Infectious Diseases of Poverty最新文献

{"title":"Gut microbiota metabolites impact immunologic responses to antiretroviral therapy in HIV-infected men who have sex with men.","authors":"Anping Feng, Heping Zhao, Chunting Qiu, Dan Luo, Hao Wu, Xiaojun Meng, Linghua Li, Huachun Zou","doi":"10.1186/s40249-025-01291-y","DOIUrl":"10.1186/s40249-025-01291-y","url":null,"abstract":"<p><strong>Background: </strong>The association between gut microbial metabolites and immunologic non-response among people living with HIV (PLHIV) receiving antiretroviral therapy (ART) has not been well established. We aimed to characterize gut microbial metabolites among HIV-infected men who have sex with men (MSM) with different immunologic responses.</p><p><strong>Methods: </strong>We recruited HIV-infected MSM from Guangzhou Eighth People's Hospital and HIV-uninfected MSM (healthy controls, HC) from a local MSM community-based organization in Guangzhou between June and October 2021. HIV-infected MSM were grouped into good immunological responders (GIR) (CD4 + T cell count ≥ 350 cells/μl) and poor immunological responders (PIR) (CD4 + T cell count < 350 cells/μl) after 24 months of ART treatment. Online questionnaires and stool samples were collected. Microbial metabolites in stool were obtained through ultra-performance liquid chromatography coupled to a tandem mass spectrometry (UPLC-MS/MS) system. Differential metabolites were identified and analyzed using the Kruskal-Wallis test, followed by pairwise comparisons with the Wilcoxon rank-sum test. The least absolute selection and shrinkage operator was used to select potential metabolites biomarkers.</p><p><strong>Results: </strong>A total of 51 HC, 56 GIR, and 42 PIR were included. No statistically significant differences were observed in the median time since HIV diagnosis and ART duration between GIR and PIR. Among the 174 quantified metabolites, 81 significantly differed among HC, GIR, and PIR (P < 0.05). Among differential metabolites, indole-3-propionic acid significantly decreased from HC (11.39 nmol/g) and GIR (8.16 nmol/g) to PIR (6.50 nmol/g). The pathway analysis showed that tryptophan metabolism differed significantly between GIR and PIR (P < 0.05). Four potential metabolites biomarkers (dimethylglycine, cinnamic acid, 3-hydroxyisovaleric acid, and propionic acid) that distinguish GIR and PIR were identified, and the corresponding area under the curve based on potential biomarkers was 0.773 (95% CI: 0.675-0.871).</p><p><strong>Conclusions: </strong>This study identified significant differences in gut microbial metabolites among HIV-infected MSM with different immunologic responses. These results indicate the potential of gut microbial metabolites as novel disease progression markers and therapeutic targets.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"21"},"PeriodicalIF":8.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Priority knowledge gaps for schistosomiasis research and development in the World Health Organization Africa Region.","authors":"Pauline N Mwinzi, Moses Chimbari, Khadime Sylla, Maurice R Odiere, Nicholas Midzi, Eugene Ruberanziza, Sylvian Mupoyi, Humphrey D Mazigo, Jean T Coulibaly, Uwem Friday Ekpo, Moussa Sacko, Sammy M Njenga, Louis-Albert Tchuem-Tchuente, Anouk N Gouvras, David Rollinson, Amadou Garba, Elizabeth A Juma","doi":"10.1186/s40249-025-01285-w","DOIUrl":"10.1186/s40249-025-01285-w","url":null,"abstract":"<p><p>Schistosomiasis, also known as bilharzia, is a widespread neglected tropical disease (NTD) in Africa, with more significant research and development (R&D) challenges and gaps compared to other preventive chemotherapy NTDs (PC-NTDs) like onchocerciasis, lymphatic filariasis, and trachoma. In response to this challenge, some global initiatives have advocated for bridging this gap, focusing on coordinated engagement with research donors. In this opinion article we highlight key R&D priorities for combating schistosomiasis in the WHO Africa region. These include defining morbidity indicators, expanding prevention, and developing innovative diagnostics, treatments, and public health strategies like test-and-treat. We emphasize integrating efforts with broader health campaigns, assessing zoonotic transmission through One Health, and using environmental surveillance tools like xenomonitoring and eDNA. We stress the need to study climate and environmental impacts on transmission, zoonotic transmission, schistosome hybridization, and snail ecology, advancing snail control, and developing vaccines, while calling for new treatments beyond praziquantel, addressing drug resistance, and improving access for children and remote populations. Further, operational research should refine hotspot interventions, enhance water, sanitation and hygiene integration, and address socio-cultural barriers. Lastly, sustainable funding and global collaboration are vital to achieve 2030 NTD Roadmap goals.