Arab Journal of Gastroenterology最新文献_第5页

Clinical efficacy of Jiawei Yinchenhao decoction combined with ursodeoxycholic acid and probiotics in the management of nonalcoholic fatty liver disease 加味银宸浩汤联合熊去氧胆酸及益生菌治疗非酒精性脂肪肝的临床疗效观察

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2026-05-01 Epub Date: 2026-03-15 DOI: 10.1016/j.ajg.2026.01.007

Dong Chen , Xinyu Li , Jinghao Fu , Yaohan Ma , Hanyue Jiang , Qiang Li

{"title":"Clinical efficacy of Jiawei Yinchenhao decoction combined with ursodeoxycholic acid and probiotics in the management of nonalcoholic fatty liver disease","authors":"Dong Chen , Xinyu Li , Jinghao Fu , Yaohan Ma , Hanyue Jiang , Qiang Li","doi":"10.1016/j.ajg.2026.01.007","DOIUrl":"10.1016/j.ajg.2026.01.007","url":null,"abstract":"<div><h3>Objective</h3><div>The study focused on evaluating the clinical effectiveness of Jiawei Yinchenhao decoction (JWYCH) combined with ursodeoxycholic acid (UDCA) and probiotics in the treatment of nonalcoholic fatty liver disease (NAFLD).</div></div><div><h3>Methods</h3><div>Patients with NAFLD were divided into an observation group (JWYCH + UDCA + probiotics) and a control group (UDCA + probiotics). Clinical efficacy, liver function, blood lipids, oxidative stress indicators, inflammatory cytokines, gut microbiota composition, and adverse events were assessed before and after 4 weeks of treatment.</div></div><div><h3>Results</h3><div>The observation group demonstrated a significantly higher clinical effective rate (90.00 %) compared to the control group (71.67 %) (<em>P</em> < 0.05). Both groups showed improved gut flora (increased <em>Bifidobacterium</em> and <em>Lactobacillus</em>, decreased <em>Escherichia coli</em> and <em>Enterococcus</em>), reduced liver enzymes (ALT, AST), bilirubin (TBil), and lipid levels (TC, LDL-C), and attenuated oxidative stress (lower MDA, higher GSH-Px and SOD) and inflammatory markers (TGF-β, TNF-α, IL-8); the observation group exhibited greater improvements across all indicators than the control group (<em>P</em> < 0.05). Adverse reactions were minimal and comparable between groups.</div></div><div><h3>Conclusion</h3><div>JWYCH combined with UDCA and probiotics provides superior therapeutic benefits for NAFLD by improving liver function, modulating intestinal microbiota, reducing inflammation and oxidative stress, and enhancing lipid metabolism, with good safety. This integrated approach holds promise for broader clinical application.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 2","pages":"Pages 192-198"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adding Senna alkaloid to laxative agents in bowel preparation for pediatric colonoscopy: a clinical trial study 在儿童结肠镜检查肠道准备中加入番泻草生物碱：一项临床试验研究。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2026-05-01 Epub Date: 2026-03-21 DOI: 10.1016/j.ajg.2026.01.003

Seyedeh Maryam Mahdavi Mortazavi , Mohammad Hadi Immanieh , Naser Honar , Mozhgan Moghtaderi , Fereshteh Karbasian , Laleh Monjezi

