Journal of Physiological Anthropology最新文献

{"title":"Upregulation of cathepsin L gene under mild cold conditions in young Japanese male adults.","authors":"Yoshiki Yasukochi, Sora Shin, Hitoshi Wakabayashi, Takafumi Maeda","doi":"10.1186/s40101-021-00267-9","DOIUrl":"10.1186/s40101-021-00267-9","url":null,"abstract":"<p><strong>Background: </strong>Physiological thermoregulatory systems in humans have been a key factor for adaptation to local environments after their exodus from Africa, particularly, to cold environments outside Africa. Recent studies using high-throughput sequencing have identified various genes responsible for cold adaptation. However, the molecular mechanisms underlying initial thermoregulation in response to acute cold exposure remain unclear. Therefore, we investigated transcriptional profiles of six young Japanese male adults exposed to acute cold stress.</p><p><strong>Methods: </strong>In a climatic chamber, the air temperature was maintained at 28°C for 65 min and was then gradually decreased to 19°C for 70 min. Saliva samples were obtained from the subjects at 28°C before and after 19°C cold exposure and were used for RNA sequencing.</p><p><strong>Results: </strong>In the cold exposure experiment, expression levels of 14 genes were significantly changed [false discovery rate (FDR) < 0.05] although the degree of transcriptional changes was not high due to experimental conditions or blunted transcriptional reaction in saliva to cold stress. As a result, differential gene expression analyses detected the cathepsin L (CTSL) gene to be significantly upregulated, with FDR < 0.05 and log₂ fold change value > 1; thus, this gene was identified as a differentially expressed gene. Given that the cathepsin L protein is related to invasion of the novel coronavirus (SARS-CoV-2), mild cold stress might alter the susceptibility to coronavirus disease-19 in humans. The gene ontology enrichment analysis for 14 genes with FDR < 0.05 suggested that immune-related molecules could be activated by mild cold stress.</p><p><strong>Conclusions: </strong>The results obtained from this study indicate that CTSL expression levels can be altered by acute mild cold stress.</p>","PeriodicalId":48730,"journal":{"name":"Journal of Physiological Anthropology","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39551488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between thyroid-stimulating hormone (TSH) and proteinuria in relation to thyroid cyst in a euthyroid general population.","authors":"Yuji Shimizu,&nbsp;Yuko Nabeshima-Kimura,&nbsp;Shin-Ya Kawashiri,&nbsp;Yuko Noguchi,&nbsp;Shigeki Minami,&nbsp;Yasuhiro Nagata,&nbsp;Takahiro Maeda,&nbsp;Naomi Hayashida","doi":"10.1186/s40101-021-00264-y","DOIUrl":"https://doi.org/10.1186/s40101-021-00264-y","url":null,"abstract":"<p><strong>Background: </strong>High normal levels of thyroid-stimulating hormone (TSH) have been reported to be associated with chronic kidney disease (CKD) among euthyroid individuals. However, there has been only limited research on the association between TSH and proteinuria, a major risk factor for the progression of renal disease.</p><p><strong>Methods: </strong>A cross-sectional study of 1595 euthyroid individuals was conducted. All participants were within the normal range for free triiodothyronine (T3), free thyroxine (T4), and TSH. Analyses were stratified by thyroid cyst status to test the hypothesis that the absence of thyroid cysts, an indicator of latent thyroid damage, is associated with declining ability to synthesis thyroid hormone.</p><p><strong>Results: </strong>For participants with thyroid cysts, a significant inverse association between TSH and proteinuria was observed (adjusted odds ratio (95% confidence intervals) of log-transformed TSH for proteinuria 0.40 (0.18, 0.89)). In participants without thyroid cysts, a significant positive association between those two factors was observed (2.06 (1.09, 3.90)).</p><p><strong>Conclusions: </strong>Among euthyroid individuals in the general population, being in the normal range of TSH was found to have an ambivalent association with proteinuria. Thyroid cyst status could be an effect modifier for those associations.</p>","PeriodicalId":48730,"journal":{"name":"Journal of Physiological Anthropology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39500357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The establishment of serum 25-hydroxyvitamin D reference intervals in children aged 0-14 years in Zigong area, China.","authors":"Jianhong Yu,&nbsp;Xiaoping He,&nbsp;Shengwei Huang","doi":"10.1186/s40101-021-00265-x","DOIUrl":"https://doi.org/10.1186/s40101-021-00265-x","url":null,"abstract":"<p><strong>Objective: </strong>To establish the reference interval of serum 25-hydroxyvitamin D (25(OH)D) in apparently healthy children in Zigong, China, using an indirect method to provide a basis for proper clinical diagnosis and treatment.