Journal of Endocrinological Investigation最新文献

{"title":"Thyroid and female fertility: a survey on the clinical practice among endocrinologists belonging to the italian thyroid association.","authors":"G Vannucchi, C Amato, M Rotondi, L Persani, M Bagnasco, R Elisei","doi":"10.1007/s40618-025-02613-5","DOIUrl":"10.1007/s40618-025-02613-5","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1903-1907"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of diabetic ketoacidosis, islet cell function, and age of onset on pancreas size, morphology, and exocrine function in children with type 1 diabetes: an abdominal MRI study.","authors":"Zheng Cai, Shaoqing Chen, Mingxin Chen, Shuang Meng, Yixuan Hu, Mei Huang, Jiawen Song, Xiaoyan Huang, Zhihan Yan, Kun Liu","doi":"10.1007/s40618-025-02591-8","DOIUrl":"10.1007/s40618-025-02591-8","url":null,"abstract":"<p><strong>Objective: </strong>To investigate pancreatic MRI parameters changes in children with T1D and to assess the effects of DKA, islet cell function, and onset age on the pancreas size, morphology, and exocrine function.</p><p><strong>Methods: </strong>176 children with newly diagnosed T1D and 100 age- and sex-matched controls were enrolled in this retrospective study. Clinical metrics and pancreatic MRI parameters were collected and compared, and correlation analyses were performed to explore the relationships.</p><p><strong>Results: </strong>Pancreas volume, pancreas volume index (PVI), pancreas body and tail diameters, pancreas surface area, pancreas tail-to-spleen signal ratio, and pancreatic border irregularity score were lower, and pancreas surface area-to-volume ratio was higher in the T1D group than in the control group. T1D-DKA subgroup had a lower pancreas tail-to-spleen signal ratio and pancreatic border irregularity score than T1D-diabetic ketosis (T1D-DK) subgroup. Subgroup with an onset age under 10 years had a lower pancreas volume, pancreas head, body, and tail diameters, and pancreas surface area than subgroup with an onset age of 10 years or older. Several pancreatic MRI indices correlated with C-peptide levels in the T1D group, T1D-DK subgroup, and T1D-DKA subgroup but not in the T1D-alone subgroup. The integrated assessment of pancreatic size, morphology, and MR signal characteristics more effectively distinguishes the pancreas of T1D children from that of controls when compared to evaluating these factors individually.</p><p><strong>Conclusion: </strong>T1D affects the size, morphology and exocrine function of the pancreas in children, which is associated with DKA, islet cell function and onset age.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1889-1901"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lomibuvir sensitizes radioiodine-resistant thyroid cancer cell lines to radioiodine treatment by targeting hTERT RNA-dependent polymerase activity.","authors":"Xian Cheng, Shichen Xu, Jing Wu, Wenjing Gao, Jiandong Bao, Huixin Yu, Li Zhang","doi":"10.1007/s40618-025-02598-1","DOIUrl":"10.1007/s40618-025-02598-1","url":null,"abstract":"<p><p>Radioactive iodine (RAI) is selectively used in the treatment of residual or recurrent differentiated thyroid cancer for over fifty years. However, radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) is difficult to treat with radioactive iodine because of the decreased sodium iodide symporter (NIS) activity. Patients with RAIR-DTC derive limited benefit from RAI therapy, necessitating the exploration of new treatment options. In the current study, we aimed to explore the mechanism underlying thyroid cancer dedifferentiation and to provide new targets for RAIR therapy. We established a RAIR thyroid cancer cell line which was verified by the colony formation ability under radioiodine-131 treatment at doses up to 100 µCi. As expected, higher expressions of cancer stem cell genes, SOX2, CD133, and OCT4 A were found in RAIR cells compared to non-RAIR cells. Correspondingly, the expression of iodine-handling genes such as NIS, TPO, and Pendrin were downregulated. Interestingly, we discovered that the RNA-dependent RNA polymerase (RdRP) activity of TERT was also upregulated in RAIR cells, evidenced by the upregulation of phosphorylated telomerase reverse transcriptase (TERT), BRG1 and CDK1. Moreover, miR-146b-5p, transcribed by TERT gene, was likewise upregulated. RdRP inhibitor lomibuvir treatment downregulated miR-146b-5p level in RAIR cells, resulting in the upregulation of NIS gene expression. Lomibuvir not only restored the expressions of TPO and NIS but also downregulated the elevated ALDH1A1 and CD133 in RAIR cells. Consequently, the uptake of radioiodine-131 was significantly enhanced in these RAIR cells. Taken together, our research identifies novel therapeutic targets and provides new insights into the management of RAIR-DTC.