Infectious Diseases of Poverty最新文献

{"title":"Assessment of Plasmodium vivax transmission and asymptomatic carriage risk among artisanal gold miners in western French Guiana, 2014-2020.","authors":"Alice Sanna, Yann Lambert, Stéphane Pelleau, Lise Musset, Yassamine Lazrek, Louise Hureau, Hedley Cairo, Stephen Vreden, Michael White, Maylis Douine","doi":"10.1186/s40249-025-01306-8","DOIUrl":"10.1186/s40249-025-01306-8","url":null,"abstract":"<p><strong>Background: </strong>The final challenge for malaria elimination in many countries is to interrupt the circulation of Plasmodium vivax. Given the unique biology of this parasite, innovative approaches are imperative, with a focus on identifying asymptomatic carriers of dormant parasite forms. This article delineates the recent epidemiological patterns of P. vivax malaria within a highly mobile and hard-to-reach population in the Guiana Shield. It further proposes an assessment of the potential reservoir of asymptomatic carriers.</p><p><strong>Methods: </strong>This analysis was based on data from: (i) two cross-sectional surveys carried out at the French-Surinamese border in 2015 and 2019, including adults returning from gold mining sites located in French Guiana (FG), [questionnaires and blood samples, tested for polymerase chain reaction (PCR) and P. vivax serological exposure markers (SEM) of recent infection]; (ii) epidemiological malaria surveillance system in Suriname, including cases imported from gold mining sites located in western FG between 2014 and 2020. Factors associated with P. vivax seropositivity were analysed by multiple logistic regression. The probability of carrying P. vivax parasites (blood-stage or hypnozoite) was estimated by a classification drawn from PCR results, SEM and reported recent history of illness.</p><p><strong>Results: </strong>Surveillance data showed a decrease in malaria imported cases from French Guiana between beginning and end of the analysed period (236 in 2014 to 74 in 2020) and an increase in the proportion of cases associated with P. vivax (52.4% in 2014 to 100% in 2020). The PCR-prevalence of P. vivax in survey samples decreased from 11.4% in 2015 to 4.0% in 2019; P. vivax seropositivity decreased from 44.7% to 28.4%. P. vivax seropositivity was positively associated with male sex, age and number of years spent in gold mining, type of activity, and reported malaria history (episode within less than nine months OR = 10.73, 95% CI: 5.87-19.6, or history of repeated older episodes OR = 5.31, 95% CI: 3.13-9.01).</p><p><strong>Conclusions: </strong>Our analysis shows an epidemiological evolution typical of a scenario of decreasing malaria circulation. Nevertheless, in 2020, gold miners in western FG still showed a moderate level of P. vivax circulation. Biological methods and epidemiological criteria can help to select potential parasite carriers, who could benefit from targeted drug administration.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"40"},"PeriodicalIF":8.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Cpb-Hsp70 typing methods reveals genetic divergence between Leishmania infantum strains causing human tegumentary leishmaniasis in northern Italy and central Spain: a retrospective study.","authors":"Tommaso Gritti, Carmen Chicharro, Eugenia Carrillo, Jose Carlos Solana, Javier Moreno, Elena Carra, Margherita Ortalli, Sara Morselli, Valeria Gaspari, Margherita Zanazzi, Tiziana Lazzarotto, Gianluca Rugna, Stefania Varani","doi":"10.1186/s40249-025-01309-5","DOIUrl":"https://doi.org/10.1186/s40249-025-01309-5","url":null,"abstract":"<p><strong>Background: </strong>Tegumentary leishmaniasis (TL) caused by Leishmania infantum is an overlooked yet re-emerging disease endemic in Mediterranean Europe. Currently, no standardized molecular surveillance of circulating Leishmania strains is performed in European endemic areas, despite the potential public health implications of parasite biodiversity. This study aims to characterize parasite population haplogroups causing TL in two active endemic areas in southern Europe, i.e. Bologna (northern Italy) and Fuenlabrada (central Spain).