Journal of Endocrinological Investigation最新文献

{"title":"Diabetes mellitus secondary to endocrine diseases: a position statement of the working group of the club of the Italian society of endocrinology (SIE)-Nutrition hormones and metabolism.","authors":"Luigi Barrea, Massimiliano Caprio, Sebastio Perrini, Elisabetta Camajani, Andrea Crafa, Elena Gangitano, Stefania Gorini, Laura Sciacca, Ludovica Verde, Manuela Albertelli, Diego Ferone, Francesco Giorgino, Annamaria Colao, Gianluca Aimaretti, Giovanna Muscogiuri","doi":"10.1007/s40618-025-02589-2","DOIUrl":"10.1007/s40618-025-02589-2","url":null,"abstract":"<p><strong>Purpose: </strong>This position statement addressed the limited scientific literature on the management of diabetes mellitus secondary to endocrinopathies, despite its frequent occurrence in hormonal diseases such as acromegaly, Cushing's syndrome, primary hyperaldosteronism, pheochromocytoma, hyperthyroidism, and neuroendocrine tumors. The aim was to review the pathophysiological mechanisms, clinical features, and management strategies, focusing on nutritional and pharmacological approaches.</p><p><strong>Methods: </strong>A comprehensive review of existing literature was conducted regarding studies on diabetes secondary to endocrinopathies and the effects of treatments for these conditions, such as somatostatin analogues and pancreatic surgery. Particular emphasis was placed on understanding glucose metabolism derangements and the interplay between endocrine excess and therapeutic interventions.</p><p><strong>Results: </strong>Secondary diabetes arises not only from hormone excess but also as a consequence of treatments for endocrine disorders. For instance, somatostatin analogues, while effective in resolving hormone hypersecretion, impair glucose metabolism by inhibiting pancreatic insulin secretion. Similarly, pancreatic surgery for neuroendocrine tumors often exacerbates glycemic disturbances. The management of secondary diabetes requires a multidisciplinary approach that includes treating the underlying endocrine disorder, tailoring antidiabetic therapy, and optimizing nutritional strategies to mitigate metabolic disruptions.</p><p><strong>Conclusion: </strong>Diabetes secondary to endocrinopathies presents unique challenges due to its complex etiology and the metabolic effects of treatments. This position statement underscores the importance of an integrated management approach, offering guidance for clinicians in addressing this multifaceted condition. Further research is needed to develop evidence-based guidelines for optimal care.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1739-1758"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension and Cushing's syndrome: hunt for the red flag.","authors":"De Martino M C, L Canu, I Bonaventura, C Vitiello, C Sparano, A Cozzolino","doi":"10.1007/s40618-024-02453-9","DOIUrl":"10.1007/s40618-024-02453-9","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of secondary hypertension is reported to be 5-15% of people with hypertension. Causes of secondary hypertension include Cushing's syndrome (CS), a rare but serious clinical condition characterized by chronic endogenous hypercortisolism associated with increased morbidity and mortality, especially for cardiovascular complications. The challenge for the clinician is thus to identify the phenotype of hypertensive patients who should be screened for endogenous hypercortisolism.</p><p><strong>Methods: </strong>This study was performed according to the PRISMA statement. The search was last updated in June 2023, and only English language studies were considered. Titles and abstracts have been screened for articles selection, identifying only those that dealt with prevalence of Cushing's syndrome in hypertensive patients. Finally, eight papers were included in the review. Data regarding year of publication, populations' characteristics, inclusion criteria, screening test and cut-off used, and CS prevalence have been extracted.</p><p><strong>Results: </strong>The study search identified eight studies, from 1977 to 2020, including a total number of 11,504 patients, ranging from 80 to 4429 patients for each study. The prevalence of CS reported was variable among the studies, ranging from 0 to 7.7%, having Cushing's disease (CD) a prevalence range of 0-1.2%. The highest prevalence has been found in selected populations of hypertensive patients younger than 40 years (6.2%) or harbouring an adrenal lesion (7.7%). The most used screening test was 1 mg overnight dexamethasone suppression test (1 mg DST), with different cut-off.