Archivos Espanoles De Urologia最新文献

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Evaluation of the Concordance Between Clinical Indications and Urodynamic Findings: A Single-Center Retrospective Study. 评价临床适应症与尿动力学结果之间的一致性:一项单中心回顾性研究。
IF 0.9 4区 医学
Archivos Espanoles De Urologia Pub Date : 2026-03-01 DOI: 10.56434/j.arch.esp.urol.20267902.27
Salim Zengin, Abdullah Gul, Caglar Boyaci
{"title":"Evaluation of the Concordance Between Clinical Indications and Urodynamic Findings: A Single-Center Retrospective Study.","authors":"Salim Zengin, Abdullah Gul, Caglar Boyaci","doi":"10.56434/j.arch.esp.urol.20267902.27","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20267902.27","url":null,"abstract":"<p><strong>Objective: </strong>The diagnostic value of urodynamic investigation, which is used to characterise the underlying pathophysiology of lower urinary tract symptoms, varies depending on the appropriateness of its clinical indications. This study aimed to assess the correlation between urodynamic indications and findings and identify the clinical factors associated with this relationship.</p><p><strong>Materials and methods: </strong>Adult patients who underwent urodynamic evaluation between December 2023 and June 2025 at the Urology Department of the University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital were retrospectively evaluated. All assessments were conducted in accordance with the International Continence Society \"Good Urodynamic Practice\" guidelines. Demographic characteristics, laboratory data, ultrasonographic findings and uroflowmetry parameters were recorded. Concordance was defined as the detection of any clinically relevant urodynamic abnormality capable of explaining the patient's presenting symptoms or the indication for testing, and its association with clinical and urodynamic variables was statistically analysed.</p><p><strong>Results: </strong>A total of 144 patients were included in the study. The overall concordance rate between clinical indications and urodynamic findings was 66%. Neurological disorders (neurogenic lower urinary tract dysfunction, NLUTD) were present in 40.3% of patients, and concordance was significantly elevated in this group (<i>p</i> = 0.002). Patients with upper urinary tract involvement also demonstrated increased concordance (<i>p</i> = 0.005). Reduced maximum flow rate (Qmax), decreased voided volume and elevated post-void residual (PVR) volume were significantly associated with concordance (<i>p</i> = 0.005, <i>p</i> = 0.007 and <i>p</i> = 0.001, respectively).</p><p><strong>Conclusions: </strong>Urodynamic evaluation is an essential tool in the diagnosis of lower urinary tract dysfunctions; However, its diagnostic yield varies across different clinical settings. Our findings indicate that the request for urodynamics is particularly justified in patients with NLUTD, upper urinary tract involvement, low flow rates or high PVR volumes. Therefore, urodynamic testing should be prioritised in cases with a high likelihood of diagnostic benefit, whereas its routine use should be carefully reconsidered in clinically uncomplicated or mild presentations, where the additional diagnostic yield may be limited.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 2","pages":"224-232"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Cinacalcet Combined With Sevelamer Hydrochloride on the Incidence of Urolithiasis in Maintenance Hemodialysis Patients With Diabetic Kidney Disease. Cinacalcet联合盐酸西维拉默对糖尿病肾病维持性血液透析患者尿石症发生率的影响。
IF 0.9 4区 医学
Archivos Espanoles De Urologia Pub Date : 2026-03-01 DOI: 10.56434/j.arch.esp.urol.20267902.39
Danyang Zhang, Jian Lu, Shimin Jiang, Danyang Li, Wenge Li
{"title":"Effect of Cinacalcet Combined With Sevelamer Hydrochloride on the Incidence of Urolithiasis in Maintenance Hemodialysis Patients With Diabetic Kidney Disease.","authors":"Danyang Zhang, Jian Lu, Shimin Jiang, Danyang Li, Wenge Li","doi":"10.56434/j.arch.esp.urol.20267902.39","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20267902.39","url":null,"abstract":"<p><strong>Background: </strong>Diabetic kidney disease is a major cause of end-stage renal disease, and patients undergoing maintenance haemodialysis are at high risk of urolithiasis due to metabolic disorders. Sevelamer hydrochloride alone has limited efficacy in preventing urolithiasis, whilst the combined effect of cinacalcet and sevelamer hydrochloride lacks sufficient evidence-based support.