Molecular & Cellular Biomechanics最新文献

{"title":"Reliability and Variability of Hepatic Venous Pressure Gradient as a Surrogate of Portal Pressure Gradient: Insights from a Computational Model-Based Study","authors":"Fuyou Liang and Tianqi Wang","doi":"10.32604/mcb.2019.05710","DOIUrl":"https://doi.org/10.32604/mcb.2019.05710","url":null,"abstract":"","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76479056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protecting the Brain from Calcification in Ischemic Stroke","authors":"Shu Q. Liu","doi":"10.32604/mcb.2019.06960","DOIUrl":"https://doi.org/10.32604/mcb.2019.06960","url":null,"abstract":"","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77350583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fully-Coupled Fluid-Structure Interaction (FSI) Simulations of Heart Valve-Left Ventricle Dynamics","authors":"Wei Sun","doi":"10.32604/mcb.2019.08533","DOIUrl":"https://doi.org/10.32604/mcb.2019.08533","url":null,"abstract":"Fluid–structure interaction (FSI) is a common phenomenon in biological systems. FSI problems of practical interest, such as fish/mammalian swimming, insect/bird flight, and human cardiac blood flow and respiration often involve multiple 3D immersed bodies with complex geometries undergoing very large structural displacements, and inducing very complex flow phenomena. Simulation of heart valve FSI is a technically challenging problem due to the large deformation of the valve leaflets through the cardiac fluid domain in the atrium and ventricular chambers. Recently, we developed a FSI computational framework [1] for modeling patient-specific left heart (LH) dynamics using smoothed particle hydrodynamics (SPH) for the blood flow, and non-linear anisotropic finite element analysis for heart valve tissues. SPH is a meshless, statistical method that relies on sampling neighboring particles to calculate fluid field variables. SPH’s mesh-free and Lagrangian nature makes it particular suitable for numerical problems where there are 1) moving boundaries and 2) large deformations, which are the conditions seen in heart valve FSI applications. In this presentation, I will explain under which scenarios that heart valve FSI simulations are needed, and give a few examples of our FSI applications. Briefly, we utilized the SPH-FE based, fully-coupled FSI modeling techniques to investigate the pathological LH dynamics under primary and secondary mitral regurgitation (MR) conditions [2], and examine the underlying biomechanics of various minimally-invasive mitral valve (MV) repair techniques. The FSI model was also used to investigate the impact of transcatheter aortic valve replacement (TAVR) on LH dynamics under bicuspid aortic valve (BAV) stenosis and concomitant significant MR [3].","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80276387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensing Traction Force Induces Cell-Cell Distant Communications for the Rapid Network Assembly of Airway Smooth Muscle Cells","authors":"Mingxing Ouyang, Zhili Qian, Yang Jin, Linhong Deng","doi":"10.32604/mcb.2019.06642","DOIUrl":"https://doi.org/10.32604/mcb.2019.06642","url":null,"abstract":"","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81627740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Identification of Heterogeneous Nonlinear Material Properties of the Aortic Wall from Clinical Gated CT Scans","authors":"Minliang Liu, L. Liang, X. Lou, Glen Iannucci, E. Chen, B. Leshnower, Wei Sun","doi":"10.32604/mcb.2019.07387","DOIUrl":"https://doi.org/10.32604/mcb.2019.07387","url":null,"abstract":"","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84291823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development History, Progress and Future Prospects of Biomechanics and Biorheology in Chongqing University","authors":"Guixue Wang, Li Yang","doi":"10.32604/mcb.2019.08410","DOIUrl":"https://doi.org/10.32604/mcb.2019.08410","url":null,"abstract":"","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81129809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical-CT Dual-Modality Mapping Base on DRR Registration","authors":"Qingyang Zang, Dongsheng Li, Chunxiao Chen, Jianfei Li","doi":"10.32604/mcb.2019.06999","DOIUrl":"https://doi.org/10.32604/mcb.2019.06999","url":null,"abstract":"Optical-CT dual-modality imaging requires the mapping between 2D fluorescence images and 3D body surface light flux. In this paper, we proposed an optical-CT dual-modality image mapping algorithm based on the Digitally Reconstructed Radiography (DRR) registration. In the process of registration, a series of DRR images were computed from CT data using the ray casting algorithm. Then, the improved HMNI similarity strategy based on Hausdorff distance was used to complete the registration of the white-light optical images and DRR virtual images. According to the corresponding relationship obtained by the image registration and the Lambert’s cosine law based on the pin-hole imaging model, the 3D light intensity distribution on the surface of the object could be solved. The feasibility and effectiveness of the mapping algorithm are verified by the irregular phantom and mouse experiments. Keyword: DRR; FMT; dual-modality registration; mapping","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85504941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Three-Dimensional Stiffness on the Proliferation, Stemness And Invasion of Hepatic Cancer Stem Cells","authors":"Mengyue Wang, Runze