{"title":"Adding Senna alkaloid to laxative agents in bowel preparation for pediatric colonoscopy: a clinical trial study","authors":"Seyedeh Maryam Mahdavi Mortazavi , Mohammad Hadi Immanieh , Naser Honar , Mozhgan Moghtaderi , Fereshteh Karbasian , Laleh Monjezi","doi":"10.1016/j.ajg.2026.01.003","DOIUrl":"10.1016/j.ajg.2026.01.003","url":null,"abstract":"<div><h3>Background and study aim</h3><div>Bowel preparation is a crucial step in ensuring the success of pediatric colonoscopy. This study aimed to investigate the effects of adding Senna alkaloid syrup to laxative agents for bowel preparation in children scheduled for colonoscopy.</div></div><div><h3>Patients and methods</h3><div>This double- blind controlled trial study compared two bowel preparation methods in children attending the gastrointestinal ward at Namazee Hospital, affiliated with Shiraz University of Medical Sciences, Shiraz, Iran. The study was conducted in 2024. Eligible patients were randomized into two groups: one receiving conventional laxative agents and the other receiving conventional agents plus polyethylene glycol-3350 (PEG-3350) syrup. Efficacy was analyzed using the Aronchick Scale, alongside safety evaluations.</div></div><div><h3>Results</h3><div>A total of 64 children completed the study: 32 patients (17 girls, 15 boys) in the Senna group and 32 patients (11 girls, 21 boys) in the control group. The mean age of participants was 11.03 ± 4.60 years (range: 1 to 18 years). There was a statistically significant difference in colon cleansing between the Senna group and the conventional group based on Aronchick Scale (p < 0.001). The Senna group had no children requiring repeat bowel preparation. No side effects were reported in either group.</div></div><div><h3>Conclusion</h3><div>These findings suggest that incorporating Senna into routine bowel preparation protocols may improve outcomes and could become standard practice for pediatric colonoscopy. (Clinical trial number: IRCT20250426065473N1)</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 2","pages":"Pages 260-262"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-195 mimic, a new therapeutic strategy for suppressing CDK6 expression and progression of hepatocellular carcinoma: a pilot study miR-195 mimic，抑制CDK6表达和肝细胞癌进展的新治疗策略：一项初步研究

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2026-05-01 Epub Date: 2026-04-24 DOI: 10.1016/j.ajg.2026.03.003

Tayyaba Wali , Saima Ejaz , Shan e Zahra , Mian Abdur Rehman Arif , Fatma Hussain , Muhammad Shahid , Muafia Baigum , Atiqa Nudrat , Fariha Naz , Saadiya Zia

{"title":"miR-195 mimic, a new therapeutic strategy for suppressing CDK6 expression and progression of hepatocellular carcinoma: a pilot study","authors":"Tayyaba Wali , Saima Ejaz , Shan e Zahra , Mian Abdur Rehman Arif , Fatma Hussain , Muhammad Shahid , Muafia Baigum , Atiqa Nudrat , Fariha Naz , Saadiya Zia","doi":"10.1016/j.ajg.2026.03.003","DOIUrl":"10.1016/j.ajg.2026.03.003","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC), a leading cause of death worldwide, is primarily caused by uncontrolled cellular proliferation, invasion and metastasis leading to tumor development in the liver. miR-195 regulates G1 to S phase transition in the cell cycle by targeting CDK6. In the current study, expression of miR-195 was significantly reduced while that of CDK6 was upregulated in HCC patients. The results of expression analysis were supported by the Pearson correlation coefficient indicating a moderate negative (r = -0.459, p = 0.02) relation between miR-195 and CDK6. However, the association of miR-195 and CDK6 with age and sex was not statistically significant. The predicted secondary and tertiary structures of miR-195 showed the presence of loops, stems, and flanking regions. Further, <em>in silico</em> analysis identified potential amino acid residues in CDK6, CDK4 and Cyclin D1 proteins interacting with the miR-195. We designed a mimic RNA of miR-195 by mutagenesis at 4 points. The mimic RNA_3 of miR-195 presented a well-defined stable structure showing strong binding interactions with CDK4 and Cyclin D1 and comparable interactions with CDK6. In conclusion, our study has demonstrated the potential of using miR-195 mimic RNA as a therapeutic strategy to target the CDK6 gene in HCC with reduced miR-195 expression.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 2","pages":"Pages 224-232"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of gut microbiota modulation in preventing and treating sarcopenia in patients with liver cirrhosis: A narrative review 肠道菌群调节在预防和治疗肝硬化患者肌肉减少症中的作用：一项叙述性综述。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2026-05-01 Epub Date: 2026-04-27 DOI: 10.1016/j.ajg.2026.03.005

