Mathew Muturi, Athman Mwatondo, Kazuki Shimizu, Khadija Chepkorir, Kanana Kimonye, Mark Nanyingi, Mario I Alguerno, Osman Dar, Dilys Morgan, Mathew Mutiiria, Serge Nzietchueng, Masika Sophie, Jayne Tusiime, Chadia Wannous, Dan Mogaka, Juliet Nabyonga-Orem, Nollascus Ganda, Guillaume Belot, Stephane de la Rocque, Tieble Traore
{"title":"First National Bridging Workshop on International Health Regulations 2005 and Performance of Veterinary Services Pathway in Kenya.","authors":"Mathew Muturi, Athman Mwatondo, Kazuki Shimizu, Khadija Chepkorir, Kanana Kimonye, Mark Nanyingi, Mario I Alguerno, Osman Dar, Dilys Morgan, Mathew Mutiiria, Serge Nzietchueng, Masika Sophie, Jayne Tusiime, Chadia Wannous, Dan Mogaka, Juliet Nabyonga-Orem, Nollascus Ganda, Guillaume Belot, Stephane de la Rocque, Tieble Traore","doi":"10.7189/jogh-14-03045","DOIUrl":"https://doi.org/10.7189/jogh-14-03045","url":null,"abstract":"","PeriodicalId":48734,"journal":{"name":"Journal of Global Health","volume":"14 ","pages":"03045"},"PeriodicalIF":4.5,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiaqi Chen, Linlin Huang, Hongli An, Zining Wang, Xiamei Kang, Rui Yin, Chenghao Jia, Xiuyan Jin, Min Yue
{"title":"One Health approach probes zoonotic non-typhoidal Salmonella infections in China: A systematic review and meta-analysis.","authors":"Jiaqi Chen, Linlin Huang, Hongli An, Zining Wang, Xiamei Kang, Rui Yin, Chenghao Jia, Xiuyan Jin, Min Yue","doi":"10.7189/jogh.14.04256","DOIUrl":"10.7189/jogh.14.04256","url":null,"abstract":"<p><strong>Background: </strong>Zoonotic infections, particularly those caused by non-typhoidal Salmonella (NTS), pose a significant disease burden. However, there is a notable lack of comprehensive and integrated studies employing the One Health approach to address Salmonella prevalence. In this study, we aimed to analyse NTS spatiotemporal prevalence, serovar distribution, and antimicrobial resistance (AMR) across China.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis to understand the dynamics of NTS in a One Health context in China. We searched the CNKI, Wanfang, and PubMed databases for Chinese and English peer-reviewed articles published before 1 January 2022 dealing with Salmonella in the context of China. We examined the dynamic prevalence along the food chain, the risk of dominant serovars and the carriers' regional contribution by principal component analysis, and the AMR burden before and after the ban on using antimicrobials as feed additives across five decades. We used the inverse variance index as an indicator of the inconsistency across studies, and we adopted the restricted maximum likelihood model due to high heterogeneity for analysis with a 95% confidence level for the pooled prevalence estimate.</p><p><strong>Results: </strong>Based on 562 retrieved high-quality studies during 1967-2021, representing 5 052 496 samples overall and 80 536 positive samples for NTS isolates, the overall average prevalence was 7.35% (95% confidence interval (CI) = 0.069-0.087), which was regionally relatively higher in northern China (8.19%; 95% CI = 0.078-0.117) than in southern China (6.94%; 95% CI = 0.067-0.088). Poultry was the primary vehicle for serovars Enteritidis and Indiana (especially in the north), while swine and ruminants for Typhimurium and Derby were the first to highlight the regional livestock contribution to serovar prevalence. The overall AMR rate was 73.63% (95% CI = 0.68-0.99), decreasing after the ban on excessive use of feed-based antibiotics in livestock since 2020, with a relatively low resistance towards front-line and last-resort drugs.</p><p><strong>Conclusions: </strong>Our study emphasises the importance of adopting a One Health framework to better understand the zoonotic nature of human NTS and highlights the dominant serovars on food contamination and human infection. The similarity in AMR patterns between poultry and human isolates further emphasises the integrated approach for evaluating disease burden and implementing targeted interventions.