</p><p><strong>Methods: </strong>In this retrospective study, we typed 87 L. infantum samples from TL cases in the areas of Bologna and Fuenlabrada; these areas hosted the main European foci of human TL occurring in the last 15 years. Two Leishmania genomic typing targets were used: the heat shock protein 70 (Hsp70) and the cysteine peptidase b (Cpb). Simpson's index was used to calculate the discriminatory power of the used typing methods.</p><p><strong>Results: </strong>Typing results depicted the presence of a heterogeneous parasite population circulating in Bologna with two main haplogroups, i.e. Hsp70(A)_Cpb(F) (n = 7, 30.4%) and Hsp70(G)_Cpb(E/F) (n = 7, 30.4%), differing from the reference L. infantum strain JPCM5 haplogroup and partially overlapping with L. donovani lineages. Among the samples from Fuenlabrada, n = 19 samples were typed by both targets, revealing a homogeneous population expressing Hsp70(A) and Cpb(E), matching the JPCM5 reference strain haplogroup. Overall, the Cpb typing method exhibited higher discrimination power as compared to the Hsp70 method (Simpson's index of diversity, P-value < 0.05).</p><p><strong>Conclusions: </strong>Our findings show differences among L. infantum populations causing TL in two southern European epidemiological foci of human leishmaniasis and support the recent discovery of L. infantum/L.donovani hybrid strains circulating in northern Italy. These results underscore the critical need to identify the circulating Leishmania strains in endemic areas and assess their potential public health implications in active foci.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"41"},"PeriodicalIF":8.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geospatial and modelling analyses reveal diverse tick and tick-associated microbes in the East African Community.","authors":"Abakundana Nsenga Ariston Gabriel, Xiao-Yang Wang, Guo-Yao Zu, Pei-Yu Zhen, Laila Jamil, Shi-Jing Shen, Cheng Li, Ntakirutimana Theoneste, Lin Zhao, Wu-Chun Cao","doi":"10.1186/s40249-025-01310-y","DOIUrl":"10.1186/s40249-025-01310-y","url":null,"abstract":"<p><strong>Background: </strong>The continuous geographic expansion of ticks and the emergence of tick-borne diseases have raised tremendous global public health concerns, particularly in the East African Community (EAC). This study aimed to investigate the distribution of ticks and tick-associated microbes and to predict the potential extension of dominant tick species in the EAC.</p><p><strong>Methods: </strong>Data were collected from literature reviews and related websites and analyzed using ArcGIS to generate maps showing the geographical distribution of ticks and associated microbes. Meta-analyses were conducted to estimate the positive rates of microbes. Ecological niche modelling was used to project the potential expansion of predominant tick species.</p><p><strong>Results: </strong>A total of 138 tick species were recorded in the seven EAC countries, including five genera of the Argasidae family, eight of the Ixodidae family, and monospecific Nuttalliellidae. Overall, 64 tick-associated microbes, including 22 viruses, 26 bacteria, and 16 protists, were identified, of which 43 (11 viruses, 21 bacteria, and 11 protists) were pathogenic to humans or animals. Among them, 5 (2 viruses and 3 bacteria) have been reported in humans, while 10 pathogens (1 virus, 4 bacteria, and 5 protists) have been reported in animals. The predictive model identified suitable habitats for four dominant tick species, with certain species flourishing under ideal conditions, such as elevation, temperature, and vegetation. Our study revealed that ticks might affect broader areas where they have never been previously reported.</p><p><strong>Conclusions: </strong>Ticks are widely prevalent in the EAC, and some ticks harbor a variety of microbial agents that can have significant pathogenetic implications for human and animal health. Therefore, EAC authorities and medical personnel should acknowledge the potential threat posed by ticks and tick-associated pathogens to the well-being of people and animals. Surveillance and etiological diagnosis should be enhanced to control ticks and prevent tick-borne infections.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"39"},"PeriodicalIF":8.