"Who and how to screen for endogenous hypercortisolism among young women presenting with clinical hyperandrogenism and/or menstrual abnormalities ".

IF 5.4 2区 医学 Q1 Medicine
Francesco Ferraù, Ylenia Alessi, Federica Nista, Anna Roux, Diego Ferone, Emanuela Arvat
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引用次数: 0

Abstract

Endogenous Cushing's syndrome (CS) is rare, with an incidence of 0.7-2.4 per million population per year according to population-based studies. However, evaluation of patients presenting disorders potentially related to cortisol excess, and therefore with a 'high risk of clinical suspicion' profile, could bring out several unrecognized cases. CS represents one of the most challenging endocrine diseases, with clinical features overlapping with those of common conditions affecting general population, invariably resulting in potential mis- or delayed diagnosis with negative consequences in terms of morbidity and mortality. CS is remarkably prevalent among young females, variably presenting with menstrual irregularities and/or signs and symptoms of hyperandrogenism. Herein we briefly reviewed literature on prevalence and clinical impact of menses abnormalities, acne and hirsutism -also coexisting in the context of a polycystic ovary syndrome- in CS, aiming at clarifying if, when and how to screen for hypercortisolism young women with these disorders.

“在临床雄激素分泌过多和/或月经异常的年轻女性中,谁以及如何筛查内源性高皮质醇症”。
内源性库欣综合征(CS)很少见,根据基于人群的研究,每年每百万人中发病率为0.7-2.4例。然而,对表现出可能与皮质醇过量相关的疾病的患者进行评估,因此具有“临床怀疑高风险”的特征,可能会发现一些未被识别的病例。CS是最具挑战性的内分泌疾病之一,其临床特征与影响普通人群的常见疾病重叠,总是导致潜在的误诊或延迟诊断,在发病率和死亡率方面产生负面影响。CS在年轻女性中非常普遍,不同的表现为月经不规则和/或雄激素过多的体征和症状。在此,我们简要回顾了有关CS中月经异常、痤疮和多毛症(也同时存在于多囊卵巢综合征的背景下)的患病率和临床影响的文献,旨在阐明是否、何时以及如何筛查患有这些疾病的高皮质醇年轻女性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Endocrinological Investigation
Journal of Endocrinological Investigation ENDOCRINOLOGY & METABOLISM-
CiteScore
8.10
自引率
7.40%
发文量
242
期刊介绍: The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.
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