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"19"},"PeriodicalIF":5.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting Schistosoma infections in endemic countries: a diagnostic accuracy study in rural Madagascar.","authors":"Eva Lorenz, Ravo Razafindrakoto, Pia Rausche, Zaraniaina Tahiry Rasolojaona, Nantenaina Matthieu Razafindralava, Alexandre Zerbo, Yannick Höppner, Heidrun von Thien, Njary Rakotozandrindrainy, Cheick Oumar Doumbia, Philipp Klein, Jean-Marc Kutz, Paul L A M Corstjens, Claudia de Dood, Pytsje T Hoekstra, Govert J van Dam, Anna Jaeger, Norbert Georg Schwarz, Egbert Tannich, Mala Rakoto Andrianarivelo, Raphael Rakotozandrindrainy, Rivo Andry Rakotoarivelo, Jürgen May, Tahinamandranto Rasamoelina, Daniela Fusco","doi":"10.1186/s40249-025-01292-x","DOIUrl":"10.1186/s40249-025-01292-x","url":null,"abstract":"<p><strong>Background: </strong>Schistosoma haematobium and S. mansoni are endemic in Madagascar, but reliable diagnostic tools are often lacking, contributing to exacerbate transmission and morbidity. This study evaluated the diagnostic accuracy of three tests for schistosome infection in Malagasy adults from areas of medium to high endemicity.</p><p><strong>Methods: </strong>This cross-sectional study enrolled adults from three primary health care centres in Madagascar. Urine and blood samples were tested for schistosome infection using polymerase chain reaction (PCR), up-converting reporter particle lateral flow for the circulating anodic antigen (UCP-LF CAA), and point-of-care circulating cathodic antigen (POC-CCA) tests. Bayesian latent class models were used to assess diagnostic accuracies and disease prevalence.</p><p><strong>Results: </strong>Of 1339 participants, 461 were from S. haematobium and 878 from S. mansoni endemic areas. Test detection rates were 52% (POC-CCA), 60% (UCP-LF CAA), and 66% (PCR) in the S. haematobium area, and 54%, 55%, and 59% respectively in the S. mansoni area. For S. haematobium, PCR and UCP-LF CAA showed high sensitivity (Se, median 95.2% and 87.8%) but moderate specificity (Sp, 60.3% and 66.2%), while POC-CCA performed moderately (Se: 64.5%; Sp: 59.6%). For S. mansoni, PCR and POC-CCA demonstrated high diagnostic accuracy (Se > 90%, Sp > 80%), while UCP-LF CAA showed good sensitivity (79.9%) but moderate specificity (69.7%).</p><p><strong>Conclusions: </strong>While population-level prevalence estimates were similar across tests, individual-level agreement was only low to moderate. Our findings suggest that optimal diagnostic strategies should be tailored to specific endemic settings, continued development of accurate diagnostics suitable for highly endemic settings remains a priority.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"20"},"PeriodicalIF":8.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Best practices for engaging with affected communities: chronic hepatitis B as a case study.","authors":"Thomas Tu, Nafisa Yussf, Lien Tran, Kim Ngo, Su Wang, Adi Mondel, Isabelle Purcell, Jacki Chen, Wendy Lo, Bright Ansah, Kenneth Kabagambe, Soumen Basu, Dee Lee, Supa Chantschool, Chris Munoz, Ivana Dragojevic, Marko Korenjak, Fiona Borondy-Jenkins, Yasmin Ibrahim, Beatrice Zovich, Chari Cohen","doi":"10.1186/s40249-025-01288-7","DOIUrl":"10.1186/s40249-025-01288-7","url":null,"abstract":"<p><p>Hepatitis B is the single most common cause of liver cancer, affecting > 250 million people worldwide (mostly in resource limited communities) and killing > 1 million people annually. The condition is marked by poor rates of diagnosis (14%) and treatment (8% of eligible individuals). As with many health conditions, engagement with the affected community is crucial for designing, promoting, and advocating for effective solutions in the health system. However, engagement with the affected community remains difficult in many instances due to variable understanding of the roles, capacities, and expertise of people with lived experience. Through community-led consensus, we provide here several practical approaches for how public health, clinical, scientific, industrial, and policy-making bodies should engage with the hepatitis B affected community. These expert consensus practices have been developed by people living with hepatitis B and/or advocating for them. We suggest that these practices should be incorporated into any engagements with communities affected by hepatitis B and can be generalisable to other health conditions.