/MSM.941928","DOIUrl":"10.12659/MSM.941928","url":null,"abstract":"BACKGROUND The split-mouth study design is used in oral health research and usually consists of 2 treatments randomly assigned to either the right or left side. This split-mouth study aimed to evaluate the efficacy of photobiomodulation on reversal of local anesthesia in 50 children aged 8-10 years. MATERIAL AND METHODS The study was conducted among 50 children: 27 girls and 23 boys, aged 8-10 years (mean age 9.38±1.15 years), who presented 2 carious maxillary permanent molars. One side was randomly assigned to the laser group (50 teeth), and the contralateral side to the control group (50 teeth). At the end of the treatment, photobiomodulation (PBM) was performed in the area of infiltration at 6 points, with 635 nm (25 children) (250 mW, 500 mW/cm², 15J) and 808 nm (25 children) (200 mW, 400 mW/cm², 12J) (SmartM PRO, Lasotronix, Poland). On the contralateral side, the laser's off-mode applicator was used. Anesthetic effect was evaluated by palpation test (soft tissues) and electrical test (dental pulp). RESULTS After 15 minutes, in the laser group the return to normal sensations in the palpation test showed 88% (808 nm) and 68% (635 nm), and only 20% in the control group (P=0.04123). After 45 minutes, all the participants from the PBM group returned to normal sensations (P=0.21458). Dental pulp's excitability threshold was lower for both wavelengths compared to the control group (P=0.000001). CONCLUSIONS The identification of factors accelerating the recovery time to normal function, such as PBM, can be used as important data to eliminate self-injury secondary to local anesthesia (LA) in children.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MRTO4 Enhances Glycolysis to Facilitate HCC Progression by Inhibiting ALDOB. MRTO4 通过抑制 ALDOB 加强糖酵解以促进 HCC 进展。

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-05-23 DOI: 10.12659/MSM.944685

Yongyuan Zheng, Yansong Huang, Weibing Li, Hongqiu Cheng

{"title":"MRTO4 Enhances Glycolysis to Facilitate HCC Progression by Inhibiting ALDOB.","authors":"Yongyuan Zheng, Yansong Huang, Weibing Li, Hongqiu Cheng","doi":"10.12659/MSM.944685","DOIUrl":"10.12659/MSM.944685","url":null,"abstract":"BACKGROUND MRT4 Homolog, Ribosome Maturation Factor (MRTO4) is often upregulated in cancer cells. However, its impact in hepatocellular carcinoma (HCC) is less well understood. Herein, we explored the prognostic and energy metabolism reprogramming role of MRTO4 in HCC. MATERIAL AND METHODS Clinical data were obtained from The Cancer Genome Atlas (TCGA), and the expression of MRTO4 in clinical samples was analyzed. The association between different variables and overall survival (OS) was studied, as well as their potential as independent prognostic factors, using Cox regression analysis. We constructed a nomogram including clinical pathological variables and MRTO4 expression to provide a predictive model for prognosis. Heatmaps, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed the relationship between energy metabolism pathways and MRTO4. We used classic molecular biology research methods, including RT-qPCR, Western blotting, CCK8, TUNEL, Clone formation, Transwell assay, ELISA, and immunohistochemistry, to study the role of MRTO4 in promoting the progression of HCC through glycolysis regulation. RESULTS Our study showed that MRTO4 is an independent prognostic risk factor for HCC and that MRTO4 accelerates glycolysis of HCC cells, promotes proliferation and invasion, and suppresses apoptosis of HCC cells. The underlying mechanism involves MRTO4 promoting glycolysis and accelerating HCC by inhibiting ALDOB. CONCLUSIONS Our study revealed a novel mechanism by which MRTO4 promotes glycolysis and accelerates HCC progression, and suggests that inhibiting MRTO4 could be a potential therapeutic strategy for HCC.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers for Early Prediction and Management of Preeclampsia: A Comprehensive Review. 用于子痫前期早期预测和管理的生物标记物：全面综述。

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-05-23 DOI: 10.12659/MSM.944104

