Arab Journal of Gastroenterology最新文献

{"title":"Image-enhanced endoscopy in intestinal tuberculosis","authors":"Daisuke Murakami , Yuji Amano , Makoto Arai","doi":"10.1016/j.ajg.2024.06.004","DOIUrl":"10.1016/j.ajg.2024.06.004","url":null,"abstract":"","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 318-319"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of capsule endoscopy in the phenotype of Crohn’s disease. Data from England 2016–2021","authors":"Priya Oka ,&nbsp;Sophie Vibhishanan ,&nbsp;Stefania Chetcuti Zammit ,&nbsp;Reena Sidhu","doi":"10.1016/j.ajg.2024.06.001","DOIUrl":"10.1016/j.ajg.2024.06.001","url":null,"abstract":"<div><h3>Background and study aims</h3><p>Isolated small bowel Crohn’s disease (SBCD) is reported to have a worse prognosis compared to other CD phenotypes. The aim of this study was to understand the correlation between Isolated SBCD and ileocolonic disease with blood and faecal biomarkers and also to identify differences in outcome and management between the two phenotypes.</p></div><div><h3>Patients and methods</h3><p>Patients with ileocolonic or isolated small bowel Crohn’s Disease (SBCD) were identified from an existing capsule endoscopy (CE) database. Harvey Bradshaw Index (HBI), biomarkers: c-reactive protein (CRP) and faecal calprotectin (FC), Lewis score and findings on CE and subsequent follow up data were collected. SPSS was used to analyse the data.</p></div><div><h3>Results</h3><p>In total 248 patients were included in the study. Patients were split into two groups- Isolated SBCD with 178 patient (median age 44 years (IQR 31–56); 41.5 % male) and Ileocolonic Crohn’s with 70 patients (median age 31 years (IQR 22.7–49); 31.5 % male). A new diagnosis of SBCD was made in 38.7 % (n = 96), whilst 60.0 % (n = 144) had established CD. Patients with ileocolonic disease had a higher HBI in comparison to isolated SBCD [HBI = 7 (IQR 5–10) vs HBI = 6(IQR 4–9); P = 0.04 ]. There was no significant difference in the FC levels between isolated SBCD and ileocolonic disease [136ug/g (IQR 53.8–363.3) vs 171ug/g (IQR 68.5–485.5); p = 0.98]. In isolated SBCD group, 30.3 % (n = 54) CE showed proximal disease, 96 % (n = 171) showed distal disease and 26.4 % (n = 47) showed extensive disease. SBCE was superior to MRI at diagnosing proximal SBCD (P &lt; 0.01). On multivariate logistic regression, we did not identify any predictors of disease severity defined as Lewis score &gt; 790. Following SBCE, 68.5 % (n = 170) of the total patients had a management change. This included commencement or dose escalation of corticosteroids in 123 (49.5 %) patients, azathioprine in 80 (33.3 %) patients, methotrexate in 22 (9.1 %) patients and biological therapy in 110 (44.3 %) patients. HBI predicted a change in management (p &lt; 0.01).</p></div><div><h3>Conclusion</h3><p>CE is an important modality for the diagnosis of active SBCD. It also helps guide treatment in patients identified with active disease.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 288-292"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of balloon occluder for specimen collection after descending duodenal ESD","authors":"Min Wang ,&nbsp;Xiaohan Jiang ,&nbsp;Xiang Wang","doi":"10.1016/j.ajg.2024.06.006","DOIUrl":"10.1016/j.ajg.2024.06.006","url":null,"abstract":"<div><p>Endoscopic submucosal dissection (ESD) is a popular technique for resecting duodenal tumors. However, there is a risk of losing resected specimens during the procedure, particularly for lesions in the descending part of the duodenum. This study aims to introduce a simple and effective method for specimen collection after descending duodenal ESD using a self-made balloon occluder. The balloon occluder, made from a spray pipe and sterile rubber glove, is utilized to prevent the loss of resected specimens. The balloon is inflated under endoscopic visualization, occluding the descending lumen. With careful timing, the resected specimen can be safely collected by grasping it from the balloon using foreign forceps. This method has been successfully applied in several cases, demonstrating its practicality and efficacy. Further evaluation and validation of this technique in a larger patient population are warranted to establish its wider application in clinical practice.