</p><p><strong>Methods: </strong>The clinical data of 120 patients in our hospital from January 2020 to December 2023 were retrospectively collected. The patients were divided into a combined group (n = 60, cinacalcet + sevelamer hydrochloride) and a control group (n = 60, sevelamer hydrochloride alone), and their baseline data were collected. The incidence, recurrence rate, maximum stone diameter, urinary pH, 24-hour urine volume and urinary calcium were compared at 6 and 12 months of treatment.</p><p><strong>Results: </strong>No statistically significant differences in baseline data were found (<i>p</i> > 0.05), indicating comparability. At 6 and 12 months, urolithiasis incidence (11.67%, 18.33%) and recurrence rate (11.11%, 33.33%) in the combined group were significantly lower than those in the control group (30.00%, 50.00% and 45.45%, 72.73%, respectively; <i>p</i> < 0.05). The combined group also exhibited higher urine pH and 24-hour urine volume, lower urinary calcium levels and smaller maximum stone diameter compared with the control group (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Cinacalcet combined with sevelamer hydrochloride can effectively reduce the incidence and recurrence rate of urolithiasis, inhibit stone enlargement and regulate urine pH in patients with diabetic kidney disease undergoing maintenance haemodialysis. It has a positive effect on the prevention and improvement of urolithiasis and can be considered as one of the preferred clinical treatment options for these patients.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 2","pages":"327-334"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Urinary Biomarkers for the Early Detection of Urological Cancers: From Proteins and Epigenetics to Gene Mutations. 泌尿系统癌症早期检测的尿液生物标志物研究进展:从蛋白质和表观遗传学到基因突变。
IF 0.9 4区 医学
Archivos Espanoles De Urologia Pub Date : 2026-03-01 DOI: 10.56434/j.arch.esp.urol.20267902.23
Huahui Li, Feng Zhang, Xiaoli Liu, Lei Wang
{"title":"Advances in Urinary Biomarkers for the Early Detection of Urological Cancers: From Proteins and Epigenetics to Gene Mutations.","authors":"Huahui Li, Feng Zhang, Xiaoli Liu, Lei Wang","doi":"10.56434/j.arch.esp.urol.20267902.23","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20267902.23","url":null,"abstract":"<p><p>Urological malignancies, primarily including renal cell carcinoma, bladder cancer and prostate cancer, underscore the critical importance of early screening, diagnosis and treatment in inhibiting disease progression and improving patient prognosis. Advancements in molecular biology have established urinary biomarkers as promising noninvasive tools with considerable potential for early tumour detection and screening high-risk populations, potentially overcoming limitations associated with traditional invasive procedures and imaging. This review systematically summarises urinary biomarkers related to renal cell carcinoma, bladder cancer and prostate cancer. It focuses on protein biomarkers (e.g., cytokeratin and nuclear matrix protein 22), epigenetic and transcriptional biomarkers (e.g., microRNAs and long noncoding RNAs), genetic biomarkers (e.g., telomerase reverse transcriptase and fibroblast growth factor receptor 3) and emerging biomarkers (metabolomic markers, circulating tumour DNA and mass spectrometry-based high-throughput proteomics). This review provides an in-depth exploration of the molecular mechanisms, diagnostic performance (sensitivity and specificity), current clinical applications and limitations of various biomarkers, placing a particular emphasis on comparing the differential expression of the same biomarker across different cancer types. By building on this foundation, this review further outlines future development pathways, including multibiomarker combination strategies, AI-assisted analysis and standardised testing protocols, to offer comprehensive references for the early, noninvasive and precise diagnosis of urological tumours.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 2","pages":"188-199"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Value of a Multiparametric Model Based on Pelvic Floor Ultrasound for Postpartum Stress Urinary Incontinence. 基于盆底超声多参数模型对产后应激性尿失禁的诊断价值。
IF 0.9 4区 医学
Archivos Espanoles De Urologia Pub Date : 2026-03-01 DOI: 10.56434/j.arch.esp.urol.20267902.41
Bo Hu, Lei Dong, Linju Zhou, Xiaofang Xiao, Yuqing Zhou, Lili Shi
