Journal of Endocrinological Investigation最新文献

{"title":"The Scribe of Saqqara: adipomastia or gynecomastia?","authors":"F Trimarchi, E Martino","doi":"10.1007/s40618-025-02574-9","DOIUrl":"https://doi.org/10.1007/s40618-025-02574-9","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The spectrum of hypophosphatemia in internal medicine: lessons from a Greek population study.","authors":"Efstathia Megapanou, Matilda Florentin, Fotios Barkas, Haralampos Milionis, Eleni Bairaktari, George Liamis","doi":"10.1007/s40618-025-02558-9","DOIUrl":"https://doi.org/10.1007/s40618-025-02558-9","url":null,"abstract":"<p><strong>Background: </strong>Hypophosphatemia, a common but often overlooked electrolyte disorder in hospitalized patients, lacks routine monitoring. This study aimed to assess the incidence, causes and associated biochemical and clinical features, as well as concurrent electrolyte and acid-base disturbances and mortality in patients with hypophosphatemia in an internal medicine ward.</p><p><strong>Methods: </strong>We prospectively included adult patients who either presented with or developed hypophosphatemia (serum phosphate levels < 2.5 mg/dL or 0.81 mmol/L) during hospitalization.</p><p><strong>Results: </strong>Among 4,095 patients, 4.3% (n = 176) had or developed hypophosphatemia. Of those, 126 patients (71.6%) had hypophosphatemia on admission, while 50 patients (28.4%) developed hypophosphatemia during hospitalization. All but one patient exhibited mild (72.2%) or moderate (27.3%) hypophosphatemia with serum phosphate levels between 2 and 2.5 mg/dL (0.65-0.81 mmol/L) and 1-2 mg/dL (0.32-0.65 mmol/L), respectively. The most common potential causes of phosphate depletion were respiratory alkalosis, malnutrition, drugs, e.g. diuretics and corticosteroids, diabetes mellitus and secondary hyperparathyroidism, with most patients (75.6%) exhibiting more than one likely causes. 64.8% of patients had at least one concomitant electrolyte disorder, the most common being hypocalcemia (40.9%), hyponatremia (38.6%), hypomagnesemia (23.9%) and hypokalemia (22.7%). 77% of patients exhibited pure or mixed acid-base disorders, mainly respiratory alkalosis (48.3%). Mortality was markedly higher in hypophosphatemic patients compared to the overall hospitalized population (15.9% vs. 4.26%). Furthermore, 8.1% of discharged patients had died within a month. Patients who developed hypophosphatemia during hospitalization were older, with higher incidence of hyponatremia and mortality rate (16% versus 5.6%). They also had higher parathyroid hormone and lower vitamin D levels, compared with those with hypophosphatemia on admission.</p><p><strong>Conclusions: </strong>Hypophosphatemia in internal medicine patients is often multifactorial and may signal greater illness severity. The high prevalence of associated electrolyte and acid-base disturbances suggests shared underlying mechanisms.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary morphological and functional features in subclinical hypothyroidism with ST-Elevation myocardial infarction.","authors":"Donghui Zhang, Qi Zhao, Shenglong Hou, Chao Qu, Ruoxi Zhang, Huimin Xian","doi":"10.1007/s40618-025-02576-7","DOIUrl":"https://doi.org/10.1007/s40618-025-02576-7","url":null,"abstract":"<p><strong>Background: </strong>Subclinical hypothyroidism (SH), characterized by normal free tetraiodothyronine (FT4) but high hyroid-stimulating hormone (TSH), gains attention for relationship with cardiovascular diseases. This study aims to investigate coronary artery features of non-culprit lesions in SH patients with ST-elevation myocardial infarction (STEMI) to understand their intracoronary morphological and functional characteristics.</p><p><strong>Methods: </strong>A retrospective study of 1,570 STEMI patients with ≥ 50% non-culprit lesions analyzed coronary angiography, optical coherence tomography (OCT) imaging, & quantitative flow ratio (QFR) data. Patients were grouped based on SH status.