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Retracted: Osteoprotegerin (OPG) Promotes Recruitment of Endothelial Progenitor Cells (EPCs) via CXCR4 Signaling Pathway to Improve Bone Defect Repair. 被撤回:骨保护素 (OPG) 通过 CXCR4 信号通路促进内皮祖细胞 (EPC) 的招募以改善骨缺损修复
IF 3.1 4区 医学
Medical Science Monitor Pub Date : 2024-06-12 DOI: 10.12659/MSM.945471
Rongfeng Zhang, Jianwei Liu, Shengpeng Yu, Dong Sun, Xiaohua Wang, Jingshu Fu, Jie Shen, Zhao Xie
{"title":"Retracted: Osteoprotegerin (OPG) Promotes Recruitment of Endothelial Progenitor Cells (EPCs) via CXCR4 Signaling Pathway to Improve Bone Defect Repair.","authors":"Rongfeng Zhang, Jianwei Liu, Shengpeng Yu, Dong Sun, Xiaohua Wang, Jingshu Fu, Jie Shen, Zhao Xie","doi":"10.12659/MSM.945471","DOIUrl":"10.12659/MSM.945471","url":null,"abstract":"<p><p>The Editors of Medical Science Monitor wish to inform you that the above manuscript has been retracted from publication due to concerns with the credibility and originality of the study, the manuscript content, and the Figure images. Reference: Rongfeng Zhang, Jianwei Liu, Shengpeng Yu, Dong Sun, Xiaohua Wang, Jingshu Fu, Jie Shen, Zhao Xie. Osteoprotegerin (OPG) Promotes Recruitment of Endothelial Progenitor Cells (EPCs) via CXCR4 Signaling Pathway to Improve Bone Defect Repair. Med Sci Monit, 2019; 25: 5572-5579. DOI: 10.12659/MSM.916838.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11181876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced Sweat Biosensing with Thread-Embedded Microfluidic Devices. 利用螺纹嵌入式微流控设备增强汗液生物传感功能
IF 3.1 4区 医学
Medical Science Monitor Pub Date : 2024-06-12 DOI: 10.12659/MSM.943321
Karunan Joseph, Fatimah Ibrahim, Saima Qureshi, Bojan Petrović, Sanja Kojić, Aung Thiha, Nurul Jamaluddin, Nuraina Dahlan, Goran Stojanović
{"title":"Enhanced Sweat Biosensing with Thread-Embedded Microfluidic Devices.","authors":"Karunan Joseph, Fatimah Ibrahim, Saima Qureshi, Bojan Petrović, Sanja Kojić, Aung Thiha, Nurul Jamaluddin, Nuraina Dahlan, Goran Stojanović","doi":"10.12659/MSM.943321","DOIUrl":"10.12659/MSM.943321","url":null,"abstract":"<p><p>BACKGROUND This study explored the integration of conductive threads into a microfluidic compact disc (CD), developed using the xurographic method, for a potential sweat biosensing platform. MATERIAL AND METHODS The microfluidic CD platform, fabricated using the xurographic method with PVC films, included venting channels and conductive threads linked to copper electrodes. With distinct microfluidic sets for load and metering, flow control, and measurement, the CD's operation involved spinning for sequential liquid movement. Impedance analysis using HIOKI IM3590 was conducted for saline and artificial sweat solutions on 4 identical CDs, ensuring reliable conductivity and measurements over a 1 kHz to 200 kHz frequency range. RESULTS Significant differences in |Z| values were observed between saline and artificial sweat treatments. 27.5 μL of saline differed significantly from 27.5 μL of artificial sweat, 72.5 μL of saline from 72.5 μL of artificial sweat, and 192.5 μL of saline from 192.5 μL of sweat. Significant disparities in |Z| values were observed between dry fibers and Groups 2, 3, and 4 (varying saline amounts). No significant differences emerged between dry fibers and Groups 6, 7, and 8 (distinct artificial sweat amounts). These findings underscore variations in fiber characteristics between equivalent exposures, emphasizing the nuanced response of the microfluidic CD platform to different liquid compositions. CONCLUSIONS This study shows the potential of integrating conductive threads in a microfluidic CD platform for sweat sensing. Challenges in volume control and thread coating degradation must be addressed for transformative biosensing devices in personalized healthcare.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11181877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Evaluation of the Italian Version of the Dichotic Digit Test: Insights from 39 Normal-Hearing Children Aged 11 to 13 years. 意大利语版二分法测试的开发与评估:39 名 11 至 13 岁听力正常儿童的启示。