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wildlife hunting and the increased risk of leprosy transmission in the tropical Americas: a pathogeographical study.","authors":"Alisa Aliaga-Samanez, Patricia D Deps, Julia E Fa, Raimundo Real, Jean-François Guégan, Marcela A Oliveira, Aline Pessutti, Simon Knoop, Juliano A Bogoni, Thais Q Morcatty, Roberta Marques, Daniel Jiménez-García, Gabriel F Massocato, Arnaud L Desbiez, Danilo Kluyber, Hani R El Bizri","doi":"10.1186/s40249-025-01301-z","DOIUrl":"10.1186/s40249-025-01301-z","url":null,"abstract":"<p><strong>Background: </strong>Leprosy remains a persistent public health challenge, where human-to-human transmission of Mycobacterium leprae via respiratory droplets is well established. In the tropical Americas, growing evidence implicates armadillos as important zoonotic reservoirs, particularly through direct contact during hunting and handling. However, such transmission has so far been considered rare and highly localised. This study provides a comprehensive spatial analysis of the role of armadillo hunting in human leprosy transmission, quantifying its contribution to disease prevalence and identifying geographic hotspots where interventions could be most effective.</p><p><strong>Methods: </strong>Using Brazil's 326,001 reported leprosy cases from 2013 to 2022, we applied a pathogeographical approach to explore transmission dynamics. We compiled data on 554 hunted armadillos across 175 municipalities and M. leprae prevalence in 376 armadillo individuals from 97 municipalities (mean prevalence = 38.5%). These were used to build spatial models assessing hunting-related infection risk and integrated as a variable into a generalised linear model alongside socioeconomic, climatic, and environmental predictors to evaluate their effects on human leprosy prevalence.</p><p><strong>Results: </strong>Key predictors of armadillo hunting included higher population density (P < 0.001) and firearm availability (P < 0.01). Infection in armadillos was negatively correlated with native habitat coverage (coefficient: - 2.28; P < 0.001), suggesting that environmental degradation can amplify infection risk. The armadillo-hunting infection risk variable-generated by combining armadillo hunting and infection favourability models-emerged as the second strongest predictor of human leprosy prevalence (coefficient: 1.69; P < 0.001), accounting for ~ 25% of cases nationally and around 40% in deforestation hotspots. Additional positive predictors included greater precipitation seasonality (coefficient: 0.82; P < 0.001) and malnutrition (coefficient: 0.01; P < 0.001), while higher population density (coefficient: - 0.64; P < 0.001), natural habitat coverage (coefficient: - 0.50; P < 0.001) and socioeconomic status (coefficient: - 0.47; P = 0.013) were linked to reduced disease prevalence.</p><p><strong>Conclusions: </strong>Armadillo hunting seems to play a more significant role in human leprosy transmission than previously recognised. To address this overlooked pathway, targeted interventions should focus on reducing unsafe and illegal hunting, improving communication around zoonotic risks, strengthening disease surveillance in high-risk areas, and conducting genetic studies to confirm wildlife-to-human transmission. Our findings highlight the importance of incorporating wildlife-associated transmission pathways into strategies to reduce disease prevalence and mitigate future outbreaks in tropical regions facing rapid environmental change and persistent poverty.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"38"},"PeriodicalIF":8.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the avian influenza viruses distribution in the environment of live poultry market in China, 2019-2023.","authors":"Hong Bo, Ye Zhang, Jie Dong, Xiyan Li, Xiang Zhao, Hejiang Wei, Zi Li, Dayan Wang","doi":"10.1186/s40249-025-01304-w","DOIUrl":"https://doi.org/10.1186/s40249-025-01304-w","url":null,"abstract":"<p><strong>Background: </strong>The prevalence and transmission of avian influenza viruses (AIVs) in the live poultry market (LPM) is a serious public health concern. This study was to investigate the prevalence of different subtypes of avian influenza viruses in environment of LPM, and to analyze the differences and seasonality of the nucleic acid positive rate (NAPR) of A type, H5, H7, and H9 subtypes in feces, sewage, drinking water, breeding cages, and chopping boards.