Journal of Endocrinological Investigation最新文献

{"title":"Attitudes toward pig islet xenotransplantation for type 1 diabetes: a scoping review.","authors":"Daniel J Hurst, Daniel Rodger, Luz A Padilla, Fernando Ovalle","doi":"10.1007/s40618-025-02626-0","DOIUrl":"https://doi.org/10.1007/s40618-025-02626-0","url":null,"abstract":"<p><strong>Background: </strong>Over 8 million people globally have type 1 diabetes. Islet allotransplantation offers an alternative to insulin therapy but is constrained by donor availability. Genetically modified pig islet transplantation presents a potential solution, yet understanding stakeholder attitudes is crucial before clinical adoption.</p><p><strong>Methods: </strong>This scoping review followed Joanna Briggs Institute methodology and PRISMA guidelines. CINAHL, EMBASE, PubMed, PsychINFO, and SCOPUS were searched for studies examining attitudes toward pig islet xenotransplantation among patients, healthcare workers, and other stakeholders.</p><p><strong>Results: </strong>From 199 sources, 16 met eligibility criteria, spanning ten countries from 2003 to 2023. The 23,780 participants included 1,535 (6.5%) patients/family members, 216 (0.9%) healthcare workers, and 22,029 (92.6%) students. Attitudes were generally positive but declined sharply in some studies when risks, such as viral transmission, were disclosed.</p><p><strong>Conclusion: </strong>Despite overall positive attitudes, risk perception significantly influences acceptance of islet xenotransplantation. The predominance of quantitative research highlights a need for qualitative studies and validated survey instruments to enhance understanding and comparability of stakeholder perspectives.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of sodium-glucose cotransporter 2 inhibitors on cardiomyopathy: a meta-analysis.","authors":"Bo Xu, Tianqiao Zhang, Jiecan Zhou","doi":"10.1007/s40618-025-02625-1","DOIUrl":"https://doi.org/10.1007/s40618-025-02625-1","url":null,"abstract":"<p><strong>Background: </strong>Cardiomyopathies can present at any age and affect individuals and families across the entire life course. Clinical effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on cardiomyopathy have not yet been fully elucidated.</p><p><strong>Objective: </strong>The primary objective of this study was to investigate whether SGLT2 inhibitors have an effect on cardiomyopathy compared to placebo.</p><p><strong>Methods: </strong>We systematically searched for randomized double-blind placebo-controlled trials on PubMed, Web of Science, EU Clinical Trials Register, and ClinicalTrials.gov. We used the Mantel-Haenszel statistical method, fixed-effects model and risk ratio (RR) with 95% confidence intervals (CI) to analyze binary data.</p><p><strong>Results: </strong>A total of 19 studies were included, covering 97,035 participants. Compared to placebo, SGLT2 inhibitors were associated with a reduced risk of cardiomyopathy (RR 0.72; 95% CI 0.56-0.92; P < 0.01; high certainty of evidence), with non-significant heterogeneity (P_{heterogeneity}=0.81; I² = 0%), especially observed in the empagliflozin subgroup (RR 0.66; 95% CI 0.46-0.94; P = 0.02), chronic kidney disease (RR 0.67; 95% CI 0.47-0.97; P = 0.03) population and heart failure (RR 0.46; 95% CI 0.23-0.91; P = 0.03) population. However, in type 2 diabetes mellitus population, the effect of SGLT2 inhibitors on cardiomyopathy incidence was less clear (RR 0.76; 95% CI 0.51-1.12; P = 0.17; moderate certainty of evidence). Additionally, SGLT2 inhibitors were associated with a reduced risk of primary cardiomyopathy (RR 0.43; 95% CI 0.21-0.87; P = 0.02) and slightly decreased the incidence of secondary cardiomyopathy compared to placebo (RR 0.75; 95% CI 0.56-1.01; P = 0.06).</p><p><strong>Conclusions: </strong>SGLT2 inhibitors significantly reduced the risk of cardiomyopathy, which further enhances the cardiovascular benefits of SGLT2 inhibitors in clinical settings, especially for patients with heart failure and chronic kidney disease.