IF 3.1 4区 医学
Medical Science Monitor Pub Date : 2024-06-11 DOI: 10.12659/MSM.944090
Milaine Dominici Sanfins, Caroline Donadon, Thais Antonelli Diniz Hein, Elzbieta Gos, Piotr Henryk Skarżyński, Nadia Giulian de Carvalho, Claudia Aimoni, Stavros Hatzopoulos, Maria Francisca Colella-Santos
{"title":"Development and Evaluation of the Italian Version of the Dichotic Digit Test: Insights from 39 Normal-Hearing Children Aged 11 to 13 years.","authors":"Milaine Dominici Sanfins, Caroline Donadon, Thais Antonelli Diniz Hein, Elzbieta Gos, Piotr Henryk Skarżyński, Nadia Giulian de Carvalho, Claudia Aimoni, Stavros Hatzopoulos, Maria Francisca Colella-Santos","doi":"10.12659/MSM.944090","DOIUrl":"10.12659/MSM.944090","url":null,"abstract":"<p><p>BACKGROUND The dichotic digit test (DDT) is one of the tests for the behavioral assessment of central auditory processing. Dichotic listening tests are sensitive ways of assessing cortical structures, the corpus callossum, and binaural integration mechanisms, showing strong correlations with learning difficulties. The DDT is presently available in a number of languages, each appropriate for the subject's native language. However, there is presently no test in the Italian language. The goal of this study was to develop an Italian version of the one-pair dichotic digit test (DDT-IT) and analyze results in 39 normal-hearing Italian children 11 to 13 years old. We used 2 conditions of presentation: free recall and directed attention (left or right ear), and looked at possible effects of sex and ear side. MATERIAL AND METHODS This study involved 3 steps: creation of the stimuli, checking their quality with Italian speakers, and assessment of the DDT-IT in our subject pool. The study involved 39 children (26 girls and 13 boys), aged 11-13 years. All participants underwent basic audiological assessment, auditory brainstem response, and then DDT-IT. RESULTS Results under free recall and directed attention conditions were similar for right and left ears, and there were no sex or age effects. CONCLUSIONS The Italian version of DDT (DDT-IT) has been developed and its performance on 39 normal-hearing Italian children was assessed. We found there were no age or sex effects for either the free recall condition or the directed attention condition.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancement of Motor Learning and Corticospinal Excitability: The Role of Electroacupuncture and Motor Training in Healthy Volunteers. 增强运动学习和皮质脊髓兴奋性:电针和运动训练在健康志愿者中的作用
IF 3.1 4区 医学
Medical Science Monitor Pub Date : 2024-06-10 DOI: 10.12659/MSM.943748
Jiahui Lin, Jiemei Li, Jianpeng Huang, Sheng Li, Jian Sun, Jianhua Liu
{"title":"Enhancement of Motor Learning and Corticospinal Excitability: The Role of Electroacupuncture and Motor Training in Healthy Volunteers.","authors":"Jiahui Lin, Jiemei Li, Jianpeng Huang, Sheng Li, Jian Sun, Jianhua Liu","doi":"10.12659/MSM.943748","DOIUrl":"10.12659/MSM.943748","url":null,"abstract":"<p><p>BACKGROUND This study embarked on an innovative exploration to elucidate the effects of integrating electroacupuncture (EA) with motor training (MT) on enhancing corticospinal excitability and motor learning. Central to this investigation is the interplay between homeostatic and non-homeostatic metaplasticity processes, providing insights into how these combined interventions may influence neural plasticity and motor skill acquisition. MATERIAL AND METHODS The investigation enrolled 20 healthy volunteers, subjecting them to 4 distinct