Current Opinion in Supportive and Palliative Care最新文献_第4页

The systemic outcomes of gastrointestinal mucositis: host-microbe interaction leading to systemic inflammatory responses. 胃肠道粘膜炎的全身后果：宿主与微生物相互作用导致全身炎症反应。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-06-01 Epub Date: 2024-04-30 DOI: 10.1097/SPC.0000000000000704

Andrea Stringer

引用次数: 0

Bridging research gaps in geriatric oncology: unraveling the potential of pragmatic clinical trials. 缩小老年肿瘤学研究的差距：发掘实用临床试验的潜力。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-03-01 Epub Date: 2023-12-22 DOI: 10.1097/SPC.0000000000000688

Carlos A Carmona-Gonzalez, Mateus T Cunha, Ines B Menjak

{"title":"Bridging research gaps in geriatric oncology: unraveling the potential of pragmatic clinical trials.","authors":"Carlos A Carmona-Gonzalez, Mateus T Cunha, Ines B Menjak","doi":"10.1097/SPC.0000000000000688","DOIUrl":"10.1097/SPC.0000000000000688","url":null,"abstract":"Purpose of review: This review examines the role of pragmatic clinical trials (PCTs) in addressing the underrepresentation of older adults with cancer (OAC) in clinical trials. Focusing on real-world evidence (RWE), it aims to provide a comprehensive overview of PCT utilization, emphasizing their potential to enhance treatment decisions and patient outcomes. Existing knowledge gaps in PCT implementation are also discussed.Recent findings: PCTs are identified as effective tools to include OACs with comorbidities and complex conditions in research, bridging the representation gap. Despite their proven value in healthcare provision, their application in OAC contexts remains limited, hindering comprehensive understanding and inclusivity in clinical trials.Summary: While randomized controlled trials (RCTs) are considered the gold standard in oncology research, OACs have historically been excluded, perpetuating underrepresentation. Furthermore, even in current oncology clinical development trials, this demographic continues to be underrepresented. PCTs offer a valuable avenue for the identification and evaluation of therapies within authentic RW contexts, encompassing various healthcare settings, such as hospitals, clinics, and physician practices. RCTs and PCTs complement one another, and the utilization of PCTs has the potential to inform clinical decision-making across the OACs entire treatment trajectory.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"3-8"},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual geriatric and frailty assessment for older adults with cancer. 为患有癌症的老年人提供虚拟老年病学和虚弱评估。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-03-01 Epub Date: 2024-01-26 DOI: 10.1097/SPC.0000000000000696

Isabel Tejero, Eva Amor, Olga Vázquez-Ibar

{"title":"Virtual geriatric and frailty assessment for older adults with cancer.","authors":"Isabel Tejero, Eva Amor, Olga Vázquez-Ibar","doi":"10.1097/SPC.0000000000000696","DOIUrl":"10.1097/SPC.0000000000000696","url":null,"abstract":"Purpose of review: Since SARS-CoV2 pandemic, many specialties have introduced virtual assessments within clinical practice. Conducting an online geriatric assessment, or relying on self-reported questionnaires, may be more challenging than a conventional medical appointment. This review aims to discuss the state of research on virtual assessment and self-reported questionnaires in the general geriatric population and specifically in Oncology.Recent findings: Virtual assessment of older adults has been the focus of two separate position papers. Aside from videoconferences or phone appointments, self-reported questionnaires have emerged in recent years as reliable tools to screen for frailty and triage patients who would benefit from a comprehensive in-person assessment, with adequate correlation with in-person tests, good acceptance by the respondents and being well received by healthcare providers. Although some have been tried in geriatric oncology, many still lack validation, and their widespread use may be limited by digital literacy, cognitive impairment, and social supports.Summary: The development, validation and adoption of self-reported questionnaires and virtual assessment in the care of older adults with cancer may overcome the staffing limitations and time constrains that frequently hampers the widespread evaluation of this population to improve their care.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"16-21"},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139567552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigating late effects in cancer survivors: harnessing personalised medicine and new models of care. 减轻癌症幸存者的晚期影响：利用个性化医疗和新的护理模式。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-03-01 Epub Date: 2024-01-31 DOI: 10.1097/SPC.0000000000000693

Joanne Bird, Sara Faithfull

引用次数: 0

Supportive and palliative care for older adults with cancer; facilitating person-centred, age friendly care. 为患有癌症的老年人提供支持性和姑息治疗；促进以人为本的老年友好型护理。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-03-01 Epub Date: 2024-01-31 DOI: 10.1097/SPC.0000000000000689

Christopher B Steer, Schroder Sattar, Ines Menjak

引用次数: 0

Age-friendly healthcare: integrating the 4Ms to enable age-friendly cancer care. 老年友好型医疗保健：整合 4Ms 以实现老年友好型癌症护理。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-03-01 Epub Date: 2024-01-04 DOI: 10.1097/SPC.0000000000000687

