Archivos Espanoles De Urologia最新文献

{"title":"Temozolomide Resistance in Smoking-Related Bladder Cancer through TNFAIP6-Mediated Post-Translational Modifications.","authors":"Xu Feng, Jianhua Huang","doi":"10.56434/j.arch.esp.urol.20257806.98","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.98","url":null,"abstract":"<p><strong>Background: </strong>Lung adenocarcinoma (LUAD) and bladder cancer (BLCA) are two major cancers that have high incidence and mortality worldwide and are particularly exacerbated by smoking, which is a primary risk factor that influences cancer progression through genetic and immune pathways. Temozolomide (TMZ), a chemotherapeutic agent, is often used to treat various cancers, including brain tumours, and is known to induce DNA damage via methylation. This study aims to identify key smoking-related genes, particularly <i>TNFAIP6</i>, and explore their mechanisms in LUAD and BLCA, focusing on their prognostic value, role in cancer progression, immune regulation, and response to TMZ.</p><p><strong>Methods: </strong>Bayesian colocalisation and pan-cancer differential analyses identified 14 key genes, including <i>TNFAIP6</i>. Pan-cancer survival and clinical stage analyses were performed using The Cancer Genome Atlas (TCGA) data. <i>TNFAIP6</i>'s functional role in cancer stages, smoking status, immune infiltration and its effect on TMZ resistance was analysed through statistical tests, gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA). Laboratory experiments were conducted to assess <i>TNFAIP6</i>'s influence on cell proliferation, apoptosis, epithelial-mesenchymal transition (EMT) markers, oxidative stress and TMZ-induced post-translational modifications (PTMs).</p><p><strong>Results: </strong><i>TNFAIP6</i> was significantly upregulated in LUAD and BLCA and linked to poorer prognosis, especially in smokers. High <i>TNFAIP6</i> expression was associated with pro-inflammatory pathways and immune suppression in the tumour microenvironment. Moreover, TMZ treatment induced considerable PTMs in <i>TNFAIP6</i>, promoting resistance to the drug, which was confirmed by functional assays showing increased cell viability and migration in <i>TNFAIP6</i>-overexpressing cells.</p><p><strong>Conclusions: </strong><i>TNFAIP6</i> is a key biomarker of poor prognosis in smoking-related cancers. Interestingly, silencing <i>TNFAIP6</i> both inhibits TMZ's anticancer effects and underscores its potential role in immune regulation, highlighting the paradoxical value of <i>TNFAIP6</i> in developing novel therapeutic strategies, including combination therapies.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"732-742"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Surgical Predictors of Erectile Dysfunction after Bilateral Nerve-Sparing Laparoscopic Radical Prostatectomy.","authors":"Hakan Tekinaslan, Osman Köse, Serkan Özcan, Sacit Nuri Görgel, Yiğit Akın","doi":"10.56434/j.arch.esp.urol.20257806.90","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.90","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the predictors of postoperative erectile dysfunction (ED) in patients who underwent bilateral nerve-sparing laparoscopic radical prostatectomy (BNLRP).</p><p><strong>Materials and methods: </strong>Patients with preoperative ED were excluded. Postoperative erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5) at 6 months postoperatively, with a cutoff score of ≤12 to define ED. The diagnostic value of associated factors was assessed using odds ratios (ORs) with 95% confidence intervals (CIs) based on univariate and multivariate logistic regression analyses. Only variables with <i>p</i> < 0.05 in univariate analysis were included in the multivariate model to avoid multicollinearity and overfitting.</p><p><strong>Results: </strong>A retrospective review was conducted on 79 patients who underwent BNLRP for localised prostate cancer between April 2020 and March 2023. Postoperative ED was observed in 37 (46.8%) patients. Univariate analysis revealed significant associations between ED and age (<i>p</i> < 0.001), diabetes mellitus (<i>p</i> < 0.001), coronary artery disease (<i>p</i> < 0.001), hypertension (<i>p</i> < 0.001), Gleason score (<i>p</i> < 0.001), operative time (<i>p</i> < 0.001) and intraoperative blood loss (<i>p</i> < 0.001). Multivariate logistic regression identified age (OR: 1.136, <i>p</i> = 0.046), diabetes mellitus (OR: 32.706, <i>p</i> = 0.003), Gleason score (OR: 4.749, <i>p</i> = 0.015), operative time (OR: 1.200, <i>p</i> = 0.001) and blood loss (OR: 1.010, <i>p</i> = 0.039) as independent predictors.