</p><p><strong>Results: </strong>Among them, a total of 214 patients had SH. In baseline characteristics, the SH group showed lower male and smoker rates, lower free triiodothyronine (FT3), and higher high-sensitivity C-reactive protein (hs-CRP), N terminal pro B-type natriuretic peptide (NT-proBNP), and TSH levels than the non-SH group. SH group had longer lesions, more micro-vessels, more cholesterol crystals, and lower QFR values for non-culprit lesions. Additionally, SH was an independent predictor for coronary parameters including micro-vessel, cholesterol crystal, and QFR values ≤ 0.8. And the effect of SH on those coronary parameters did not show any interaction in different subgroups.</p><p><strong>Conclusions: </strong>There was an association between SH and specific coronary artery characteristics, including increased plaque inflammation and plaque instability (the increase of micro-vessels and cholesterol crystal detected by OCT) and potential endothelial dysfunction (the decrease of QFR value detected by QFR). Our forthcoming research will prioritize extensive, multi-center prospective studies aimed at elucidating the precise mechanisms and long-term prognosis of SH on coronary artery lesions.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The immune mechanism of the mTOR/ACC1/CPT1A fatty acid oxidation signaling pathway in Hashimoto's thyroiditis.","authors":"Lu Zhang, Mengfan He, Yanyan Liu, Baohua Wang, Xingjie Xie, Haixia Liu","doi":"10.1007/s40618-024-02501-4","DOIUrl":"10.1007/s40618-024-02501-4","url":null,"abstract":"<p><strong>Background: </strong>Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease (AITD), which is distinguished by high thyroid peroxidase antibody (TPOAb) or thyroglobulin antibody (TgAb). The differentiation of CD4⁺T cell subsets in patients with HT is imbalanced, with Treg cells decreased and Th17 cells abnormally activated. Fatty acid oxidation supports the differentiation of Th17 cells and induces inflammation, but the specific mechanism is still unknown. This study aimed to explore the role of fatty acid oxidation and its pathway in the pathogenesis of autoimmune thyroiditis and the immune mechanism.</p><p><strong>Methods: </strong>In in vitro experiments, a total of 60 HT patients and 20 healthy controls were selected and their CD4⁺T cells were sorted by magnetic beads. All 80 samples were divided into 4 groups on average: HC group (Healthy control group), HT group (Hashimoto thyroiditis CD4⁺T cell inactive group), TCC group(Hashimoto thyroiditis CD4⁺T cell activation), TCC + ETO group(Hashimoto thyroiditis CD4⁺T cell activation + Etomoxir group). In in vivo experiments, the mice were randomly divided into 3 groups: Con group(Control group), mTg group (CBA/J mice were injected with mTg for modeling, that is EAT mice group), and mTg + ETO group (Etomoxir intervention in EAT mice group). Fatty acid oxidation substrates of CD4⁺T cells in human peripheral blood were detected by targeted metabolomics. The expressions of key fatty acid oxidation proteins mTOR, ACC1 and CPT1A were detected by Western blotting. The proportion of CD4⁺T cell subtype differentiation in human and mouse models was detected by flow cytometry. The severity of EAT was detected by HE staining.</p><p><strong>Results: </strong>Compared with healthy controls, the level of CPT1A in CD4⁺T cells of HT patients was increased, and the intracellular fatty acid content was significantly decreased, indicating that the level of fatty acid oxidation was enhanced in HT patients. After adding Etomoxir, the level of fatty acid oxidation was significantly inhibited, and the imbalance of CD4⁺T cell subpopulation differentiation in HT patients was reversed. In EAT mice, the mTOR/ACC1/CPT1A pathway was significantly activated, and its expression level was decreased after adding Etomoxir. At the same time, Etomoxir could reverse the reprogramming of abnormal metabolism in EAT mice cells, reduce the spleen index, and improve lymphocyte infiltration in the thyroid.