Arab Journal of Gastroenterology最新文献

{"title":"Natural history and the outcome of complications of children with progressive familial intrahepatic cholestasis in a resource-limited setting: A cohort study","authors":"Nasrin Motazedian,&nbsp;Seyed Mohsen Dehghani,&nbsp;Alireza Shamsaeefar,&nbsp;Kourosh Kazemi,&nbsp;Ali Ghorbanpour,&nbsp;Mehrab Sayadi,&nbsp;Maryam Ataollahi,&nbsp;Seyed Ali Moosavi,&nbsp;Saman Nikeghbalian","doi":"10.1016/j.ajg.2026.06.001","DOIUrl":"10.1016/j.ajg.2026.06.001","url":null,"abstract":"<div><h3>Background</h3><div>PFIC comprises a heterogeneous group of rare genetic cholestatic liver disorders that lead to progressive liver damage, cirrhosis, and the need for liver transplantation. Understanding its clinical course and survival outcomes is essential for improving management, particularly in resource-limited settings like Iran. This study aimed to evaluate the clinical characteristics, survival outcomes, and predictors of mortality in children with PFIC.</div></div><div><h3>Methods</h3><div>This cohort study was conducted as part of the Shiraz Pediatric Liver Cirrhosis Cohort Study (SPLCCS), initiated in 2018. Data on demographic characteristics, clinical features, and laboratory findings were collected. Cox regression analysis was used to identify risk factors for mortality.</div></div><div><h3>Results</h3><div>A total of 100 children with PFIC were included, with a mortality rate of 35%. Younger age at diagnosis and higher Pediatric End-Stage Liver Disease (PELD) scores were significantly associated with increased mortality risk. Liver transplantation (LTx) was performed in 50% of cases, with post-transplant survival rates of 74%, 70%, and 66% at 12, 24, and 60 months, respectively. Elevated white blood cell (WBC) counts, aspartate aminotransferase (AST), and direct bilirubin levels were also significant predictors of mortality.</div></div><div><h3>Conclusions</h3><div>Early diagnosis and timely liver transplantation are critical for improving survival in children with PFIC. Higher PELD scores, WBC counts, AST, and direct bilirubin levels are strongly associated with increased mortality risk, highlighting the need for early intervention and consistent monitoring.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 311-316"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal incontinence among patients with ulcerative colitis and relation with disease activity, and extent: A cross-sectional study","authors":"Masakazu Hanayama,&nbsp;Shinya Furukawa,&nbsp;Teruki Miyake,&nbsp;Osamu Yoshida,&nbsp;Kana Shiraishi,&nbsp;Kazuhiro Tange,&nbsp;Yu Hashimoto,&nbsp;Seiyuu Suzuki,&nbsp;Katsuhisa Ohashi,&nbsp;Hideomi Tomida,&nbsp;Yasunori Yamamoto,&nbsp;Eiji Takeshita,&nbsp;Yoshio Ikeda,&nbsp;Yoichi Hiasa","doi":"10.1016/j.ajg.2026.07.004","DOIUrl":"10.1016/j.ajg.2026.07.004","url":null,"abstract":"<div><h3>Background and study aims</h3><div>Fecal incontinence reduces patients' quality of life. However, evidence regarding fecal incontinence in ulcerative colitis is limited.</div></div><div><h3>Patients and methods</h3><div>To cross-sectionally examine disease activity, disease extent, the combination of disease activity and disease extent, along with fecal incontinence in ulcerative colitis. Fecal incontinence and severe fecal incontinence were defined on the basis of the frequency of incontinence obtained using a self-administered questionnaire. Complete mucosal healing and mucosal healing were defined as Mayo endoscopic subscores of 0 and 1, respectively. Information on clinical remission and disease extent was collected from the medical records.</div></div><div><h3>Results</h3><div>This study included 290 ulcerative colitis patients (mean age: 50.3 ± 16.0 years). Disease extents were 119, 80, 84, and 7 cases of total colitis, left-sided colitis, proctitis, and others, respectively. The rates of male sex, complete mucosal healing (CMH), mucosal healing (MH), clinical remission (CR), fecal incontinence, and severe fecal incontinence were 57.6%, 25.2%, 61.0%, 59.3%, 13.8%, and 5.9%, respectively. CMH, MH, and CR were independently inversely associated with fecal incontinence and severe fecal incontinence, respectively. During the active stage of total colitis in ulcerative colitis there was an independent and positive association with fecal incontinence and severe fecal incontinence (adjusted OR 2.51 [95% CI 1.22–5.18], and adjusted OR 3.95 [95% CI 1.38–11.85]). Other disease extents were not associated with fecal incontinence or severe fecal incontinence, regardless of active stage.</div></div><div><h3>Conclusions</h3><div>In ulcerative colitis, disease activity was independently inversely associated with fecal incontinence. The total colitis with active stage was significantly positively associated with fecal incontinence.