</p><p><strong>Conclusions: </strong>ED after BNLRP is associated with patient-related and surgical factors. Identifying these predictors may improve preoperative counselling and support early postoperative rehabilitation strategies. Prospective multicentre studies are necessary to externally validate these findings.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"671-676"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Transobturator Tape and Minisling Methods in the Treatment of Stress Urinary Incontinence.","authors":"Suleyman Sagir, Ozlem Basgut, Adem Tuncekin, Muslum Ergun, Omer Turgut","doi":"10.56434/j.arch.esp.urol.20257806.91","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.91","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate and compare the transobturator tape and minisling surgical techniques in the treatment of stress urinary incontinence, focusing on their effectiveness and postoperative outcomes.</p><p><strong>Methods: </strong>This retrospective analysis included 113 patients who underwent midurethral sling surgery for stress urinary incontinence at Islahiye State Hospital between January 2016 and October 2022. The patients were divided into two groups: Those treated with transobturator tape (Group 1, n = 70) and those treated with minisling (Group 2, n = 43). Data were collected from medical records and follow-up interviews. The variables assessed included demographics (age and body mass index), preoperative and postoperative Urinary Incontinence Quality of Life Scale scores, and postoperative pain details. Operative details, such as procedure duration and hospital stay length, were recorded. Patients were also asked about postoperative symptoms, including groin pain and dyspareunia. Additionally, the duration of symptom-free months following surgery was documented. Binary logistic regression analysis was conducted to evaluate the effect of surgical methods on long-term well-being.</p><p><strong>Results: </strong>The transobturator tape and minisling techniques demonstrated similar improvements in postoperative Urinary Incontinence Quality of Life Scale scores (<i>p</i> = 0.213). However, the minisling procedure had significantly shorter operative time (29.2 min vs. 52.2 min, <i>p</i> < 0.001) and hospital stay (1.33 days vs. 1.96 days, <i>p</i> = 0.003) than transobturator tape. Postoperative complications were notably higher in the transobturator tape group, with significantly more patients reporting groin pain (28.6% vs. 4.7%, <i>p</i> = 0.002) and dyspareunia (20.0% vs. 0.0%, <i>p</i> = 0.002). Logistic regression analysis identified surgical method as the primary predictor of long-term well-being beyond one year (<i>p</i> = 0.040).</p><p><strong>Conclusions: </strong>While the transobturator tape and minisling surgeries are effective for treating stress urinary incontinence, the minisling method offers advantages, such as shorter operative time, reduced hospital stay, and fewer postoperative complications, over the transobturator tape method. These findings suggest that the minisling approach may provide a more favorable patient experience, particularly due to reduced postoperative pain and quick recovery, than the transobturator tape method.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"677-683"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of Recurrence in Elderly Patients with Kidney Stone by Using the Knowledge-Attitude-Practice Education Model: A Single-Centre, Retrospective Study.","authors":"Jianying Li, Dan Wang, Jing Zhu, Yanru Wang, Lidan Qi, Jing Li","doi":"10.56434/j.arch.esp.urol.20257806.94","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.94","url":null,"abstract":"<p><strong>Background: </strong>Kidney stones are common in elderly patients, and their high recurrence rate after surgery is a significant clinical issue. This single-centre retrospective study aimed to assess the impact of the knowledge-attitude-practice (KAP) education model on preventing kidney stone recurrence in elderly patients.</p><p><strong>Methods: </strong>Elderly patients who underwent kidney stone surgery from January 2022 to January 2023 were divided into an intervention group and a control group based on the KAP education model intervention. The recurrence of stones, renal function, calcium and phosphorus metabolism, and urine indices were compared before and 3 months after treatment in the two groups.