Journal of Endocrinological Investigation最新文献

{"title":"Aromatase inhibitor (Anastrozole) improves near adult height (AH) in growth hormone treated adolescents with Prader-Willi syndrome.","authors":"Moris A Angulo, Merlin G Butler","doi":"10.1007/s40618-026-03046-4","DOIUrl":"https://doi.org/10.1007/s40618-026-03046-4","url":null,"abstract":"<p><strong>Purpose: </strong>Prader-Willi syndrome (PWS) is a complex multisystemic genetic condition characterized by obesity, short stature and growth with other hormone deficiencies. Aromatase inhibitors (AI) delay estrogen-driven epiphyseal fusion and may enhance near adult height (AH). We investigated whether Anastrozole, a potent aromatase inhibitor, could impact AH in adolescent boys with PWS treated with growth hormone (GH).</p><p><strong>Methods: </strong>We undertook a retrospective designed study of two groups of boys diagnosed with PWS at a young age and treated with GH. Eighteen boys treated with GH alone (GHA) were compared to 19 boys treated with GH and AI added between 10 and 13 years of age. Height, weight and bone age were tracked. We analyzed AH achieved in those treated with GH alone (GHA) vs. GH plus AI (GHAI). ANOVA was used for data analysis.</p><p><strong>Results: </strong>More advanced bone age and a higher body mass index were found in both subject groups and a slowdown of skeletal maturation in the treated GHAI group. Mean age after reaching AH for the GHA group was 14.2 years and 17.2 years for the GHAI group. The mean AH standard deviation score (AH-SDS) before and after treatment in the GHA group was -1.8 ± 1.5 /0.11 ± 1.0 and -0.85 ± 0.7/0.81 ± 0.9 for GHAI, both significant (p < 0.0001), and difference between AH-SDS was also significantly greater in the GHAI group [1.01 ± 0.33 (p = 0.004)].</p><p><strong>Conclusion: </strong>Increased adiposity and premature adrenarche may accelerate growth velocity in PWS children and decreased AH. Anastrozole was effective in slowing bone maturation and improving AH in GH treated adolescents without significant side effects.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149326469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtle diastolic dysfunction in children with idiopathic subclinical hypothyroidism: effect of two years of l-thyroxine treatment.","authors":"M Arcopinto, M Salerno, R Di Mase, A Salzano, F R Rotondo, S Vasaturo, A Cittadini, D Capalbo","doi":"10.1007/s40618-026-03002-2","DOIUrl":"10.1007/s40618-026-03002-2","url":null,"abstract":"<p><strong>Purpose: </strong>Data about clinical implications of subclinical hypothyroidism (SH) in children are scanty, and the management of this condition is still challenging particularly for mild forms (TSH levels ranging between 4.5 and 10 mU/L). Aim of this study is to compare left ventricular (LV) geometry and function in SH children and matched euthyroid controls, and to evaluate the cardiac effects of L-thyroxine (L-T₄) therapy.</p><p><strong>Methods: </strong>Thirty-six children (19 females), aged 8.3 ± 0.7 years, with persistent and idiopathic SH were enrolled in the study. Thirty-six euthyroid children comparable for sex, age and body mass index were enrolled as controls. Baseline echocardiography and biochemical assessment was performed in all subjects. Thereafter, SH children started L-T₄ therapy. Both assessments were repeated after 2 years of therapy in patients and 2 year -follow-up in controls.</p><p><strong>Results: </strong>The LV cavity size was comparable between SH and controls, at baseline, and increased similarly over time. LV systolic function was normal at baseline in both groups and remained comparable at end-study. With regard to diastolic function, SH children showed a significant prolongation of isovolumic relaxation time (IVRT) compared with controls (92.95 ± 3.74 vs 76.13 ± 2.75 msec, p = 0.0006), with normal E/A and E/E' ratios in both populations, consistent with subclinical, mild diastolic dysfunction. After L-T₄ therapy, IVRT significantly decreased (81.43 ± 4.28 msec p < 0.05) becoming similar to controls (82.20 ± 2.14 msec).</p><p><strong>Conclusion: </strong>Long-lasting mild SH in children is associated with subtle abnormality of LV relaxation which improves with L-T₄ therapy. Whether these subtle alterations may lead to significant clinical consequences require further investigation.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"3325-3334"},"PeriodicalIF":3.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of C-reactive protein to albumin ratio with progression of CKD and all-cause mortality in diabetic CKD.","authors":"Junwen Mao, Haibo Li, Jiaxin Wang, Shuangzhu Yang, Yanjun Wang","doi":"10.1007/s40618-026-02980-7","DOIUrl":"10.1007/s40618-026-02980-7","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The C-reactive protein to albumin ratio (CAR), an integrative biomarker of inflammation and malnutrition, has shown prognostic value in various diseases, but its role in diabetic chronic kidney disease (CKD) remains inadequately defined. This study aimed to evaluate the independent association of CAR with progression of chronic kidney disease (CKD) and all-cause mortality.