</p><p><strong>Conclusion: </strong>The most fitting CS profile encompasses younger age (i.e., < 40 years old), rapidly evolving hypertension and the presence of adrenal adenomas, along with subjects with pituitary lesions, who should still be prioritized in the diagnostic pathway. Overall, in the case of hypertensive patients presenting a clinical picture highly suggestive of CS, it is advisable to perform one of the available screening tests (UFC, 1 mg DST, LNSC). LNSC is likely the most discriminatory test and may be preferred, depending on its availability. Conversely, for hypertensive patients with an adrenal incidentaloma, the 1 mg DST is recommended as the screening test to exclude CS.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1909-1918"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trabecular bone score as a possible new surgical recommendation in patients with asymptomatic primary hyperparathyroidism.","authors":"Nicolò Bisceglia, Matteo Malagrinò, Cristiana Cantone, Sara Capra, Anna Piazza, Giulia Vandi, Guido Zavatta","doi":"10.1007/s40618-025-02590-9","DOIUrl":"10.1007/s40618-025-02590-9","url":null,"abstract":"<p><strong>Purpose: </strong>TBS usefulness in primary hyperparathyroidism (PHPT) management is uncertain. The primary aim was to evaluate the significance of performing Trabecular Bone Score (TBS) in addition to classical PHPT surgical recommendations. The explorative objective was to characterize bone quality in a cohort of patients with asymptomatic PHPT.</p><p><strong>Methods: </strong>From 1/1/2021 to 5/31/2024, of 265 consecutively evaluated PHPT patients, 125 met inclusion and exclusion criteria. Patients underwent complete biochemical evaluation in the same laboratory, Dual Energy X-ray Absorptiometry (DXA) at three sites, TBS with the same densitometer, and renal ultrasound. We retrospectively applied to each patient all the criteria to recommend parathyroidectomy as per the Fifth International Workshop, adding also TBS ≤ 1.2.</p><p><strong>Results: </strong>Almost one-third of patients presented degraded TBS (≤ 1.2), 36.0% partially degraded TBS, and 31.2% preserved TBS (≥ 1.35). Mean TBS was partially degraded (1.286 ± 0.134). Osteoporotic patients had lower TBS than osteopenic patients (1.207 ± 0.101 vs. 1.27 9 ± 0.110; p <.001). Patients with degraded TBS had a greater number of fragility fractures than those with TBS > 1.2 (34.2% vs. 8.3%; p <.001). In the group of osteopenic patients (34.4%), 10/43 (23.3%) showed degraded TBS. 13 patients (10.4%) did not meet any surgical criteria, and of these, 3/13 (23.1%) had degraded TBS and were osteopenic.</p><p><strong>Conclusion: </strong>More than one-fifth of patients who did not meet the current surgical recommendations presented degraded TBS and osteopenia. The combination of degraded TBS and osteopenia as a possible new surgical recommendation could increase the number of patients who might benefit from curative parathyroidectomy, with potential reduction of fracture risk.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1819-1828"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual health in adult women with complete androgen insensitivity syndrome: a single centre cross-sectional study.","authors":"Alessandra Mangone, Eriselda Profka, Giulia Rodari, Claudia Giavoli, Giovanna Mantovani","doi":"10.1007/s40618-025-02592-7","DOIUrl":"10.1007/s40618-025-02592-7","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to assess sexual health and body uneasiness in patients with complete androgen insensitivity syndrome (CAIS) using validated questionnaires, since literature is limited and heterogeneous.</p><p><strong>Methods: </strong>Single-center, cross-sectional study on 34 adults with 46, XY karyotype and confirmed androgen receptor mutation (age = 34 ± 8.6 years), 29 gonadectomized and 5 with gonads in situ. All gonadectomized patients but 3 were receiving hormonal replacement therapy (HRT): 14 with transdermal oestradiol, 10 with oral oestradiol, 2 with testosterone. We measured hormonal levels and adherence to HRT, and we administered Female Sexual Function Index (FSFI), Female Sexual Distress Scale-Revised (FSDS-R) and Body Uneasiness Test (BUT) questionnaires.