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"18"},"PeriodicalIF":8.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing epidemiology of leptospirosis in China from 1955 to 2022.","authors":"Zengliang Wang, Ke Li, Yuanhua Liu, Michael P Ward, Yue Chen, Shuting Li, Jidan Zhang, Yu Zhao, Na Wang, Haiyan Qiu, Yueran Lian, Cuicai Zhang, Zhijie Zhang, Biao Kan","doi":"10.1186/s40249-025-01284-x","DOIUrl":"10.1186/s40249-025-01284-x","url":null,"abstract":"<p><strong>Background: </strong>Leptospirosis, a zoonotic disease caused by pathogenic species of the genus Leptospira, is an important public health concern globally. Leptospirosis has been notifiable under statute in China since 1955, and its epidemiological characteristics have evolved during near 70 years. This study aimed to describe the spatial and temporal patterns and demographic characteristics of leptospirosis from 1955 to 2022 in China, and explore the possible factors that influence leptospirosis transmission risk.</p><p><strong>Methods: </strong>Wavelet time series analysis, global Moran's I coefficients, space-time scanning statistics, and so on were used to analyze temporal, seasonal, geographic, and demographic trends in leptospirosis using reported national surveillance data from Chinese mainland from 1955 to 2022. Additionally, a Bayesian spatiotemporal model was used in a preliminary analysis to explore potential factors associated with leptospirosis occurrence.</p><p><strong>Results: </strong>Between 1955 and 2022, China reported 25,236,601 leptospirosis cases, with 91% occurring from July to October. The annual incidence rate peaked at 38.28/100,000 during outbreaks in the 1960s-1980s but stabilized at a low level (0.07/100,000) between 2005 and 2022, with over 99% of cases in southern China. Clustering increased over time, being greatest during the period 2015-2022 (Moran's I = 0.41, P < 0.01). Space-time cluster analysis indicated that the most likely clusters were in northern provincial-level administrative divisions (PLADs) from 1955 to 1984, in southern PLADs from 1985 to 2022. The main identified risk factors of leptospirosis occurrence were annual average precipitation (3.68, 95% CI: 2.50 to 5.12), GDP per capita (-3.70, 95% CI: - 5.97 to - 1.41), and the total power of agricultural machinery (- 2.51, 95% CI: - 3.85 to - 1.17).</p><p><strong>Conclusions: </strong>Over past 70 years, leptospirosis in China has occurred as significant outbreaks but has ultimately declined to stable, low levels of occurrence. However, a clear north-south disparity persists, with tropical and subtropical regions in southern China remaining high-risk areas. The nearly 70-year dataset underscores the complex interplay of climate and socioeconomic factors influencing the disease's occurrence. Targeted prevention and control measures are critical to prevent outbreaks, especially in regions prone to extreme climatic events like heavy rainfall and floods, which may signal the resurgence of leptospirosis.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"17"},"PeriodicalIF":8.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial autocorrelation with environmental factors related to tuberculosis prevalence in Nepal, 2020-2023.","authors":"Roshan Kumar Mahato, Kyaw Min Htike, Alex Bagas Koro, Rajesh Kumar Yadav, Vijay Sharma, Alok Kafle, Suvash Chandra Ojha","doi":"10.1186/s40249-025-01283-y","DOIUrl":"10.1186/s40249-025-01283-y","url":null,"abstract":"<p><strong>Background: </strong>Despite global efforts to reduce tuberculosis (TB) incidence, Nepal remains burdened by approximately 70,000 new cases annually, with an incidence rate of 229 per 100,000 people in 2022. This study investigated the geographic patterns of TB notifications in Nepal from fiscal year 2020 to 2023, focusing on environmental determinants such as land surface temperature (LST), urbanization, precipitation and cropland coverage.