Minyuan Yang , Tianyu Liu , Yang Qin , Rui Cai , Xiaoqin Yang , Chuandong Tang

引用次数: 0

The mutational and transcriptional status of RYR in CRC and its indication for prognosis 结直肠癌中RYR的突变和转录状态及其对预后的指示。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2026-05-01 Epub Date: 2026-04-23 DOI: 10.1016/j.ajg.2026.03.002

Jiangping Hu, Minxuan Peng, Qi Ou, Yi Zhou

{"title":"The mutational and transcriptional status of RYR in CRC and its indication for prognosis","authors":"Jiangping Hu, Minxuan Peng, Qi Ou, Yi Zhou","doi":"10.1016/j.ajg.2026.03.002","DOIUrl":"10.1016/j.ajg.2026.03.002","url":null,"abstract":"<div><div>Aberrant calcium signaling, particularly the ryanodine receptor (RYR) signaling, is linked to cancer development. Currently, little is known about the status of RYR in colorectal cancer (CRC), and the correlation of RYR with CRC phenotypes remains unclear. We analyzed genetic alterations in RYRs using data from 587 patients with CRC in the TCGA database. Mutations were spread across RYR channels without identified hotspot mutations. RYR2 exhibited the highest mutation frequency (59%), with mutually exclusive mutations between RYR2 and RYR1/RYR3. RYR2 revealed significantly elevated transcription in CRC tissues, while RYR1 and RYR3 revealed decreased transcription. Patients with RYR mutations had higher tumor mutational burden (TMB). Stage-related differences in RYR1 and RYR2 transcription were detected. Although age was correlated with RYR1 mutation status, no significant differences in age or BMI were found between patients with low and high RYR transcription. Age, clinical stage, and tumor location were identified as prognostic factors, with age, clinical stage, and location being independent risk factors. In conclusion, RYRs exhibited variable mutational and transcriptional profiles in CRC, with RYR2 revealing unique patterns. Age, clinical stage, and tumor location represent independent risk factors in CRC with RYR mutations.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 2","pages":"Pages 213-223"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correspondence on “A. Changes in liver stiffness and non-invasive markers in chronic hepatitis C virus patients with and without HIV co-infection following interferon-free antiviral treatment” “A.合并和不合并艾滋病毒感染的慢性丙型肝炎患者在无干扰素抗病毒治疗后肝脏僵硬度和非侵入性标志物的变化”

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2026-05-01 Epub Date: 2026-04-24 DOI: 10.1016/j.ajg.2026.02.004

Hinpetch Daungsupawong , Viroj Wiwanitkit

引用次数: 0

The effect of HBE1 on resistance to gemcitabine in pancreatic cancer cells HBE1在胰腺癌细胞对吉西他滨耐药中的作用。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2026-05-01 Epub Date: 2026-03-15 DOI: 10.1016/j.ajg.2026.01.006

Jiyun Cheng , Haixing Jiang , Xianen Yu , Peining Huang , Yihan Lu , Shudan Tan , Xiaojun Liu , Shanyu Qin

{"title":"The effect of HBE1 on resistance to gemcitabine in pancreatic cancer cells","authors":"Jiyun Cheng , Haixing Jiang , Xianen Yu , Peining Huang , Yihan Lu , Shudan Tan , Xiaojun Liu , Shanyu Qin","doi":"10.1016/j.ajg.2026.01.006","DOIUrl":"10.1016/j.ajg.2026.01.006","url":null,"abstract":"<div><h3>Background</h3><div>Chemotherapy resistance remains a major challenge in pancreatic cancer treatment, with gemcitabine-based therapy being a primary approach. However, the mechanisms underlying gemcitabine resistance in pancreatic cancer cells are not yet fully understood. This study aimed to investigate the role ofHBE1in conferring resistance to gemcitabine and explore its effects on reactive oxygen species (ROS) production, mitochondrial apoptosis, and endoplasmic reticulum (ER) stress.</div></div><div><h3>Materials and methods</h3><div>A gemcitabine-resistant pancreatic cancer cell line was systematically developed through gradual, six-month exposure to increasing concentrations of gemcitabine. The role ofHBE1was examined by assessing its impact on ROS levels, mitochondrial-mediated apoptosis, and ER stress pathways, includingIRE1α phosphorylationandGRP78 expression.</div></div><div><h3>Results</h3><div>Overexpression ofHBE1was found to suppress ROS generation and inhibit mitochondrial-dependent apoptosis. Additionally, it attenuated ER stress by reducingIRE1α phosphorylationwhile upregulatingGRP78.</div></div><div><h3>Conclusion</h3><div>These findings demonstrate a strong correlation between elevatedHBE1expression and gemcitabine resistance in pancreatic cancer cells, suggesting its potential as a therapeutic target to overcome chemoresistance.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 2","pages":"Pages 184-191"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Shugan Hewei Decoction in treating chronic atrophic gastritis and its influence on gastric mucosal pathology 疏肝和胃汤治疗慢性萎缩性胃炎的疗效及对胃粘膜病理的影响。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2026-05-01 Epub Date: 2026-01-29 DOI: 10.1016/j.ajg.2026.01.002