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design and methods: &lt;/strong&gt;We retrospectively retrieved 231 CKD patients with diabetes who had not received erythropoietin stimulants or iron therapy. The primary outcomes were mortality and progression of CKD (composite), specifically, progression to end-stage renal disease (ESRD) and initiation of renal replacement therapy (RRT), or a doubling of serum creatinine (SCr) levels in patients not receiving RRT. We used Kaplan-Meier survival curves and constructed multivariate Cox proportional hazards models adjusted for potential confounding factors, to estimate the association of CAR with progression of CKD and all-cause mortality; in addition, we employed restricted cubic spline analysis to explore nonlinear relationships. We used the SHAP machine learning algorithm to evaluate the predictive performance of CAR and to analyze the predictive increment of CAR for clinical outcomes. Subgroup analyses were conducted to assess the robustness of the results across different subgroups and modeling choices.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The analysis cohort included a total of 231 adults. Kaplan-Meier curves showed a progressive and significant increase in cumulative CKD progression and mortality across CAR quartiles. In the fully adjusted model of the Cox multivariate regression analysis, a 1-unit increase in CAR (log-transformed) was associated with a 59% increase in the risk of CKD progression (HR = 1.59, 95% CI 1.20-2.09; P = 0.001) and a 32% increase in the risk of mortality (HR = 1.32, 95% CI 1.03-1.68, P = 0.029); participants in the highest quartile had a significantly higher mortality risk compared to those in the lowest quartile (Q4 vs. Q1, HR = 3.8, 95% CI 1.24-11.67; P = 0.02). Restricted cubic spline analysis revealed a significant linear relationship (nonlinear P &gt; 0.05). Subgroup analysis indicated that CAR was consistently associated with outcomes across different age, sex, and BMI groups, with no significant interactions observed, confirming the robustness of these results. In machine learning models, SHAP analysis identified CAR as a key predictor. Compared with the baseline risk model (UTP, eGFR), adding CAR improved predictive performance for CKD progression and mortality, with enhanced C-statistic, improved discriminatory index (IDI), and improved net reclassification index (NRI).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The CAR serves as a robust, independent predictor of CKD progression and all-cause mortality in patients with diabetic CKD. As a readily accessible biomarker, it holds significant potential to enhance ri","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"3541-3554"},"PeriodicalIF":3.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148399697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional adipose tissue redistribution and infiltration in primary osteoporosis: A comprehensive body composition study.","authors":"Zixiang Geng, Long Yuan, Ning Wang, Xuliang Wu, Yongfang Zhao","doi":"10.1007/s40618-026-02987-0","DOIUrl":"10.1007/s40618-026-02987-0","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Primary osteoporosis (OP) has traditionally been viewed as a skeletal disorder; however, its complex interactions with muscle and adipose tissue are increasingly recognized. Nevertheless, the specific characteristics of body composition alterations in OP, particularly regional distribution and qualitative changes, and their independent roles remain poorly defined.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to systematically investigate the characteristics of whole-body and regional body composition changes in patients with primary osteoporosis, and to specifically assess the independent associations of paravertebral muscle fat infiltration and trunk-to-appendicular fat distribution with osteoporosis risk.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Based on diagnostic criteria, participants were categorized into an OP group and a non-OP group. Dual-energy X-ray absorptiometry (DXA) was used to assess bone mineral density (BMD), muscle mass, and fat mass across the whole body and specific regions (trunk, limbs, upper limbs, lower limbs). Computed tomography (CT) was employed to quantitatively evaluate fat infiltration (represented by muscle density) in the psoas major, erector spinae, and multifidus muscles. Spearman correlation analysis was used to assess associations between body composition indicators. Multivariable logistic regression models and restricted cubic spline (RCS) analyses were applied to examine the independent associations of fat infiltration and distribution with OP. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the discriminative ability of the identified adipose measures, with area under the curve (AUC) calculated before and after adjustment for confounders.dipose measures, with area under the curve (AUC) calculated before and after adjustment for confounders.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Compared to the non-OP group, OP patients exhibited significant systemic alterations, including concurrent reductions in whole-body skeletal muscle mass, fat mass, and bone mineral content (all P &lt; 0.01). Regional analysis revealed that bone and fat loss were more pronounced in the trunk than in the limbs (both P &lt; 0.05). CT analysis revealed significantly lower muscle density in the paravertebral muscles of OP patients (all P &lt; 0.05). After adjusting for sex, age, height, weight, total muscle mass, smoking, and alcohol consumption, multivariable logistic regression identified both decreased multifidus muscle density (OR: 0.98 per HU, 95% CI: 0.96-1.00; P = 0.023) and an increased limbs-to-trunk fat ratio (OR: 14.35, 95% CI: 2.90-76.35; P = 0.001) as factors independently associated with OP. Further analysis revealed distinct risk patterns: the limbs-to-trunk fat ratio demonstrated a significant linear dose-response relationship (P for overall association from RCS = 0.015). For multifidus muscle density, while a significant association was observed in the linear model, the more ","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"3475-3485"},"PeriodicalIF":3.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinant factors for headache at acromegaly diagnosis: findings from an Iberian multicenter study encompassing 726 patients.","authors":"Marta Vaz Lopes, Mariana de Griné Severino, Ema Lacerda Nobre, Luís Miguel Cardoso, Carmen Fajardo-Montañana, Concepción Blanco, Edelmiro Menéndez Torre, Betina Biagetti, Rogelio García-Centeno, Laura González Fernandéz, María Dolores Ollero García, Ana Irigaray Echarri, Fernando Cordido, Claudia Lozano-Aida, Fernando Vidal-Ostos De Lara, Fernando Guerrero-Pérez, Cristina Novo-Rodríguez, Carmen Tenorio-Jiménez, María Dolores Moure Rodríguez, Miguel Paja Fano, Beatriz Rodríguez Jiménez, Rosario Oliva Rodríguez, Inmaculada González Molero, Pedro Iglesias, Mónica Marazuela, Manel Puig-Domingo, Pedro Marques, Marta Araujo-Castro","doi":"10.1007/s40618-026-03016-w","DOIUrl":"10.1007/s40618-026-03016-w","url":null,"abstract":"<p><strong>Purpose: </strong>Headache is a debilitating symptom in acromegaly, often attributed to mass effect in patients with large tumors, however other factors beyond size may contribute. We aimed to identify determinant factors for headache at diagnosis in a large acromegaly cohort.</p><p><strong>Methods: </strong>We performed a registry-based multicentric retrospective study including patients diagnosed with acromegaly between 1970 and 2025 from 35 Iberian centers. Primary outcome was presence of headache at acromegaly diagnosis recorded as a binary variable (present/absent). Variables associated with headache in univariable regression and/or deemed clinically relevant were included in the multivariable regression.</p><p><strong>Results: </strong>Out of 726 patients, 321 (44.2%) had headaches at acromegaly diagnosis. Patients with headache at diagnosis were younger (45.8 ± 15.4 vs. 50.4 ± 14.2 years, p < 0.001), had higher prevalence of macroadenoma (86.1 vs. 72.4%, p < 0.001), larger volume (2650 vs. 1147 mm³, p < 0.001), and more invasive tumors (Knosp > 2: 34.2 vs. 20.2%, p < 0.001). Hyperprolactinemia (32.5 vs. 24.1%, p = 0.01) and hypopituitarism (26.8 vs. 16.3%, p < 0.001) were also more frequent in patients with headache. In the univariable analysis, younger age, larger volume, higher Knosp grade, higher growth hormone levels, hypopituitarism and hyperprolactinemia were associated with headache. In the multivariable analysis, macroadenomas, larger volume remained independent factors for headache.</p><p><strong>Conclusion: </strong>Headache is common in acromegaly, particularly in young patients with larger and invasive pituitary tumors, and in cases presenting with hyperprolactinemia and hypopituitarism. Tumor size was the dominant and independent determinant contributing to headache at acromegaly diagnosis. Future studies should integrate detailed headache phenotyping and investigate other factors relevant to acromegaly-related headache.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"3335-3343"},"PeriodicalIF":3.