interventions to parse out the individual and combined effects of EA and MT. These interventions were EA alone, MT alone, EA-priming followed by MT, and MT-priming followed by EA. The assessment of changes in primary motor cortex (M1) excitability was conducted through motor-evoked potentials (MEPs), while the grooved pegboard test (GPT) was used to evaluate alterations in motor performance. RESULTS The findings revealed that EA and MT independently contributed to enhanced M1 excitability and motor performance. However, the additional priming with EA or MT did not yield further modulation in MEPs amplitudes. Notably, EA-priming was associated with improved GPT completion times, underscoring its potential in facilitating motor learning. CONCLUSIONS The study underscores that while EA and MT individually augment motor cortex excitability and performance, their synergistic application does not further enhance or inhibit cortical excitability. This points to the involvement of non-homeostatic metaplasticity mechanisms. Nonetheless, EA emerges as a critical tool in preventing M1 overstimulation, thereby continuously fostering motor learning. The findings call for further research into the strategic application of EA, whether in isolation or with MT, within clinical settings to optimize rehabilitation outcomes.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Repeated Steam Sterilization Cycles on the Efficacy of Chairside Adjustment Kits for Polishing Monolithic Multi-Layered Zirconia Dental Restoration Material. 重复蒸汽灭菌循环对用于抛光单片多层氧化锆牙修复材料的椅旁调整套件功效的影响
IF 3.1 4区 医学
Medical Science Monitor Pub Date : 2024-06-10 DOI: 10.12659/MSM.944502
Mohammed E Sayed, Honey Lunkad, Enas Jaber Mohana, Sara Ahmad Mesawa, Fatimah Ibrahim Dowairi, Emad Aldeen A Alharbi, Hayat Ali Hakami, Hossam F Jokhadar, Nasser M Alqahtani, Abdullah Hasan Alshehri, Ebrahim Fihaid Alsubaiy, Saeed M Alqahtani, Nagam Mohammed Mohsen, Mohammed H D Al Wadei, Khurshid Mattoo
{"title":"The Impact of Repeated Steam Sterilization Cycles on the Efficacy of Chairside Adjustment Kits for Polishing Monolithic Multi-Layered Zirconia Dental Restoration Material.","authors":"Mohammed E Sayed, Honey Lunkad, Enas Jaber Mohana, Sara Ahmad Mesawa, Fatimah Ibrahim Dowairi, Emad Aldeen A Alharbi, Hayat Ali Hakami, Hossam F Jokhadar, Nasser M Alqahtani, Abdullah Hasan Alshehri, Ebrahim Fihaid Alsubaiy, Saeed M Alqahtani, Nagam Mohammed Mohsen, Mohammed H D Al Wadei, Khurshid Mattoo","doi":"10.12659/MSM.944502","DOIUrl":"10.12659/MSM.944502","url":null,"abstract":"<p><p>BACKGROUND Before insertion, chairside adjustment kits are heat sterilized for positioning and polishing dental restorations. This study aimed to evaluate the effects of 2 steam sterilization cycles on the efficacy of polishing highly translucent monolithic zirconia (HTMLZ) dental restoration material. MATERIAL AND METHODS 100 HTMLZ disc-shaped specimens were adjusted (grinding, finishing, polishing) with EVE Diacera kit. Two steam sterilization techniques [standard (Gp S), immediate/flash (Gp (F)] of CAK were further subgrouped based on number of sterilization cycles [cycle 1 (control), cycle 5, 10, 15, and 20 (experimental)] (n=10 each). Each subgroup accordingly was evaluated for average surface roughness (Ra) and root mean square roughness (Rq) using a profilometer. Mean and standard deviation of 5 subgroups were statistically analyzed using one-way ANOVA/post hoc Tukey's test. Scanning electron microscopy complemented Ra, Rq measurements. Statistical differences of P≤0.05 were considered significant. RESULTS HTMLZ specimens in both groups showed increased (Ra/Rq) values after repeated sterilization of EVE Diacera kit, with Gp F showing lesser increase than Gp S (20 cycles). Gp F at 10 cycles and Gp S at 15 cycles showed clinically unacceptable roughness threshold (0.25 μm). Differences between subgroups for Ra and Rq values were significant (P≤0.05) with less differences within groups observed in early cycles (1, 10). Results validate the manufacturer's recommendations of using flash sterilization/10 cycles for EVE Diacera kit. CONCLUSIONS Repeated sterilization reduces efficacy of chairside adjustment kit to produce smooth surfaces on HTMLZ. This study recommends flash sterilization to a maximum of 10 times to get the clinically acceptable results of Ra and Rq.