</p><p><strong>Methods: </strong>This study examined the spatial association between environmental factors and TB prevalence in Nepal at the district level, utilizing Geographic Information System (GIS) techniques, bivariate Local Indicators of Spatial Association (LISA) and spatial regression analyses. The tuberculosis prevalence data were obtained from the National Tuberculosis Control Center (NTCC) Nepal for the fiscal years (FY) 2020-2023.</p><p><strong>Results: </strong>Over the three fiscal years, high TB prevalence consistently clustered in districts such as Banke, Parsa, and Rautahat, while low prevalence areas included Mustang and Kaski. Significant positive spatial autocorrelation was found between environmental factors and TB prevalence. Moran's I values were as follows: for LST (day), 0.379, 0.424, and 0.423; for LST (night), 0.383, 0.420, and 0.425; for cropland coverage, 0.325, 0.339, and 0.373; for urbanization, 0.197, 0.245, and 0.246; and for precipitation, 0.222, 0.349, and 0.104 across FY 2020-2021, FY 2021-2022 and FY 2022-2023, respectively. Regression analyses, including Ordinary Least Squares (OLS), Spatial Lag Model (SLM), and Spatial Error Model (SEM), demonstrated that Land Surface Temperature Night (LSTN), urbanization, and precipitation significantly influenced TB prevalence, explaining up to 72.1% of the variance in FY 2021-2022 (R²: 0.721).</p><p><strong>Conclusions: </strong>Environmental factors significantly influence the spatial distribution of TB in Nepal. This underscores the importance of integrating disease management strategies with environmental health policies in effectively addressing TB prevalence.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"15"},"PeriodicalIF":8.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of integrating traditional and modern healthcare systems on tuberculosis case detection in Ethiopia: a cluster randomized controlled study.","authors":"Desalegne Amare, Kefyalew Addis Alene, Fentie Ambaw","doi":"10.1186/s40249-024-01270-9","DOIUrl":"10.1186/s40249-024-01270-9","url":null,"abstract":"<p><strong>Background: </strong>Low tuberculosis (TB) case detection remains a major challenge in achieving the End TB targets. New strategies that consider local contexts are needed in countries with high TB burdens like Ethiopia. This study examined the effect of integrating traditional and modern TB care to increase the TB case detection rate.</p><p><strong>Methods: </strong>A cluster randomized controlled trial was conducted from February 2023 to January 2024 in six districts of South Gondar Zone, Northwest Ethiopia, where districts were randomly assigned to intervention or control groups. The interventions included training, screening, and referral of presumptive TB patients, delivered over one year, while the control group continued with the standard passive case detection approach. A paired t-test and two sample independent t-test were used to compare baseline and end line data for both groups. Cohen's d was also used to compare the effect size between the intervention and the control groups. A mixed-effect Poisson regression was employed to determine the association between the dependent variable and the exposure variables.</p><p><strong>Results: </strong>In the intervention group, a total of 620 TB cases were identified post-intervention, compared with 473 cases pre-intervention, including 14 cases identified through referrals by traditional care providers. In contrast, the control group identified 298 TB cases post-intervention and 279 pre-intervention. The TB detection rate increased to 93 cases per 100,000 population in the intervention group, making an approximate 29.2% improvement, compared to a 2.9% increase in the control group. Integrating traditional care with the modern healthcare system significantly increased case detection, with a standardized mean difference of 2.6 (95% confidence interval CI: (1.8, 3.5; t = 8.3; P < 0.001) in a two-sample independent t-test.</p><p><strong>Conclusions: </strong>Integrating traditional care with the modern healthcare system significantly increased TB case detection in high-burden settings. This approach not only enhances current TB control strategies but also has potential applications in managing other chronic diseases in resource-limited areas. Future research should evaluate the cost-effectiveness, scalability, and sustainability of this integrative model. Trial registration Unique Protocol ID: 353/2021.