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CT-based radiomic model for predicting vertebral fractures in older patients with type 2 diabetes mellitus: A longitudinal study.","authors":"Zicheng Wei, Rui Yu, Yiping Zhang, Yu Wang, Jianhua Wang, Cao Xie, Xiao Chen","doi":"10.1007/s40618-025-02627-z","DOIUrl":"https://doi.org/10.1007/s40618-025-02627-z","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenic obesity and physical function in acromegaly: impact of disease control and evaluation using dual X-ray absorptiometry and multifrequency bioelectrical impedance analysis.","authors":"Arthur Costa Inojosa, Ana Vitória Hirt, Thaís Araújo, Maria Eduarda Ferreira, Luma Andrade, Vinícius Cunha, Daniella Rego, Aline Lopes, Francisco Bandeira","doi":"10.1007/s40618-025-02624-2","DOIUrl":"https://doi.org/10.1007/s40618-025-02624-2","url":null,"abstract":"<p><strong>Purpose: </strong>To assess sarcopenia, sarcopenic obesity, physical performance in patients with acromegaly and compare the diagnostic performance of dual-energy X-ray absorptiometry (DXA) and multifrequency bioelectrical impedance analysis (BIA).</p><p><strong>Methods: </strong>This cross-sectional study included 27 patients with acromegaly and 27 age-, sex-, and BMI-matched patients without acromegaly. Body composition was assessed using BIA and DXA. Lean mass indices included fat-free mass index (FFMI) and skeletal muscle index (SMI) via BIA, and the Baumgartner (BMG) and Foundation for the National Institutes of Health indices via DXA. Obesity parameters included fat mass index (FMI) and body fat percentage via BIA. Physical performance was evaluated using handgrip strength (HGS), Timed Up and Go (TUG), 4-m gait speed (4MGS), and the Short Physical Performance Battery (SPPB) tests. The strength, assistance in walking, rising from a chair, climbing stair and falls (SARC-F) questionnaire was also performed.</p><p><strong>Results: </strong>Strong correlations were observed between BIA and DXA body composition measures (r = 0.83, p < 0.01 for %BIA fat mass vs. %DXA fat mass; r = 0.80, p < 0.01 for SMI vs. BMG and r = 0.80, p < 0.01 for FFMI vs. BMG). Patients with acromegaly had significantly higher FFMI than patients without the disease (p = 0.03), but no difference in sarcopenic obesity prevalence (p = 0.50). Patients with acromegaly performed worse in the TUG and 4MGS tests, even after adjustment for confounders (p < 0.01 for both). No significant associations were found between SARC-F scores and lean mass or physical performance.</p><p><strong>Conclusion: </strong>Patients with acromegaly showed impaired physical performance despite higher FFMI, with no differences in sarcopenic obesity. The SARC-F questionnaire showed limited diagnostic value in this population.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and obesity related disease in adulthood: the dark side of early life exposure to Environmental Chemical Disruptors.","authors":"Mariana Di Lorenzo, Laura Aurino, Maria Serena Lonardo, Nunzia Cacciapuoti, Gilda Nasti, Annamaria Belfiore, Bruna Guida, Martina Chiurazzi","doi":"10.1007/s40618-025-02620-6","DOIUrl":"https://doi.org/10.1007/s40618-025-02620-6","url":null,"abstract":"<p><strong>Purpose: </strong>The present review aims to summarize and collect data in support of the obesogenic theory to broaden knowledge regarding the intriguing relationship between exposure to environmental chemical disruptors (EDCs), obesity and obesity related diseases.</p><p><strong>Methods: </strong>A comprehensive search of the literature from 1990 to 2024 was performed in Pubmed using the word endocrine disruptor chemicals or obesogens and: adipose tissue, metabolic diseases, weight gain, gut microbiota.</p><p><strong>Results: </strong>In the past, genetic factors, an unbalanced diet and a sedentary lifestyle were considered the only risk factors for obesity development. On the other hand, recent studies described the obesogenic theory, suggesting that an interaction between exposure to EDCs with obesogenic activity, especially during early life development, and the endocrine system can play a key role in the greater susceptibility to the onset of obesity, not even excluding the involvement of the gut microbiota and its alterations.