</p><p><strong>Methods: </strong>Feces, breeding cages swabs, drinking water, sewage and chopping boards swabs were collected from live poultry market during 2019-2023 from southern and northern China. Real-time PCR was used to screen for virus subtypes. Viruses were isolated, and deep sequencing was performed to obtain whole-genome sequences. Chi-square test was used for statistical analysis of categorical variable, GraphPad Prism software were used to construct graphs.</p><p><strong>Results: </strong>A total of 64,599 environmental samples were collected from live poultry markets in the southern China and northern China between 2019 and 2023. The average NAPR of the A type was significantly higher in the samples collected from the southern China than in those collected from the northern China (P < 0.05). The NAPR of H5, H7, and H9 subtypes carried by the five types of environmental samples in the southern China were significantly different (P < 0.05), and a higher NAPR was detected in chopping boards (10.84%), breeding cages (0.28%), and drinking water (40.97%) respectively. The average NAPR of the H9 and H5 subtypes displayed seasonality, reaching a peak in January and February in the southern China, while the peak of the H9 subtype was from October to February in the northern China. A total of 19 subtypes were identified. The H5 subtype significantly decreased, the H7 subtype was almost undetectable, and other subtypes, such as the H3 subtype, increased.</p><p><strong>Conclusions: </strong>The highly pathogenic H5 subtype has significantly decreased in the live poultry market in China since 2022. However, the proportion of some subtypes, such as the H3 subtype, with low pathogenicity to poultry, has increased, while the H9 subtype remains at a high level. It must be noted that these low pathogenic avian influenza viruses often have no obvious symptoms, can circulate asymptomatically in infected poultry, and are highly pathogenic to humans. Our findings provide insights into the control and prevention of avian influenza viruses and the risk of pandemics associated with avian influenza viruses in the live poultry market.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"36"},"PeriodicalIF":8.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of the sterile insect technique for Aedes aegypti in Lee County, Florida, USA.","authors":"Rachel Morreale, Steven Stenhouse, Johanna Bajonero, Danilo O Carvalho, Nicole Foley, Roxanne Connelly, Aaron Lloyd, David Hoel","doi":"10.1186/s40249-025-01307-7","DOIUrl":"https://doi.org/10.1186/s40249-025-01307-7","url":null,"abstract":"<p><strong>Background: </strong>Lee County Mosquito Control District (LCMCD) is an independent taxing district that works to protect human health and improve quality of life in Lee County, Florida, USA. With local dengue transmission in southern Florida, LCMCD prioritized the control of Aedes aegypti. Due to the cryptic larval habitats of Ae. aegypti and insecticide resistance, effective control using conventional methods is difficult. Thus, the sterile insect technique (SIT) program, using X-ray irradiated male mosquitoes, was created to target Ae. aegypti. The goal of this program was to suppress Ae. aegypti through establishing a robust SIT program and performing a pilot study in the field to assess the impacts of SIT releases.</p><p><strong>Main text: </strong>The SIT program at LCMCD released sterile male Ae. aegypti from 2020 to 2022 in Captiva Island, Florida. The SIT program works within a larger Integrated Mosquito Management (IMM) framework and is not a standalone tool. The SIT program consists of nine employees, one of which is dedicated to quality assurance. Quality assurance assessments are performed routinely and periodically. Due to widespread destruction throughout Captiva and Sanibel Islands from Hurricane Ian in September 2022, the SIT pilot in Captiva Island was concluded and moved to Fort Myers, Florida. During the pilot study on Captiva Island, various lessons were learned and this knowledge has been applied to efforts in Fort Myers.