Journal of Endocrinological Investigation最新文献

{"title":"Adrenal causes of endocrine hypertension in childhood or adolescence.","authors":"Bianca Pellegrini, Ilaria Bonaventura, Valeria Hasenmajer, Chiara Simeoli, Claudia Pivonello, Davide Ferrari, Sabrina Criscuolo, Alessandra Tomaselli, Andrea M Isidori, Ashley B Grossman, Andrea Lenzi, Maria Cristina De Martino, Martin O Savage","doi":"10.1007/s40618-025-02633-1","DOIUrl":"https://doi.org/10.1007/s40618-025-02633-1","url":null,"abstract":"<p><p>Arterial hypertension is characterised by elevated blood pressure (BP) leading to cardiovascular morbidity and mortality, and organ damage. Its prevalence in childhood is around 5% and children should be screened from 3 years of age. Hypertension in childhood or adolescence requires exclusion of a secondary cause. Adrenal disorders frequently underlie secondary hypertension. presenting with imbalances of BP and pleiotropic clinical presentations. Examples are rare genetic defects leading to increased mineralocorticoid activity such as Congenital Adrenal Hyperplasia (CAH) due to 11β-hydroxylase gene (CYP11B1) or 17-hydroxylase gene (CYP17A1) mutation, and Familial Hyperaldosteronism (FH), due to 11β-hydroxylase 1 (CYP11B1) and 11β-hydroxylase 2 (CYP11B2) gene fusion, or to mutations of other genes involved in aldosterone production such as those codifying the chloride-voltage gated channel 2 (CLCN2), the potassium inwardly rectifying channel subfamily J member 5 (KCNJ5), and the calcium voltage-gated channel subunitsα1 H and D (CACNA1H and CACNA1D). The differential diagnosis of childhood hypertension also includes endogenous hypercortisolism (Cushing's syndrome) or phaeochromocytomas/paragangliomas, neoplastic conditions potentially caused by germinal genetic alterations, in a specific familial syndrome. Lastly, peripheral glucocorticoid and mineralocorticoid pathway disorders due to germline mutations in HSD-11B2, codifying the enzyme 11β-dehydrogenase type 2, NR3C1 and NR3C2 genes codifying the nuclear receptor subfamily 3 group C members 1 and 2 may also be responsible. A systematic diagnostic approach based on published guidelines is still lacking, and diagnostic suspicions with referral for gene sequencing need to be identified. This review discusses the known causes of endocrine hypertension in children and adolescents, with an emphasis on prevalence, clinical presentation, genetic predisposition and therapeutic strategies.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional dysregulation, obsessive-compulsive traits, and eating disorders: three constructs for one spectrum?","authors":"Silvia Tempia Valenta, Valentina Beghelli, Federica Marcolini, Magda Rosinska, Diana De Ronchi, Fernando Fernandez-Aranda, Anna Rita Atti","doi":"10.1007/s40618-025-02617-1","DOIUrl":"https://doi.org/10.1007/s40618-025-02617-1","url":null,"abstract":"<p><strong>Purpose: </strong>Dysfunctional eating behaviors are associated with emotional dysregulation and obsessive-compulsive symptoms. Traditionally, obsessiveness has been linked to anorexia nervosa (AN), while dysregulation has been associated with bulimia nervosa (BN) and binge eating disorder (BED). However, this dichotomous view fails to account for the frequent diagnostic crossover observed among individuals with eating disorders (EDs). This study aimed to identify specific clusters in individuals with EDs based on emotional dysregulation, obsessive-compulsive symptoms, eating symptoms, and body uneasiness.</p><p><strong>Methods: </strong>An observational cross-sectional study was conducted at the ED Unit of Clinical Psychiatry, Bologna, Italy. Participants (N = 360) completed the Difficulties in Emotion Regulation Scale (DERS), Obsessive Compulsive Inventory-Revised (OCI-R), Eating Disorders Examination Questionnaire (EDE-Q), and Body Uneasiness Test (BUT). Hierarchical and two-step cluster analyses were applied. Cluster differences were examined using Kruskal-Wallis tests and post-hoc comparisons.</p><p><strong>Results: </strong>The analysis identified three clusters with increasing levels of emotional dysregulation, obsessive-compulsive symptoms, eating symptoms, and body uneasiness (Cluster size ratio = 2.04; Silhouette = 0.30). Symptom severity ranged from more functional (Cluster 1) to moderate (Cluster 2) to more dysfunctional (Cluster 3).</p><p><strong>Conclusion: </strong>This study identified three clusters representing a progressive gradient in the symptoms assessed, challenging the traditional dichotomy linking obsessiveness solely to AN and dysregulation solely to BN/BED.