Zhao, Fan Feng, Tingting Xia, Li Yang","doi":"10.32604/mcb.2019.07154","DOIUrl":"https://doi.org/10.32604/mcb.2019.07154","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the third most common cancer in the world. Previous studies have shown that hard matrix promotes the proliferation of liver tumor cells. However, the role of matrix stiffness on hepatic cancer stem cells (HCSCs) is still unclear. Three-dimensional hydrogels with different stiffness were used to mimic the normal liver tissue (4kPa) and cancerous liver tissue (26kPa) stiffness. The proliferation, stemness and invasion properties of HCSCs under 3D different stiffness were detected. METHOD: HSCSs were screened and cultured by enrichment method, and the effect of matrix stiffness on HCSCs was studied by three-dimensional culture of HCSCs in hydrogels of different stiffness. CCK-8, clonal size measurement and QRT-PCR were used to examine the effects of different matrix stiffness on the proliferation of HCSCs. CD133 and CD90 were used to examine the effects of different matrix stiffness on the stemness of HCSCs. Immunofluorescence was used to detect epithelial mesenchymal transition-related proteins to investigate the effects of different matrix stiffness on the invasion ability of HCSCs. RESULTS: The matrix stiffness of 4 kPa significantly inhibited the proliferation, stemness maintenance and invasion ability of HCSCs. The matrix stiffness of 26 kPa significantly promoted the proliferation, stemness maintenance and invasion ability of HCSCs. Subsequently, we culture the HCSCs in 4kPa and 26kPa hydrogels for matrix stiffness exchange. The results showed that the stemness and invasive ability of HCSCs in 26kPa-4kPa decreased significantly, while the stem cell stemness of liver cancer within 4kPa-26kPa and the invasive ability is significantly increased. Animal experiments have further validated this result. CONCLUSION: The mechanical environment of HCSCs has a significant regulatory effect on their proliferation, stemness and invasion ability. The stiffness of pathological liver tissue plays a significant role in promoting the occurrence and development of tumor. Our study provides new ideas for further understanding the pathogenesis and treatment of liver cancer.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87618903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contour-Based Data Analysis: Loading Rate Dependence in Dynamic Catch of Integrin-Ligand Bonds","authors":"Xueyi Yang, Yue Xu, Chun Yang","doi":"10.32604/mcb.2019.07117","DOIUrl":"https://doi.org/10.32604/mcb.2019.07117","url":null,"abstract":": Cell-matrix interactions guide various cell behaviors, including proliferation, differentiation, migration, etc. Integrins, as a known transmembrane mechanosensor, undergo conformational changes in response to mechanical stimuli, and manipulate cell-matrix chemical-mechanical coupled signaling transduction [1]. The integrin-ligand bond kinetics has gain increasing attention among researchers. Independent studies showed that the integrin-ligand bond has been reported to be reinforced by the applied force f , while the loading rate df/dt had little effect on the bond lifetime [2]. We previously observed a dramatic increase in bond lifetime beyond a loading rate threshold for the integrin α2β1-DGEA bond, by introducing AFM (Atomic Force Microscopy) -based SCFS (single-cell force spectroscopy) and contour-based data analysis algorithm [3]. Here, we used AFM SMFS (single-molecule force spectroscopy)/SCFS [4] and contour-based data analysis to study the kinetic properties of α2β1-DGEA and α5β1-RGD bonds. Both bonds possessed loading-rate-dependent lifetimes on a molecular level and in living cells. In conclusion, with the help of AFM force spectroscopy and contour-based data analysis, we illustrated the complex relationship between the rupture force and the loading rate of the integrin-ligand bonds. At least two subunits of the integrin family showed loading-rate-dependent dynamic catch with their ligands. It worth more efforts on whether loading-rate-strengthened receptor-ligand bond is a general property of the integrin family.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88118218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Progress in Medical Biomaterials","authors":"Qiqing Zhang, Y. Zhang, Linzhao Wang, Yongzhen Xing","doi":"10.32604/mcb.2019.07301","DOIUrl":"https://doi.org/10.32604/mcb.2019.07301","url":null,"abstract":"Guided tissue regeneration (GTR) is a technique that selectively guides cells to attach and proliferate towards an injured site to achieve tissue regeneration through a physical barrier membrane. In this review, we presented a brief overview of the development of GTR technology and GTR materials. Nowadays, new technologies such as electrospinning, nanotechnology, controlled release technique, and 3D printing have been introduced into the study of GTR materials. Resorbable membrane as GTR materials are available as alternatives to conventional non-resorbable membranes. Current GTR materials not only act as a physical barrier membrane but also as a scaffold to play a role in promoting cell proliferation and tissue regeneration. The development trend in GTR materials will be multi-component, functional, and biomimetic composite materials. At the end, we show the research and industrialization of GTR materials in our group.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90051586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}