</p>","PeriodicalId":48734,"journal":{"name":"Journal of Global Health","volume":"14 ","pages":"04256"},"PeriodicalIF":4.5,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disclosures of conflicts of interest from the editors of the Journal of Global Health - 2024.","authors":"Harry Campbell, Igor Rudan","doi":"10.7189/jogh.14.01001","DOIUrl":"https://doi.org/10.7189/jogh.14.01001","url":null,"abstract":"","PeriodicalId":48734,"journal":{"name":"Journal of Global Health","volume":"14 ","pages":"01001"},"PeriodicalIF":4.5,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Building on the COVID-19 in Pregnancy in Scotland study to support ongoing surveillance, research, and pandemic preparedness for maternal and child health.","authors":"Rachael Wood, Sarah J Stock, Aziz Sheikh","doi":"10.7189/jogh.14.03046","DOIUrl":"https://doi.org/10.7189/jogh.14.03046","url":null,"abstract":"","PeriodicalId":48734,"journal":{"name":"Journal of Global Health","volume":"14 ","pages":"03046"},"PeriodicalIF":4.5,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Building capacity for maternal, newborn and child health research in low-income country settings: A research fellowship experience in Ethiopia.","authors":"Kassahun Alemu, Lisanu Taddesse, Clara Pons-Duran, Bezawit Mesfin Hunegnaw, Robera Olana Fite, Abebe Belayneh Bekele, Frederick Gb Goddard, Assaye K Nigussie, Yifru Berhan, Delayehu Bekele, Theodros Getachew, Ebba Abate, Getachew Tollera, Grace J Chan","doi":"10.7189/jogh.14.04198","DOIUrl":"10.7189/jogh.14.04198","url":null,"abstract":"<p><strong>Background: </strong>There is a need to build research capacity to improve maternal, newborn, and child health (MNCH) in low- and middle-income countries (LMICs). To address this gap, we co-designed the HaSET (meaning 'happiness' in Amharic) MNCH Research Fellowship programme for academics and policymakers in collaboration with the Ministry of Health (MOH) and academic institutions in Ethiopia.</p><p><strong>Methods: </strong>Based on interviews and focus group discussions regarding a landscape analysis of the MNCH research environment, we developed an innovative 'learning by doing' model in which fellows identified research questions, developed proposals, obtained institutional review board (IRB) approvals, conducted research, analysed data, disseminated their findings, and developed policy briefs. Postdoctoral fellows were paired with policymakers and health professionals at the MoH to facilitate the translation of research findings into policy and programmes. Each pair received mentorship from a member of the HaSET's scientific advisory group (SAG) who had expertise in research methods, data analysis, dissemination, and translation of evidence into policy.</p><p><strong>Results: </strong>The HaSET MNCH Research Fellowship curriculum included 10 modules covering topics from biostatistics to study operations and professional development. From March 2021 to July 2023, five postdoctoral fellows from local universities and four policymakers from the MoH and government research institutes underwent the HaSET programme, where they learned to gather high-quality evidence on priority research questions and guide the implementation of national policies and programmes. Leveraging existing data, the fellows produced 15 manuscripts and 11 policy briefs. The programme established a functional research link between the MoH, regional health bureaus, and local universities, while utilising the SAG's expertise in mentorship.</p><p><strong>Conclusions: </strong>This robust and comprehensive HaSET MNCH Research Fellowship produced the first cohort of dedicated fellows trained in evidence-based medicine and mentored them to become effective public health professionals. They conducted high-quality studies to inform policy decisions on MNCH interventions in Ethiopia. Given its sustainability and scalability, researchers and academic institutions can further adapt the fellowship curriculum within capacity-building programmes to educate the next generation of research leaders in LMICs.</p>","PeriodicalId":48734,"journal":{"name":"Journal of Global Health","volume":"14 ","pages":"04198"},"PeriodicalIF":4.5,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bereket Kefale, Jonine Jancey, Amanuel T Gebremedhin, Sylvester Dodzi Nyadanu, Daniel G Belay, Gavin Pereira, Gizachew A Tessema