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determining the Optimal Dosage of Dexmedetomidine for Smooth Emergence in Older Patients Undergoing Spinal Surgery: A Study of 44 Cases. 确定右美托咪定的最佳剂量,使接受脊柱手术的老年患者顺利苏醒:44 例病例研究。
IF 3.1 4区 医学
Medical Science Monitor Pub Date : 2024-06-09 DOI: 10.12659/MSM.944427
Hyoeun Ahn, Yun Jeong Chae, Gyu Bin Choi, Min Gyu Lee, Ji Young Yoo
{"title":"Determining the Optimal Dosage of Dexmedetomidine for Smooth Emergence in Older Patients Undergoing Spinal Surgery: A Study of 44 Cases.","authors":"Hyoeun Ahn, Yun Jeong Chae, Gyu Bin Choi, Min Gyu Lee, Ji Young Yoo","doi":"10.12659/MSM.944427","DOIUrl":"10.12659/MSM.944427","url":null,"abstract":"<p><p>BACKGROUND Emergence agitation, or delirium, occurs during early recovery from general anesthesia and involves disorientation, excitation, and uncontrolled physical movements. Dexmedetomidine is an alpha agonist that has sedative, anxiolytic, analgesic, and sympatholytic activities and is used as a continuous infusion to prevent emergence agitation. This study aimed to evaluate patients aged 65 years and older undergoing general anesthesia to determine the 90% effective dose (ED90) of dexmedetomidine continuous intraoperative infusion to prevent emergence agitation. MATERIAL AND METHODS We enrolled 44 patients aged 65 years and older undergoing spinal surgery under general anesthesia. Dexmedetomidine administration commenced 30 minutes before surgery completion, with a predetermined infusion dose (μg/kg/h), without a loading dose. The initial dose was 0.2 μg/kg/h, and subsequent step size was ±0.05 μg/kg/h. We tried to find ED90 of dexmedetomidine using the biased-coin design. Vital signs, extubation quality scores, extubation-related complications, and postoperative outcomes were monitored. RESULTS Dexmedetomidine ED₉₀ for smooth emergence in older patients was 0.34 μg/kg/h. Peri-extubation vital signs remained within 20% of baseline values, without requiring pharmacological intervention. No hypoxia, hypoventilation, or post-extubation agitation occurred. In the recovery room, 1 patient briefly exhibited excitement but quickly calmed. Nine patients initially unresponsive in the recovery room fully awoke and were promptly discharged. CONCLUSIONS For older patients who are vulnerable to adverse effects of anesthetics and opioids, dexmedetomidine enables gentle awakening without adverse vital sign changes, respiratory depression, excessive sedation, or emergence agitation (ED₉₀=0.34 μg/kg/h). Further studies should involve a larger patient cohort, considering diverse medical conditions in older individuals.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11171429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine Learning-Based Prediction of Helicobacter pylori Infection Study in Adults. 基于机器学习的成人幽门螺旋杆菌感染预测研究。
IF 3.1 4区 医学
Medical Science Monitor Pub Date : 2024-06-08 DOI: 10.12659/MSM.943666
Min Liu, Shiyu Liu, Zhaolin Lu, Hu Chen, Yuling Xu, Xue Gong, Guangxia Chen