{"title":"Diagnostic Value of a Multiparametric Model Based on Pelvic Floor Ultrasound for Postpartum Stress Urinary Incontinence.","authors":"Bo Hu, Lei Dong, Linju Zhou, Xiaofang Xiao, Yuqing Zhou, Lili Shi","doi":"10.56434/j.arch.esp.urol.20267902.41","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20267902.41","url":null,"abstract":"<p><strong>Background: </strong>To explore the diagnostic value of a multiparametric model based on pelvic floor ultrasound for postpartum stress urinary incontinence (SUI).</p><p><strong>Methods: </strong>Between November 2023 and December 2024, 102 postpartum SUI patients (SUI group) and 96 healthy controls (control group) were enrolled. After 1:1 propensity score matching (caliper width = 0.02), 60 cases per group were analysed. Pelvic floor ultrasound was used to measure posterior urethrovesical angle at rest (Ar)/angle during Valsalva (As), urethral rotation angle (URA), bladder neck mobility (BNM), and bladder neck funnel formation. A multiparametric model was constructed using logistic regression and evaluated using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>The SUI group exhibited significantly higher URA, BNM, and bladder neck funnel formation rates than the control group (all <i>p</i> < 0.05). These three parameters were identified as independent SUI predictors with no multicollinearity (variance inflation factor (VIF) < 5). The multiparametric model achieved an area under the ROC curve of 0.863 (95% confidence interval (CI): 0.798-0.927), significantly higher than any single parameter (<i>p</i> < 0.05), with a sensitivity of 78.50% and a specificity of 89.80% at the optimal cut-off value.</p><p><strong>Conclusions: </strong>The multiparametric pelvic floor ultrasound model, which integrated URA, BNM, and bladder neck funnel formation, demonstrated good diagnostic performance for postpartum SUI. This non-invasive tool, complemented by a constructed nomogram, provides a methodological basis for early identification of postpartum SUI in clinical practice, pending further multicentre validation.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 2","pages":"344-351"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of an Innovative Multi-disciplinary Perioperative Nursing Model on Outcomes and Quality of Life in Kidney Transplant Recipients. 创新的多学科围手术期护理模式对肾移植受者预后和生活质量的影响。
IF 0.9 4区 医学
Archivos Espanoles De Urologia Pub Date : 2026-03-01 DOI: 10.56434/j.arch.esp.urol.20267902.35
Mengmeng Wang, Lina Guo, Wenting Wang, Xiangyu Zhang, Qingqing Shi, Guangyun Ji
{"title":"Influence of an Innovative Multi-disciplinary Perioperative Nursing Model on Outcomes and Quality of Life in Kidney Transplant Recipients.","authors":"Mengmeng Wang, Lina Guo, Wenting Wang, Xiangyu Zhang, Qingqing Shi, Guangyun Ji","doi":"10.56434/j.arch.esp.urol.20267902.35","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20267902.35","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplantation remains the optimal treatment for end-stage renal disease. Perioperative management is crucial for short-term recovery and long-term graft outcomes. The Rosenthal effect demonstrates how positive expectations enhance results via self-fulfilling predictions, exhibiting advantages in healthcare settings; however, it remains understudied in transplant care. This study evaluated an innovative multi-disciplinary perioperative nursing model incorporating the Rosenthal effect for kidney transplant recipients compared with standard care.</p><p><strong>Methods: </strong>A retrospective cohort study included 144 kidney transplant recipients (July 2021-May 2025) divided into the innovative care (n = 74) and standard care (n = 70) groups. The innovative care group received multi-disciplinary team support with Rosenthal effect-based psychological care protocols, Enhanced Recovery After Surgery protocols and 3-month digital follow-up. The primary outcomes were graft survival and acute rejection rates. The secondary outcomes included psychological status (anxiety and depression), quality of life, medication adherence, 36-Item Short-Form Health Survey (SF-36) and Pittsburgh Sleep Quality Index. Statistical analysis included independent <i>t</i>-tests, chi-square tests and Kaplan-Meier survival analysis.</p><p><strong>Results: </strong>The innovative care group achieved superior 1-year graft survival (97.30% vs 91.43%, <i>p</i> = 0.042), reduced acute rejection (10.81% vs 24.29%, <i>p</i> = 0.031), lowered anxiety scores (40.34 ± 4.32 vs 44.36 ± 4.15, <i>p</i> < 0.001) and improved quality of life with higher SF-36 physical (48.76 ± 8.12 vs 42.34 ± 9.45, <i>p</i> < 0.001) and mental component scores (68.44 ± 8.91 vs 63.75 ± 9.12, <i>p</i> = 0.002).</p><p><strong>Conclusions: </strong>The novel multi-disciplinary nursing model was associated with significantly improved clinical outcomes, psychological status and quality of life in kidney transplant recipients. These findings support further investigation through prospective randomised trials.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 2","pages":"290-297"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress in Integrated Traditional Chinese and Western Medicine for Perimenopausal Urinary Incontinence Based on Assessment of Urinary Function Parameters. 基于尿功能参数评估的中西医结合治疗围绝经期尿失禁的研究进展