{"title":"Risk factors of under-five and infant mortality: An umbrella review of systematic reviews and meta-analyses.","authors":"Bereket Kefale, Jonine Jancey, Amanuel T Gebremedhin, Sylvester Dodzi Nyadanu, Daniel G Belay, Gavin Pereira, Gizachew A Tessema","doi":"10.7189/jogh.14.04260","DOIUrl":"10.7189/jogh.14.04260","url":null,"abstract":"<p><strong>Background: </strong>Ensuring child survival is a critical global challenge, requiring a robust and comprehensive understanding of the risk factors contributing to under-five mortality (U5M). We aimed to synthesise and summarise the current available evidence on risk factors of U5M and infant mortality worldwide to inform global child health programmes.</p><p><strong>Methods: </strong>We searched six major databases (Embase, Medline, Scopus, CINAHL, Web of Science, and Global Health) and repositories of systematic reviews, as well as grey literature sources to identify systematic reviews and meta-analyses that examined the associations between risk factors of U5M and infant mortality between 1 January 1990 and 4 March 2024. The quality of reviews was assessed using A Measurement Tool to Assess Systematic Reviews, Version 2 (AMSTAR 2). The strength of evidence and direction of associations was graded.</p><p><strong>Results: </strong>Of 5684 records, we included 32 reviews (including five systematic reviews without meta-analysis) which comprised 1042 primary studies. We synthesised 28 and 29 unique risk factors associated with U5M and infant mortality, respectively. Although there was no convincing evidence for the risk factors, we found probable evidence of association between exclusive breastfeeding (consistent negative association), and maternal death (consistent positive association) with U5M. There was also probable evidence for the association of short (<18 months) interpregnancy intervals (less consistent negative association), pre-pregnancy maternal obesity (consistent positive association), and maternal HIV infection (consistent positive association) with infant mortality.</p><p><strong>Conclusions: </strong>While the review identified a broad range of risk factors, the overall evidence for most factors associated with under-five and infant mortality was 'limited-suggestive' or 'limited and no conclusive'. Thus, further high-quality studies are required to strengthen the evidence on these risk factors.</p><p><strong>Registration: </strong>PROSPERO CRD42023455542.</p>","PeriodicalId":48734,"journal":{"name":"Journal of Global Health","volume":"14 ","pages":"04260"},"PeriodicalIF":4.5,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"All-cause and cardiovascular mortality in dual sensory impairment patients: A meta-analysis of cohort studies.","authors":"Shuyi Liu, Tao Qin, Don O Kikkawa, Wei Lu","doi":"10.7189/jogh.14.04258","DOIUrl":"10.7189/jogh.14.04258","url":null,"abstract":"<p><strong>Background: </strong>This meta-analysis is to determine the risk of all-cause mortality and cardiovascular mortality of dual sensory impairment (DSI).</p><p><strong>Methods: </strong>Relevant cohort studies were searched in Medline with PubMed, Cochrane Library, and EMBASE databases. The quality of the included studies was assessed based on the Newcastle-Ottawa Quality Assessment Scale (NOS). STATA software (USA) was used to conduct statistical analyses. To determine the source of heterogeneity, subgroup and sensitivity analyses were carried out. Funnel plots and the Egger's test were used for detecting publication bias.</p><p><strong>Results: </strong>This meta-analysis incorporated 12 cohort studies (1992-2024), containing 310 211 patients. Pooled analysis showed that DSI patients had a higher risk of all-cause mortality (hazard ratio (HR) = 1.442; 95% confidence interval (CI) = 1.303-1.596, I<sup>2</sup> = 49.5%, P < 0.001), and cardiovascular mortality (HR = 1.832; 95% CI = 1.343-2.500, I<sup>2</sup> = 0%, P < 0.001). Subgroup analyses on sex and territory type revealed that DSI were all associated with an increased risk of all-cause mortality.</p><p><strong>Conclusions: </strong>This study shows that DSI is linked to higher risks of all-cause and cardiovascular mortality, suggesting that DSI should be regarded as an independent mortality risk factor. Physicians treating individuals with DSI should assess its impact on life expectancy.</p><p><strong>Registration: </strong>The protocol was previously registered on the International Prospective Register of Systematic Reviews (PROSPERO) platform (CRD42024527256).</p>","PeriodicalId":48734,"journal":{"name":"Journal of Global Health","volume":"14 ","pages":"04258"},"PeriodicalIF":4.5,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiahe Cui, Fangfang Xie, Hongyu Yue, Chaoqun Xie, Jianwen Ma, Haotian Han, Min Fang, Fei Yao