{"title":"Machine Learning-Based Prediction of Helicobacter pylori Infection Study in Adults.","authors":"Min Liu, Shiyu Liu, Zhaolin Lu, Hu Chen, Yuling Xu, Xue Gong, Guangxia Chen","doi":"10.12659/MSM.943666","DOIUrl":"10.12659/MSM.943666","url":null,"abstract":"<p><p>BACKGROUND Helicobacter pylori has a high infection rate worldwide, and epidemiological study of H. pylori is important. Artificial intelligence has been widely used in the field of medical research and has become a hotspot in recent years. This paper proposed a prediction model for H. pylori infection based on machine learning in adults. MATERIAL AND METHODS Adult patients were selected as research participants, and information on 30 factors was collected. The chi-square test, mutual information, ReliefF, and information gain were used to screen the feature factors and establish 2 subsets. We constructed an H. pylori infection prediction model based on XGBoost and optimized the model using a grid search by analyzing the correlation between features. The performance of the model was assessed by comparing its accuracy, recall, precision, F1 score, and AUC with those of 4 other classical machine learning methods. RESULTS The model performed better on the part B subset than on the part A subset. Compared with the other 4 machine learning methods, the model had the highest accuracy, recall, F1 score, and AUC. SHAP was used to evaluate the importance of features in the model. It was found that H. pylori infection of family members, living in rural areas, poor washing hands before meals and after using the toilet were risk factors for H. pylori infection. CONCLUSIONS The model proposed in this paper is superior to other models in predicting H. pylori infection and can provide a scientific basis for identifying the population susceptible to H. pylori and preventing H. pylori infection.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autism Spectrum Disorders: Etiology, Epidemiology, and Challenges for Public Health. 自闭症谱系障碍:病因学、流行病学和对公共卫生的挑战。
IF 3.1 4区 医学
Medical Science Monitor Pub Date : 2024-06-04 DOI: 10.12659/MSM.944161
Janusz Ostrowski, Urszula Religioni, Beata Gellert, Janusz Sytnik-Czetwertyński, Jarosław Pinkas
{"title":"Autism Spectrum Disorders: Etiology, Epidemiology, and Challenges for Public Health.","authors":"Janusz Ostrowski, Urszula Religioni, Beata Gellert, Janusz Sytnik-Czetwertyński, Jarosław Pinkas","doi":"10.12659/MSM.944161","DOIUrl":"10.12659/MSM.944161","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a growing public health problem. American psychiatrist Leo Kanner is considered the \"father of autism.\" ASD encompasses a range of neurodevelopmental disorders that last throughout life. Symptoms of ASD include impairments in social skills, including specific repetitive behaviors, as well as abnormal sensory responses. The clinical symptoms of ASD vary among patients. Their severity also differs, both in the area of social communication and cognitive functioning. The etiology of ASD is still unclear, although a role is attributed to both genetic and environmental factors. According to the World Health Organization, 1/100 children have ASD, but these estimates vary depending on the methodology used. Nevertheless, early detection of ASD and initiation of appropriate therapy may be essential in the continued functioning of patients and their families. The purpose of this article is to provide an overview of current knowledge about autism spectrum disorders. We discuss factors associated with autism and the prevalence of ASD in various parts of the world, and identify the most common diseases comorbid with ASD, pointing to limitations in the quality of life of patients with ASD and their families.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11162141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ANXA5: A Key Regulator of Immune Cell Infiltration in Hepatocellular Carcinoma. ANXA5:肝细胞癌中免疫细胞浸润的关键调控因子
IF 3.1 4区 医学
Medical Science Monitor Pub Date : 2024-06-02 DOI: 10.12659/MSM.943523
