The WHO guidelines: the new and the old.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-10 DOI:10.1097/spc.0000000000000722

Jo Thompson

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引用次数: 0

Abstract

PURPOSE OF THE REVIEW The original World Health Organisation (WHO) cancer pain guidelines were published in 1986 and used globally. Updated guidance was released in 2018. This review compares the 'old' with the 'new' with a closer look at the relevance of the WHO analgesic ladder in the current climate. RECENT FINDINGS The new guidelines provide a more evidence based, rigorously developed document including recommendations relating to radiotherapeutic management. There is a more detailed focus on safe opioid prescribing, opioid stewardship and the importance of integrating pain management expertise early on in the cancer journey. There remains a lack of evidence for certain therapies despite their widespread use particularly in relation to adjuvants. The pitfalls of the original renowned analgesic ladder are highlighted including a recognition that omitting 'step 2' is safe, feasible and cost effective. SUMMARY The new guidelines offer more detailed recommendations relevant to clinical practice with a strong focus on safety of opioid prescribing making it relevant in the current climate. The original WHO analgesic ladder is no longer recommended as a strict protocol for cancer pain management.

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世界卫生组织指南：新与旧。

综述目的世界卫生组织（WHO）最初的癌痛指南于 1986 年发布，并在全球范围内使用。更新版指南于 2018 年发布。本综述对 "新""旧 "指南进行了比较，并对世卫组织镇痛阶梯在当前环境下的相关性进行了深入探讨。最新发现新指南提供了一份更加循证、严谨的文件，包括与放射治疗管理相关的建议。新指南更详细地关注了阿片类药物的安全处方、阿片类药物的管理以及在癌症治疗早期整合疼痛管理专业知识的重要性。尽管某些疗法被广泛使用，但仍缺乏相关证据，尤其是与辅助治疗有关的疗法。新指南提供了更多与临床实践相关的详细建议，重点关注阿片类药物处方的安全性，使其在当前形势下具有现实意义。世界卫生组织最初的镇痛阶梯不再被推荐为严格的癌痛治疗方案。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.