</p><p><strong>Conclusions: </strong>LCMCD has established a successful SIT program to suppress populations of Ae. aegypti. Through connections with the International Atomic Energy Agency (IAEA) and the University of Florida, LCMCD received guidance from experts in the field to help ensure the program's success. Stable funding through taxes levied specifically for mosquito control provided essential consistency, allowing the program to grow and evolve. Consistent trapping routines provided immense amounts of entomological data. Thoughtful and intentional community engagement was essential in ensuring acceptance of the SIT program in Lee County. Following the phased conditional approach suggested by IAEA, LCMCD has built an effective and resilient SIT program. The integration of the SIT as a tool of an area-wide mosquito control program is a feature that distinguishes LCMCD's SIT program from others.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"37"},"PeriodicalIF":8.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of loiasis: a review of clinical management recommendations.","authors":"Dorothea Ekoka Mbassi, Rike Dreeßen, Rella Zoleko Manego, Saskia Dede Davi, Tamara Nordmann, Johannes Mischlinger, Michael Ramharter","doi":"10.1186/s40249-025-01300-0","DOIUrl":"https://doi.org/10.1186/s40249-025-01300-0","url":null,"abstract":"<p><strong>Background: </strong>Loiasis affects more than 20 million residents of endemic regions in Central and West Africa causing chronic and often lifelong disease. Antifilarial treatment options for loiasis include diethylcarbamazine, ivermectin, and albendazole. Safe and effective management requires classifying patients into occult, microfilaremia, and hypermicrofilaremia categories. Treatment is complicated by the risk of severe adverse events, particularly encephalitis. Clear guidance on the appropriate use of antifilarial therapy is therefore of utmost importance. The aim of this review is to evaluate current treatment recommendations and assess their quality and consistency.</p><p><strong>Methods: </strong>A scoping review was conducted to evaluate treatment recommendations for loiasis. The literature search encompassed multiple databases, including PubMed and specialized medical repositories, without restrictions on publication date or language. The approach included a systematic search with specific loiasis-related keywords and an unstructured search of guidelines from health ministries in endemic countries, along with grey literature and professional recommendations. Renowned tropical medicine textbooks were also consulted. Data were extracted with a detailed table collaboratively developed and reviewed by multiple researchers to ensure consistency and accuracy.</p><p><strong>Results: </strong>The review identified 33 sources, consisting of nine guidelines, ten reviews, and 14 textbook excerpts. Publications reviewed spanned from 2001 to 2024 with no major innovations in treatment noted. Evidence quality was often low, with only two guidelines detailing their development process. Variability was particularly noted in dosage protocols for diethylcarbamazine, typically dosed incrementally. Ivermectin and albendazole were mostly noted as alternatives based on microfilarial levels. The common microfilarial threshold was 8000 microfilariae per millilitre, dictating treatment strategy adjustments. Adjunctive treatments, such as corticosteroids and antihistamines, were inconsistently proposed to mitigate side effects.</p><p><strong>Conclusions: </strong>Inconsistencies between some recommendations were observed. There is an urgent need for internationally harmonized, evidence-based guidelines to address these inconsistencies, improve patient outcomes and minimize treatment-associated severe adverse events and fatalities.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"35"},"PeriodicalIF":8.