</p><p><strong>Clinicaltrials: </strong>gov ID: NCT05236452. The date recruitment began: July 1, 2022. Registration date: July 22, 2022.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"16"},"PeriodicalIF":8.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance surveillance and trends in armed conflict, fragile, and non-conflict countries of the Eastern Mediterranean Region.","authors":"Rima Moghnieh, Nazih Bizri, Dania Abdallah, Mohamed H Sayegh","doi":"10.1186/s40249-025-01287-8","DOIUrl":"10.1186/s40249-025-01287-8","url":null,"abstract":"<p><strong>Background: </strong>The WHO Eastern Mediterranean Region (EMR) faces major social, economic, and demographic challenges, with nearly half of its countries affected by conflicts that severely disrupt health systems. This study compared antimicrobial resistance (AMR) rates and surveillance efforts in conflict-affected, fragile, and non-conflict countries, further subdivided by income.</p><p><strong>Methods: </strong>Data on bacteriologically confirmed bloodstream infections (BC-BSIs) from 2017 to 2021 were extracted from the WHO GLASS database. Countries were classified as conflict-affected, fragile, or non-conflict (subdivided by income) using World Bank criteria. Descriptive statistics (mean ± SD) were calculated, and group comparisons were performed using unpaired t-tests with Welch's correction. Mean differences (MD) and 95% confidence intervals (CI) were reported.</p><p><strong>Results: </strong>Conflict-affected countries reported significantly fewer surveillance sites than non-conflict countries (MD: 0.60, 95% CI: 0.361 to 0.836, P < 0.001) and fewer BC-BSIs per million population (MD: 31.00, 95% CI: 17.210 to 44.790, P < 0.001). In conflict zones, Acinetobacter spp. and S. aureus represented a higher proportion of BSIs compared to non-conflict countries (Acinetobacter spp. MD: -11.86, 95% CI: - 27.130 to 3.399, P = 0.099; S. aureus MD: - 10.68, 95% CI: - 30.030 to 8.680, P = 0.203). Carbapenem resistance in Acinetobacter spp. exceeded 65% across the groups, peaking in fragile zones (83.38%). Third-generation cephalosporin-resistant E. coli (3GCREC) prevalence ranged from 47.99% to 76.34%, peaking in conflict zones (76.34%). Carbapenem-resistant E. coli (CREC) prevalence ranged from 2.31% to 15.95%, highest in non-conflict low-middle income countries (15.95%). Third-generation cephalosporin-resistant K. pneumoniae (3GCRKP) exceeded 50% in all groups, peaking in conflict zones (80.42%). The prevalence of carbapenem-resistant K. pneumoniae (CRKP) ranged from 14.49% to 45.70%, peaking in conflict zones and non-conflict low-middle income countries (45.70%). Methicillin-resistant S. aureus (MRSA) exceeded 30%, peaking in conflict zones (70.09%).</p><p><strong>Conclusions: </strong>Conflict-affected countries have weaker AMR surveillance and lower BC-BSI detection but a higher burden of resistant pathogens, notably carbapenem-resistant Acinetobacter spp. and MRSA. Tailored strategies are essential to restore infrastructure, strengthen surveillance, and mitigate the long-term impact of AMR in these zones.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"14"},"PeriodicalIF":8.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of acute respiratory infection and diarrhea among children under 5 years old in low-middle wealth household, Indonesia.","authors":"Tri Bayu Purnama, Keita Wagatsuma, Reiko Saito","doi":"10.1186/s40249-025-01286-9","DOIUrl":"10.1186/s40249-025-01286-9","url":null,"abstract":"<p><strong>Background: </strong>Acute respiratory infection (ARI) and diarrhea remain critical public health concerns. In Indonesia, various interventions have been implemented to reduce the prevalence of ARIs and diarrhea among children in low- and middle-income households. Hence, the absence of detailed data on the prevalence of ARIs and diarrhea among children under five in low- and middle-income households in Indonesia restricts the formulation of targeted health interventions and policies. This study sought to evaluate the prevalence of ARI and diarrhea while examining modifiable risk factors related to malnutrition, sanitation, and social protection characteristics in Indonesia.</p><p><strong>Methods: </strong>This study utilized a cross-sectional design based on data from the Nutrition Status Survey 2022 covering 514 districts/cities in Indonesia. It analyzed 289,631 children under five years out of 334,848 households with low and middle wealth indices. Multivariable binary logistic regression analysis was employed to calculate the risk associated with cases of ARI and diarrhea.