评估尼泊尔儿童呼吸道合胞病毒和非呼吸道合胞病毒急性呼吸道感染的费用。

IF 4.5 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Neele Rave, Arun K Sharma, Ram H Chapagain, Rupesh Shrestha, An Nguyen, Clint Pecenka, Farina L Shaaban, Prakash Joshi, Louis J Bont
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引用次数: 0

摘要

背景:低收入和中等收入国家(LMICs)承担着全球呼吸道合胞病毒(RSV)发病率和死亡率的最大负担,但缺乏成本数据来评估RSV负担对家庭、卫生保健系统和社会的健康经济影响。这项前瞻性观察性研究由RSV GOLD III -健康经济研究小组进行,并估计了尼泊尔与RSV疾病相关的成本。方法:我们收集儿童医疗资源利用资料。结果:我们纳入730例患者,平均年龄为6.8(标准差= 5.8)个月。急性呼吸道感染住院患者中有72.6% (n/ n = 469/646)确诊为RSV感染。非严重患者每次RSV发作的平均总成本为43美元(95%可信区间(CI) = 25-62),严重患者为312美元(95% CI = 293-332),生命危险患者为664美元(95% CI = 381-947)。在总成本中,医疗保健系统在每种疾病类别中分别花费了16美元(36.3%)、58美元(18.6%)和57美元(8.6%)。非重症患者的家庭层面成本占该国人均国内生产总值的1.4%(19美元),重症患者的家庭层面成本占15.1%(200美元),生命垂危患者的家庭层面成本占35.7%(472美元),住院患者的成本往往达到灾难性水平。结论:我们的研究结果显示了尼泊尔RSV疾病的重大医疗和经济负担,强调了优先考虑RSV预防策略的必要性。我们的成本负担数据可以为尼泊尔未来RSV干预的成本和收益建模提供信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessing the cost of illness of RSV and non-RSV acute respiratory infections in Nepali children.

Background: Low- and middle-income countries (LMICs) bear the greatest burden of the global respiratory syncytial virus (RSV) morbidity and mortality, but lack cost data to evaluate the health-economic impact of RSV burden on families, the healthcare system, and society. This prospective observational study was performed by the RSV GOLD III - Health Economic Research Group and estimated the costs associated with RSV illness in Nepal.

Methods: We collected healthcare resource utilisation data from children <2 years old fulfilling the World Health Organization (severe) acute respiratory infections ((S)ARI) case definition over one local respiratory season (July to November 2023) at two public hospitals in Nepal. We used hospital records and caregiver interviews to collect direct medical, direct non-medical, and indirect cost data to generate total per-patient costs.

Results: We included 730 patients with a mean age of 6.8 (standard deviation = 5.8) months. RSV infection was confirmed in 72.6% of the inpatients (n/N = 469/646) with SARI. The mean total cost per RSV episode was USD 43 (95% confidence interval (CI) = 25-62) for non-severe, USD 312 (95% CI = 293-332) for severe, and USD 664 (95% CI = 381-947) for life-threatened patients. Of the total costs, the healthcare system incurred USD 16 (36.3%), USD 58 (18.6%), and USD 57 (8.6%) in each category of illness. Household-level costs were 1.4% (USD 19) of the country's gross domestic product per capita for non-severe, 15.1% (USD 200) for severe, and 35.7% (USD 472) for life-threatened patients, with costs for inpatients often reaching catastrophic levels.

Conclusions: Our findings show a significant healthcare and economic burden of RSV illness in Nepal, highlighting the need to prioritise RSV prevention strategies. Our cost burden data can inform the modelling of costs and benefits of future RSV interventions in Nepal.

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来源期刊
Journal of Global Health
Journal of Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -
CiteScore
6.10
自引率
2.80%
发文量
240
审稿时长
6 weeks
期刊介绍: Journal of Global Health is a peer-reviewed journal published by the Edinburgh University Global Health Society, a not-for-profit organization registered in the UK. We publish editorials, news, viewpoints, original research and review articles in two issues per year.
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