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sterile Aedes aegypti males releases on vector dynamics: insights from Malaysian field trials.","authors":"Wasi Ahmad Nazni, Guat-Ney Teoh, Mohd Adnan Nuradila, Shaikh Ismail Shaikh Norman Hakimi, Maheswaran Tanusshni, Mohd Azam Muhammad Arif, Achim Nurfarahin Hanini, Irfan Ahmad Shazia, Aik-Meng Tan, Hamzah Rabizah, Mohamad Dzomir Ahmad Zainuri, Asim Hasnor Hadi, Ahmad Norazah, Han-Lim Lee, Hamidou Maiga, Jeremy Bouyer, Yoon-Ling Cheong","doi":"10.1186/s40249-025-01303-x","DOIUrl":"https://doi.org/10.1186/s40249-025-01303-x","url":null,"abstract":"<p><strong>Background: </strong>The Sterile insect technique (SIT) has been successfully used in agricultural pest control, leading to interest in its application for public health, particularly in controlling Aedes mosquitoes in the USA, Italy, Cuba, and Greece. Malaysia has conducted a small-scale SIT pilot trial since 2019 for dengue control. This study evaluates mosquito populations in treated and untreated sites through three objectives: (1) comparing mean larvae per trap (MLT) and dengue cases for Ae. aegypti and Aedes albopictus; (2) estimating survival rates and wild populations using mark-release-recapture (MRR); and (3) analysing spatial distribution in treated and untreated sites.</p><p><strong>Methods: </strong>Ae. aegypti males, irradiated at 55 Gray, were released in three locations: Pangsapuri Kota Laksamana (KT), Malacca (19 months), Pangsapuri Taman Tasik Utama (TTU), Malacca (8 months), and the Customs, Immigration, and Quarantine Complex (CIQ), Johor (7 months). Statistical analyses assessed SIT effectiveness, including T-tests for larval density and ovitrap indices, Mulla's formula and relative variance (RV) for population reduction, and the Lincoln Index for estimating wild male populations and probability of daily survival.</p><p><strong>Results: </strong>Weekly releases of sterile Ae. aegypti males at doses of 1278-7942 males/ha achieved a sterile-to-wild male ratio of 5.85 and a mean daily survival rate of 0.61, leading to significant reductions in larval densities: 76.25% in Kota Laksamana (KT), 96.74% in Taman Tasik Utama (TTU), and 89.00% in CIQ Gelang Patah, thereby supporting dengue control efforts. In KT, the MLT was initially low but increased, although with suppression < 90%, there was a reduce of dengue cases throughout the release period. The MRR's mean survival rate (± standard deviation) in KT was 0.61 (± 0.08). The spatial clustering of Ae. aegypti was observed in central blocks during the high MLT period. However, larval densities rebounded after releases ceased. Spatial clustering revealed no initial clustering, though clustering patterns emerged over time in KT.</p><p><strong>Conclusions: </strong>SIT effectively suppressed Ae. aegypti populations and supported dengue control. Optimizing sterile-to-wild male ratios, spatial distribution, and monitoring strategies is essential for sustainable vector control. These findings provide insights for scaling up SIT field trials, with future efforts focusing on refining release and monitoring strategies to enhance SIT as an effective dengue control tool. Trial registration NMRR-17-2652-39,099 \"Field evaluation of Sterile Insect for Aedes aegypti Suppression.\"</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"33"},"PeriodicalIF":8.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity study of the \"5Cs\" hesitancy scale for maternal influenza vaccination among pregnant and postpartum women.","authors":"Fanyu Zeng, Bingcheng Du, Hong Jiang, Min Zheng, Xiu Qiu, Fen Li, Nianhua Yi, Yinglan Wu, Yuanying Ma, Changhui Li, Chunyi Gu, Lei Wang, Fengyun Yang, Longmei Jin, Yanran Yang, Xu Qian","doi":"10.1186/s40249-025-01295-8","DOIUrl":"https://doi.org/10.1186/s40249-025-01295-8","url":null,"abstract":"<p><strong>Background: </strong>Maternal influenza vaccine hesitancy plays a vital role in the low rates of vaccination. However, instruments to appropriately assess perinatal influenza vaccine hesitancy are unavailable. This study aimed to develop the Maternal Influenza Vaccine Hesitancy Scale based on the 5C vaccination hesitancy scale, containing the subscales of confidence, complacency, constraints, calculative, and collective responsibility, and to provide a preliminary overview of the current hesitancy on maternal influenza vaccination in China.</p><p><strong>Methods: </strong>A cross-sectional survey, from January to March 2024, was carried out among 2035 pregnant and postpartum women from nine provincial-level administrative divisions representing eastern, central, western, and northeastern areas of China. Reliability was evaluated by internal consistency reliability and split-half reliability, and a Cronbach's alpha coefficient > 0.7 was considered acceptable. Construct validity was assessed using confirmatory factor analysis (CFA), with good model fit defined as root mean square error of approximation (RMSEA) < 0.100, normed fit index (NFI) > 0.9, comparative fit index (CFI) > 0.9, and Tucker-Lewis index (TLI) > 0.9.