{"title":"Physical activity and constipation: A systematic review of cohort studies.","authors":"Jiahe Cui, Fangfang Xie, Hongyu Yue, Chaoqun Xie, Jianwen Ma, Haotian Han, Min Fang, Fei Yao","doi":"10.7189/jogh.14.04197","DOIUrl":"10.7189/jogh.14.04197","url":null,"abstract":"<p><strong>Background: </strong>Constipation significantly impacts quality of life and is a common public health issue. For affected individuals, especially those who are inactive and experience constipation symptoms, it is recommended to engage in physical activity (PA) to improve their condition. However, the relationship between PA and improvement in constipation remains unclear. We performed this systematic review of cohort studies to evaluate this potential association.</p><p><strong>Methods: </strong>We systematically searched the Embase, Cochrane Library, PubMed, and CINAHL databases for all cohort studies examining the relationship between PA and constipation from the inception of the databases up to 5 November 2023. We calculated the reported risk ratios (RRs) and 95% confidence intervals (CIs), conducted a random effects model, and performed a subgroup analysis based on factors such as gender, geographic region, and PA intensity to comprehensively explore the link between PA and constipation. Furthermore, we used the Newcastle-Ottawa Scale to evaluate the quality of the studies included in our analysis.</p><p><strong>Results: </strong>The analysis included 13 studies with 119 426 participants and 63 713 cases. The results indicated that higher levels of PA were associated with a decreased risk of constipation compared with lower levels of PA (RR = 0.69; 95% CI = 0.88-0.83) and moderate levels of PA (RR = 0.87; 95% CI = 0.79-0.95). Furthermore, adherence to international PA guidelines was correlated with a significantly reduced risk of constipation (RR = 0.87; 95% CI = 0.81-0.93). Notably, the risk of constipation was lowered among Asian populations (RR = 0.67; 95% CI = 0.56-0.79) and Oceanian populations (RR = 0.72; 95% CI = 0.63-0.83) who engaged in regular PA. Moreover, when comparing the risk of constipation between men and women collectively, PA was associated with a 34% lower risk (RR = 0.66; 95% CI = 0.55-0.80).</p><p><strong>Conclusions: </strong>The study findings indicated that moderate to high levels of PA significantly reduced the risk of constipation, showing a negative correlation between PA and constipation.</p><p><strong>Registration: </strong>PROSPERO: CRD42023479653.</p>","PeriodicalId":48734,"journal":{"name":"Journal of Global Health","volume":"14 ","pages":"04197"},"PeriodicalIF":4.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael N Onah, Gul Nawaz Khan, Sumra Kureishy, Jessica Bourdaire, Saskia de Pee, Cecilia Garzon, Yasir Ihtesham, Naveed Akbar, Sajid Bashir Soofi
{"title":"The cost-effectiveness of a cash-based transfer, specialised nutritious food, and social and behaviour change communication intervention package to prevent undernutrition among children 6-23 months in Pakistan: A cluster randomised controlled trial.","authors":"Michael N Onah, Gul Nawaz Khan, Sumra Kureishy, Jessica Bourdaire, Saskia de Pee, Cecilia Garzon, Yasir Ihtesham, Naveed Akbar, Sajid Bashir Soofi","doi":"10.7189/jogh.14.04186","DOIUrl":"10.7189/jogh.14.04186","url":null,"abstract":"<p><strong>Background: </strong>There is mixed evidence on the cost-effectiveness of cash transfers, along with food supplements and behaviour change communication interventions in improving child nutrition outcomes. To add to existing literature, we examined the cost-effectiveness of medium-quantity lipid-based nutrient supplement (LNS) and social and behaviour change communication (SBCC) messaging, separately and combined, compared to an existing unconditional cash transfers (UCT) programme in children 6-23 months of age in the district Rahim Yar Khan, Pakistan.