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1797-1810"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of response to burosumab in adults with X-linked hypophosphatemia: real-world data from an Italian cohort.","authors":"Gaetano Paride Arcidiacono, Valentina Camozzi, Giovanni Tripepi, Cristina Eller-Vainicher, Giuseppe Vezzoli, Maria Luisa Brandi, Gemma Marcucci, Giuseppe Girasole, Antonio Aversa, Corrado Vitale, Gaetana Cerbone, Maria Michela D'Alessandro, Martina Zaninotto, Maria Fusaro, Marco Onofrio Torres, Michele Cannito, Alberta Cecchinato, Martin Diogo, Mor Peleg Falb, Francesca Guidolin, Marta Zampogna, Mario Plebani, Elena Campello, Paolo Simioni, Stefania Sella, Sandro Giannini","doi":"10.1007/s40618-025-02596-3","DOIUrl":"10.1007/s40618-025-02596-3","url":null,"abstract":"<p><strong>Purpose: </strong>X-linked hypophosphatemia (XLH) is a genetic disorder characterized by elevated FGF23 levels, leading to phosphate wasting and hypophosphatemia, causing skeletal and extraskeletal abnormalities. Burosumab, an antibody targeting FGF23, improves hypophosphatemia and clinical outcomes. This study evaluated the real-world efficacy of burosumab and identify predictors of treatment response.</p><p><strong>Methods: </strong>Twenty-seven adult XLH patients (mean age 42 years; 48% female) from an Italian multicenter cohort were treated with burosumab for up to 24 weeks. Laboratory tests were evaluated at midpoints and endpoints (14 and 28 days) of the dosing interval. In a subset of patients (N = 11) followed for 48 weeks, laboratory tests and patient-reported outcomes were also assessed.</p><p><strong>Results: </strong>After initiating burosumab, median serum phosphate levels increased from 1.5 mg/dL (IQR 1.3-1.8) to 2.0 mg/dL (IQR 1.7-2.4) (p < 0.05), remaining higher than baseline at the midpoints of the dosing interval for up to 24 weeks. Higher baseline phosphate predicted higher midpoint levels (p < 0.05), whereas higher baseline PTH (p < 0.05) and FGF23 (p < 0.001) were associated with lower phosphate levels at midpoints. In patients (N = 11) followed for 48 weeks, significant improvements in patient-reported outcomes in all patients were observed. Both WOMAC Pain (r = 0.94, p = 0.02) and BPI Worst Pain (r = 0.98, p < 0.001) were positively correlated with increased phosphate at week 48.</p><p><strong>Conclusion: </strong>Burosumab effectively increased serum phosphate levels and improved clinical outcomes in a real-world setting, particularly in patients with more substantial increases in serum phosphate levels. Baseline serum phosphate, PTH, and FGF23 levels predicted response, helping tailor treatment strategies and improve long-term patient management.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1857-1869"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A model with thyroid swelling portrayed by Achille Funi in the painting \"maternità\".","authors":"F Trimarchi, E Martino, L Bartalena","doi":"10.1007/s40618-025-02588-3","DOIUrl":"10.1007/s40618-025-02588-3","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1925-1926"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of clinical factors and gut microbiota composition to weight loss in a pre-post dietary intervention pilot study in male children with obesity.","authors":"Sanja Kovačević, Ana Djuković, Miloš Vratarić, Ljupka Gligorovska, Biljana Bursać, Danijela Vojnović Milutinović, Ana Teofilović, Snežana Lešović, Joao Xavier, Ana Djordjevic","doi":"10.1007/s40618-025-02672-8","DOIUrl":"https://doi.org/10.1007/s40618-025-02672-8","url":null,"abstract":"<p><strong>Purpose: </strong>Childhood obesity is a global health problem that may be linked to changes in the gut microbiota. The aim of this pilot study was to link the clinical parameters of children with obesity, who underwent a dietary intervention, with their gut microbiota profiles to better understand the factors associated with weight loss.</p><p><strong>Methods: </strong>The study focused on 36 male children with obesity (aged 12-15 years) who were referred for treatment of primary obesity. Personal medical history information was collected at enrollment. Body composition was assessed before and after a three-week balanced hypocaloric diet with preserved nutritional value. Bacterial taxa were analyzed by 16S rRNA gene amplicon sequencing. Linear regression models and machine learning algorithms were used to determine how subjects' clinical factors and gut microbiota contribute to weight loss efficacy.</p><p><strong>Results: </strong>Results showed that higher abundance of Lachnospiraceae members (Blautia and Anaerostipes) prior to the diet intervention, and later introduction of non-dairy food were positively related to weight loss efficacy, while higher abundance of Erysipelotrichaceae UCG-003 and Faecalibacterium in the pre-diet samples was negatively correlated with BMI change. The change in the abundance of Enterobacteriaceae and Bacteroidetes members between the pre- and post-diet samples was negatively associated with delta BMI.