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 405-409"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessment of non-visible non-invasive neoplasia on gastric mucosa: Case series from a referral centre","authors":"Angelo Zullo,&nbsp;Giulio Cozza,&nbsp;Irene Ligato,&nbsp;Emanuele Dilaghi,&nbsp;Emanuela Pilozzi,&nbsp;Bruno Annibale,&nbsp;Gianluca Esposito","doi":"10.1016/j.ajg.2026.06.014","DOIUrl":"10.1016/j.ajg.2026.06.014","url":null,"abstract":"<div><h3>Background and study aims</h3><div>Unexpected finding of non-invasive neoplasia (NiN) on normal-appearing gastric mucosa at random biopsies constitutes a clinical challenge. We evaluated how frequently non-visible NiN is confirmed in a referral centre.</div></div><div><h3>Patients and methods</h3><div>Over a nine-year period, patients diagnosed with non-visible NiN referred to our tertiary center underwent advanced endoscopy. All macroscopic irregularities identified with High-Definition chromoendoscopy were biopsied. When no lesion was detected, large mapping of gastric mucosa was performed. All histological assessments were performed by an expert pathologist.</div></div><div><h3>Results</h3><div>A total of 60 patients (Females: 55%; Median age: 70 years, range 38–88) were evaluated. All patients underwent one or more gastroscopies. At first endoscopy, the presence of NiN was confirmed in only 3 (5%; 95% CI = 0–10.5) patients in whom visible lesions were removed at endoscopy through Endoscopic Submucosal Dissection. No other cases of NiN were observed at the available follow-up on 22 and 7 patients who underwent a second and third endoscopic control, respectively.</div></div><div><h3>Conclusions</h3><div>Our data found that patients with NiN detected at random gastric biopsies in community hospitals should be referred to a tertiary endoscopy centre to identify the few patients deserving prompt treatment and follow-up.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 402-404"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning prediction of complications after surgery in cirrhotic patients: Integrating nutritional risk with liver function","authors":"Yao Yao,&nbsp;Xinxin Chen,&nbsp;Zijie Wei","doi":"10.1016/j.ajg.2026.06.009","DOIUrl":"10.1016/j.ajg.2026.06.009","url":null,"abstract":"<div><div>Liver disease is among the most common medical conditions in the world, leading to high rates of morbidity and death. Early identification of liver diseases enables prompt care, which may prevent many conditions from progressing to more serious stages, like cirrhosis or liver cancer. Traditionally, models often overlook the predictive importance of nutritional status and focus primarily on liver-specific measures. This research aims to propose a machine learning (ML) approach to predict surgical complications in patients with liver cirrhosis by integrating existing liver function metrics with a comprehensive nutritional risk assessment. In this study, we used the MIMIC-IV dataset, which consists of patient medical records. We utilized a 504-patient cohort with features such as age, gender, bilirubin, albumin, INR (International Normalized Ratio), Child-Pugh score, MELD score (Model for End-Stage Liver Disease), NRS (Nutritional Risk Screening), complication, and composite risk. Mortality was used as the primary outcome variable for prediction. ML models were utilized for training, along with correlation analysis and Explainable Artificial Intelligence (XAI) approaches like SHAP and LIME to interpret the model. The stackable ensemble model was employed to enhance the model's performance and robustness. The proposed model achieved an accuracy of 94% and an AUC of 0.97. This methodology emphasizes the critical importance of nutritional assessment in surgical risk classification. It offers a clinically relevant framework to guide preparatory strategies, promote collaborative decision-making, and improve perioperative care pathways for this vulnerable population.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 382-390"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic full-thickness resection for the treatment of ectopic splenic tissue in the gastric fundus: A case report and literature review.","authors":"Junzhu Lu, Zhihao Chen, Fajun Yang","doi":"10.1016/j.ajg.2026.07.002","DOIUrl":"https://doi.org/10.1016/j.ajg.2026.07.002","url":null,"abstract":"<p><p>Ectopic splenic autotransplantation (ESAT) refers to the presence of splenic parenchyma outside its normal anatomical location, most commonly resulting from autotransplantation following splenic trauma or splenectomy. Although often asymptomatic and discovered incidentally, it can clinically mimic gastrointestinal stromal tumors or other submucosal lesions, posing diagnostic challenges and potentially leading to unnecessary surgical resection.This article presents a case of a submucosal mass in the gastric fundus discovered via gastroscopy. The patient underwent endoscopic full-thickness resection (EFTR) and was ultimately diagnosed with ectopic splenic tissue in the gastric fundus. To our knowledge, this represents only the second reported case of gastric splenosis treated with EFTR. And then we conduct a literature review of PubMed-indexed MEDLINE articles published between May 1969 and January 2025 on gastric ESAT, and summarize its clinical characteristics to facilitate preoperative diagnosis and prevent unnecessary surgical interventions.