</p><p><strong>Results: </strong>The prevalence of ARI and diarrhea among low- and middle-wealth households were 5.7% and 6.0%, respectively, with infants under six months being the most vulnerable group to these infections, including malnutrition. The most significant risk factors for ARI and diarrhea are unclean cooking fuel [adjusted odds ratio (aOR) = 1.53, 95% CI 1.47-1.60] and shared toilet facilities (aOR = 1.45, 95% CI 1.38-1.51), with households using shared toilets having 1.45 times higher risk of diarrhea (aOR = 1.45, 95% CI 1.38-1.51) compared to those with private access. Additionally, households lacking social protection support are also at increased risk for these infections and malnutrition issues.</p><p><strong>Conclusions: </strong>This study revealed a notable prevalence of ARI and diarrhea among low- and middle-wealth households, particularly affecting infants under six months. Vulnerable children, especially those who were stunted or underweight, and households lacking sanitation and social protection faced heightened risks for these health issues.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"13"},"PeriodicalIF":8.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity of monkeypox virus surface proteins and cross-reactive antibody responses in vaccinated and infected individuals: implications for vaccine and therapeutic development.","authors":"Jing Liu, Xun Wang, Yiting Zhang, Changyi Liu, Meng Zhang, Chen Li, Peiling Liu, Shanshan Li, Kaifeng Wei, Yiming Cai, Hongjie Yu, Zhiliang Hu, Pengfei Wang, Yanliang Zhang","doi":"10.1186/s40249-025-01280-1","DOIUrl":"10.1186/s40249-025-01280-1","url":null,"abstract":"<p><strong>Background: </strong>The monkeypox virus (MPXV) has raised global health concerns due to its widespread transmission. This study evaluated the MPXV immunogenic antigens and the impact of vaccinia virus (VACV) vaccination and MPXV infection on cross-reactive antibody responses to conserved proteins from representative MPXV strains that reflected the evolutionary trajectory.</p><p><strong>Methods: </strong>Phylogenetic analyses were first conducted to reveal the evolutionary trajectory of MPXV from 1970 to 2024. A total of 84 serum samples were collected: 42 from VACV-vaccinated individuals, 12 from MPXV-infected participants in the early stage, 13 from the late stage, and 17 from naive individuals. Demographic data, MPXV and HIV status, as well as other clinical information were collected using standardized forms. Immunogenicity, cross-reactive antibody responses, and amino acid similarity to 15 MPXV surface proteins were assessed using enzyme-linked immunosorbent assays, VACV neutralization tests, and sequence alignment. Data analysis methods included analysis of variance, Mann-Whitney U test, binary logistic regression, Pearson correlation, and linear regression, with a significance threshold of P < 0.05.</p><p><strong>Results: </strong>The 186 complete genome sequences were classified into different clades and lineages, ranging from clade Ia to clade IIb C.1.1. Individuals infected with MPXV demonstrated strong antibody responses to antigens A35R, B6R, H3L, and E8L. VACV-vaccinated individuals exhibited broader cross-reactivity, particularly against A21L (P = 0.0003), A28L (P = 0.0028), A29L (P = 0.0324), G2R (P = 0.0003), and H2R (P = 0.0008), compared to MPXV-infected individuals. Pearson correlation analysis revealed significant associations (P = 0.0049) between antibody responses and the amino acid sequence similarity with other orthopoxviruses. Furthermore, MPXV-infected individuals exhibited greater neutralizing activity against VACV than those VACV-vaccinated individuals (P < 0.0001), while the vaccinated group retained cross-protective immunity even decades post-vaccination.</p><p><strong>Conclusions: </strong>A35R, B6R, H3L, and E8L are the main immunogenic antigens of MPXV. VACV-vaccination triggers a cross-reactive antibody response to MPXV surface proteins. Our findings suggest the need for targeted vaccines and antibody treatments for MPXV, as well as the reintroduction of smallpox vaccinations with booster doses for high-risk groups.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"12"},"PeriodicalIF":8.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}