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 315-317"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of IBD disease activity by Interleukin-6 and serum amyloid A in relation with fecal calprotectin and endoscopic indices","authors":"Ahmed Bahaa ,&nbsp;Tamer Elbaz ,&nbsp;Hesham Elmakhzangy ,&nbsp;Mohammed Shehata ,&nbsp;Dalia Abd El-Kareem ,&nbsp;AbdelAziz Gaber ,&nbsp;Mohamed B. Hashem ,&nbsp;Maissa El Raziky","doi":"10.1016/j.ajg.2024.07.003","DOIUrl":"10.1016/j.ajg.2024.07.003","url":null,"abstract":"<div><h3>Background and study aims</h3><p><span><span>Close monitoring of disease activity in </span>IBD<span> patients is essential to avoid long term complications. Although endoscopic assessment is the ideal monitoring tool, the usage of noninvasive biomarkers is more practical and patient friendly. We aimed to study the performance of Interleukin-6(IL-6) and Serum Amyloid A(SAA) as serum biomarkers in assessment of the disease activity of IBD patients in correlation to C-reactive protein (CRP), Fecal </span></span>Calprotectin (FC) and endoscopic indices.</p></div><div><h3>Methods</h3><p><span>83 IBD (26 CD and 57 UC) patients on stable treatment regimen were recruited. Serum markers included CRP, CBC, IL-6, SAA were analyzed, together with FC. These markers were compared with the endoscopic and clinical disease parameters. Harvey-Bradshaw Index (HBI) and the Simple Clinical Colitis Activity Index (SCCAI) were used to assess clinical activity in CD and UC patients, respectively. Endoscopic activity was recorded using the Simple Endoscopic Score (SES) for Crohn’s disease or the Mayo Endoscopic Score (MES) for </span>ulcerative colitis.</p></div><div><h3>Results</h3><p>In prediction of disease activity, IL-6, SAA and CRP demonstrated good area under receiver operating characteristics (AUC) (&gt;0.7), with FC being the best (0.94) for endoscopically active disease (P &lt; 0.01). Combining FC and IL-6 or SAA improved its discriminative accuracy with an AUC (∼0.96).</p></div><div><h3>Conclusions</h3><p>FC most accurately predicts endoscopic disease activity in IBD patients, in comparison to other studied serological biomarkers. The serum IL-6 and SAA are potential predictors of endoscopic disease activity, and they might be valuable for assessment of disease activity. Finally, a composite score of FC and SAA or IL-6 can increased its diagnostic accuracy.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 299-305"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutational and transcriptional profile predicts the prognosis of stage IV gastric cancer – Prognostic factors for metastatic gastric cancer","authors":"Zhengyong Xie ,&nbsp;Wenzhen Zhao ,&nbsp;Yongzhong He ,&nbsp;Yongli Ke ,&nbsp;Zehang Li ,&nbsp;Xuhui Zhang","doi":"10.1016/j.ajg.2024.05.001","DOIUrl":"10.1016/j.ajg.2024.05.001","url":null,"abstract":"<div><h3>Background and study aims</h3><p>The clinicopathological risk factors in the prognosis of stage IV gastric cancer have been comprehensively studied. However, the influencing factors of stage IV gastric cancer prognosis at genomic and transcriptional levels have not been well defined.</p></div><div><h3>Patients and methods</h3><p>The mutational and transcriptional data, along with demographic, clinicopathological and prognostic information of 44 stage IV gastric cancer patients were downloaded from the TCGA database. Univariate and multivariate analyses were performed to identify the significant risk factors and a Nomogram model was established to predict the patient prognosis.