Korean Journal of Internal Medicine最新文献_第7页

Treatment strategies for octogenarians with esophageal cancer: changing age-based treatment paradigms. 八十多岁食管癌患者的治疗策略：改变基于年龄的治疗模式。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 DOI: 10.3904/kjim.2025.029

Jaewon Hyung

引用次数: 0

Current perspectives on interstitial lung abnormalities. 间质性肺异常的当前观点。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 DOI: 10.3904/kjim.2024.335

Ju Hyun Oh, Jin Woo Song

{"title":"Current perspectives on interstitial lung abnormalities.","authors":"Ju Hyun Oh, Jin Woo Song","doi":"10.3904/kjim.2024.335","DOIUrl":"10.3904/kjim.2024.335","url":null,"abstract":"Interstitial lung abnormalities (ILAs) are early indicators of interstitial lung disease, often identified incidentally via computed tomography of the chest. This review explores the diagnostic criteria for ILAs as outlined by the Fleischner Society, highlights associated risk factors, examines their impact on patient outcomes, and discusses management strategies. The prevalence of ILAs varies significantly, ranging from 3% to 17% across populations. Key risk factors include advanced age, smoking status, and underlying genetic predispositions. Recent advancements in imaging analysis, particularly through automated quantitative systems, have enhanced the accuracy of ILA detection. Although often subtle in presentation, ILAs hold clinical significance due to their associations with impaired lung function, progressive fibrosis, and increased mortality. Therefore, monitoring and management plans should be individualized to the risk profile of patients. Further studies are needed to refine ILA diagnostic criteria, enhance our understanding of their clinical implications, and establish optimal timing for therapeutic interventions.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 2","pages":"208-218"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute gouty arthritis of the atlantoaxial joint. 寰枢关节急性痛风性关节炎。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-21 DOI: 10.3904/kjim.2024.247

Su Jin Choi, Min Wook So, Sunggun Lee, Seung Won Choi, Doo-Ho Lim

引用次数: 0

Characteristics and outcomes of portal vein thrombosis in patients with inflammatory bowel disease in Korea. 韩国炎症性肠病患者门静脉血栓形成的特点和结局。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.3904/kjim.2024.181

Ki Jin Kim, Su-Bin Song, Jung-Bin Park, June Hwa Bae, Ji Eun Baek, Ga Hee Kim, Min-Jun Kim, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Chang Sik Yu, Yong-Sik Yoon, Jong-Lyul Lee, Min Hyun Kim, Ho-Su Lee, Sang Hyoung Park

{"title":"Characteristics and outcomes of portal vein thrombosis in patients with inflammatory bowel disease in Korea.","authors":"Ki Jin Kim, Su-Bin Song, Jung-Bin Park, June Hwa Bae, Ji Eun Baek, Ga Hee Kim, Min-Jun Kim, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Chang Sik Yu, Yong-Sik Yoon, Jong-Lyul Lee, Min Hyun Kim, Ho-Su Lee, Sang Hyoung Park","doi":"10.3904/kjim.2024.181","DOIUrl":"10.3904/kjim.2024.181","url":null,"abstract":"Background/aims: Portal vein thrombosis (PVT) frequently occurs in patients with inflammatory bowel disease (IBD), particularly when influenced by factors such as abdominal infections, IBD flare-ups, or surgical procedures. The implications of PVT range from immediate issues such as intestinal ischemia to long-term concerns including portal hypertension and its complications. However, there is a notable gap in comprehensive studies on PVT in IBD, especially with the increasing incidence of IBD in Asia. This research aimed to evaluate the clinical features and outcomes of PVT in patients with IBD at a leading hospital in South Korea.Methods: This retrospective analysis reviewed adult patients diagnosed with both IBD and PVT from 1989 to 2021 at a renowned South Korean medical center. The study focused on patient characteristics, specifics of PVT, administered treatments, and outcomes, all confirmed through enhanced CT scans.Results: A total of 78 patients met the study's criteria. Notably, only 20.5% (16/78) were treated with oral anticoagulants; however, a vast majority (96.2%; 75/78) achieved complete radiographic resolution (CRR). When comparing patients receiving anticoagulants to those who did not, a significant preference for anticoagulant use was observed in cases where the main portal vein was affected, as opposed to just the left or right veins (p = 0.006). However, multivariable analysis indicated that neither anticoagulant use nor previous surgeries significantly impacted CRR.Conclusion: Patients with IBD and PVT generally had favorable outcomes, regardless of anticoagulant use.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"243-250"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pandemics extend beyond infectious diseases: the emerging threat of non-communicable diseases. 大流行病不仅限于传染病：非传染性疾病的新威胁。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 DOI: 10.3904/kjim.2025.046