</p><p><strong>Conclusions: </strong>The mTOR/ACC1/CPT1A fatty acid oxidation pathway of CD4⁺T cells in Hashimoto's thyroiditis was increased, and treatment with Etomoxir could inhibit the activation of this pathway, and reverse the reprogramming of abnormal metabolism in CD4⁺T cells, thereby reducing Hashimoto's thyroiditis.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"845-859"},"PeriodicalIF":5.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary titin as a biomarker of sarcopenia in diabetes: a propensity score matching analysis.","authors":"Y Takiguchi, R Tsutsumi, M Shimabukuro, H Tanabe, A Kawakami, M Hyodo, K Shiroma, H Saito, M Matsuo, H Sakaue","doi":"10.1007/s40618-024-02490-4","DOIUrl":"10.1007/s40618-024-02490-4","url":null,"abstract":"<p><strong>Purpose: </strong>Measuring urinary titin levels is expected to be useful in screening for muscle damage or injury in various diseases. We evaluated whether urinary titin levels were elevated in individuals with type 2 diabetes mellitus (T2DM) and how urinary titin levels were associated with the diagnosis of sarcopenia in T2DM.</p><p><strong>Methods: </strong>We performed a cross-sectional analysis of 114 controls and 515 patients with T2DM. Multivariate-adjusted models were used to determine the odds ratios (OR) of urinary titin cutoff values for diagnosing sarcopenia.</p><p><strong>Results: </strong>Urinary titin levels were higher in the T2DM group than in the non-diabetes group after propensity score matching (median [IQR] 3.2 [2.3, 4.6] vs. 4.4 [2.7, 6.9] pmol/mg·creatinine). T2DM was associated with high titin levels after correction for comorbidities (odds ratio 2.46, 95% confidence interval (CI) 1.29-4.70, P = 0.006) but not after correction for sarcopenia-associated factors. Urinary titin levels above the cutoff value showed an odd ratio of 6.61 (age- and body mass index-adjusted, 1.26-34.6, P = 0.021) for the diagnosis of sarcopenia in men with T2DM aged ≥ 75 years.</p><p><strong>Conclusion: </strong>Results indicated that T2DM was associated with a high-titin state and that the urinary titin cutoff value could be useful for identifying candidates at high risk for sarcopenia, such as elderly men.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1041-1056"},"PeriodicalIF":5.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Androgen receptor CAG repeat polymorphism might be a possible cause of familial constitutional delay of growth and puberty.","authors":"Gözde Akın Kağızmanlı, Reyhan Deveci Sevim, Hayrullah Manyas, Ahu Paketçi, Korcan Demir, Ece Böber, Gönül Çatlı, Ahmet Anık, Ayhan Abacı","doi":"10.1007/s40618-024-02502-3","DOIUrl":"10.1007/s40618-024-02502-3","url":null,"abstract":"<p><strong>Background: </strong>Induction of puberty in boys with constitutional delay of growth and puberty (CDGP) through a short course of low-dose testosterone therapy indicates the critical interaction between testosterone and the androgen receptor (AR) during the activation and maturation of the hypothalamic-pituitary-gonadal axis at puberty onset. Previous studies have shown an inverse relationship between the CAG repeat length and the transactivation function or expression level of the AR gene.</p><p><strong>Objective: </strong>We aimed to investigate whether the AR CAG repeat polymorphism has any implications on pubertal delay.</p><p><strong>Subjects and methods: </strong>Thirty-three male patients with CDGP were enrolled in the study group, while 53 age-matched healthy individuals who had entered puberty on time were included in the control group. The CAG repeat length was determined through direct DNA sequencing analysis.