</p></div><div><h3>Results</h3><p><span><span>TTN, TP53, FLG, LRP1B, SYNE1 and ARID1A<span> were among the top mutated genes without hot-spot mutations. The mutational status of AHNAK2, ASCC3, DNAH3, DOP1A, MYLK, SIPA1L1, SORBS2, SYNE1 and ANF462 significantly stratified the patient prognosis. The transcription of several genes, such as AQP10, HOXC8/9/10, COL10A1/COL11A1, WNT7B, KRT17 and KLK6 was significantly up-regulated or down-regulated. Enrichment analysis on mutations and transcription revealed </span></span>cell skeleton<span> and membrane function, extracellular matrix function, HPV infection, and several cancer-related pathways as the main aberrancies. </span></span>Univariate analyses revealed a series of significant factors stratifying patient prognosis, mainly including cancer location, several mutated genes and many up- or down-regulated genes. However, subsequent multivariate analysis revealed SYNE1 mutation, DNAH3 mutation, COMMD3 transcription level, and cancer location as the independent risk factors. A Nomogram model has been established with these significant risk factors to predict the patient prognosis. Further validation is needed to ensure the effectiveness of the model in real clinical practice.</p></div><div><h3>Conclusions</h3><p>Cancer location, along with the mutational status of SYNE1 and DNAH3 and the transcriptional level of COMMD3 were independent risk factors of stage IV gastric cancer. A Nomogram model was established with these factors for prognosis prediction.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 275-283"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthodontic rubber band traction to facilitate endoscopic resection of gastric submucosal tumor","authors":"","doi":"10.1016/j.ajg.2024.03.007","DOIUrl":"10.1016/j.ajg.2024.03.007","url":null,"abstract":"<div><h3>Background and study aims</h3><p>Endoscopic submucosal excavation (ESE) and endoscopic full-thickness resection (EFTR) are common endoscopic minimally invasive methods<span> for treatment of gastric submucosal tumors (SMTs). However, it is sometimes difficult to expose the tumor optimally. This study aimed to explore the safety and effectiveness of tumor traction using orthodontic rubber band (ORB) combined with clips to assist ESE and EFTR of gastric SMTs.</span></p></div><div><h3>Patients and methods</h3><p><span>The data of patients with gastric SMTs who underwent ESE or EFR at the Endoscopy Center of the 900th Hospital of PLA from January 2021 to May 2022 were retrospectively analyzed. Baseline characteristics and clinical outcomes, including operation time and postoperative </span>adverse events, were compared between patients receiving ORB-ESE/EFTR and conventional ESE/EFTR.</p></div><div><h3>Results</h3><p>A total of 52 patients were enrolled: 16 patients who underwent ORB-ESE /EFTR and 36 patients who underwent conventional ESE/EFTR. Median procedure time was significantly shorter in the ORB-ESE/EFTR group than in the conventional ESE/EFTR group (32 [IQR, 23.8, 38.0] minutes vs. 39.0 [IQR, 34.6–67.3] minutes, <em>P</em> = 0.002). Baseline characteristics, en bloc resection rate, incidence of postoperative adverse events, and postoperative pathology results were comparable between the two groups (<em>P</em> &gt; 0.05).</p></div><div><h3>Conclusion</h3><p>Use of ORB with clips–assisted traction during ESE/EFTR of gastric SMT can shorten the surgical time. Further large prospective studies are needed to confirm the findings of this study.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 263-268"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Simo Decoction and Golden Bifid alleviates functional dyspepsia through a mechanism involving intestinal microbiota and short-chain fatty acids","authors":"","doi":"10.1016/j.ajg.2023.12.009","DOIUrl":"10.1016/j.ajg.2023.12.009","url":null,"abstract":"<div><h3>Background and study aims</h3><p><span>The integration of traditional Chinese medicine and Western medicine holds promise for the treatment of </span>gastrointestinal disorders<span><span><span>, which are influenced by intestinal microbiota and metabolites. This study reports a possible mechanism for the combination of Simo </span>Decoction and Golden Bifid in </span>functional dyspepsia (FD) by regulating intestinal microbiota and short-chain fatty acids (SCFAs).