</p><p><strong>Results: </strong>Confirmatory factor analysis results supported the five-factor structure of the scale (RMESA = 0.098, CFI = 0.921, TLI = 0.903, NFI = 0.918). The Cronbach's alpha coefficients for the scale as well as the subscales ranged from 0.802 to 0.958. Among five subscales, collective responsibility (2.73 ± 0.63) scored highest, while complacency (2.16 ± 0.69) and constraints (2.17 ± 0.69) were the lowest.</p><p><strong>Conclusions: </strong>The Maternal Influenza Vaccine Hesitancy Scale developed in this study is a reliable and valid instrument to measure the influenza vaccine hesitancy of pregnant and postpartum women. It is recommended that interventions including health education and improving the access to the vaccination service be carried out to reduce the maternal influenza vaccination hesitancy.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"34"},"PeriodicalIF":8.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of tenofovir-based HIV pre-exposure prophylaxis in preventing HBV infection among men who have sex with men: insights from China.","authors":"Zhen-Hao Wu, Yan-Yan Zhu, Xiao-Jie Huang, Shuo Chen, Zhen-Xing Chu, Hui Wang, Yao-Kai Chen, Yong-Jun Jiang, Hong Shang, Qing-Hai Hu","doi":"10.1186/s40249-025-01305-9","DOIUrl":"https://doi.org/10.1186/s40249-025-01305-9","url":null,"abstract":"<p><strong>Background: </strong>Oral emtricitabine-tenofovir disoproxil fumarate (F/TDF) for HIV pre-exposure prophylaxis (PrEP) demonstrates dual potential through antiviral activity against hepatitis B virus (HBV). While F/TDF lacks activity against hepatitis C virus (HCV), the use of F/TDF for HIV PrEP may elevate HCV risk through risk compensation. This study aims to investigate HBV/HCV incidence among men who have sex with men (MSM) using F/TDF-based HIV PrEP, addressing evidence gaps in low- and middle-income countries.</p><p><strong>Methods: </strong>We conducted a secondary analysis of the China Real-World Oral Intake of PrEP (CROPrEP) study, a multicenter prospective cohort of MSM (F/TDF users/non-users) from Beijing, Shenyang, Shenzhen, and Chongqing. Participants underwent HBV/HCV testing at baseline and at the 12-month follow-up. Only HBV-susceptible (hepatitis B surface antigen-negative, hepatitis B surface and core antibody-negative) MSM were included in the secondary analysis, to calculate HBV incidence. The primary outcomes were HBV/HCV incidence rates at the 12-month follow-up. Bayesian Poisson regression identified HBV/HCV infection risk factors.</p><p><strong>Results: </strong>The CROPrEP cohort prospectively recruited 1023 F/TDF users and 507 F/TDF non-users at baseline. This secondary analysis included 259 F/TDF users and 120 non-users identified as HBV-susceptible at baseline. At the 12-month of follow-up, no incident HBV infections occurred in the F/TDF users group, and only one incident HBV infection occurred in the F/TDF non-users group. The incidence of new HBV infections was 0.00/100 person-years (PY) [95% confidence interval (CI): 0.00-1.32] among HBV-susceptible F/TDF users and 0.77/100 PY (95% CI: 0.02-4.20) among HBV-susceptible F/TDF non-users. HBV incidence was reduced with F/TDF compared with no F/TDF [adjusted incidence rate ratio (aIRR): 0.00; 95% CI: 0.00-0.00]. HCV incidence among F/TDF users and non-users was 0.31/100 PY (95% CI: 0.06-0.90) and 0.00/100 PY (95% CI: 0.00-0.74) after 12 months, respectively. HCV incidence was lower in F/TDF non-users than in F/TDF users (aIRR: 0.00; 95% CI: 0.00-0.25).</p><p><strong>Conclusions: </strong>This study suggests a potential benefit in reducing HBV incidence among MSM using F/TDF as HIV PrEP, highlighting the potential for integrated prevention strategies addressing both HIV and HBV risks in PrEP programmes.</p><p><strong>Trial registration: </strong>ChiCTR, ChiCTR-IIN-17013762. Registered 8 December 2017, https://www.chictr.org.cn/showproj.html?proj=22916 .</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"14 1","pages":"31"},"PeriodicalIF":8.1,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}