Moojun Kim, Chan Joo Lee

引用次数: 0

Persistent influence of past obesity on current adiponectin levels and mortality in patients with type 2 diabetes. 既往肥胖对2型糖尿病患者当前脂联素水平和死亡率的持续影响

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 DOI: 10.3904/kjim.2024.221

Min-Ji Kim, Sung-Woo Kim, Bitna Ha, Hyang Sook Kim, So-Hee Kwon, Jonghwa Jin, Yeon-Kyung Choi, Keun-Gyu Park, Jung Guk Kim, In-Kyu Lee, Jae-Han Jeon

{"title":"Persistent influence of past obesity on current adiponectin levels and mortality in patients with type 2 diabetes.","authors":"Min-Ji Kim, Sung-Woo Kim, Bitna Ha, Hyang Sook Kim, So-Hee Kwon, Jonghwa Jin, Yeon-Kyung Choi, Keun-Gyu Park, Jung Guk Kim, In-Kyu Lee, Jae-Han Jeon","doi":"10.3904/kjim.2024.221","DOIUrl":"10.3904/kjim.2024.221","url":null,"abstract":"Background/aims: Adiponectin, a hormone primarily produced by adipocytes, typically shows an inverse relationship with body mass index (BMI). However, some studies have reported a positive correlation between the two. Thus, this study aimed to examine the relationship between adiponectin level and BMI in diabetic patients, focusing on the impact of past obesity on current adiponectin levels.Methods: We conducted an observational study analyzing data from 323 diabetic patients at Kyungpook National University Hospital. Based on past and current BMIs, participants were categorized into never-obese (nn, n = 106), previously obese (on, n = 43), and persistently obese (oo, n = 73) groups based on a BMI threshold of 25 kg/m2. Adiponectin level and BMI were key variables. Kaplan-Meier analysis assessed their impact on all-cause mortality up to August 2023, with survival differences based on adiponectin quartiles and follow-up starting from patient enrollment (2010-2015).Results: The analysis revealed a significant inverse correlation between adiponectin level and past maximum BMI. The on group exhibited approximately 10% lower adiponectin levels compared to the nn group. This association remained significant after adjusting for current BMI, age, and sex, highlighting the lasting influence of previous obesity on adiponectin levels. Furthermore, survival analysis indicated that patients in the lowest adiponectin quartile had reduced survival, with a statistically significant trend (p = 0.062).Conclusion: Findings of this study suggest that lower adiponectin levels, potentially reflecting past obesity, are associated with decreased survival in diabetic patients, underscoring a critical role of adiponectin in long-term health outcomes.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 2","pages":"299-309"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of tracheostomy on clinical outcomes in ventilated patients with severe pneumonia: a propensity-matched cohort study. 气管切开术对重症肺炎呼吸机患者临床疗效的影响：倾向匹配队列研究。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 DOI: 10.3904/kjim.2024.248

Hayoung Seong, Hyojin Jang, Wanho Yoo, Saerom Kim, Soo Han Kim, Kwangha Lee

{"title":"Impact of tracheostomy on clinical outcomes in ventilated patients with severe pneumonia: a propensity-matched cohort study.","authors":"Hayoung Seong, Hyojin Jang, Wanho Yoo, Saerom Kim, Soo Han Kim, Kwangha Lee","doi":"10.3904/kjim.2024.248","DOIUrl":"10.3904/kjim.2024.248","url":null,"abstract":"Background/aims: Tracheostomy is a crucial intervention for severe pneumonia patients requiring prolonged mechanical ventilation (MV). However, debate persists regarding the influence of tracheostomy timing and performance on long-term survival outcomes. This study utilized propensity score matching to assess the impact of tracheostomy timing and performance on patient survival outcomes.Methods: A retrospective observational study employing propensity score matching was conducted of respiratory intensive care unit (ICU) patients who underwent prolonged acute MV due to severe pneumonia from 2008 to 2023. The primary outcome was the 90-day cumulative mortality rate, with secondary outcomes including ICU medical resource utilization rates.Results: Out of 1,078 patients, 545 underwent tracheostomy with a median timing of 7 days. The tracheostomy group exhibited lower 90-day cumulative mortality and a higher survival probability (hazard ratio [HR] 0.52, 95% confidence interval [CI] 0.43-0.63) than the no-tracheostomy group. The tracheostomy group had higher ICU medical resource utilization rates and medical expenditures. The early tracheostomy group (≤ 7 days) had lower ICU medical resource utilization rates and medical expenditures than the late tracheostomy group (> 7 days). However, there were no significant differences in the 90-day cumulative mortality rate and survival probability based on tracheostomy timing (HR 0.94, 95% CI 0.70-1.28).Conclusion: Tracheostomy in patients with severe pneumonia requiring prolonged MV significantly reduced the 90-day mortality rate, and early tracheostomy may offer additional benefits for resource utilization efficiency. These findings underscore the importance of considering tracheostomy timing in optimizing patient outcomes and healthcare resource allocation.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 2","pages":"286-298"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal recovery from membranous lupus nephritis with antineutrophil cytoplasmic antibody-associated glomerulonephritis with belimumab. 使用贝利木单抗治疗膜性狼疮肾炎合并抗中性粒细胞胞浆抗体相关性肾小球肾炎的肾功能恢复情况。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.3904/kjim.2024.278