</p><p><strong>Results: </strong>We registered sexual dysfunction with FSFI score < 26.55 and FSDS-R score > 11 respectively in 77% and 52.9% of the cohort; body uneasiness (BUT-Global Severity Index > 1.2) was also present in 50%. In patients with gonads in situ, body uneasiness and sexual distress were common, with 4/5 pathological scores at FSFI and BUT, and 2/5 at FSDS-R. In gonadectomized patients, no significant differences among type of HRT and questionnaires' results were registered. Despite receiving HRT and referring optimal compliance, most (69%) patients still had oestradiol concentration < 50 pg/ml, with no significant correlation with sexual function. 10/34 patients (29%) had vaginal hypoplasia and 9 underwent vaginal dilation treatment, with no correlation with sexual scores.</p><p><strong>Conclusions: </strong>Sexual dysfunction and body uneasiness are worryingly common in CAIS. Preservation of gonads and HRT do not guarantee adequate sexual function nor optimal hormone levels. Psychological and sexual aspects must be considered in the management and therapeutic choices for these patients, as they highly impact quality of life.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1849-1855"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving care for individuals with gender incongruence: Establishing a multidisciplinary approach in Italy.","authors":"Alberto Scala, Chiara Ceolin, Marina Miscioscia, Daniela Basso, Elena Campello, Valentina Camozzi, Annamaria Cattelan, Michela Gatta, Sandro Giannini, Massimo Iafrate, Giulia Musso, Paolo Meneguzzo, Giancarlo Ottaviano, Rossella Perilli, Roberta Rosin, Ilaria Ruzza, Carlo Saccardi, Lolita Sasset, Giuseppe Sergi, Benedetta Tascini, Tommaso Vezzaro, Fabrizio Vianello, Paolo Simioni, Alberto Ferlin, Andrea Garolla","doi":"10.1007/s40618-025-02580-x","DOIUrl":"10.1007/s40618-025-02580-x","url":null,"abstract":"<p><strong>Purpose: </strong>To present a multidisciplinary care model designed to provide personalized gender-affirming care and assess general health for transgender and gender-diverse (TGD) individuals.</p><p><strong>Methods: </strong>Drawing from our experience in a tertiary center in Padua (Italy), the Interdisciplinary Group for Gender Incongruence (GIIG) model employs a multidisciplinary approach to provide diverse gender-affirmation services. Mental health support, gender-affirming medical and surgical treatments (GAMST), screening programs, and regular follow-up ensure treatment safety and efficacy. The GIIG model promotes collaboration among specialists, primary health services, and LGBTQ + associations. Furthermore, it advocates for training healthcare professionals and raising awareness in the population.</p><p><strong>Results: </strong>The GIIG involves mental health professionals, endocrinologists, surgeons (plastic, urological, and gynaecological), voice specialists, internists, and associations. Associations serve as a point of reference for the community and offer psychological and legal services. Initial contact at the Center is made with MHP, who provide a safe space to explore gender identity, receive information, and support mental well-being. Endocrinologists prescribe hormone therapy and monitor its potential risks and overall health. Surgical interventions include chest, genital, and laryngeal surgery. Internists and other specialists assess osteo-muscular, hemo-coagulative, oncological, and infectious risks.</p><p><strong>Conclusions: </strong>Our experience emphasizes the need for personalized care tailored to individuals' desires while ensuring the safety of gender-affirming treatments. By adhering to the Standards of Care and offering comprehensive services, our center aims to serve as a model for modern transgender care.