Junhua Gong , Wen Ding, Guanheng Xu

{"title":"Efficacy of Shugan Hewei Decoction in treating chronic atrophic gastritis and its influence on gastric mucosal pathology","authors":"Junhua Gong , Wen Ding, Guanheng Xu","doi":"10.1016/j.ajg.2026.01.002","DOIUrl":"10.1016/j.ajg.2026.01.002","url":null,"abstract":"<div><div><strong>Background and study aims</strong>: To investigate the efficacy of Shugan Hewei Decoction in the treatment of chronic atrophic gastritis (CAG) and its effect on gastric mucosal pathology. <strong>Patients and methods</strong>: A total of 72 patients with CAG admitted from October 2022 to December 2023 were enrolled and divided into two groups using a random number table method. The control group (36 cases) was treated with oral Weifuchun, while the study group (36 cases) received oral Shugan Hewei Decoction. The two groups were compared in terms of total treatment effectiveness rate, incidence of adverse reactions, scores of primary and secondary symptoms (before and after treatment), gastric function indices (pepsinogenⅠ [PGⅠ], pepsinogenⅠ/pepsinogenⅡ [PGⅠ/PGⅡ], and gastrin-17 [G-17]), and scores of gastric mucosal pathological indices (intestinal metaplasia, glandular atrophy, and dysplasia). <strong>Results</strong>: The total treatment effectiveness rate in the study group was significantly higher than that in the control group, while the total incidence of adverse reactions was significantly lower (both P < 0.05). Before treatment, there were no significant differences between the two groups in scores of primary and secondary symptoms, gastric function indices, or scores of gastric mucosal pathological indices (all P > 0.05). After treatment, the study group showed significantly lower scores of primary and secondary symptoms and gastric mucosal pathological indices, as well as significantly higher gastric function indices compared with the control group (all P < 0.05). <strong>Conclusion</strong>: Shugan Hewei Decoction exhibits favorable efficacy and high safety in the treatment of CAG. It can significantly improve the gastric mucosal pathological state, thus holding relatively high application value in CAG patients.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 2","pages":"Pages 167-171"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-126-3p serves as a biomarker of inflammatory bowel disease (IBD) and modulates the molecular mechanisms of IBD through regulation of DICER1 miR-126-3p作为炎症性肠病（IBD）的生物标志物，通过调节DICER1调节IBD的分子机制。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2026-05-01 Epub Date: 2026-03-16 DOI: 10.1016/j.ajg.2026.01.005