</p><p><strong>Methods: </strong>A total of 1851 apparently healthy children of the Children's Health Care Department in Zigong First People's Hospital between January 2016 and December 2020 were included in the study. The Kolmogorov-Smirnov test was used to analyze the data for normality, and the non-normally distributed data were transformed into approximately normal distribution by Blom's normal rank transformation, and the transformed data were excluded from outliers by the quartile spacing method, and the data were stratified and analyzed according to sex, age, and season. The data were stratified according to sex, age, and season, and the area between the 2.5% and 97.5% percentile points was used as the reference interval.</p><p><strong>Results: </strong>The serum 25(OH)D data were non-normally distributed. The data were normally distributed after Blom's normality rank transformation, and 92 cases of outliers were excluded from the transformed data according to the interquartile spacing method. The differences in serum 25(OH)D levels between sex were not statistically significant (P > 0.05), and there was no need to establish reference intervals based on sex. There was no statistically significant difference in serum 25-hydroxyvitamin D levels between winter and spring, and also no difference between summer and autumn (P > 0.05), and the levels were lower in winter-spring than in summer-autumn. Comparison between age groups showed that there was no statistically significant difference in serum 25(OH)D levels between the < 6 months group and the 6 ~ 11 months group, and between the 6 ~ 9 years group and the 10 ~ 14 years group (P > 0.05); serum 25(OH)D levels decreased with increasing age. There was an interactive effect of season and age group on 25(OH)D levels, and the corresponding reference intervals were established according to different seasons and age groups. In summer and autumn, the reference intervals of serum 25(OH)D for < 1 year, 1 ~ 2 years, 3 ~ 5 years, and 6 ~  14 years were 39.86 ~ 151.43, 31.54 ~ 131.65, 22.05 ~ 103.75, and 15.36 ~ 85.53 ng/ml and 24.42 ~ 144.20, 31.54 ~ 131.65, 16.80 ~ 165.68, and 15.46 ~ 85.54 ng/ml in winter and spring, respectively.</p><p><strong>Conclusion: </strong>Reference intervals for serum 25(OH)D in children of different seasons and ages in Zigong, China, were established to provide a reference for clinical disease diagnosis, treatment, and prognosis determination.</p>","PeriodicalId":48730,"journal":{"name":"Journal of Physiological Anthropology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2021-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39490997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating thigh skeletal muscle volume using multi-frequency segmental-bioelectrical impedance analysis.","authors":"Masashi Taniguchi,&nbsp;Yosuke Yamada,&nbsp;Masahide Yagi,&nbsp;Ryusuke Nakai,&nbsp;Hiroshige Tateuchi,&nbsp;Noriaki Ichihashi","doi":"10.1186/s40101-021-00263-z","DOIUrl":"https://doi.org/10.1186/s40101-021-00263-z","url":null,"abstract":"<p><strong>Background: </strong>The primary aim of this study was to investigate whether using the extracellular water/intracellular water (ECW/ICW) index and phase angle combined with segmental-bioimpedance analysis (BIA) improved the model fitting of skeletal muscle volume (SMV) estimation. The secondary aim was to compare the accuracy of segmental-BIA with that of ultrasound for estimating the quadriceps SMV measured with MRI.</p><p><strong>Methods: </strong>Seventeen young men (mean age, 23.8 ± 3.3 years) participated in the study. The T-1 weighted images of thigh muscles were obtained using a 1.5 T magnetic resonance imaging (MRI) scanner. Thigh and quadriceps SMVs were calculated as the sum of the products of anatomical cross-sectional area and slice thickness of 6 mm across all slices. Segmental-BIA was applied to the thigh region, and data on the 50-kHz bioelectrical impedance (BI) index, ICW index, ECW/ICW index, and phase angle were obtained. The muscle thickness index was calculated as the product of the mid-thigh muscle thickness, determined using ultrasound, and thigh length. The standard error of estimate (SEE) of the regression equation was calculated to determine the model fitting of SMV estimation and converted to %SEE by dividing the SEE values by the mean SMV.</p><p><strong>Results: </strong>Multiple regression analysis indicated that the combination of 50-kHz BI and the ECW/ICW index or phase angle was a significant predictor when estimating thigh SMV (SEE = 7.9 and 8.1%, respectively), but were lower than the simple linear regression (SEE = 9.4%). The ICW index alone improved the model fitting for the estimation equation (SEE = 7.6%). The model fitting of the quadriceps SMV with the 50-kHz BI or ICW index was similar to that with the skeletal muscle thickness index measured using ultrasound (SEE = 10.8, 9.6 and 9.7%, respectively).