</p><p><strong>Methods: </strong>This was a four-arm, community-based cluster randomised controlled trial. The UCT provided a quarterly sum of USD 32, the medium-quantity LNS contained a daily ration of 50 g of LNS, and the SBCC included monthly and quarterly messaging on nutrition, health, and hygiene to eligible households. Cost data were collected from a provider perspective through the review of procurement invoices and budgets, as well as interviews with stakeholders. We examined cost-effectiveness via statistically significant differences between the intervention and control arms, and estimated as cost per case of stunting, and disability-adjusted life years (DALYs) averted at six and 18 months of intervention.</p><p><strong>Results: </strong>Costs were higher for SBCC intervention combinations (UCT + SBCC and UCT + LNS + SBCC) due to high training costs for lady health workers. UCT + LNS achieved a reduction in stunting at a per-case cost of USDS 278.74 at six months and USD 897.15 at 18 months. UCT + LNS + SBCC achieved a reduction in stunting at per case cost of USD 846.48 at six months and USD 2324.58 at 18 months. The cost per DALYs averted for preventing stunting was USD 234 to USD 557.42 at six months, and USD 787.73 to USD 1537 at 18 months without discounting and age-weights.</p><p><strong>Conclusions: </strong>Although the affordability of such interventions is arguable, combining UCTs with LNS appears to be very cost-effective for reducing undernutrition and averting DALYs, while combining cash transfers with LNS and SBCC showed limited cost-effectiveness when targeting stunting.</p><p><strong>Registration: </strong>Clinicaltrials.gov: NCT03299218.</p>","PeriodicalId":48734,"journal":{"name":"Journal of Global Health","volume":"14 ","pages":"04186"},"PeriodicalIF":4.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chih-Chi Yang, Yun-Ju Shih, Helen Ayles, Peter Godfrey-Faussett, Mareli Claassens, Hsien-Ho Lin
{"title":"Cost-effectiveness analysis of a prediction model for community-based screening of active tuberculosis.","authors":"Chih-Chi Yang, Yun-Ju Shih, Helen Ayles, Peter Godfrey-Faussett, Mareli Claassens, Hsien-Ho Lin","doi":"10.7189/jogh.14.04226","DOIUrl":"10.7189/jogh.14.04226","url":null,"abstract":"<p><strong>Background: </strong>Active case finding could effectively detect tuberculosis (TB) patients, but it can be costly. Therefore, a feasible, cost-saving, and efficient algorithm for community-based TB screening is needed.</p><p><strong>Methods: </strong>The study population was based on a previous TB prevalence survey conducted in the Zambia/South Africa Tuberculosis and HIV/AIDS Reduction trial. We developed predictive scoring models for HIV-positive and HIV-negative/unknown populations for practical purposes. We compared the cost-effectiveness of our models with that of WHO tools through average cost-effectiveness ratio (ACER) and incremental cost-effectiveness ratio.</p><p><strong>Results: </strong>The prediction model for HIV-positive population presented higher area under the curve (AUC) = 0.652, 95% confidence interval (CI) = 0.602-0.701) than WHO-recommended four-symptom screen (AUC = 0.568, 95% CI = 0.524-0.612) among South African participants. The AUC of the model for HIV-negative/unknown population was 0.673 (95% CI = 0.648-0.697), which was higher than that of the WHO tools as well. The ACER of our model can range from 246 to 1670 USD per TB case detected in the South African communities.</p><p><strong>Conclusions: </strong>The scoring system for active TB case finding presented a better performance and showed cost-effectiveness, which can provide new strategies for active TB case finding with multiple options under budget considerations.</p>","PeriodicalId":48734,"journal":{"name":"Journal of Global Health","volume":"14 ","pages":"04226"},"PeriodicalIF":4.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}