Yingying Geng , Jingjing Peng , Qingzhi Chen

{"title":"miR-126-3p serves as a biomarker of inflammatory bowel disease (IBD) and modulates the molecular mechanisms of IBD through regulation of DICER1","authors":"Yingying Geng , Jingjing Peng , Qingzhi Chen","doi":"10.1016/j.ajg.2026.01.005","DOIUrl":"10.1016/j.ajg.2026.01.005","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory bowel disease (IBD) imposes a dual burden, physiological and psychological, on patients. This study focused on miR-126-3p to explore its role in the progression of IBD and its potential clinical value.</div></div><div><h3>Methods</h3><div>Patients with IBD (including 45 ulcerative colitis [UC] and 36 Crohn’s disease [CD]) and controls (50) were enrolled, and clinical data were collected. RT-qPCR was used to quantify miR-126-3p and DICER1 expression. ROC curve analysis was used to assess the diagnostic value of miR-126-3p. Pearson analysis was used to evaluate the associations between miR-126-3p and inflammatory markers (CRP, ESR, TNF-α, IFN-γ) and disease activity scores. In vitro IBD models were established by treating the HT-29 cells with DSS and IEC-6 cells with LPS. Bioinformatics approaches and luciferase reporter assays confirmed that miR-126-3p targets DICER1. Cell viability was assessed using the CCK-8 assay. ELISA was used to quantify inflammatory cytokines across groups.</div></div><div><h3>Results</h3><div>miR-126-3p was upregulated in UC and CD patients, and correlated with inflammatory markers and disease activity, showing strong ability to distinguish patients from healthy individuals. miR-126-3p targeted DICER1. Downregulation of miR-126-3p reduced the production of proinflammatory factors and ROS induced by DSS or LPS, while silencing DICER1 partially attenuated the protective effect of miR-126-3p inhibition.</div></div><div><h3>Conclusion</h3><div>miR-126-3p is a promising biomarker for IBD diagnosis and assessment of disease activity. The miR-126-3p/DICER1 axis is involved in IBD pathophysiology, suggesting that modulating this axis may provide a therapeutic intervention for IBD.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 2","pages":"Pages 176-183"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chat-based Artificial Intelligence model as a source of information for Inflammatory bowel disease 基于聊天的人工智能模型作为炎症性肠病的信息来源。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2026-05-01 Epub Date: 2026-03-16 DOI: 10.1016/j.ajg.2026.02.008

Anuraag Jena , Shubham Jain , Sanjay Chandnani , Anupam K Singh , Sameet Tariq Patel , Pravin Rathi , Vishal Sharma

{"title":"Chat-based Artificial Intelligence model as a source of information for Inflammatory bowel disease","authors":"Anuraag Jena , Shubham Jain , Sanjay Chandnani , Anupam K Singh , Sameet Tariq Patel , Pravin Rathi , Vishal Sharma","doi":"10.1016/j.ajg.2026.02.008","DOIUrl":"10.1016/j.ajg.2026.02.008","url":null,"abstract":"<div><h3>Background</h3><div>Artificial intelligence models could be a promising tool for providing scientific information to patients. The aim was to study the accuracy of the responses provided by Chat GPT (Generative Pre-trained Transformer tool) to common questions related to inflammatory bowel diseases (IBD).</div></div><div><h3>Methods</h3><div>Questions about broad domains of IBD (basic knowledge, symptomatology, diagnosis, therapeutics, prevention, nutrition, emotional, and social domains) were entered as new chat options in Chat GPT twice. The responses were assessed for quality (very poor, poor, acceptable, good, or very good) and accuracy (comprehensive, correct but inadequate, mixed − correct with incorrect/outdated data, and completely incorrect).</div></div><div><h3>Results</h3><div>A total of 340 questions were included. The quality of responses in Chat GPT to overall questions in IBD was predominantly acceptable to good quality (82.4% in the first response and 78.2% in the second response). Poor quality responses constituted a minority (4.1% in the first response and 3.2% in the second response). The accuracy of responses to questions in all domains of IBD was correct but inadequate in 76.7% in the first response and 67.3% in the second response. Mixed correct with incorrect or outdated responses to questions in IBD were seen in 9.4% and 11.2% in the first responses and second responses, respectively. Each domain has variable quality and accuracy in responses.</div></div><div><h3>Conclusion</h3><div>Chat GPT predominantly provided correct but inadequate answers to common questions in IBD, with good to acceptable quality answers. The model could be optimized in ducing the incorrect responses for better use.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 2","pages":"Pages 199-204"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0