</p><p><strong>Conclusions: </strong>Combining the traditionally used 50-kHz BI index with the ECW/ICW index and phase angle can improve the model fitting of estimated SMV measured with MRI. We also showed that the model suitability of SMV estimation using segmental-BIA was equivalent to that on using ultrasound. These data indicate that segmental-BIA may be a useful and cost-effective alternative to the gold standard MRI for estimating SMV.</p>","PeriodicalId":48730,"journal":{"name":"Journal of Physiological Anthropology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39473127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent face cooling reduces perceived exertion during exercise in a hot environment.","authors":"Taiki Miyazawa,&nbsp;Mirai Mizutani,&nbsp;John Patrick Sheahan,&nbsp;Daisuke Ichikawa","doi":"10.1186/s40101-021-00262-0","DOIUrl":"https://doi.org/10.1186/s40101-021-00262-0","url":null,"abstract":"<p><strong>Background: </strong>Facial cooling (FC) is effective in improving endurance exercise performance in hot environments. In this study, we evaluated the impact of intermittent short-lasting FC on the ratings of perceived exertion (RPE) during exercise.</p><p><strong>Methods: </strong>Ten healthy men performed 40 continuous minutes of ergometric cycle exercise at 65% of the peak heart rate in a climatic chamber controlled at an ambient temperature of 35 °C and a relative humidity of 50%. In the control (CONT) trial, the participants performed the exercise without FC. In two cooling trials, each participant underwent 10 s of FC at 2- (FC2) and 4-min (FC4) intervals while continuing to exercise. FC was achieved by applying two soft-gel packs (cooled to 0 °C) directly and bilaterally on the forehead, eyes, and cheeks. In another cooling trial, 10 s of FC was performed at 2-min intervals using two soft-gel packs cooled to 20 °C (FC2-20).</p><p><strong>Results: </strong>The RPE values in the FC4 trial were significantly lower than those in the CONT trial at 20 min (FC4, 11.6 ± 2.2 points; CONT, 14.2 ± 1.3 points; P < 0.01). Further, significant differences in the RPE values were observed between the FC4 and CONT trials at 5-15 min and 25-40 min (P < 0.05). RPE values were also significantly lower in the FC2 trial than in the CONT trial (5-40 min). Although the RPE values in the FC2-20 trial were significantly lower (5-10 min; 15-20 min) than those in the CONT trial, there were no significant differences in the RPE between the FC2-20 and CONT trials at 25-40 min. At 35 min, the RPE values were significantly higher in the FC2-20 trial than in the FC2 trial (P < 0.05).</p><p><strong>Conclusion: </strong>Intermittent short-lasting FC was associated with a decrease in RPE, with shorter intervals and lower temperatures eliciting greater attenuation of increase in the RPE.</p>","PeriodicalId":48730,"journal":{"name":"Journal of Physiological Anthropology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2021-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39407403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico.","authors":"Pilar E Núñez Ortega,&nbsp;María E Meneses,&nbsp;Iván Delgado-Enciso,&nbsp;César Antonio Irecta-Nájera,&nbsp;Itandehui Castro-Quezada,&nbsp;Roberto Solís-Hernández,&nbsp;Elena Flores-Guillén,&nbsp;Rosario García-Miranda,&nbsp;Adán Valladares-Salgado,&nbsp;Daniel Locia-Morales,&nbsp;Héctor Ochoa-Díaz-López","doi":"10.1186/s40101-021-00259-9","DOIUrl":"https://doi.org/10.1186/s40101-021-00259-9","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas.</p><p><strong>Methods: </strong>In a cross-sectional study, sociodemographic, anthropometric, clinical, and biochemical data were obtained from 291 adult women from three regions of Chiapas, Mexico. The prevalence of MetS and the allele and genotype frequencies of the rs9939609-FTO were estimated. Multivariate logistic regression models were used to assess the association of the single nucleotide polymorphism (SNP) with each of the MetS components.</p><p><strong>Results: </strong>The MetS prevalence was 60%. We found a statistically significant association between rs9939609-FTO and hyperglycemia in the dominant model (OR 2.6; 95% CI 1.3-5.3; p = 0.007).</p><p><strong>Conclusions: </strong>Women from Mayan communities of Chiapas presented a high prevalence of MetS and a relevant association of the FTO variant with hyperglycemia. This is the first study carried out in these Mayan indigenous communities from Chiapas.