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of bone density and microstructure by DXA, TBS and HR-pQCT: an assessment of cortical porosity and its association with vertebral fractures in patients with acromegaly.","authors":"P G Ornellas, Emf Gama, Lmc Mendonça, C Villela-Nogueira, F P Paranhos-Neto, L Kasuki, M R Gadelha, Mlf Farias, M Madeira","doi":"10.1007/s40618-025-02619-z","DOIUrl":"https://doi.org/10.1007/s40618-025-02619-z","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with acromegaly are at increased risk of fractures, regardless of areal bone mineral density (BMD). This study aimed to identify whether vertebral fractures (VFs) are related to decreases in bone volumetric density and microstructure via high-resolution peripheral quantitative computed tomography (HR-pQCT) and the trabecular bone score (TBS).</p><p><strong>Methods: </strong>VF was evaluated in 49 patients with acromegaly (22 men and 27 women) via spine X-ray. Areal BMD, volumetric BMD, and bone microstructure were analyzed via dual-energy X-ray absorptiometry (DXA) and HR-pQCT. Lumbar spine trabecular quality was assessed via TBS.</p><p><strong>Results: </strong>Morphometric VFs were identified in 22 patients (11 men and 11 women), accounting for 44.9% of the cohort. Hypogonadism was more common in patients with VFs (59.1% vs. 22.2%; p = 0.017). BMD measured by DXA or HR-pQCT did not differ between patients with and without VFs. The proportion of patients classified as having partially degraded or degraded bone microstructure according to a TBS < 1.310 was 26% (with VF) vs. 32% (without VF; p = 0.749). There was no difference in bone geometry (trabecular and cortical area, cortical perimeter) or microstructure (number, thickness, separation, and trabecular heterogeneity, as well as cortical thickness), except for a trend toward greater cortical porosity at the distal radius in patients with VFs (p = 0.067).</p><p><strong>Conclusions: </strong>VFs were identified in 44.9% of patients with acromegaly, and hypogonadism was more common among those with VFs. There were no significant differences in bone density or microstructure measured by DXA, TBS, or HR-pQCT in patients with or without VFs.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary modulation of pubertal timing: gut microbiota-derived SCFAs and neurotransmitters orchestrate hypothalamic maturation via the gut-brain axis.","authors":"Xiaoqing You, Wei Yang, Xiuyun Li, Xiaoli Li, Ying Huang, Congfu Huang","doi":"10.1007/s40618-025-02615-3","DOIUrl":"https://doi.org/10.1007/s40618-025-02615-3","url":null,"abstract":"<p><strong>Background: </strong>The global rise in early pubertal activation is closely linked to dietary patterns and gut microbiota (GM) dysbiosis. This review synthesizes evidence on how GM-derived metabolites modulate hypothalamic maturation and pubertal timing through the gut-brain axis.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we conducted a systematic review of human and animal studies (PubMed, Medline, CNKI, Wanfang) up to October 2024, focusing on dietary impacts (high-fat/high-sugar) on GM composition and puberty onset. Inclusion criteria prioritized studies linking GM metabolites to HPGA activation.</p><p><strong>Results: </strong>High-fat/high-sugar diets reduce GM diversity and short-chain fatty acid (SCFA) production (e.g., butyrate, acetate), impair gut barrier integrity, and promote systemic inflammation. Dysbiosis in SCFA-producing taxa (Roseburia, Faecalibacterium) and neurotransmitter-modulating genera (Bifidobacterium, Lactobacillus) disrupts leptin/insulin signaling and kisspeptin-GnRH interactions, accelerating HPGA activation. Animal studies demonstrate SCFA supplementation delays puberty by reducing hypothalamic inflammation, while human data reveal ethnic and dietary variability in GM profiles. Western diets heighten altered pubertal timing risk via GM-mediated HPGA dysregulation, whereas fiber-rich Mediterranean diets exhibit protective effects.</p><p><strong>Conclusion: </strong>GM dysbiosis and SCFA depletion are pivotal in diet-driven alterations of pubertal timing. Culturally adapted interventions targeting microbiota-metabolite interactions may mitigate risks of early puberty onset.