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1839-1848"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost analysis and resource allocation in the management of benign thyroid nodules: a comparison of surgery and thermal ablation techniques.","authors":"Enrico Papini, Michele Basile, Roberto Novizio, Agostino Paoletta, Agnese Persichetti, Irene Samperi, Alessandro Scoppola, Anna Crescenzi, Annamaria D'Amore, Maurilio Deandrea, Andrea Frasoldati, Roberto Garberoglio, Rinaldo Guglielmi, Giovanni Mauri, Celestino Pio Lombardi, Soraya Puglisi, Teresa Rago, Vincenzo Triggiani, Dominique Van Doorne, Domenico Salvatore, Rosella Saulle, Roberto Attanasio","doi":"10.1007/s40618-025-02597-2","DOIUrl":"10.1007/s40618-025-02597-2","url":null,"abstract":"<p><strong>Introduction: </strong>Benign thyroid nodules are common in adults, with incidental detection rates reaching 50-60% in women. While most nodules are asymptomatic and require no treatment, some grow and cause compressive symptoms.</p><p><strong>Objective: </strong>This study evaluates the economic impact of various treatment modalities for benign thyroid nodules within the Italian healthcare system, comparing total thyroidectomy, hemithyroidectomy, and minimally invasive thermal ablation. The analysis considers both direct healthcare costs and indirect social costs, such as productivity losses, from the perspective of the Italian National Health Service.</p><p><strong>Methods: </strong>A literature review and clinician survey were conducted to collect cost data across treatment phases: pre-hospitalization, procedure, and post-operative care. An Activity-Based Costing approach was used to estimate full treatment costs, including medical expenses, staff involvement, material usage, and indirect costs related to work absences.</p><p><strong>Results: </strong>The findings indicate that total thyroidectomy has the highest overall cost (€ 5,185.36), followed by hemithyroidectomy (€ 4,211.92), and thermal ablation (€ 1,560.06). The analysis also highlighted significant cost savings associated with thermal ablation when compared to surgical options, especially in terms of reduced hospital stay and lower indirect costs. Nevertheless, surgical procedures remain the mainstay treatment due to long-term efficacy and well-established clinical guidelines.</p><p><strong>Conclusion: </strong>Thermal ablation represents a cost-effective alternative to surgery for managing benign thyroid nodules. Treatment selection should be individualized, considering clinical factors, patient preferences, and long-term outcomes. These results underscore the importance of updating management guidelines to incorporate economic considerations, promoting optimized care and efficient resource allocation in the healthcare context.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1769-1780"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response association between OGTT and adverse perinatal outcomes after IVF treatment: A cohort study based on a twin population.","authors":"Wei-Zhen Tang, Kang-Jin Huang, Xia Li, Ya Chen, Lan Wang, Ying-Xiong Wang, Yue Tang, Bo-Yuan Deng, Tai-Hang Liu, Xia Lan","doi":"10.1007/s40618-025-02585-6","DOIUrl":"10.1007/s40618-025-02585-6","url":null,"abstract":"<p><strong>Background: </strong>Investigate the association between Oral Glucose Tolerance Test (OGTT) after in vitro fertilization (IVF) treatment and adverse maternal and neonatal outcomes in twin pregnancies.</p><p><strong>Methods: </strong>This retrospective study encompassed 2,541 twin pregnancies conceived through IVF treatment. Adverse maternal and neonatal outcomes were compared across different subgroups based on individual and combined OGTT classifications. A Spearman correlation regression model examined associations between OGTT levels at different time points and parameters such as gestational age, birth weight, and length. Subsequently, a Logistic regression model with restricted cubic splines (RCS) explored the relationships between OGTT levels at different time points and adverse pregnancy outcomes. Ultimately, nine types of machine learning models were developed using OGTT glucose values at different times to predict the risk of adverse pregnancy outcomes.