</p><p><strong>Results: </strong>The median chronological age of boys with CDGP was 14.2 (14.1-14.6) years, compared to 14.2 (13.65-14.8) years for healthy subjects (p = 0.5). In the CDGP group, 22 (66.7%) children had a family history of the condition. There was no significant difference between the groups in terms of AR CAG repeat length (median AR CAG repeat length: 21 (20-24.5) and 20 (20-24), respectively, p = 0.1). However, in boys with CDGP with a similar family history (n = 22), a significantly longer AR CAG repeat length was found compared to the control group (n = 53) (median AR CAG repeat length: 22 (20-25) and 20 (20-24), respectively, p = 0.03). The median AR CAG repeat length in boys without a family history was 21 (20-22) triplets. Although boys with a family history had a slightly longer AR CAG repeat length than those without, the difference was not statistically significant (p = 0.07). Additionally, no significant differences were observed between boys with non-familial CDGP and control subjects (p = 0.8). Furthermore, no significant differences in anthropometric characteristics or hormonal parameters were found when patients with CDGP were categorized by AR CAG repeat length quartiles.</p><p><strong>Conclusion: </strong>This is the first study to investigate the role of AR CAG polymorphism in the etiopathogenesis of CDGP. Our findings suggest that the AR CAG repeat length may be associated with familial CDGP.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"959-966"},"PeriodicalIF":5.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predictive risk factors of hypertensive disorders in pregnant women at high risk for gestational diabetes. The PREeclampsia in DIabetiC gestaTION (PREDICTION) study.","authors":"Francesca Nicolì, Fabrizia Citro, Lorella Battini, Michele Aragona, Giovanni De Gennaro, Piero Marchetti, Stefano Del Prato, Alessandra Bertolotto, Cristina Bianchi","doi":"10.1007/s40618-024-02520-1","DOIUrl":"10.1007/s40618-024-02520-1","url":null,"abstract":"<p><strong>Purpose: </strong>Women with gestational diabetes (GDM) have increased risk of hypertensive disorders in pregnancy (HDP). However, knowledge remains limited for women with high-risk metabolic profiles, regardless of GDM diagnosis. This study aimed to evaluate the prevalence of HDP among women at high risk for GDM, while simultaneously identifying potential predictive clinical risk factors of HDP.</p><p><strong>Methods: </strong>Pregnant women who performed a 75-gr Oral Glucose Tolerance Test for the selective screening (based on pre-pregnancy risk factors) of GDM were prospectively enrolled (October 2019-June 2022). The development of HDPwas assessed. Logistic regression and ROC-curve analysis were used to identify predictive risk factors for HDP.</p><p><strong>Results: </strong>Of the 398 women enrolled (53.5% with GDM), 30 (8%) developed HDP. Women developing HDP had more frequently a family history of type 2 diabetes, a personal history of GDM or preeclampsia, and showed higher pregestational BMI and first-trimester fasting plasma glucose. Moreover, at GDM screening, they had higher fasting and 1-hour glucose levels, and higher systolic and diastolic blood pressure. At logistic regression, systolic and diastolic blood pressure were the strongest risk factors for HDP. The risk increased for systolic blood pressure ≥ 127 mmHg (61% sensitivity, 86% specificity, PPV:27%, NPV:86%) and diastolic blood pressure ≥ 82 mmHg (57% sensitivity, 92% specificity, PPV:38%, NPV:96%).</p><p><strong>Conclusion: </strong>Women at high risk for GDM with poor metabolic profile have higher prevalence of HDP. Systolic and diastolic blood pressure at the time of GDM screening may identify women with higher risk of developing HDP, regardless of GDM diagnosis.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1033-1040"},"PeriodicalIF":5.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aetiology, diagnosis and treatment of thalassemia-associated osteoporosis of the adult.","authors":"Maria Rosaria Ambrosio, Camilla Alice Cattaneo, Irene Gagliardi, Aldo Carnevale, Maria Chiara Zatelli","doi":"10.1007/s40618-024-02503-2","DOIUrl":"10.1007/s40618-024-02503-2","url":null,"abstract":"<p><strong>Aim: </strong>This review aims to overview factors contributing to TAO development and addresses the targeted diagnostic work-up and treatment management in adult thalassemic patients.