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mannequin resembling a young woman with Graves' disease.","authors":"F Trimarchi, E Martino, L Bartalena","doi":"10.1007/s40618-025-02628-y","DOIUrl":"https://doi.org/10.1007/s40618-025-02628-y","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of shear wave elastography in diagnosing sarcopenia in patients with type 2 diabetes.","authors":"Li An, Jinjun Shi, Ye Pan, Yu Ding, Wei Gao, Liqun Ren, Jing Wang, Yao Wang","doi":"10.1007/s40618-025-02623-3","DOIUrl":"https://doi.org/10.1007/s40618-025-02623-3","url":null,"abstract":"<p><strong>Objective: </strong>To assess the utility of shear wave elastography (SWE) for the diagnosis of sarcopenia in individuals with type 2 diabetes (T2D).</p><p><strong>Methods: </strong>In this study, we measured the shear wave velocity (SWV) in the medial gastrocnemius muscle (GCM) in both the relaxed and stretched states via SWE. The study involved 273 T2D patients at Zhongda Hospital Southeast University and was conducted between March 2022 and June 2023. In addition to the SWV, we evaluated the appendicular skeletal muscle mass index (ASMI), muscle strength as measured by handgrip strength, and gait speed as measured by the 6-meter walk test. We analyzed the relationships between conventional sarcopenia indicators and SWV variables and developed diagnostic models based on significant predictors.</p><p><strong>Results: </strong>The age of the patients ranged from 60 to 72 years, with a median age of 66 years, and nearly half (48.0%, n = 131) were female. On the basis of the 2019 criteria set by the Asian Working Group for Sarcopenia (AWGS), the participants were categorized into nonsarcopenia (212, 77.7%) and sarcopenia (61, 22.3%) groups. There was a notable difference in the SWV between those with and without sarcopenia (p < 0.01). A robust positive correlation was identified between traditional sarcopenia indicators and the SWV_bent. A logistic regression model incorporating BMI, ASMI, SWV_straight, and SWV_bent demonstrated high sensitivity (96.7%) and specificity (82.5%), with an AUC of 0.946.</p><p><strong>Conclusion: </strong>Our findings suggest that SWE could be a valuable tool for the objective assessment of sarcopenia in T2D patients. However, additional large-scale, multicenter, and prospective studies are warranted to validate these results.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes toward pig islet xenotransplantation for type 1 diabetes: a scoping review.","authors":"Daniel J Hurst, Daniel Rodger, Luz A Padilla, Fernando Ovalle","doi":"10.1007/s40618-025-02626-0","DOIUrl":"https://doi.org/10.1007/s40618-025-02626-0","url":null,"abstract":"<p><strong>Background: </strong>Over 8 million people globally have type 1 diabetes. Islet allotransplantation offers an alternative to insulin therapy but is constrained by donor availability. Genetically modified pig islet transplantation presents a potential solution, yet understanding stakeholder attitudes is crucial before clinical adoption.</p><p><strong>Methods: </strong>This scoping review followed Joanna Briggs Institute methodology and PRISMA guidelines. CINAHL, EMBASE, PubMed, PsychINFO, and SCOPUS were searched for studies examining attitudes toward pig islet xenotransplantation among patients, healthcare workers, and other stakeholders.</p><p><strong>Results: </strong>From 199 sources, 16 met eligibility criteria, spanning ten countries from 2003 to 2023. The 23,780 participants included 1,535 (6.5%) patients/family members, 216 (0.9%) healthcare workers, and 22,029 (92.6%) students. Attitudes were generally positive but declined sharply in some studies when risks, such as viral transmission, were disclosed.</p><p><strong>Conclusion: </strong>Despite overall positive attitudes, risk perception significantly influences acceptance of islet xenotransplantation. The predominance of quantitative research highlights a need for qualitative studies and validated survey instruments to enhance understanding and comparability of stakeholder perspectives.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of sodium-glucose cotransporter 2 inhibitors on cardiomyopathy: a meta-analysis.","authors":"Bo Xu, Tianqiao Zhang, Jiecan Zhou","doi":"10.1007/s40618-025-02625-1","DOIUrl":"https://doi.org/10.1007/s40618-025-02625-1","url":null,"abstract":"<p><strong>Background: </strong>Cardiomyopathies can present at any age and affect individuals and families across the entire life course. Clinical effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on cardiomyopathy have not yet been fully elucidated.</p><p><strong>Objective: </strong>The primary objective of this study was to investigate whether SGLT2 inhibitors have an effect on cardiomyopathy compared to placebo.