IF 0.9 4区 医学
Archivos Espanoles De Urologia Pub Date : 2026-03-01 DOI: 10.56434/j.arch.esp.urol.20267902.22
Yufeng Zhang, Hongyu Ji, Zhen Liu, Yujuan Jiao
{"title":"Research Progress in Integrated Traditional Chinese and Western Medicine for Perimenopausal Urinary Incontinence Based on Assessment of Urinary Function Parameters.","authors":"Yufeng Zhang, Hongyu Ji, Zhen Liu, Yujuan Jiao","doi":"10.56434/j.arch.esp.urol.20267902.22","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20267902.22","url":null,"abstract":"<p><p>Integrated traditional Chinese medicine (TCM) and Western medicine for perimenopausal urinary incontinence combines the holistic regulatory concepts of TCM with the targeted therapeutic approaches of Western medicine, aiming to synergistically improve patients'incontinence symptoms and overall quality of life. Whilst effective, conventional Western therapies, such as pharmacotherapy and pelvic floor muscle training, can be limited by side effects (e.g., dry mouth from anticholinergics) and suboptimal long-term compliance. Conversely, the advantages of TCM interventions, including acupuncture and herbal formulations, have often been constrained by a reliance on subjective symptom scores, lacking robust objective metrics in efficacy evaluation. Quantitative urodynamic parameters, such as maximum cystometric capacity, detrusor pressure at end filling, abdominal leak point pressure and maximum urethral closure pressure, provide a critical and objective toolset for quantifying lower urinary tract function and therapeutic outcomes. In recent years, alongside the broadened clinical adoption of urodynamic studies, research has increasingly focused on evaluating the specific effects of combined therapies (e.g., acupuncture or herbal medicine integrated with pelvic floor rehabilitation or pharmacotherapy) on these objective parameters. This article reviews the clinical research progress in evaluating integrated TCM and Western medicine treatment for perimenopausal urinary incontinence, using urinary function parameters as the core assessment tool. Key findings, mechanistic insights and prevalent methodological limitations within the existing literature are synthesised. The review aims to provide a scientific reference to inform clinical decision-making and future research directions in treatment strategy selection for this prevalent condition.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 2","pages":"179-187"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Study of the Efficacy and Complications of Urethral Realignment and Primary Urethral Anastomosis for Traumatic Urethral Injuries in Emergency Surgical Management. 尿道调整术与原尿道吻合术在创伤性尿道损伤急诊外科治疗中的疗效及并发症比较研究。
IF 0.9 4区 医学
Archivos Espanoles De Urologia Pub Date : 2026-03-01 DOI: 10.56434/j.arch.esp.urol.20267902.40
Zhijun Wang, Xiao Wang, Jiehao Zhou
{"title":"Comparative Study of the Efficacy and Complications of Urethral Realignment and Primary Urethral Anastomosis for Traumatic Urethral Injuries in Emergency Surgical Management.","authors":"Zhijun Wang, Xiao Wang, Jiehao Zhou","doi":"10.56434/j.arch.esp.urol.20267902.40","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20267902.40","url":null,"abstract":"<p><strong>Objective: </strong>Traumatic urethral injuries (TUI) represent a critical urological emergency. This study aims to compare the efficacy and complications of urethral realignment and primary urethral anastomosis in the management of TUI.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients treated at Fuyang People's Hospital between January 2022 and December 2024. The patients were categorised into urethral realignment and primary anastomosis groups according to the surgical procedure performed. Outcomes assessed included operative time, blood loss, hospital stay, catheterisation duration, pain (Visual Analogue Scale), inflammatory markers (C-reactive protein, interleukin-6 and tumour necrosis factor-α), functional parameters (maximum urinary flow rate, Q<sub>max</sub>; post-void residual volume; International Index of Erectile Function-5, IIEF-5) after 3 months of follow-up and postoperative complications within 6 months.