Oliver Hodge, Tshepo Rasekaba, Irene Blackberry, Christopher B Steer

{"title":"Age-friendly healthcare: integrating the 4Ms to enable age-friendly cancer care.","authors":"Oliver Hodge, Tshepo Rasekaba, Irene Blackberry, Christopher B Steer","doi":"10.1097/SPC.0000000000000687","DOIUrl":"10.1097/SPC.0000000000000687","url":null,"abstract":"Purpose of review: There is a growing movement towards person-centred, age-friendly healthcare in the care of older adults, including those with cancer. The Age-Friendly Health Systems (AFHS) initiative uses the 4Ms framework to enable this change. This review documents the utility and implications of 4Ms implementation across different settings, with a particular focus on cancer care.Recent findings: The AFHS initiative 4Ms framework uses a set of core, evidence-based guidelines (focussing on What Matters, Medication, Mentation and Mobility) to improve person-centred care. The successful implementation of the 4Ms has been documented in many different healthcare settings including orthopaedics primary care, and cancer care. Implementation of the 4Ms framework into existing workflows complements the use of geriatric assessment to improve care of older adults with cancer. Models for implementation of the 4Ms within a cancer centre are described. Active engagement and education of healthcare providers is integral to success. Solutions to implementing the What Matters component are addressed.Summary: Cancer centres can successfully implement the 4Ms framework into existing workflows through a complex change management process and development of infrastructure that engages healthcare providers, facilitating cultural change whilst employing quality improvement methodology to gradually adapt the status quo to age-friendly processes.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"9-15"},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139514014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence, description, predictors, and consequences of persistent taxane-induced peripheral neuropathy. 持续性紫杉类药物诱发的周围神经病变的发生率、描述、预测因素和后果。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2023-12-06 DOI: 10.1097/spc.0000000000000684

Daniel L Hertz

引用次数: 0

Exercise interventions for frail older adults with cancer. 对患有癌症的体弱老年人进行运动干预。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2023-12-06 DOI: 10.1097/spc.0000000000000685

Schroder Sattar, Kristen R Haase, Kayoung Lee, Kristin L Campbell

引用次数: 0

Mechanisms inherent in acute-to-chronic pain after surgery - risk, diagnostic, predictive, and prognostic factors. 手术后急性到慢性疼痛的内在机制——风险、诊断、预测和预后因素。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2023-12-01 Epub Date: 2023-09-08 DOI: 10.1097/SPC.0000000000000673

Daniela C Rosenberger, Daniel Segelcke, Esther M Pogatzki-Zahn

{"title":"Mechanisms inherent in acute-to-chronic pain after surgery - risk, diagnostic, predictive, and prognostic factors.","authors":"Daniela C Rosenberger, Daniel Segelcke, Esther M Pogatzki-Zahn","doi":"10.1097/SPC.0000000000000673","DOIUrl":"10.1097/SPC.0000000000000673","url":null,"abstract":"Purpose of review: Pain is an expected consequence of a surgery, but it is far from being well controlled. One major complication of acute pain is its risk of persistency beyond healing. This so-called chronic post-surgical pain (CPSP) is defined as new or increased pain due to surgery that lasts for at least 3 months after surgery. CPSP is frequent, underlies a complex bio-psycho-social process and constitutes an important socioeconomic challenge with significant impact on patients' quality of life. Its importance has been recognized by its inclusion in the eleventh version of the ICD (International Classification of Diseases).Recent findings: Evidence for most pharmacological and non-pharmacological interventions preventing CPSP is inconsistent. Identification of associated patient-related factors, such as psychosocial aspects, comorbidities, surgical factors, pain trajectories, or biomarkers may allow stratification and selection of treatment options based on underlying individual mechanisms. Consequently, the identification of patients at risk and implementation of individually tailored, preventive, multimodal treatment to reduce the risk of transition from acute to chronic pain is facilitated.Summary: This review will give an update on current knowledge on mechanism-based risk, prognostic and predictive factors for CPSP in adults, and preventive and therapeutic approaches, and how to use them for patient stratification in the future.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"324-337"},"PeriodicalIF":2.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10215493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should opioids be used for breathlessness and in whom? A PRO and CON debate of the evidence. 阿片类药物应该用于治疗呼吸困难吗?用于治疗谁?证据的正反辩论。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2023-12-01 Epub Date: 2023-10-26 DOI: 10.1097/SPC.0000000000000674

Magnus Ekström, Daisy J A Janssen

{"title":"Should opioids be used for breathlessness and in whom? A PRO and CON debate of the evidence.","authors":"Magnus Ekström, Daisy J A Janssen","doi":"10.1097/SPC.0000000000000674","DOIUrl":"10.1097/SPC.0000000000000674","url":null,"abstract":"Purpose of review The net clinical benefit of opioids for chronic breathlessness has been challenged by recent randomized clinical trials. The purpose was to review and weigh the evidence for and against opioid treatment for chronic breathlessness in people with serious disease. Recent findings Evidence to date on the efficacy and safety of opioids for chronic breathlessness was reviewed. Findings supporting a benefit from opioids in meta-analyses of earlier, mostly smaller trials were not confirmed by recent larger trials. Evidence pertains mostly to people with chronic obstructive pulmonary disease but also to people with pulmonary fibrosis, heart failure, and advanced cancer. Taken together, there is no consistent evidence to generally recommend opioids for severe breathlessness or to identify people who are more likely to benefit. Opioid treatment may be tested in patients with intractable breathlessness and limited other treatment options, such as in end-of-life care. Knowledge gaps were identified and recommendations were made for future research. Summary Key Points Supportive findings of net benefit of opioids for chronic breathlessness in earlier trials have not been confirmed by recent larger randomized clinical trials. There is no evidence that the opioid treatment improves the person’s exercise capacity or quality of life, and it increases the risk of adverse events. Evidence to date does not support that opioids should generally be recommended for treating breathlessness. In people with intractable symptoms and short expected survival, with few or no treatment options, it may still be reasonable to try opioid treatment with the aim to alleviate severe breathlessness. Research is needed to explore the potential benefit of opioids in selected patient groups. Opioids cannot be generally recommended for treating breathlessness based on insufficient evidence for net clinical benefit.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"263-269"},"PeriodicalIF":2.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10291345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0