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes, and practices in pediatric hypoglycemia in Italy (KAPPHy study).","authors":"Arianna Maiorana, Roberta Pajno, Francesco Tagliaferri, Alessandro Rossi, Enza Mozzillo, Maurizio Delvecchio","doi":"10.1007/s40618-026-02992-3","DOIUrl":"10.1007/s40618-026-02992-3","url":null,"abstract":"<p><strong>Purpose: </strong>Childhood hypoglycemia is associated with relevant morbidity and likely long-term neurological sequelae. Diagnostic thresholds and management strategies remain quite heterogeneous, particularly beyond the neonatal period. We aimed to evaluate current diagnostic and therapeutic practices for pediatric hypoglycemia management in Italy among members of the Italian Society of Pediatric Endocrinology and Diabetology (SIEDP) and the Italian Society of Metabolic Diseases and Newborn Screening (SIMMESN).</p><p><strong>Methods: </strong>An anonymous electronic survey including 43 questions about management of pediatric hypoglycemia was sent to SIEDP and SIMMESN members. Descriptive statistics and comparative statistical analysis between respondents of the two societies were run.</p><p><strong>Results: </strong>A total of 118 respondents participated. Most of them reported direct clinical experience in pediatric hypoglycemia and routinely used critical sampling during hypoglycemic episodes. Diagnostic thresholds were heterogeneous: 34.7% reported 50 mg/dL, 33.1% 60 mg/dL, and 22.0% 70 mg/dL. Comparative analysis between societies showed no differences in most diagnostic procedures, but significant differences emerged in diagnostic thresholds (p = 0.005), with SIMMESN members selected 60 mg/dL more frequently (adjusted p = 0.020), and SIEDP members more frequently 70 mg/dL (adjusted p = 0.013). SIMMESN members reported more frequent use of genetic testing for etiological diagnosis. SIEDP respondents showed a frequent used of continuous glucose monitoring in the follow-up.</p><p><strong>Conclusion: </strong>Management of pediatric hypoglycemia in Italy is largely aligned with international recommendations. Clinically relevant variability persists, particularly in diagnostic thresholds, adoption of molecular analysis, and technologies, likely reflecting different clinical focus and patient populations. Our findings highlight the need for harmonized national recommendations and shared diagnostic definitions across scientific societies.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"3463-3473"},"PeriodicalIF":3.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between long-term exposure to environmental coarse particulate matter and the prevalence of thyroid disorders: a cross-sectional study in China.","authors":"Changyuan Liu, Jie Li, Bingxin You, Zhongyan Shan, Weiping Teng, Yongze Li","doi":"10.1007/s40618-026-02982-5","DOIUrl":"10.1007/s40618-026-02982-5","url":null,"abstract":"<p><strong>Background: </strong>Evidence linking long-term exposure to particulate matter with thyroid dysfunction is increasing, but data on particulate matter 10 micrometers or less (PM10) exposure and thyroid disorders remain limited.</p><p><strong>Methods: </strong>73,900 subjects aged ≥ 18 years from a nationwide population-based study were included. Thyroid disorders were determined using standardized biochemical testing and thyroid ultrasound examination. Individual long-term PM10 exposure was estimated at a 1 × 1 km spatial resolution using a Space-Time Extra Trees model, and the five-year average concentration preceding enrollment was assigned to each participant's residential address. Weighted estimates were calculated to account for the complex sampling design.</p><p><strong>Results: </strong>The average long-term exposure to PM10 at residential addresses was 111.74 µg/m³, ranging from 35.08 µg/m³ to 374.8 µg/m³. Compared with those in the first quartile (35.08 to 75.50 µg/m³), participants in the highest PM10 quartile (130.80 to 374.80 µg/m³) had higher odds of overt hypothyroidism (OR 1.36 [CI 1.03-1.79]), subclinical hypothyroidism (1.14 [1.04-1.25]), autoimmune thyroiditis (1.10 [1.01-1.20]) and thyroglobulin antibody positivity (1.24 [1.12-1.37]). Each 10 µg/m³ increase in the PM10 concentration was associated with higher odds of overt hypothyroidism (OR 1.16 [1.07-1.25]) and subclinical hypothyroidism (1.07 [1.04-1.10]). TgAb positivity showed an increasing exposure-response pattern across PM10 concentrations. No consistent significant associations were observed for overt hyperthyroidism, subclinical hyperthyroidism, Graves' disease, or thyroid peroxidase antibody positivity.</p><p><strong>Conclusion: </strong>Long-term PM10 exposure was associated with higher odds of overt hypothyroidism, subclinical hypothyroidism, autoimmune thyroiditis, and TgAb positivity among Chinese adults. These findings suggest that coarse particulate pollution may be a modifiable environmental factor related to hypothyroidism and thyroid autoimmunity.