</p><p><strong>Conclusion: </strong>The efficacy of weight loss in male children with obesity under dietary treatment is related to the composition of the gut microbiota and the timing of the introduction of non-dairy food. Promoting beneficial gut bacteria could increase the success of dietary treatment for weight loss and improve long-term health outcomes in children with obesity.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of cardiac dysfunction in non-functioning adrenal adenomas, primary aldosteronism, and essential hypertension.","authors":"L Liu, X Li, W Ma, F Fan, Y Yang, L Zhang, T Yi, J Zhang, J Guo, Y Gao","doi":"10.1007/s40618-025-02594-5","DOIUrl":"10.1007/s40618-025-02594-5","url":null,"abstract":"<p><strong>Background: </strong>Speckle tracking echocardiography (STE) provides a quantitative assessment of left ventricular systolic performance, including myocardial motion and deformation. Global longitudinal strain (GLS) is a reliable and sensitive indicator of systolic function, with clinical and prognostic value in various settings, including secondary hypertension. There is limited data on GLS evaluation in patients with non-functioning adrenal adenomas (NF), despite emerging evidence suggesting its association with subclinical cardiovascular dysfunction. Investigating the cardiac impact of NF is essential for understanding its role in early cardiac remodeling compared to primary aldosteronism (PA) and essential hypertension (EH).</p><p><strong>Objective: </strong>To retrospectively evaluate the utility of GLS in detecting early cardiac dysfunction in patients with NF, PA, and EH without adrenal adenoma or hyperplasia.</p><p><strong>Methods: </strong>This retrospective study included 33 patients with NF, 33 with PA, and 33 with EH, matched by gender and age. Speckle tracking echocardiography was used to assess the GLS of the left ventricle. Data analysis was conducted using IBM SPSS Statistics version 29.0, with a significance threshold set at P < 0.050.</p><p><strong>Results: </strong>The GLS in NF patients (-20.63 ± 3.10%) was significantly lower than in EH patients (-22.17 ± 3.03%) but higher than in PA patients (-18.55 ± 2.45%), despite NF patients having the lowest prevalence of hypertension and systolic blood pressure. GLS was significantly correlated with cortisol levels, impaired glucose tolerance, and ARR across all patient groups, highlighting the complex interplay between metabolic and hormonal factors in cardiac dysfunction.</p><p><strong>Conclusion: </strong>Cardiac function impairment in NF patients lies between that observed in EH and PA patients, suggesting a nuanced impact of non-functioning adrenal adenomas on cardiac health.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1811-1817"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination of people with solid tumors and diabetes: existing evidence and recommendations. A position statement from a multidisciplinary panel of scientific societies.","authors":"Marco Gallo, Angioletta Lasagna, Valerio Renzelli, Lelio Morviducci, Alessio Cortellini, Matteo Monami, Giampiero Marino, Stefania Gori, Matteo Verzé, Alberto Ragni, Enzo Tuveri, Laura Sciacca, Stella D'Oronzo, Dario Giuffrida, Annalisa Natalicchio, Francesco Giorgino, Nicola Marrano, Maria Chiara Zatelli, Monica Montagnani, Francesco Felicetti, Rossella Mazzilli, Stefano Fogli, Tindara Franchina, Antonella Argentiero, Riccardo Candido, Francesco Perrone, Gianluca Aimaretti, Angelo Avogaro, Nicola Silvestris, Antongiulio Faggiano","doi":"10.1007/s40618-025-02586-5","DOIUrl":"10.1007/s40618-025-02586-5","url":null,"abstract":"<p><p>Diabetes and cancer are two of the most common public health concerns worldwide. The complex interplay of these two conditions is a growing area of research, as patients with diabetes are at increased risk for developing cancer, and vice versa. Furthermore, both patient populations show increased risk of many communicable infectious diseases and their adverse consequences, while vaccination can play a crucial role in their prevention, improving patient outcomes. Vaccination should represent a standard part of care for patients with cancer, diabetes, and both the diseases simultaneously, including people undergoing cancer treatment or in remission. Several international guidelines provide recommendations for vaccinating people with cancer or diabetes, but the two conditions have not been specifically evaluated together. Here we present a multidisciplinary consensus position paper on vaccination in patients with cancer and diabetes. The position paper is the result of a collaborative effort between experts from the Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE), and Italian Society of Pharmacology (SIF). The paper provides a comprehensive overview of the current state-of-the-art knowledge on vaccination in patients with cancer and diabetes. It discusses the importance of vaccination in preventing infections, focuses attention on the need to consider the unique challenges faced by patients with cancer and diabetes when it comes to vaccine administration, and highlights the need for coordinated care to optimize treatment outcomes. Overall, the consensus position paper provides healthcare professionals caring for patients with cancer and diabetes recommendations on the use of various vaccines, including influenza, COVID-19, HZV, and HPV vaccines, as well as guidance on how to address common concerns and challenges related to vaccine administration.