</p><p><strong>Results: </strong>The recurrence rates of kidney stones in the intervention group at 6 months, 1 year and 2 years after the surgery were all lower than the control group (<i>p</i> < 0.05). The levels of serum creatinine, blood urea nitrogen, uric acid and cystatin C in both groups 3 months after the intervention were lower than those before the treatment, and the reduction of each renal function index in the intervention group was more significant (<i>p</i> < 0.05). The total 24-hour urine volume in both groups was higher than before treatment, while urinary calcium, urinary oxalate and urinary uric acid (UA) were lower. The improvement of each urine index was more obvious in the intervention group (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>The KAP education model has a significant effect on preventing the recurrence of kidney stones in elderly patients.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"703-709"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Diagnostic Value of Combined Urinary Dry Chemistry Analysis and Urinary Sediment Analysis for Urinary Tract Infections.","authors":"Jinyang Li, Yijia Liang, Yanli Zou, Yun Zhao","doi":"10.56434/j.arch.esp.urol.20257806.97","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.97","url":null,"abstract":"<p><strong>Objective: </strong>Urinary dry chemistry and urinary sediment microscopy have gradually become important auxiliary methods for the diagnosis of urinary tract infection (UTI). This study aimed to explore the application value of the combination of the two in diagnosing UTI.</p><p><strong>Methods: </strong>Patients with suspected UTI who were admitted to our hospital from October 2022 to October 2024 were retrospectively collected. All patients underwent urinary dry chemistry and urinary sediment microscopy. The number of red blood cells (RBCs), white blood cells (WBCs) and hyaline casts in the urine samples of the two groups was observed and compared. The diagnostic results of urine bacterial culture were used as the \"unified standard\" for diagnosis. The positive results of UTI in patients with two test methods and combined test method were compared. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value and consistency analysis were compared.</p><p><strong>Results: </strong>A total of 622 patients were enrolled, and 601 patients were finally included. No significant difference was found in the indices of urine RBCs, WBCs and hyaline casts between the two test methods (<i>p</i> > 0.05). Amongst the 601 patients who underwent urine culture and urine examination, 390 cases were finally confirmed to have UTI by urine culture, with a positive rate of 64.89%. The positive rate of urinary dry chemistry was 88.97%, and the positive rate of urinary sediment microscopy was 83.33%. The positive rate of combined detection was 93.85%, which was high (<i>p</i> < 0.05). According to the results of urine bacterial culture, the sensitivity, accuracy, negative predictive value and positive predictive value of the combined test were significantly higher than those of the single application test (<i>p</i> < 0.05). The diagnostic results of the combined test were highly consistent with the results of urine bacterial culture (κ = 0.795, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Combined testing has a high value in diagnosing UTI. It can significantly improve the diagnostic efficiency of UTI.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"726-731"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Transcutaneous Electrical Acupoint Stimulation at the Sanyinjiao Point on Preventing Bladder Spasm after Transurethral Laser Prostatectomy.","authors":"Kaiyue Sui, Qi Yang, Mingwei Li, Jinhui Yang","doi":"10.56434/j.arch.esp.urol.20257806.99","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.99","url":null,"abstract":"<p><strong>Background: </strong>Bladder spasm is a common complication after transurethral laser prostatectomy. Herein, we aimed to assess the effect of transcutaneous electrical acupoint stimulation (TEAS) at the Sanyinjiao point on relieving bladder spasm after transurethral laser prostatectomy.</p><p><strong>Methods: </strong>The medical data of patients undergoing transurethral laser prostatectomy were retrospectively collected from May 2021 to May 2024. Patients were divided into treatment (with TEAS at the Sanyinjiao point) and control (without TEAS at the Sanyinjiao point) groups. Basic characteristics, postoperative spasticity, prostate function, bladder function, urinary function and adverse events were compared between the groups.