</p><p><strong>Conclusions: </strong>Data collected show that there is a close link between environmental exposure to EDCs during early life of development and the onset of obesity and related dysmetabolic diseases that may occur later in life.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of cardiac dysfunction in non-functioning adrenal adenomas, primary aldosteronism, and essential hypertension.","authors":"L Liu, X Li, W Ma, F Fan, Y Yang, L Zhang, T Yi, J Zhang, J Guo, Y Gao","doi":"10.1007/s40618-025-02594-5","DOIUrl":"https://doi.org/10.1007/s40618-025-02594-5","url":null,"abstract":"<p><strong>Background: </strong>Speckle tracking echocardiography (STE) provides a quantitative assessment of left ventricular systolic performance, including myocardial motion and deformation. Global longitudinal strain (GLS) is a reliable and sensitive indicator of systolic function, with clinical and prognostic value in various settings, including secondary hypertension. There is limited data on GLS evaluation in patients with non-functioning adrenal adenomas (NF), despite emerging evidence suggesting its association with subclinical cardiovascular dysfunction. Investigating the cardiac impact of NF is essential for understanding its role in early cardiac remodeling compared to primary aldosteronism (PA) and essential hypertension (EH).</p><p><strong>Objective: </strong>To retrospectively evaluate the utility of GLS in detecting early cardiac dysfunction in patients with NF, PA, and EH without adrenal adenoma or hyperplasia.</p><p><strong>Methods: </strong>This retrospective study included 33 patients with NF, 33 with PA, and 33 with EH, matched by gender and age. Speckle tracking echocardiography was used to assess the GLS of the left ventricle. Data analysis was conducted using IBM SPSS Statistics version 29.0, with a significance threshold set at P < 0.050.</p><p><strong>Results: </strong>The GLS in NF patients (-20.63 ± 3.10%) was significantly lower than in EH patients (-22.17 ± 3.03%) but higher than in PA patients (-18.55 ± 2.45%), despite NF patients having the lowest prevalence of hypertension and systolic blood pressure. GLS was significantly correlated with cortisol levels, impaired glucose tolerance, and ARR across all patient groups, highlighting the complex interplay between metabolic and hormonal factors in cardiac dysfunction.</p><p><strong>Conclusion: </strong>Cardiac function impairment in NF patients lies between that observed in EH and PA patients, suggesting a nuanced impact of non-functioning adrenal adenomas on cardiac health.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolactin serum concentrations in childhood-onset craniopharyngioma patients.","authors":"Panjarat Sowithayasakul, Julia Beckhaus, Jale Özyurt, Brigitte Bison, Carsten Friedrich, Hermann L Müller","doi":"10.1007/s40618-025-02622-4","DOIUrl":"https://doi.org/10.1007/s40618-025-02622-4","url":null,"abstract":"<p><strong>Introduction: </strong>Adamantinomatous craniopharyngiomas (CPs) are rare embryonic tumors originating from the sellar area. Neuroendocrine deficiencies affecting the hypothalamic-pituitary axes are well-known but the mechanisms underlying prolactin secretion in CP patients are unclear. This study analyzed the factors associated with prolactin serum concentrations in CP patients.</p><p><strong>Methods: </strong>Patients with adamantinomatous CP, diagnosed as children, adolescents or young adults (< 26 years) were included in this study. In 98 cases, serum prolactin concentrations were measured before breakfast after fasting for at least 10 h, using an electrochemiluminescence assay, with concentrations analyzed for associations with diagnostic, clinical, and therapeutic parameters.</p><p><strong>Results: </strong>Serum prolactin concentrations were within normal, age- and gender-specific ranges in 39 cases (38%), with decreased concentrations in 22 cases (21%) and elevated concentrations in 37 cases (36%). Factors positively associated with increased prolactin levels were age at CP diagnosis, degree of surgical resection, and suprasellar tumor location. Decreased prolactin levels correlated with irradiation and pituitary deficiencies of thyroid-stimulating hormone and vasopressin. Patients with decreased prolactin concentrations exhibited lower event-free survival. Prolactin concentrations were not associated with functional capacity, tumor volume, calcifications, or anthropometric parameters at diagnosis or at the time of study.