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1717-1738"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying the impact and critical windows of extreme temperatures on the risk of gestational diabetes mellitus in twin pregnancies.","authors":"Yun-Ren Pan, Wei-Zhen Tang, Wei-Ze Xu, Ying-Xiong Wang, Li Wen, Yong-Heng Wang, Cheng-Zhi Hu, Shu-Juan Luo, Ya Chen, Chen-Yang Liu, Si-Ning Chen, Zhe-Ming Kang, Lan Wang, Qin-Yu Cai, Tai-Hang Liu","doi":"10.1007/s40618-025-02632-2","DOIUrl":"https://doi.org/10.1007/s40618-025-02632-2","url":null,"abstract":"<p><p>Extreme temperature events have become more frequent due to industrialization, urbanization, and climate change, leading to health risks. Women with twin pregnancies are particularly vulnerable, yet research on how these temperatures affect gestational diabetes mellitus (GDM) remains limited. This study investigates the impact of extreme temperatures on GDM incidence in twin pregnancies, focusing on identifying critical periods of susceptibility. Data from 3,769 twin pregnancies were analyzed using temperature information from local meteorological stations. Extreme temperatures, defined as heat waves and cold spells, were categorized by daily maximum, minimum, and mean temperatures. The relationship between the frequency and duration of these events and GDM risk was evaluated through multivariable logistic regression, while a distributed lag nonlinear logistic model assessed temperature impacts across gestational weeks. Results from 1,063 GDM cases revealed significant differences in incidence across screening temperatures. GDM risk increased with days exceeding the 90th percentile temperature in the four weeks prior to screening, as well as with the frequency of cold spells and heatwaves earlier in pregnancy. Both high and low extreme temperatures during specific gestational weeks were associated with higher GDM risk, suggesting these factors should be considered in preventive strategies for twin pregnancies.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced high-sensitivity C-reactive protein levels following weekly somapacitan in adults with growth hormone deficiency: a prospective pilot study.","authors":"Yasufumi Seki, Satoshi Morimoto, Makiko Ikemoto, Saya Takebe, Saori Kitayama, Kiyotaka Hirata, Noriyoshi Takano, Daisuke Watanabe, Atsuhiro Ichihara","doi":"10.1007/s40618-025-02664-8","DOIUrl":"https://doi.org/10.1007/s40618-025-02664-8","url":null,"abstract":"<p><strong>Introduction: </strong>Growth hormone (GH) deficiency (GHD) elevates high-sensitivity C-reactive protein (hs-CRP) levels, an inflammatory marker. While daily GH replacement has been shown to reduce hs-CRP levels, the effects of long-acting GH therapyon hs-CRP remain unclear.</p><p><strong>Purpose: </strong>This pilot study aimed to investigate the association between a once-weekly GH derivative, somapacitan, and hs-CRP in adult patients with GHD.</p><p><strong>Methods: </strong>This study prospectively evaluated serum hs-CRP levels and metabolic parameters in adult patients with untreated GHD during a 6-month course of weekly somapacitan therapy.</p><p><strong>Results: </strong>Among 13 adult patients with GHD (9 men; 10 with adult-onset GHD), serum hs-CRP levels significantly decreased following somapacitan therapy (0.24 [0.07-0.51] to 0.07 [0.06-0.25] mg/dL, P <.001), whereas serum insulin-like growth factor (IGF)-1 levels (80 ± 53 to 148 ± 74 ng/mL, P <.001) and IGF-1 SD scores (- 2.8 ± 2.3 to - 0.4 ± 1.7, P <.001) significantly increased. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels showed slight but statistically insignificant decreases after the treatment. Changes in hs-CRP levels correlated significantly with changes in IGF-1 SD scores (r = -.66, P =.01), AST (r =.67, P =.01), and ALT (r =.74, P =.004). In partial correlation analyses, changes in hs-CRP levels remained significantly associated with ALT changes (r =.59, P =.04), independent of IGF-1 SD score changes.</p><p><strong>Conclusion: </strong>The reduction in hs-CRP levels after somapacitan therapy for GHD suggests that somapacitan has a protective role against inflammation, possibly mediated by the liver.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}