</p><p><strong>Results: </strong>Among 129 eligible patients, 71 underwent urethral realignment and 58 underwent primary urethral anastomosis. The realignment group had a shorter average operative time (98.43 ± 23.67 vs. 143.27 ± 31.85 min, <i>p</i> < 0.001), less blood loss (87.62 ± 28.41 vs. 152.89 ± 45.73 mL, <i>p</i> < 0.001), lower pain scores (3.62 ± 0.89 vs. 4.28 ± 1.13, <i>p</i> < 0.001) and reduced inflammatory markers (all <i>p</i> < 0.01). The anastomosis group showed better urinary flow (Q<sub>max</sub>: 22.47 ± 3.88 vs. 18.93 ± 4.26 mL/s, <i>p</i> < 0.001), lower residual volume (18.59 ± 9.46 vs. 26.84 ± 12.73 mL, <i>p</i> < 0.001), higher IIEF-5 scores (19.42 ± 2.39 vs. 18.27 ± 2.23, <i>p</i> = 0.006) and a lower stricture rate (5.17% vs. 18.31%, <i>p</i> = 0.024).</p><p><strong>Conclusions: </strong>Urethral realignment offers advantages in operative efficiency and early postoperative recovery parameters (pain, inflammation), whereas primary urethral anastomosis provides superior long-term functional outcomes with a lower risk of stricture and a shorter catheterisation period.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 2","pages":"335-343"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distribution of PD-1.5 Gene Variant (rs2227981): A Possible Approach for Risk Assessment in Bladder Cancer. PD-1.5基因变异(rs2227981)的分布:膀胱癌风险评估的可能方法
IF 0.9 4区 医学
Archivos Espanoles De Urologia Pub Date : 2026-03-01 DOI: 10.56434/j.arch.esp.urol.20267902.28
Kemal Kayar, Levent Verim, Dilara Sonmez, Mustafa Kadihasanoglu, Seyda Demirkol, Ozlem Kucukhuseyin, Mehmet Tolgahan Hakan, Yosra Lamami, Bayram Kiran, Ilhan Yaylim
{"title":"Distribution of PD-1.5 Gene Variant (rs2227981): A Possible Approach for Risk Assessment in Bladder Cancer.","authors":"Kemal Kayar, Levent Verim, Dilara Sonmez, Mustafa Kadihasanoglu, Seyda Demirkol, Ozlem Kucukhuseyin, Mehmet Tolgahan Hakan, Yosra Lamami, Bayram Kiran, Ilhan Yaylim","doi":"10.56434/j.arch.esp.urol.20267902.28","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20267902.28","url":null,"abstract":"<p><strong>Background/aim: </strong>Immune checkpoint pathways are central to tumor immune evasion, and genetic variants of programmed death-1 (PD-1) may influence cancer susceptibility. This study evaluates the association between the PD-1.5 (rs2227981) polymorphism and the risk of bladder cancer (BC) in the Turkish population.</p><p><strong>Materials and methods: </strong>The study included 151 participants, consisting of 53 patients with BC and 98 healthy control individuals. Genotyping of the PD-1.5 (C/T) polymorphism was carried out using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Genotype and allele distributions were compared between groups, and logistic regression models were applied to calculate odds ratios (ORs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>The CC, CT, and TT genotypes were observed in 33.96%, 43.40%, and 22.64% of patients and in 48.98%, 40.82%, and 10.20% of controls, respectively. The recessive model (TT vs. CC + CT) differed significantly between cases and controls (<i>p</i> = 0.023), and the C allele was less frequent in patients (<i>p</i> = 0.039). In univariate logistic regression, carriage of the T allele showed a borderline association with increased BC risk (OR = 1.867, 95% CI = 0.934-3.732; <i>p</i> = 0.077), whereas carriage of the C allele was significantly associated with reduced risk (OR = 0.388, 95% CI = 0.155-0.972; <i>p</i> = 0.043). In multivariate models adjusted for age, sex, and smoking status, the C allele remained an independent protective factor (adjusted OR = 0.319, 95% CI = 0.112-0.906; <i>p</i> = 0.045), while older age, male sex, and smoking were independently associated with an elevated risk of BC.</p><p><strong>Conclusions: </strong>The PD-1.5 (rs2227981) polymorphism appears to influence bladder cancer susceptibility in the Turkish population, with the TT genotype conferring increased risk and the C allele providing protection. These findings highlight the potential role of PD-1.5 as a genetic marker for BC risk, although validation in larger and more diverse cohorts is required.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 2","pages":"233-240"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spanish Cross-Cultural Adaptation and Psychometric Validation of the Pelvic Floor Bother Questionnaire. 西班牙跨文化适应和骨盆底困扰问卷的心理测量验证。
IF 0.9 4区 医学
Archivos Espanoles De Urologia Pub Date : 2026-03-01 DOI: 10.56434/j.arch.esp.urol.20267902.24
Marta María Córdoba-Peláez, Guadalupe Molina-Torres, Leticia Amiano-López, Anna Rutkowska, Irene Sandoval-Hernández, Manuel Gonzalez-Sanchez
