Current Opinion in Supportive and Palliative Care最新文献_第5页

Digital clinics for diagnosing and treating migraine. 诊断和治疗偏头痛的数字诊所。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI: 10.1097/SPC.0000000000000715

Johan Nyberg, Rikard Rosenbacke, Elinor Ben-Menachem

引用次数: 0

Mechanistic insights into behavioral clusters associated with cancer-related systemic inflammatory response. 洞察与癌症相关的全身炎症反应行为集群的机制。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-09-01 Epub Date: 2024-05-27 DOI: 10.1097/SPC.0000000000000706

Taichi Goto, Leorey N Saligan

{"title":"Mechanistic insights into behavioral clusters associated with cancer-related systemic inflammatory response.","authors":"Taichi Goto, Leorey N Saligan","doi":"10.1097/SPC.0000000000000706","DOIUrl":"10.1097/SPC.0000000000000706","url":null,"abstract":"Purpose of review: This focused, narrative review mostly describes our team's investigations into the potential inflammatory mechanisms that contribute to the development of cancer-related gastrointestinal (GI) mucositis and its associated symptoms. This review summarizes details of our clinical and preclinical findings to test the role of inflammation in the development and occurrence of these cancer-related conditions.Recent findings: GI mucositis (GIM) is a common, distressing condition reported by cancer patients. GIM is often clustered with other behaviors including fatigue, pain, anorexia, depression, and diarrhea. It is hypothesized that there is a common biologic mechanism underpinning this symptom cluster. Our multi-platform investigations revealed that GIM and its associated cluster of behaviors may be triggered by local inflammation spreading systemically causing pro-inflammatory-mediated toxicities, leading to alterations in immune, metabolic, and nervous system functions and activities. For example, behavioral toxicities related to local irradiation for non-metastatic cancer may be triggered by mGluR5 activation influencing prolonged T cell as well as NF-κB transcription factor activities. Thus, interventions targeting inflammation and associated pathways may be a reasonable strategy to alleviate GIM and its symptom cluster.Summary: GIM may be a sign of a broader systemic inflammatory response triggered by cancer or its treatment. Addressing GIM and its associated symptoms primarily involves supportive care strategies focused on relieving symptoms, promoting healing, and preventing complications.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"161-167"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In support of rigor and reproducibility in cancer cachexia research. 支持癌症恶病质研究的严谨性和可重复性。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-09-01 Epub Date: 2024-07-31 DOI: 10.1097/SPC.0000000000000708

Aminah Jatoi, Barry Laird

引用次数: 0

Mirogabalin: a novel gabapentinoid or another false dawn? 米罗加巴林：新型加巴喷丁类药物还是另一个假曙光？

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-09-01 Epub Date: 2024-07-31 DOI: 10.1097/SPC.0000000000000714

Thomas J Craig, Paul Farquhar-Smith

{"title":"Mirogabalin: a novel gabapentinoid or another false dawn?","authors":"Thomas J Craig, Paul Farquhar-Smith","doi":"10.1097/SPC.0000000000000714","DOIUrl":"https://doi.org/10.1097/SPC.0000000000000714","url":null,"abstract":"Purpose of review: Mirogabalin is a novel gabapentinoid medication for the treatment of neuropathic pain. The purpose of this review is to discuss current evidence for its use. Gabapentinoids are widely prescribed for neuropathic pain. Mirogabalin offers theoretical advantages over traditional gabapentinoids due to its specificity for the α2δ-1 subunit of voltage-gated calcium channels. It is theorised that this specificity may reduce adverse drug reactions by minimising binding to the α2δ-2 subunit which is responsible for many of the gabapentinoid side effects.Recent findings: Mirogabalin's slower dissociation from the α2δ-1 compared with α2δ-2, and its higher potency may also impart an efficacy benefit over traditional gabapentinoids. These theoretical advantages of mirogabalin remain inconclusive in clinical practice, with mixed evidence regarding mirogabalin versus traditional gabapentinoids. Some studies suggest a reduced side effect profile yet, others fail to demonstrate significant differences. Regarding efficacy, mirogabalin may be superior to placebo for several neuropathic pain syndromes, but evidence of widespread benefit over traditional gabapentinoids is currently lacking.Summary: Mirogabalin offers theoretical promise, but large, independent studies are required to further assess its performance versus traditional gabapentinoids.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":"18 3","pages":"113-117"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The systemic outcomes of gastrointestinal mucositis: host-microbe interaction leading to systemic inflammatory responses. 胃肠道粘膜炎的全身后果：宿主与微生物相互作用导致全身炎症反应。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-06-01 Epub Date: 2024-04-30 DOI: 10.1097/SPC.0000000000000704

Andrea Stringer

引用次数: 0

Bridging research gaps in geriatric oncology: unraveling the potential of pragmatic clinical trials. 缩小老年肿瘤学研究的差距：发掘实用临床试验的潜力。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-03-01 Epub Date: 2023-12-22 DOI: 10.1097/SPC.0000000000000688