Wenfeng Wang, Zishan Lin, Bingjing Jiang, Yanfang Xu

引用次数: 0

Glial cell line-derived neurotrophic factor and its role in attenuating renal fibrosis: a review. 神经胶质细胞系源性神经营养因子及其在减轻肾脏纤维化中的作用：综述。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 Epub Date: 2023-12-13 DOI: 10.3904/kjim.2023.246

Yousuf Abdulkarim Waheed, Wokuheleza Buberwa, Dong Sun

{"title":"Glial cell line-derived neurotrophic factor and its role in attenuating renal fibrosis: a review.","authors":"Yousuf Abdulkarim Waheed, Wokuheleza Buberwa, Dong Sun","doi":"10.3904/kjim.2023.246","DOIUrl":"10.3904/kjim.2023.246","url":null,"abstract":"Chronic kidney disease is estimated to affect approximately 10 to 15% of the Chinese population. Renal fibrosis is characterized by progressive extracellular matrix deposition in the kidney parenchyma with eventual tissue scarring and inevitable deterioration of renal function. Vascular rarefaction, glomerulosclerosis, interstitial inflammation, and fibrogenesis are associated with or contribute to renal fibrosis. Recent studies have revealed that glial cell-derived neurotrophic factor (GDNF) is involved in kidney morphogenesis and amelioration of renal injury. Ideal therapies targeting the pathogenesis of renal fibrosis should have the potential to inhibit glomerular and tubulointerstitial fibrosis by targeting multiple pathological events. GDNF plays a unique role in both renal development and improvement of renal fibrosis, and GDNF kidney receptors and signaling pathways can ameliorate renal apoptosis and inflammation. Our work contributes to the establishment of GDNF as an emerging therapy that can increase the effectiveness of currently used interventions to improve renal fibrosis. This literature review focuses on the important role of GDNF in renal development and its relationship with renal fibrosis.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"219-229"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Explainable paroxysmal atrial fibrillation diagnosis using an artificial intelligence-enabled electrocardiogram. 可解释的阵发性心房颤动诊断使用人工智能启用心电图。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-21 DOI: 10.3904/kjim.2024.130

Yeongbong Jin, Bonggyun Ko, Woojin Chang, Kang-Ho Choi, Ki Hong Lee

{"title":"Explainable paroxysmal atrial fibrillation diagnosis using an artificial intelligence-enabled electrocardiogram.","authors":"Yeongbong Jin, Bonggyun Ko, Woojin Chang, Kang-Ho Choi, Ki Hong Lee","doi":"10.3904/kjim.2024.130","DOIUrl":"10.3904/kjim.2024.130","url":null,"abstract":"Background/aims: Atrial fibrillation (AF) significantly contributes to global morbidity and mortality. Paroxysmal atrial fibrillation (PAF) is particularly common among patients with cryptogenic strokes or transient ischemic attacks and has a silent nature. This study aims to develop reliable artificial intelligence (AI) algorithms to detect early signs of AF in patients with normal sinus rhythm (NSR) using a 12-lead electrocardiogram (ECG).Methods: Between 2013 and 2020, 552,372 ECG traces from 318,321 patients were collected and split into training (n = 331,422), validation (n = 110,475), and test sets (n = 110,475). Deep neural networks were then trained to predict AF onset within one month of NSR. Model performance was evaluated using the area under the receiver operating characteristic curve (AUROC). An explainable AI technique was employed to identify the inference evidence underlying the predictions of deep learning models.Results: The AUROC for early diagnosis of PAF was 0.905 ± 0.007. The findings reveal that the vicinity of the T wave, including the ST segment and S-peak, significantly influences the ability of the trained neural network to diagnose PAF. Additionally, comparing the summarized ECG in NSR with those in PAF revealed that nonspecific ST-T abnormalities and inverted T waves were associated with PAF.Conclusion: Deep learning can predict AF onset from NSR while detecting key features that influence decisions. This suggests that identifying undetected AF may serve as a predictive tool for PAF screening, offering valuable insights into cardiac dysfunction and stroke risk.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"251-261"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0