</p><p><strong>Methods: </strong>We systematically searched for randomized double-blind placebo-controlled trials on PubMed, Web of Science, EU Clinical Trials Register, and ClinicalTrials.gov. We used the Mantel-Haenszel statistical method, fixed-effects model and risk ratio (RR) with 95% confidence intervals (CI) to analyze binary data.</p><p><strong>Results: </strong>A total of 19 studies were included, covering 97,035 participants. Compared to placebo, SGLT2 inhibitors were associated with a reduced risk of cardiomyopathy (RR 0.72; 95% CI 0.56-0.92; P < 0.01; high certainty of evidence), with non-significant heterogeneity (P_{heterogeneity}=0.81; I² = 0%), especially observed in the empagliflozin subgroup (RR 0.66; 95% CI 0.46-0.94; P = 0.02), chronic kidney disease (RR 0.67; 95% CI 0.47-0.97; P = 0.03) population and heart failure (RR 0.46; 95% CI 0.23-0.91; P = 0.03) population. However, in type 2 diabetes mellitus population, the effect of SGLT2 inhibitors on cardiomyopathy incidence was less clear (RR 0.76; 95% CI 0.51-1.12; P = 0.17; moderate certainty of evidence). Additionally, SGLT2 inhibitors were associated with a reduced risk of primary cardiomyopathy (RR 0.43; 95% CI 0.21-0.87; P = 0.02) and slightly decreased the incidence of secondary cardiomyopathy compared to placebo (RR 0.75; 95% CI 0.56-1.01; P = 0.06).</p><p><strong>Conclusions: </strong>SGLT2 inhibitors significantly reduced the risk of cardiomyopathy, which further enhances the cardiovascular benefits of SGLT2 inhibitors in clinical settings, especially for patients with heart failure and chronic kidney disease.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenic obesity and physical function in acromegaly: impact of disease control and evaluation using dual X-ray absorptiometry and multifrequency bioelectrical impedance analysis.","authors":"Arthur Costa Inojosa, Ana Vitória Hirt, Thaís Araújo, Maria Eduarda Ferreira, Luma Andrade, Vinícius Cunha, Daniella Rego, Aline Lopes, Francisco Bandeira","doi":"10.1007/s40618-025-02624-2","DOIUrl":"https://doi.org/10.1007/s40618-025-02624-2","url":null,"abstract":"<p><strong>Purpose: </strong>To assess sarcopenia, sarcopenic obesity, physical performance in patients with acromegaly and compare the diagnostic performance of dual-energy X-ray absorptiometry (DXA) and multifrequency bioelectrical impedance analysis (BIA).</p><p><strong>Methods: </strong>This cross-sectional study included 27 patients with acromegaly and 27 age-, sex-, and BMI-matched patients without acromegaly. Body composition was assessed using BIA and DXA. Lean mass indices included fat-free mass index (FFMI) and skeletal muscle index (SMI) via BIA, and the Baumgartner (BMG) and Foundation for the National Institutes of Health indices via DXA. Obesity parameters included fat mass index (FMI) and body fat percentage via BIA. Physical performance was evaluated using handgrip strength (HGS), Timed Up and Go (TUG), 4-m gait speed (4MGS), and the Short Physical Performance Battery (SPPB) tests. The strength, assistance in walking, rising from a chair, climbing stair and falls (SARC-F) questionnaire was also performed.</p><p><strong>Results: </strong>Strong correlations were observed between BIA and DXA body composition measures (r = 0.83, p < 0.01 for %BIA fat mass vs. %DXA fat mass; r = 0.80, p < 0.01 for SMI vs. BMG and r = 0.80, p < 0.01 for FFMI vs. BMG). Patients with acromegaly had significantly higher FFMI than patients without the disease (p = 0.03), but no difference in sarcopenic obesity prevalence (p = 0.50). Patients with acromegaly performed worse in the TUG and 4MGS tests, even after adjustment for confounders (p < 0.01 for both). No significant associations were found between SARC-F scores and lean mass or physical performance.</p><p><strong>Conclusion: </strong>Patients with acromegaly showed impaired physical performance despite higher FFMI, with no differences in sarcopenic obesity. The SARC-F questionnaire showed limited diagnostic value in this population.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CT-based radiomic model for predicting vertebral fractures in older patients with type 2 diabetes mellitus: A longitudinal study.","authors":"Zicheng Wei, Rui Yu, Yiping Zhang, Yu Wang, Jianhua Wang, Cao Xie, Xiao Chen","doi":"10.1007/s40618-025-02627-z","DOIUrl":"https://doi.org/10.1007/s40618-025-02627-z","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}