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"3305-3313"},"PeriodicalIF":3.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and immunohistochemical characterization of cribriform-morular thyroid carcinoma: insights into its origin and therapeutic targets.","authors":"Joo Yeon Koo, Ji Young Lee, Nah Ihm Kim, Yoo-Duk Choi, Tae Mi Yoon, Sung Sun Kim, Kyung-Hwa Lee","doi":"10.1007/s40618-026-02995-0","DOIUrl":"10.1007/s40618-026-02995-0","url":null,"abstract":"<p><strong>Background: </strong>Cribriform-morular thyroid carcinoma (CMTC) is a rare thyroid malignancy with distinctive morphology that occurs sporadically or in association with familial adenomatous polyposis. Despite known WNT/β-catenin pathway involvement, CMTC's cellular origin and therapeutic targets remain poorly characterized.</p><p><strong>Methods: </strong>Five CMTC cases diagnosed between 2012 and 2022 were retrospectively analyzed using next-generation sequencing and comprehensive immunohistochemical profiling to elucidate molecular characteristics and potential therapeutic targets.</p><p><strong>Results: </strong>All patients were young females (mean age 28 years, range 19-47) presenting with small tumors (mean 19.4 mm, range 7-28 mm) without lymph node metastasis. Histologically, all cases demonstrated characteristic cribriform and morular architecture. Nuclear β-catenin positivity was observed in four cases, while CD56 was expressed in all cases. Low-level HER2 expression was present across all tumors. Next-generation sequencing revealed somatic APC mutations in three cases, concurrent APC/CTNNB1 mutations in one case, and CTNNB1 mutations in both lobes of one case. High tumor mutational burden was detected in two cases.</p><p><strong>Conclusions: </strong>The consistent presence of APC or CTNNB1 mutations coupled with CD56 positivity supports CMTC's origin from thyroid follicular epithelial cells that acquire an intestinal-like phenotype through characteristic genetic alterations. The presence of HER2 expression and high tumor mutational burden in a subset of cases identifies potential therapeutic targets for this rare malignancy.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"3315-3323"},"PeriodicalIF":3.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total thyroidectomy versus limited thyroidectomy for isthmic papillary thyroid carcinoma: a systematic review and meta-analysis of oncologic outcomes and surgical morbidity.","authors":"Ziliang Ding, Yukun Wei, Xiaoxiao Yao, Fengli Guo, Shujian Xu, Yong Han, Pengfei Gu","doi":"10.1007/s40618-026-02968-3","DOIUrl":"10.1007/s40618-026-02968-3","url":null,"abstract":"<p><strong>Background: </strong>The optimal surgery for isthmic papillary thyroid carcinoma (IPTC) remains controversial. This meta-analysis compared oncologic and complication outcomes between total (TT) and limited thyroidectomy (LT).</p><p><strong>Methods: </strong>PubMed, Embase, and Web of Science were searched up to December 2025 for retrospective cohort studies comparing TT and LT for IPTC. Outcomes were recurrence and complications. Risk ratios (RR) with 95% confidence intervals (CI) were calculated using random-effects models.</p><p><strong>Results: </strong>Eight studies comprising 1,285 patients (696 LT, 589 TT) were included. Recurrence rates were comparable (LT: 6.61% vs. TT: 4.07%; pooled RR = 1.40, 95% CI: 0.79-2.47, P = 0.25; I² = 13%). LT significantly reduced overall complications (RR = 0.39, 95% CI: 0.30-0.50, P < 0.00001), including transient complications (RR = 0.39), parathyroid dysfunction (RR = 0.30), and hoarseness (RR = 0.44).</p><p><strong>Conclusion: </strong>In selected patients with isthmic papillary thyroid carcinoma, limited thyroidectomy may achieve similar short-term oncologic outcomes to total thyroidectomy while reducing complications, although the available evidence remains insufficient to establish oncologic equivalence. However, given methodological limitations, these findings are hypothesis-generating and require validation through prospective studies with standardized outcome definitions and extended follow-up.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"3131-3146"},"PeriodicalIF":3.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Deciphering ¹⁸F-DOPA uptake in SDH-related head and neck paragangliomas: a radiomics approach.","authors":"Valentina Berti, Elsa Fasciglione, Anne Charpiot, Flavio Montanini, Miriam Pepponi, Andrea Leo, Fabrice Hubele, David Taieb, Karel Pacak, Bernard Goichot, Alessio Imperiale","doi":"10.1007/s40618-026-02985-2","DOIUrl":"10.1007/s40618-026-02985-2","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"3589"},"PeriodicalIF":3.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148473660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}