</span></p></div><div><h3>Patients and Methods</h3><p><span>A mouse model of food stagnation was constructed and treated with Simo Decoction combined with different concentrations of Golden Bifid. Meta-genomics sequencing was conducted to analyze the cecum contents of the mice. Following analyses of the composition and abundance of intestinal microbiota, gas chromatography-mass spectrometry was performed to measure SCFAs in the colonic content of mice. Finally, ELISA was utilized to determine the levels of pro-inflammatory factors in the </span>duodenal mucosa<span> of mice and the infiltration of eosinophils<span> in the duodenum was observed by immunohistochemical staining.</span></span></p></div><div><h3>Results</h3><p>Combination of Simo Decoction and Golden Bifid more significantly alleviated dyspepsia in mice with food stagnation compared with Simo Decoction alone. The optimal ratio of combined treatment was 0.0075 mL/g (body weight) Simo Decoction and 0.0032 mg/g (body weight) Golden Bifid. The combined treatment increased the abundance of <span><span>Bifidobacterium</span></span> and <span><span>Bacteroides</span></span> in the intestine. The levels of SCFAs in the colonic contents of mice were increased after the combined treatment, contributing to diminished pro-inflammatory factors in the duodenal mucosa and reduced eosinophil infiltration.</p></div><div><h3>Conclusion</h3><p>Combination of Simo Decoction and Golden Bifid increases the abundance of <em>Bacteroides</em> and <em>Bifidobacterium</em> and promotes the production of SCFAs, which is instrumental for alleviation of FD.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 239-249"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukocyte telomere length in subjects with metabolic dysfunction-associated steatotic liver disease","authors":"Debora Goncalves da Silva ,&nbsp;Nadyellem Graciano da Silva ,&nbsp;Angelica Amorim Amato","doi":"10.1016/j.ajg.2024.06.005","DOIUrl":"10.1016/j.ajg.2024.06.005","url":null,"abstract":"<div><h3>Background and study aims</h3><p>This study aimed to examine the association between peripheral leukocyte telomere length and indicators of metabolic abnormalities in subjects with metabolic dysfunction-associated steatotic liver disease (MASLD) assessed by magnetic resonance imaging (MRI).</p></div><div><h3>Patients and methods</h3><p><span>This cross-sectional study included adults over 20 years with body mass index (BMI) of over &gt;25 kg/m</span>²<span> and sonographic evidence of hepatic steatosis<span>. The subjects were evaluated by clinical and biochemical variables, determination of hepatic fat fraction by MRI and relative peripheral leukocyte telomere length by quantitative real-time polymerase chain reaction.</span></span></p></div><div><h3>Results</h3><p>Thirty-two subjects (22 men and 10 women) with MASLD were included, with a median age of 40 years, median BMI of 33.75 kg/m²<span><span><span><span>, median HFF 19 %, and median relative T/S ratio of 0.64. Subjects with relative T/S ratio below the median had significantly higher age, lower BMI, higher AST serum levels, higher </span>GGT<span> serum levels, lower serum </span></span>ferritin levels, and higher FIB4 score. In a multivariable </span>logistic regression model considering relative T/S ratio below or above the median only age was significantly associated with relative T/S ratio. Our findings suggest that age is the most important factor associated with telomere length among subjects with MASLD.</span></p></div><div><h3>Conclusion</h3><p>Our findings suggest that age is the most important factor associated with telomere length among subjects with MASLD.