Carlos A Carmona-Gonzalez, Mateus T Cunha, Ines B Menjak

{"title":"Bridging research gaps in geriatric oncology: unraveling the potential of pragmatic clinical trials.","authors":"Carlos A Carmona-Gonzalez, Mateus T Cunha, Ines B Menjak","doi":"10.1097/SPC.0000000000000688","DOIUrl":"10.1097/SPC.0000000000000688","url":null,"abstract":"Purpose of review: This review examines the role of pragmatic clinical trials (PCTs) in addressing the underrepresentation of older adults with cancer (OAC) in clinical trials. Focusing on real-world evidence (RWE), it aims to provide a comprehensive overview of PCT utilization, emphasizing their potential to enhance treatment decisions and patient outcomes. Existing knowledge gaps in PCT implementation are also discussed.Recent findings: PCTs are identified as effective tools to include OACs with comorbidities and complex conditions in research, bridging the representation gap. Despite their proven value in healthcare provision, their application in OAC contexts remains limited, hindering comprehensive understanding and inclusivity in clinical trials.Summary: While randomized controlled trials (RCTs) are considered the gold standard in oncology research, OACs have historically been excluded, perpetuating underrepresentation. Furthermore, even in current oncology clinical development trials, this demographic continues to be underrepresented. PCTs offer a valuable avenue for the identification and evaluation of therapies within authentic RW contexts, encompassing various healthcare settings, such as hospitals, clinics, and physician practices. RCTs and PCTs complement one another, and the utilization of PCTs has the potential to inform clinical decision-making across the OACs entire treatment trajectory.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"3-8"},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteoradionecrosis - an old problem with new consequences. 骨坏死--老问题，新后果。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-03-01 Epub Date: 2024-12-22 DOI: 10.1097/SPC.0000000000000690

{"title":"Osteoradionecrosis - an old problem with new consequences.","authors":"","doi":"10.1097/SPC.0000000000000690","DOIUrl":"10.1097/SPC.0000000000000690","url":null,"abstract":"Purpose of review: Osteoradionecrosis (ORN) is a devasting complication of radiation therapy (RT), especially in head and neck cancers (HNC), and is still poorly understood. The aim of this review is to report its incidence and consider the risk factors associated with ORN to highlight prevention strategies to decrease its incidence.Recent findings: The average incidence of ORN is between 2% and 23%, with incidence decreasing in more recent years with the introduction of modern RT technology and better oral health care. Smoking, diabetes mellitus, oropharyngeal and oral cavity cancers, pre- and post-RT dental extractions and a total radiation dose of over 60 Gy were all identified as risk factors for ORN. In prevention, strategies were mainly structured around minimising risk factors or targeting possible mechanisms of ORN's pathophysiology.Summary: At present, the controversy surrounding the risk factors and pathogenesis of ORN makes it difficult to establish a set of prevention guidelines for its incidence. In order to achieve this, more research examining its aetiology must be conducted as well as a universal staging system within which ORN may be classified.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"v-vii"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual geriatric and frailty assessment for older adults with cancer. 为患有癌症的老年人提供虚拟老年病学和虚弱评估。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-03-01 Epub Date: 2024-01-26 DOI: 10.1097/SPC.0000000000000696

Isabel Tejero, Eva Amor, Olga Vázquez-Ibar

{"title":"Virtual geriatric and frailty assessment for older adults with cancer.","authors":"Isabel Tejero, Eva Amor, Olga Vázquez-Ibar","doi":"10.1097/SPC.0000000000000696","DOIUrl":"10.1097/SPC.0000000000000696","url":null,"abstract":"Purpose of review: Since SARS-CoV2 pandemic, many specialties have introduced virtual assessments within clinical practice. Conducting an online geriatric assessment, or relying on self-reported questionnaires, may be more challenging than a conventional medical appointment. This review aims to discuss the state of research on virtual assessment and self-reported questionnaires in the general geriatric population and specifically in Oncology.Recent findings: Virtual assessment of older adults has been the focus of two separate position papers. Aside from videoconferences or phone appointments, self-reported questionnaires have emerged in recent years as reliable tools to screen for frailty and triage patients who would benefit from a comprehensive in-person assessment, with adequate correlation with in-person tests, good acceptance by the respondents and being well received by healthcare providers. Although some have been tried in geriatric oncology, many still lack validation, and their widespread use may be limited by digital literacy, cognitive impairment, and social supports.Summary: The development, validation and adoption of self-reported questionnaires and virtual assessment in the care of older adults with cancer may overcome the staffing limitations and time constrains that frequently hampers the widespread evaluation of this population to improve their care.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"16-21"},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139567552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigating late effects in cancer survivors: harnessing personalised medicine and new models of care. 减轻癌症幸存者的晚期影响：利用个性化医疗和新的护理模式。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-03-01 Epub Date: 2024-01-31 DOI: 10.1097/SPC.0000000000000693

Joanne Bird, Sara Faithfull

引用次数: 0

Supportive and palliative care for older adults with cancer; facilitating person-centred, age friendly care. 为患有癌症的老年人提供支持性和姑息治疗；促进以人为本的老年友好型护理。

IF 2.1 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2024-03-01 Epub Date: 2024-01-31 DOI: 10.1097/SPC.0000000000000689

Christopher B Steer, Schroder Sattar, Ines Menjak

引用次数: 0