</p>","PeriodicalId":48730,"journal":{"name":"Journal of Physiological Anthropology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39364917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An anthropogenic model of cardiovascular system adaptation to the Earth's gravity as the conceptual basis of pathological anthropology.","authors":"G S Belkaniya, L R Dilenyan, D G Konkov, A Wsol, A K Martusevich, L G Puchalska","doi":"10.1186/s40101-021-00260-2","DOIUrl":"10.1186/s40101-021-00260-2","url":null,"abstract":"<p><p>Applying human biological evolution to solve topical problems of medicine and preventive cardiology was inspired by the realization of the need for clinical and experimental studies of biological (evolutionary) prerequisites in the occurrence of a pathology. Although it has been stated that there is a need to provide a full biological understanding of features, including those that increase an animal's vulnerability to diseases, unfortunately, in this regard, erectile and associated adaptations to the Earth's gravity in their physiological and pathological manifestations have not been considered. At the same time, it should be noted that humans, unlike other animal species, have the greatest vulnerability of the cardiovascular system (CVS). The latter is associated with fundamental differences in the functioning and regulation of the CVS by the influence of gravity on blood circulation in humans as upright creatures. Based on a review of comparative physiological, ontogenetic, and clinical studies from an evolutionary perspective, the idea of adaptation to the Earth's gravity when walking upright in humans is justified as an anthropogenic basis for the physiology and pathology of the cardiovascular system and hemodynamic support systems (physio-anthropology and pathological anthropology).</p>","PeriodicalId":48730,"journal":{"name":"Journal of Physiological Anthropology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39360497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infant weight gain and DXA-measured adolescent adiposity: data from the Japan Kids Body-composition Study.","authors":"Yuki Fujita,&nbsp;Katsuyasu Kouda,&nbsp;Kumiko Ohara,&nbsp;Harunobu Nakamura,&nbsp;Chikako Nakama,&nbsp;Toshimasa Nishiyama,&nbsp;Masayuki Iki","doi":"10.1186/s40101-021-00261-1","DOIUrl":"https://doi.org/10.1186/s40101-021-00261-1","url":null,"abstract":"<p><strong>Background: </strong>Rapid weight gain in early life is associated with adiposity later in life. However, there is limited information on the association between weight gain and body fat mass measured using precise methods. This study aimed to investigate whether weight gain is associated with body fat mass measured by dual-energy X-ray absorptiometry (DXA) in adolescents.</p><p><strong>Methods: </strong>Participants of this retrospective cohort study were 423 adolescents born at full-term who were enrolled in the Japan Kids Body-composition Study. Anthropometric measurements related to pregnancy, delivery, and child health were obtained from the Japanese Maternal and Child Health Handbook. Fat mass in adolescents was measured with a DXA scanner. Weight gain was defined as the change in body weight from birth to age 1.5 years. Associations between birthweight and fat mass, and between weight gain and fat mass, were evaluated using multiple regression analysis.</p><p><strong>Results: </strong>There was a significant positive association between weight gain from birth to age 1.5 years and fat mass in adolescents (boys: standardized regression coefficient (β) = 0.253, p < 0.01; girls: β = 0.246, p < 0.01), but not between birthweight standardized for gestational age and fat mass.</p><p><strong>Conclusion: </strong>Children with a greater change in weight from birth to age 1.5 years tended to have increased fat mass in adolescence. Weight gain in early life has a greater impact on fat mass in adolescents than birthweight.</p>","PeriodicalId":48730,"journal":{"name":"Journal of Physiological Anthropology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39362886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambient-task combined lighting to regulate autonomic and psychomotor arousal levels without compromising subjective comfort to lighting.","authors":"Junichiro Hayano,&nbsp;Norihiro Ueda,&nbsp;Masaya Kisohara,&nbsp;Yutaka Yoshida,&nbsp;Emi Yuda","doi":"10.1186/s40101-021-00258-w","DOIUrl":"https://doi.org/10.1186/s40101-021-00258-w","url":null,"abstract":"<p><strong>Background: </strong>Although evidence of both beneficial and adverse biological effects of lighting has accumulated, biologically favorable lighting often does not match subjectively comfortable lighting. By controlling the correlated color temperature (CCT) of ambient lights, we investigated the feasibility of combined lighting that meets both biological requirements and subjective comfort.</p><p><strong>Methods: </strong>Two types of combined lightings were compared; one consisted of a high-CCT (12000 K) light-emitting diode (LED) panel as the ambient light and a low-CCT (5000 K) LED stand light as the task light (high-low combined lighting), and the other consisted of a low-CCT (4500 K) LED panel as the ambient light and the same low-CCT (5000 K) stand light as the task light (low-low combined lighting) as control. Ten healthy subjects (5 young and 5 elderly) were exposed to the two types of lighting on separate days. Autonomic function by heart rate variability, psychomotor performances, and subjective comfort were compared.