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 293-298"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of diagnosis model for inflammatory bowel diseases based on a serologic biomarker panel: A decision tree model study.","authors":"Junxiang Zeng, Manxiu Huai, Wensong Ge, Zhigang Yang, Xiujun Pan","doi":"10.1016/j.ajg.2024.05.003","DOIUrl":"https://doi.org/10.1016/j.ajg.2024.05.003","url":null,"abstract":"<p><strong>Background and study aims: </strong>Currently, an increasing amount of experimental data is available on newly discovered biomarkers in inflammatory bowel diseases (IBD), but the role of these biomarkers is often questionable due to their limited sensitivity. Therefore, this study aimed to build a diagnostic tool incorporating a panel of serum biomarkers into a computational algorithm to identify patients with IBD and differentiate those with Crohn's disease (CD) from those with ulcerative colitis (UC).</p><p><strong>Patients and methods: </strong>We studied sera from 192 CD patients, 118 UC patients, 60 non-IBD controls and 60 healthy controls. Indirect immunofluorescence (IIF) assays were utilized to determine several serum biomarkers previously associated with IBD, and the decision tree algorithm was used to construct the diagnosis model. Performances of models were evaluated by prediction accuracy, precision, AUC and Matthews's correlation coefficient (MCC). The \"Inflammatory Bowel Disease Multi-omics Database (IBDMDB)\" cohorts were used to validate the model as external validation set.</p><p><strong>Results: </strong>The prediction rates were determined and compared for decision tree models after each data was developed using C5.0, C&RT, QUEST and CHAID. The C5.0 and CHAID algorithms, which ranked top for the prediction rate in the IBD vs. non-IBD model and the CD vs. UC model, respectively, were utilized for final pattern analysis. The final decision tree model achieved higher classification accuracy than the approach based on conservative marker combinations (sensitivity 75.0% vs. 79.5%, specificity 93.8% vs. 78.3% for differentiating IBD from non-IBD; and sensitivity 84.3% vs. 73.4%, specificity 92.5% vs. 54.9% for differentiating CD from UC, respectively). The model prediction consistency was 93% (28/30) in the external validation set.</p><p><strong>Conclusion: </strong>The decision-tree-based approach used in this study, based on serum biomarkers, has shown to be a valid and useful approach to identifying IBD and differentiating CD from UC.</p>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education level and biologic therapy are the related factors of mucosal healing in Patients with Crohn's disease.","authors":"Limin Zhang, Shanbing Yang, Kangmei Jia, Shuwen Du, Yan Jia, Xiaojuan Lu, Jiheng Wang","doi":"10.1016/j.ajg.2024.06.003","DOIUrl":"https://doi.org/10.1016/j.ajg.2024.06.003","url":null,"abstract":"<p><strong>Background and study aims: </strong>Mucosal healing (MH) is a crucial indicator of therapeutic effectiveness and prognosis in Crohn's disease (CD). Rapid achievement and long-term maintenance of MH can alleviate the financial and psychological burden on patients. This study aimed to investigate the factors associated with MH in CD patients and enhance clinicians' understanding.</p><p><strong>Patients and methods: </strong>Patients diagnosed with CD between January 2010 and December 2019 at our hospital were included and divided into two groups based on the attainment of MH during the follow-up period. Demographic data, symptoms, disease classification, laboratory examination results, and treatments were collected and compared between the two groups. Factors with a P-value <0.2 were subjected to multivariate logistic regression analysis to identify the related factors of MH.</p><p><strong>Results: </strong>Multivariate logistic regression analysis of CD patients revealed that educational level [odds ratio (OR) = 8.167, 95 % confidence interval (CI) 1.440-46.303, P = 0.018] and biological therapy (OR = 15.291, 95 % CI 1.404-166.543, P = 0.025) were associated with MH.</p><p><strong>Conclusion: </strong>Educational level and biological therapy are factors related to MH in CD patients. These findings suggest that the use of biological therapy and patients' better understanding of the disease contribute to achieving MH.</p>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}