Julia Tomkiewicz, Dorota A Darmochwał-Kolarz

{"title":"Biomarkers for Early Prediction and Management of Preeclampsia: A Comprehensive Review.","authors":"Julia Tomkiewicz, Dorota A Darmochwał-Kolarz","doi":"10.12659/MSM.944104","DOIUrl":"10.12659/MSM.944104","url":null,"abstract":"Preeclampsia is a common complication of pregnancy. It is a multi-organ disorder that remains one of the main causes of maternal morbidity and mortality. Additionally, preeclampsia leads to many complications that can occur in the fetus or newborn. Preeclampsia occurs in about 1 in 20 pregnant women. This review focuses on the prediction of preeclampsia in women, using various biomarkers, in particular, a factor combining the use of soluble FMS-like tyrosinokinase-1 (sFlt-1) and placental growth factor (PlGF). A low value of the sFlt-1/PlGF ratio rules out the occurrence of preeclampsia within 4 weeks of the test result, and its high value predicts the occurrence of preeclampsia within even 1 week. The review also highlights other factors, such as pregnancy-associated plasma protein A, placental protein 13, disintegrin and metalloprotease 12, ß-human chorionic gonadotropin, inhibin-A, soluble endoglin, nitric oxide, and growth differentiation factor 15. Biomarker testing offers reliable and cost-effective screening methods for early detection, prognosis, and monitoring of preeclampsia. Early diagnosis in groups of women at high risk for preeclampsia allows for quick intervention, preventing the undesirable effects of preeclampsia. However, further research is needed to validate and optimize the use of biomarkers for more accurate prediction and diagnosis. This article aims to review the role of biomarkers, including the sFlt1/PlGF ratio, in the prognosis and management of preeclampsia.","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Reconstruction of Type IV Hypoplasia of the Thumb (Floating Thumb) in Infants: A Retrospective Analysis of Functional Outcomes and Radiographic Alignment 婴儿 IV 型拇指发育不良（浮动拇指）的手术重建：功能结果和放射学对位的回顾性分析

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-05-23 DOI: 10.12659/msm.943686

Shaoyan Shi, Honghao Duan, Xuehai Ou

引用次数: 0

Systemic Immune-Inflammation Index (SII) as a Predictor of Short-Term Mortality Risk in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Study 全身免疫炎症指数 (SII) 作为败血症相关急性肾损伤短期死亡风险的预测因子：一项回顾性队列研究

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-05-23 DOI: 10.12659/msm.943414

Jie Sun, Ying Qi, Wenxin Wang, Pengpeng Meng, Changjin Han, Bing Chen

引用次数: 0

Retracted: MD-1 Deficiency Accelerates Myocardial Inflammation and Apoptosis in Doxorubicin-Induced Cardiotoxicity by Activating the TLR4/MAPKs/Nuclear Factor kappa B (NF-κB) Signaling Pathway. 被撤回：MD-1 缺陷通过激活 TLR4/MAPKs/Nuclear Factor kappa B (NF-κB) 信号通路，加速多柔比星诱导的心脏毒性中的心肌炎症和凋亡。

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-05-22 DOI: 10.12659/MSM.945188

Ying-Jun Zhang, He Huang, Yu Liu, Bin Kong, Guangji Wang

引用次数: 0

Anterior Plate-Supported Cannulated Screw Surgery for Ankle Arthrodesis: Clinical and Radiologic Results in Patients with Trauma-Related End-Stage Ankle Osteoarthritis 用于踝关节固定的前板支撑套管螺钉手术：创伤导致的终末期踝关节骨性关节炎患者的临床和放射学结果

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-05-22 DOI: 10.12659/msm.944452

M. Y. Gökmen, M. Uluöz, T. Dülgeroğlu

引用次数: 0

Comparative Evaluation of Digital Cephalometric Tracing Applications on Mobile Devices and Manual Tracing 移动设备上的数字头颅测量描记应用与手动描记的比较评估

IF 3.1 4区医学

Medical Science Monitor Pub Date : 2024-05-21 DOI: 10.12659/msm.944628

Mosab Mohammed Hassan, W. H. Alfaifi, Abdullah Mohammed Qaysi, A. Alfaifi, Zainab Murtadha AlGhafli, K. Mattoo, Shahad Mohammed Daghriri, Lamis Mohammed Hawthan, R. M. Daghriri, A. Moafa, Mohammed M. Al Moaleem

引用次数: 0