</p><p><strong>Conclusions: </strong>Prolactin levels in CP patients are influenced by the impact of the tumor on the hypothalamic-pituitary axes, resulting in either increased or decreased serum concentrations. Prolactin levels could serve as a clinical marker for certain sequelae after CP diagnosis. Patients with abnormal prolactin levels should be monitored for signs of hypothalamic syndrome.</p><p><strong>Clinical trial registration numbers: </strong>NCT00258453; NCT01272622; NCT04158284.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving care for individuals with gender incongruence: Establishing a multidisciplinary approach in Italy.","authors":"Alberto Scala, Chiara Ceolin, Marina Miscioscia, Daniela Basso, Elena Campello, Valentina Camozzi, Annamaria Cattelan, Michela Gatta, Sandro Giannini, Massimo Iafrate, Giulia Musso, Paolo Meneguzzo, Giancarlo Ottaviano, Rossella Perilli, Roberta Rosin, Ilaria Ruzza, Carlo Saccardi, Lolita Sasset, Giuseppe Sergi, Benedetta Tascini, Tommaso Vezzaro, Fabrizio Vianello, Paolo Simioni, Alberto Ferlin, Andrea Garolla","doi":"10.1007/s40618-025-02580-x","DOIUrl":"https://doi.org/10.1007/s40618-025-02580-x","url":null,"abstract":"<p><strong>Purpose: </strong>To present a multidisciplinary care model designed to provide personalized gender-affirming care and assess general health for transgender and gender-diverse (TGD) individuals.</p><p><strong>Methods: </strong>Drawing from our experience in a tertiary center in Padua (Italy), the Interdisciplinary Group for Gender Incongruence (GIIG) model employs a multidisciplinary approach to provide diverse gender-affirmation services. Mental health support, gender-affirming medical and surgical treatments (GAMST), screening programs, and regular follow-up ensure treatment safety and efficacy. The GIIG model promotes collaboration among specialists, primary health services, and LGBTQ + associations. Furthermore, it advocates for training healthcare professionals and raising awareness in the population.</p><p><strong>Results: </strong>The GIIG involves mental health professionals, endocrinologists, surgeons (plastic, urological, and gynaecological), voice specialists, internists, and associations. Associations serve as a point of reference for the community and offer psychological and legal services. Initial contact at the Center is made with MHP, who provide a safe space to explore gender identity, receive information, and support mental well-being. Endocrinologists prescribe hormone therapy and monitor its potential risks and overall health. Surgical interventions include chest, genital, and laryngeal surgery. Internists and other specialists assess osteo-muscular, hemo-coagulative, oncological, and infectious risks.</p><p><strong>Conclusions: </strong>Our experience emphasizes the need for personalized care tailored to individuals' desires while ensuring the safety of gender-affirming treatments. By adhering to the Standards of Care and offering comprehensive services, our center aims to serve as a model for modern transgender care.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Plasticity deficits of Tregs remodeling toward Th1-like and Th17-like Tregs in individuals with type 1 diabetes.","authors":"Yao Qin, Yuxiao Li, Yueshu Wang, Qianying Wei, Liuyan Dai, Mei Huang, Yang Chen, Yong Gu, Tao Yang, Mei Zhang","doi":"10.1007/s40618-025-02584-7","DOIUrl":"https://doi.org/10.1007/s40618-025-02584-7","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intriguing image of a secret agent in the eighteenth century: gender dysphoria, cross-dressing, or queer?","authors":"F Trimarchi, L Vignozzi","doi":"10.1007/s40618-025-02618-0","DOIUrl":"https://doi.org/10.1007/s40618-025-02618-0","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}