</p><p><strong>Results: </strong>Osteoporosis management in Thalassemia is challenging because several factors contributing to its pathogenesis should be considered and controlled starting from child- hood. A multidisciplinary approach is crucial. Evidence concerning the efficacy of available anti-osteoporosis drugs in thalassemic patients is scarce. In this scenario, clinical experience and center resources often guide the treatment choice. More efforts should be made to share knowledge in this field in order to indicate specific treatment strategies for TAO management.</p><p><strong>Methods: </strong>We performed a literature search in Pubmed from 1992 to March 2024 using the words Thalassemia and: osteoporosis, Bisphosphonates, Denosumab, Teriparatide, Romosozumab, hormone replacement therapy, growth hormone, hypogonadism, calcium, vitamin D, bone disease, sarcopenia. The search was limited to English literature including original studies, reviews, meta-analyses, case reports.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"799-815"},"PeriodicalIF":5.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additive effect of Bisphenol A and Pefluoro-sulphoctanoic acid exposure at subacute toxic levels, on a murine model of sertoli cell.","authors":"I Sabovic, L De Toni, A Di Nisio, C M Radu, D Gabbia, S De Martin, A Ferlin","doi":"10.1007/s40618-024-02498-w","DOIUrl":"10.1007/s40618-024-02498-w","url":null,"abstract":"<p><strong>Purpose: </strong>Endocrine disruptors (EDs) interfere with the endocrine system leading to health consquences and reproductive derangements. Most EDs are environmental pollutants whose risk evaluation is hampered by the simultaneous exposure to a number of chemicals. Here we investigated the possible mechanistic involvement of Sertoli cells, the nurse cell population in the seminiferous tubule, in the reproductive toxicity of Bisphenol A (BPA) and perfluoro-octane sulphonate (PFOS), two acknowledged EDs, at recognized subacute toxic levels.</p><p><strong>Methods: </strong>Mouse Sertoli cell line TM4 were exposed for 24 h to 40 ng/mL BPA or 30 ng/mL PFOS or their association. Cell proliferation was measuerd by MTT assay. Cell apoptosis was evaluated with Annexin-V/propidium iodide staining. Protein expression analysis was peformed by western blotting.</p><p><strong>Results: </strong>Compared to unexposed controls (100.0 ± 3.5%), cells exposed to BPA (79.5 ± 3.5%) or PFOS (76.0 ± 7.9%) showed reduced survival rate (P < 0.001 vs control). The exposure to the mixture of BPA and PFOS was associated with a further reduction of cell survival (63.9 ± 7.2%, P < 0.001 vs control) and an increase of the percentage of apoptotic cells (13.7 ± 4.6% control, 40.3 ± 13.5% BPA, PFOS 28.7 ± 5.6%, 67.1 ± 19.6% BPA + PFOS P = 0.001 vs control; P = 0.022 vs BPA). The exposure to the combination of BPA and PFOS was associated with Akt-signaling pathway activation and with the downstream caspase 3 cleavage. In addition, the exposure to the combination of BPA and PFOS was associated with NF-κB activation and increased expression of FasL.</p><p><strong>Conclusion: </strong>Subacute toxic levels of BPA and PFOS display additive effects on Sertoli cell apoptosis with the possible involvement of FasL-dependent germ cell apoptosis.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"951-958"},"PeriodicalIF":5.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emperor Leo I \"the Thracian\": a possible case of Graves' orbitopathy.","authors":"Remo Accorona, Alice Cremasco","doi":"10.1007/s40618-024-02529-6","DOIUrl":"10.1007/s40618-024-02529-6","url":null,"abstract":"<p><p>Representation of exophthalmos in ancient artworks is reported by several authors. In the present paper we analyze a sculpture belonging to the V century AD, likely embodying the eastern Roman emperor Leo I. As the portrait statue is sculpted with uncommon prominent eyes, we discuss the possibility that the historical personage was affected by exophthalmos due to Graves' orbitopathy.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1057-1060"},"PeriodicalIF":5.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}