</p><p><strong>Results: </strong>A total of 150 patients were enrolled and classified according to whether they were treated with TEAS at the Sanyinjiao point: 67 cases in the treatment group and 83 cases in the control group. After a 5-day treatment, postoperative spasticity was mitigated in the treatment group compared with the control group, as evidenced by decreases in postoperative bladder spasm duration, frequency of spasm, visual analogue scale score and use of drotaverine hydrochloride (<i>p</i> < 0.05). After a 1-month treatment, prostate, bladder and urinary function showed considerable improvement in the treatment group compared with the control group, as evidenced by a decrease in International Prostate Symptom Scale score, Patient Perception Of Bladder Condition score, Overactive Bladder Symptom Score, residual urine volume, urinary incontinence and uroschesis and an increase in maximum urine flow rate (<i>p</i> < 0.05). No considerable difference in the incidence of adverse events was observed between groups (<i>p</i> = 0.174).</p><p><strong>Conclusions: </strong>TEAS at the Sanyinjiao point effectively relieves bladder spasm after transurethral laser prostatectomy, with a reasonable degree of safety.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"743-750"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin E Supplementation is Effective in Improving Clinical Symptoms and Reducing Renal Scarring in Children with Acute Pyelonephritis: A Retrospective Study.","authors":"Xiaomei Zhong, Juan Tang, Hong Jiang, Mingcheng Zhang, Yuanwei Zhai","doi":"10.56434/j.arch.esp.urol.20257806.95","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.95","url":null,"abstract":"<p><strong>Background: </strong>Urinary tract infection (UTI) is common in children. In particular, acute pyelonephritis (APN) may cause irreversible renal scarring (RS). This retrospective study aimed to evaluate the effects of vitamin E (VE) supplementation on children with APN.</p><p><strong>Methods: </strong>A retrospective analysis was performed on the medical records of children with APN who were admitted to our hospital from January 2022 to January 2024. The patients were divided into two groups according to treatment method: The conventional group (received conventional antibiotic treatment) and the VE group (received vitamin E supplement on the basis of antibiotic treatment). Symptom improvement time, laboratory indices and RS were compared between the two groups.</p><p><strong>Results: </strong>This study enrolled 86 patients, including 41 in the VE group and 45 in the conventional group. Baseline characteristics were not significantly different between the two groups (<i>p</i> > 0.05). The improvement time of fever and other clinical symptoms in the VE group was shorter than that in the conventional group (<i>p</i> < 0.05). Before treatment, the levels of red blood cells, white blood cells, squamous epithelial cells, bacteria, interleukin-6, interleukin-8 and heparin-binding protein in urine were not significantly different between the two groups (<i>p</i> > 0.05). After treatment, these values in the VE group were lower than those in the conventional group (<i>p</i> < 0.05). After 6 months of follow-up, the incidence of RS in the VE group was significantly lower than that in the conventional group (<i>p</i> < 0.05). Further subgroup analyses showed that vitamin E reduced the incidence of RS in children of all ages and genders (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>Vitamin E can effectively shorten the time to improvement of clinical symptoms and laboratory indicators in children with APN and reduce the incidence of RS.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"710-715"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Re: Research Progress on the Correlation between PI-RADS v2.1 Combined with ADC Values and Prostate Gleason Risk Stratification.","authors":"Guangling Kou, Zhiyun Wang, Lin Chen, Fei Gao","doi":"10.56434/j.arch.esp.urol.20257806.105","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.105","url":null,"abstract":"","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"788-789"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Selenoprotein P and Glutathione Expression in Relation to Sperm Kinetic Parameters in Patients with Asthenospermia.","authors":"Qianjin Xu, Ning Zhao","doi":"10.56434/j.arch.esp.urol.20257806.96","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.96","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the relationship amongst serum selenoprotein P (SeP), glutathione (GSH) expression and sperm kinetic parameters in patients with asthenospermia.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on men of reproductive age who underwent preconception testing at the Center for Reproductive Medicine between October 2022 and October 2024. The study subjects were divided into a case group and a healthy group based on the percentage of progressive motile sperm. Comparative analysis was performed to analyse the serum SeP of the two groups, GSH and spermatozoa kinetic parameters.