Weichen Wang, Dongquan Liu, Jiaming Yao, Zhongxu Yuan, Liang Yan, Baoqiang Cao
{"title":"ANXA5: A Key Regulator of Immune Cell Infiltration in Hepatocellular Carcinoma.","authors":"Weichen Wang, Dongquan Liu, Jiaming Yao, Zhongxu Yuan, Liang Yan, Baoqiang Cao","doi":"10.12659/MSM.943523","DOIUrl":"10.12659/MSM.943523","url":null,"abstract":"<p><p>BACKGROUND Hepatocellular carcinoma (HCC) poses a significant threat to human life and is the most prevalent form of liver cancer. The intricate interplay between apoptosis, a common form of programmed cell death, and its role in immune regulation stands as a crucial mechanism influencing tumor metastasis. MATERIAL AND METHODS Utilizing HCC samples from the TCGA database and 61 anoikis-related genes (ARGs) sourced from GeneCards, we analyzed the relationship between ARGs and immune cell infiltration in HCC. Subsequently, we identified long non-coding RNAs (lncRNAs) associated with ARGs, using the least absolute shrinkage and selection operator (LASSO) regression analysis to construct a robust prognostic model. The predictive capabilities of the model were then validated through examination in a single-cell dataset. RESULTS Our constructed prognostic model, derived from lncRNAs linked to ARGs, comprised 11 significant lncRNAs: NRAV, MCM3AP-AS1, OTUD6B-AS1, AC026356.1, AC009133.1, DDX11-AS1, AC108463.2, MIR4435-2HG, WARS2-AS1, LINC01094, and HCG18. The risk score assigned to HCC samples demonstrated associations with immune indicators and the infiltration of immune cells. Further, we identified Annexin A5 (ANXA5) as the pivotal gene among ARGs, with it exerting a prominent role in regulating the lncRNA gene signature. Our validation in a single-cell database elucidated the involvement of ANXA5 in immune cell infiltration, specifically in the regulation of mononuclear cells. CONCLUSIONS This study delves into the intricate correlation between ARGs and immune cell infiltration in HCC, culminating in the development of a novel prognostic model reliant on 11 ARGs-associated lncRNAs. Furthermore, our findings highlight ANXA5 as a promising target for immune regulation in HCC, offering new perspectives for immune therapy in the context of HCC.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals. 社论:奶牛和其他哺乳动物中发现 H5N1 亚型高致病性禽流感 (HPAI) 病毒引发的担忧。
IF 3.1 4区 医学
Medical Science Monitor Pub Date : 2024-06-01 DOI: 10.12659/MSM.945315
Dinah V Parums
{"title":"Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals.","authors":"Dinah V Parums","doi":"10.12659/MSM.945315","DOIUrl":"10.12659/MSM.945315","url":null,"abstract":"<p><p>Highly pathogenic avian influenza (HPAI) virus subtypes have been increasingly identified in poultry and wild birds since 2021. Between 2020-2023, 26 countries have reported that the H5N1 virus had infected more than 48 mammalian species. On 1 April 2024, a public health alert was issued in Texas when the first confirmed case of human infection with the H5N1 influenza virus was reported in a dairy worker. Cases of H5N1, clade 2.3.4.4b in dairy cows have been reported in several states in the US but were unexpected, even though H5N1 was previously identified in mammalian species, including cats, dogs, bears, foxes, tigers, coyotes, goats, and seals. On 29 April 2024, almost one month after the first reported cases of H5N1 infection in dairy cows, measures were to be implemented by the US Department of Agriculture (USDA) to prevent the progression of H5N1 viral transmission. This editorial summarizes what is currently known about the epidemiology, transmission, and surveillance of the HPAI virus of the H5N1 subtype in birds, mammals, and dairy cows, and why there are concerns regarding transmission to humans.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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