</p><p><strong>Results: </strong>Both at sitting rest and during psychomotor workload, heart rate was higher and the parasympathetic index of heart rate variability was lower under the high-low combined lighting than the low-low combined lighting in both young and elderly subject groups. Increased psychomotor alertness in the elderly and improved sustainability of concentration work performance in both age groups were also observed under the high-low combined lighting. However, no significant difference was observed in the visual-analog-scale assessment of subjective comfort between the two types of lightings.</p><p><strong>Conclusions: </strong>High-CCT ambient lighting, even when used in combination with low-CCT task lighting, could increase autonomic and psychomotor arousal levels without compromising subjective comfort. This finding suggests the feasibility of independent control of ambient and task lighting as a way to achieve both biological function regulation and subjective comfort.</p>","PeriodicalId":48730,"journal":{"name":"Journal of Physiological Anthropology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39296450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of newly developed body mass index cut-off for diagnosing obesity among Ethiopian adults.","authors":"Makeda Sinaga,&nbsp;Tilahun Yemane,&nbsp;Elsah Tegene,&nbsp;David Lidstrom,&nbsp;Tefera Belachew","doi":"10.1186/s40101-019-0205-2","DOIUrl":"https://doi.org/10.1186/s40101-019-0205-2","url":null,"abstract":"<p><strong>Background: </strong>Obesity is defined as unhealthy excess body fat, which increases the risk of premature mortality from noncommunicable diseases. Early screening and prevention of obesity is critical for averting associated morbidity, disability, and mortality. Ethiopia has been using the international (WHO's) BMI cut-off for diagnosing obesity even though its validity among Ethiopian population was questioned. To address this problem, a new body mass index cut-off was developed for Ethiopian adults using population-specific data. However, its performance in diagnosing obesity has not been validated. Therefore, this study determined the performance of the newly developed Ethiopian and World Health Organization (WHO) BMI cut-offs in detecting obesity among Ethiopian adults.</p><p><strong>Methods: </strong>A cross-sectional study was carried out among 704 employees of Jimma University from February to April 2015. The study participants were selected using simple random sampling technique based on their payroll. Data on sociodemographic variables were collected using an interviewer-administered structured questionnaire. Anthropometric parameters including body weight and height were measured according to WHO recommendation. Body fat percentage (BF%) was measured using the air displacement plethysmography (ADP) after calibration of the machine. The diagnostic accuracy of the WHO BMI cut-off (≥ 30 kg/m²) for obesity in both sexes and Ethiopian BMI cut-off (> 22.2 kg/m² for males and >  24.5 kg/m² for females) were compared to obesity diagnosed using ADP measured body fat percentage (> 35% for females and >  25% for males). Sensitivity, specificity, predictive values, and kappa agreements were determined to validate the performance of the BMI cut-offs.</p><p><strong>Results: </strong>In males, WHO BMI cut-off has a sensitivity of 5.3% and specificity of 99.4% (Kappa = 0.047) indicating a slight agreement. However, the Ethiopian cut-off showed a sensitivity of 87.5% and specificity of 87.7% (Kappa = 0.752) indicating a substantial agreement. Similarly, in females, the WHO BMI cut-off showed a sensitivity of 46.9%, while its specificity was 100% (Kappa = 0.219) showing a fair agreement. The Ethiopian BMI cut-off demonstrated a sensitivity 80.0% and a specificity 95.6% (Kappa = 0.701) showing a substantial agreement. The WHO BMI cut-off underestimated the prevalence of obesity by a maximum of 73.7% and by a minimum of 28.3% among males, while the values for underestimation ranged from 31.4-54.1% in females. The misclassification was minimal using the newly developed Ethiopian BMI cut-off. The prevalence of obesity was underestimated by a maximum of 9.2% and overestimated by a maximum of 6.2%. The WHO BMI cut-off failed to identify nearly half (46.6%) of Ethiopian adults who met the criteria for obesity using BF% in the overall sample.</p><p><strong>Conclusions: </strong>The findings suggest that WHO BMI cut-o","PeriodicalId":48730,"journal":{"name":"Journal of Physiological Anthropology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2019-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40101-019-0205-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41216798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}