</p><p><strong>Results: </strong>A total of 147 cases were included in the case group and 151 cases into the healthy group. Significant differences in body mass index (BMI), smoking addicted population, regular drinking behavioural population and daily sleep hours were observed between the two groups (<i>p</i> < 0.001). Forward-moving spermatozoa, sperm concentration and total sperm survival were significantly higher in the healthy group than in the case group, whereas the number of non-anterior motion force was significantly lower in the healthy group than in the case group (<i>p</i> < 0.001). The serum SeP and GSH levels of the case group were significantly lower than those in the healthy group (<i>p</i> < 0.001). SeP was negatively correlated with non-anterior motion force (r = -0.476) and positively correlated with other sperm kinetic parameters (r_{forward-moving spermatozoa} = 0.473/r_{sperm concentration} = 0.485/r_{Total sperm viability} = 0.518). GSH was negatively correlated with non-anterior motion force (r = -0.601) and positively correlated with other sperm kinetic parameters (r_{forward-moving spermatozoa} = 0.518/r_{sperm concentration} = 0.554/r_{Total sperm viability} = 0.524), with all correlations being statistically significant (<i>p</i> < 0.001). Multivariate linear regression analyses showed that the BMI (β = -0.217, <i>p</i> < 0.001), daily sleep time (β = 0.236, <i>p</i> < 0.001), SeP (β = 0.253, <i>p</i> < 0.001), GSH (β = 0.325, <i>p</i> < 0.001), presence of smoking addictive behaviours (β = -0.085, <i>p</i> = 0.031) and presence of regular alcohol consumption behaviours (β = -0.083, <i>p</i> = 0.034) were the factors influencing forward-moving spermatozoa. Malondialdehyde showed a negative correlation with SeP and GSH (r = -0.471, -0.543, <i>p</i> < 0.001). SeP and GSH showed good efficacy in the diagnosis of asthenospermia (area under curve (AUC) = 0.824, 0.852).</p><p><strong>Conclusions: </strong>Serum SeP and GSH levels are closely associated with sperm kinetic parameters in patients with asthenospermia, and the mechanism may be related to an imbalance in the antioxidant defence system and oxidative stress damage.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"716-725"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between Mini-Percutaneous Nephrolithotomy and Flexible Ureteroscopy for Patients with Upper Calyceal Calculi Larger than 2 cm.","authors":"Zafer Gokhan Gurbuz, Kadir Karkin, Mubariz Aydamirov, Bugra Aksay, Ediz Vuruskan","doi":"10.56434/j.arch.esp.urol.20257806.88","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.88","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the results of flexible ureteroscopy with holmium laser lithotripsy (FURSL) and mini-percutaneous nephrolithotomy (mini-PNL) for the treatment of >2 cm upper calyceal stones.</p><p><strong>Methods: </strong>The data of patients who underwent FURSL and mini-PNL surgery for kidney stones between May 2011 and June 2023 were retrospectively examined. Patients with single or multiple kidney stones located in the upper calyx and varying in diameter from 2 cm to 4 cm were included in the study. Operation time, hospitalisation time, complication rates and 1 month stone-free rate (SFR) were compared between the two surgical methods. Stone-free status was evaluated by performing non-contrast computed tomography 1 month after the surgery.</p><p><strong>Results: </strong>A total of 73 (49.3%) and 75 (50.7%) patients were included in the FURSL and mini-PNL groups, respectively. The mean operation time (72.5 vs. 89.7 min) and hospital stay (1.2 vs. 2.1 days) were shorter in the FURSL group (<i>p</i> < 0.001). Although complications were less common in the FURSL group, the difference was not statistically significant (12.3% vs. 21.3%, <i>p</i> = 0.199). The 1 month SFRs were 83.6% and 90.7% in the FURSL and mini-PNL groups, respectively, without statistically significant difference between the groups (<i>p</i> = 0.461).</p><p><strong>Conclusions: </strong>Both surgical approaches are equally effective and safe for the treatment of >2 cm upper calyceal stones. Short surgery and hospitalisation times are the most important advantages of FURSL. This type of surgery can be recommended as an alternative treatment to mini-PNL, with lower complication rates in selected patients.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"653-659"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}