Examining the Association between ERG/PTEN Expression and Biochemical Recurrence in Prostate Cancer: A Comprehensive Meta-Analysis.

IF 0.6 4区医学 Q4 UROLOGY & NEPHROLOGY

Archivos Espanoles De Urologia Pub Date : 2025-01-01 DOI:10.56434/j.arch.esp.urol.20257801.4

Weijun Zhu, Weifei Chen

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引用次数: 0

Abstract

Background: ETS-related gene (ERG) rearrangement and tensin homolog (PTEN) deletion are common molecular alterations in prostate cancer. Their prognostic significance for biochemical recurrence (BCR) after radical prostatectomy is not fully understood. This study aimed to conduct a systematic review and meta-analysis to assess the association between ERG and PTEN status and BCR risk.

Methods: We systematically searched PubMed, Embase, Web of Science, and the Cochrane Library for studies on ERG/PTEN status and BCR following radical prostatectomy. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using fixed-effects and random-effects models to determine the risk associated with these biomarkers.

Results: The meta-analysis showed that ERG positivity was linked to a 35.38% increased risk of BCR (HR = 1.3538 (0.9517; 1.9256), p = 0.0920) with significant heterogeneity (I² = 69.3%, p = 0.0001). In subgroup analysis, ERG positivity was associated with increased BCR risk in both Asian (HR = 2.2538) and Caucasian (HR = 1.4387) populations. PTEN loss was associated with an 83.73% higher BCR risk (HR = 1.8373, 95% CI: 1.6469-2.0496, p < 0.0001) with low heterogeneity (I² = 16.3%, p = 0.2974).

Conclusions: Both ERG rearrangement and PTEN deletion are associated with an increased risk of BCR after radical prostatectomy. While these biomarkers may improve prognostic stratification, the prognostic value of ERG status varies across different populations, suggesting a need for personalized management strategies in prostate cancer based on molecular markers.

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ERG/PTEN表达与前列腺癌生化复发的关系：一项综合meta分析

背景：ets相关基因（ERG）重排和紧张素同源基因（PTEN）缺失是前列腺癌中常见的分子改变。它们对根治性前列腺切除术后生化复发（BCR）的预后意义尚不完全清楚。本研究旨在进行系统回顾和荟萃分析，以评估ERG和PTEN状态与BCR风险之间的关系。方法：我们系统地检索PubMed、Embase、Web of Science和Cochrane Library，获取根治性前列腺切除术后ERG/PTEN状态和BCR的相关研究。使用固定效应和随机效应模型计算合并风险比（hr）和95%置信区间（ci），以确定与这些生物标志物相关的风险。结果：meta分析显示，ERG阳性与BCR风险增加35.38%相关(HR = 1.3538 (0.9517；1.9256), p = 0.0920)，异质性显著（I2 = 69.3%, p = 0.0001）。在亚组分析中，ERG阳性与亚洲人群（HR = 2.2538）和高加索人群（HR = 1.4387） BCR风险增加相关。PTEN丢失与BCR风险增加83.73%相关（HR = 1.8373, 95% CI: 1.6469-2.0496, p < 0.0001），异质性较低（I2 = 16.3%, p = 0.2974）。结论：ERG重排和PTEN缺失与根治性前列腺切除术后BCR风险增加相关。虽然这些生物标记物可以改善预后分层，但ERG状态的预后价值在不同人群中存在差异，这表明需要基于分子标记物的前列腺癌个性化管理策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archivos Espanoles De Urologia UROLOGY & NEPHROLOGY-

CiteScore

0.90

自引率

0.00%

发文量

111

期刊介绍： Archivos Españoles de Urología published since 1944, is an international peer review, susbscription Journal on Urology with original and review articles on different subjets in Urology: oncology, endourology, laparoscopic, andrology, lithiasis, pediatrics , urodynamics,... Case Report are also admitted.