</p><p><strong>Results: </strong>In subgroup analysis based on individual OGTT diagnosis, three time points were examined: fasting glucose (OGTT0), 1-hour post-glucose (OGTT1), and 2-hour post-glucose (OGTT2). OGTT0 ≥ 5.1 mmol/L was significantly associated with increased risks of ICP and neonatal hypoglycemia (p = 0.031; p = 0.022). OGTT1 ≥ 10 mmol/L correlated with higher risks of ICP and neonatal hyperbilirubinemia (p = 0.001; p = 0.002). OGTT2 ≥ 8.5 mmol/L was also linked to neonatal hyperbilirubinemia (p < 0.001). In combined impaired OGTT subgroups, the impaired fasting glucose (IFG) group had a higher incidence of neonatal hypoglycemia than the impaired glucose tolerance (IGT) group and IFG & IGT group, but a lower risk of neonatal hyperbilirubinemia. OGTT2 was negatively correlated with gestational age at delivery (β = - 0.08, p = 0.018), and both OGTT1 and OGTT2 were negatively correlated with neonatal birth weight (β = - 10.54, p = 0.008; β = - 15.04, p < 0.001), as well as OGTT2 with birth length (β = - 0.16, p = 0.009). The RCS logistic regression model indicated that the increase OGTT values was associated with the ICP risk, and the relationship between OGTT2 and neonatal hyperbilirubinemia was U-shaped. Among the various machine learning models predicting adverse outcomes, RandomForest exhibited superior performance.</p><p><strong>Conclusion: </strong>OGTT values in twin pregnancies under IVF treatment are closely linked to adverse maternal and neonatal outcomes, with post-load glucose levels potentially serving as an early biomarker for identifying poorer outcomes. The inflection points in the RCS suggest a new indication point for the association between OGTT and adverse pregnancy outcomes in twin pregnancies conceived through IVF.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1871-1888"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Association between osteocalcin and residual β-cell function in children and adolescents newly diagnosed with type 1 diabetes: a pivotal study.","authors":"M Valenzise, B Bombaci, F Lombardo, S Passanisi, C Lombardo, C Lugarà, F D'Amico, L Grasso, M Aguennouz, A Catalano, G Salzano","doi":"10.1007/s40618-025-02569-6","DOIUrl":"10.1007/s40618-025-02569-6","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1919"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brachyury and IGF1R: potential opposing roles in pediatric thyroid nodular pathology.","authors":"Ayelen Martin, María Celia Fernandez, Sofía Miraglia, Marcela Venara, Florencia Clément, Patricia Papendieck, Elena De Matteo, Patricia A Pennisi","doi":"10.1007/s40618-025-02667-5","DOIUrl":"https://doi.org/10.1007/s40618-025-02667-5","url":null,"abstract":"<p><p>Solid thyroid nodules are the most common presentation of thyroid cancer in children, with a higher risk of malignancy than in adults. Pediatric thyroid cancer often presents aggressively, with advanced disease, lymph node involvement, and metastasis. Papillary Thyroid Carcinoma (PTC) is the predominant type, with genetic alterations distinct from those in adults. The epithelial-to-mesenchymal transition (EMT) plays a role in tumor development and is influenced by transcription factors such as Brachyury (Brachy). Insulin-Like Growth Factors (IGFs) impact thyroid function and tumorigenesis. This study examines Brachy and Insulin-Like Growth Factor receptor type 1 (IGF1R) expression in 62 pediatric thyroid nodule samples and explores the effects of Brachy and IGF1R overexpression in Thyroid Papillary Carcinoma cells (TPC-1) both in vitro and in vivo. A total of 29 PTC, 9 follicular adenomas (FA), and 24 benign thyroid nodule (BTN) samples were analyzed. Immunohistochemical analysis revealed Brachy and IGF1R expression in papillary thyroid carcinoma and follicular adenomas but not in benign nodules. In vitro, Brachy overexpression in TPC-1 cells promoted mesenchymal traits, increasing viability, motility, and EMT markers, while IGF1R overexpression enhanced epithelial characteristics and reduced cell growth. IGF1 stimulation further increased Brachy-induced cell proliferation. In vivo, tumors derived from Brachy-overexpressing clones exhibited faster growth compared to those derived from IGF1R-overexpressing clones. Taken together, our results indicate that Brachy promotes EMT, leading to a more aggressive phenotype, while IGF1R favors epithelial features and reduces proliferation, suggesting opposing roles for Brachy and IGF1R in thyroid tumor biology.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Plasticity deficits of Tregs remodeling toward Th1-like and Th17-like Tregs in individuals with type 1 diabetes.","authors":"Yao Qin, Yuxiao Li, Yueshu Wang, Qianying Wei, Liuyan Dai, Mei Huang, Yang Chen, Yong Gu, Tao Yang, Mei Zhang","doi":"10.1007/s40618-025-02584-7","DOIUrl":"10.1007/s40618-025-02584-7","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1923-1924"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}