{"title":"Spanish Cross-Cultural Adaptation and Psychometric Validation of the Pelvic Floor Bother Questionnaire.","authors":"Marta María Córdoba-Peláez, Guadalupe Molina-Torres, Leticia Amiano-López, Anna Rutkowska, Irene Sandoval-Hernández, Manuel Gonzalez-Sanchez","doi":"10.56434/j.arch.esp.urol.20267902.24","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20267902.24","url":null,"abstract":"<p><strong>Background: </strong>Pelvic floor dysfunction (PFD) affects all aspects of life in women. The Pelvic Floor Bother Questionnaire (PFBQ) is a comprehensive questionnaire that objectively assesses how PFD affects a patient's quality of life (QoL). However, owing to the absence of a Spanish version of this questionnaire, it cannot be used in Spanish-speaking countries.</p><p><strong>Methods: </strong>A cross-cultural adaptation process was performed in five steps in accordance with the International Test Commission Guidelines. Subsequently, a validation study of the Spanish version of the PFBQ (PFBQ-Sp) was conducted. Reliability, internal consistency and validity were analysed using the Urogenital Distress Inventory, EuroQol 5-Dimension Health Questionnaire (EuroQoL-5D), 12-Item Short Form Health Survey (SF-12), Female Sexual Function Index and measures of error and responsiveness. A total of 243 women participated in this study, and data were collected between March and December 2022.</p><p><strong>Results: </strong>A total of 243 women were enrolled. The instrument showed good reliability, as indicated by a Cronbach's α of 0.915 and test-retest reproducibility (intraclass correlation coefficient: 0.773-0.868). Measurement error, expressed as the standard error of measurement, was 1.155, and the corresponding minimal detectable change at 90% confidence was 2.695.</p><p><strong>Conclusions: </strong>The PFBQ-Sp has been shown to be a valid and reliable measure, suitable for the clinical and research assessment of PFDs in Spanish women.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 2","pages":"200-209"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Analysis Between Burst-Wave Lithotripsy vs Standard Ultrasound- Guided Extracorporeal Shock Wave Lithotripsy for 5-10 mm Ureteral Stones. 冲击波碎石术与标准超声引导体外冲击波碎石术治疗5 ~ 10mm输尿管结石的比较分析。
IF 0.9 4区 医学
Archivos Espanoles De Urologia Pub Date : 2026-03-01 DOI: 10.56434/j.arch.esp.urol.20267902.36
Ankang Yu, Pin Wu
{"title":"Comparative Analysis Between Burst-Wave Lithotripsy vs Standard Ultrasound- Guided Extracorporeal Shock Wave Lithotripsy for 5-10 mm Ureteral Stones.","authors":"Ankang Yu, Pin Wu","doi":"10.56434/j.arch.esp.urol.20267902.36","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20267902.36","url":null,"abstract":"<p><strong>Background: </strong>Although burst-wave lithotripsy (BWL) and ultrasound-guided extracorporeal shock wave lithotripsy (US-guided ESWL) are used for ureteral stones, direct comparative evidence to guide optimal clinical choice between them is limited. This work aimed to compare the efficacy differences between BWL and US-guided ESWL in treating 5-10 mm ureteral stones.</p><p><strong>Methods: </strong>This retrospective study included 100 patients with 5-10 mm ureteral stones treated between January 2022 and January 2024. The patients were divided into two groups of 50 patients each on the basis of treatment modality: the BWL group and the US-guided ESWL group. Baseline characteristics were balanced and comparable between groups ( <i>p</i> > 0.05). The efficacy and safety of the two therapies were systematically evaluated by comparing various indicators across both groups.</p><p><strong>Results: </strong>For ureteral stones measuring 5-10 mm, BWL demonstrated superior outcomes in terms of stone clearance rate (88.0% vs. 64.0%), reduced retreatment rates (6.0% vs. 24.0%) and treatment costs compared with US-guided ESWL. The BWL group also demonstrated greater improvements in postoperative pain, stone passage time and quality of life (85.5 ± 5.2 vs. 80.3 ± 6.7 points, all <i>p</i> < 0.05). Although the procedure duration of BWL was longer, no statistically significant difference was found in the complication rates between the two groups.</p><p><strong>Conclusions: </strong>For ureteral stones measuring 5-10 mm, BWL demonstrates significant advantages in key efficacy indicators. It should be considered the preferred treatment option.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 2","pages":"298-305"},"PeriodicalIF":0.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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