</p>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IGF2BP1 regulates the malignant progression of intrahepatic cholangiocarcinoma by recognizing the m6A modification of FN1.","authors":"Qirilatu Sa, Xiaodong Wang, Guangpeng Jia, Xidong Wang, Riguga Su, A Sigen","doi":"10.1016/j.ajg.2026.07.005","DOIUrl":"https://doi.org/10.1016/j.ajg.2026.07.005","url":null,"abstract":"<p><strong>Background and study aims: </strong>Although advances have been made in intrahepatic cholangiocarcinoma (ICC) treatment, ICC prognosis remains unsatisfactory. Thus, in-depth exploration of ICC pathogenesis to identify new therapeutic targets is crucial for optimizing treatment strategies.</p><p><strong>Patients and methods: </strong>Acquisition of single-cell sequencing data encompassing ICC tumor tissues and adjacent normal tissues was performed via the GEO database. Key cell populations and genes were screened through cell annotation, differential expression gene analysis, and KEGG enrichment analysis. In constructed in vitro cell models, qPCR and western blot were respectively implemented to capture mRNA and protein expression levels. Cell migration, proliferation, and invasion abilities were assessed via wound healing, EdU, and Transwell invasion assays. RIP assay was implemented to evaluate RNA-protein interactions, and MeRIP-qPCR was employed to detect m6A modification levels on RNA.</p><p><strong>Results: </strong>Bioinformatics analysis revealed an evident increase in the proportion of cholangiocytes in ICC tumor tissues compared to adjacent normal tissues. Within the IGF2BP1 + Malignant subpopulation, which had the highest malignancy score, the expression of IGF2BP1 and FN1 was significantly upregulated. Cellular experiments demonstrated that IGF2BP1 recognizes the m6A modification on FN1 mRNA, thereby stabilizing its expression. Furthermore, significant enhancement of ICC cell proliferation, migration, and invasion capabilities resulted from IGF2BP1 overexpression, while FN1 knockdown markedly attenuated these promoting effects.</p><p><strong>Conclusion: </strong>Through recognition of the m6A modification on FN1 mRNA, IGF2BP1 facilitates the proliferative, migratory, and invasive capabilities of ICC cells.</p>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autophagy in gastrointestinal cancers: Therapeutic and biological perspectives.","authors":"Milad Ashrafizadeh","doi":"10.1016/j.ajg.2026.06.011","DOIUrl":"https://doi.org/10.1016/j.ajg.2026.06.011","url":null,"abstract":"<p><p>Gastrointestinal (GI) neoplasms are among the most common and lethal tumors around the world. In spite of the introduction of multiple conventional therapeutics for GI tumors, the treatment of these cancers is challenging. Moreover, they are able to mediate resistance to therapeutics. Therefore, the novel therapeutics should be developed for the treatment of GI tumors based on the underlying mechanisms. Autophagy is a programmed cell death mechanism dysregulated in human cancers and it is a potential therapeutic target. In the current review, a special focus is placed on the role of autophagy in GI neoplasms. The current studies have highlighted the fact that genomic and epigenetic factors can participate in the regulation of autophagy in GI tumors. Autophagy can exert protective function to enhance survival of cancer cells, while it decreases apoptosis, ferroptosis and other cell death mechanisms. On the other hand, the pro-death autophagy impairs the progression of GI tumors. In order to regulate autophagy in GI tumor therapy, the studies have focused on the development of drugs (synthetic drugs and natural compounds) along with nanoparticles for the autophagy modulation in GI cancer therapy. The autophagy-related factors can be considered as prognostic and diagnostic factors in GI tumors.</p>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A solid pseudopapillary neoplasm overlooked for a decade: Long-term stability and development of distal pancreatic atrophy","authors":"Tuğba Öztürk ,&nbsp;Ahmet Tanyeri ,&nbsp;Mehmet B. Çildağ","doi":"10.1016/j.ajg.2025.11.002","DOIUrl":"10.1016/j.ajg.2025.11.002","url":null,"abstract":"<div><div>Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor with low malignant potential, most commonly observed in young women. These tumors are frequently asymptomatic and are often detected incidentally during imaging performed for unrelated reasons. We present a unique case of a 27-year-old female with a pancreatic SPN that remained undiagnosed for ten years due to its isodense appearance on initial computed tomography imaging. The lesion remained stable in size and configuration over a decade and was eventually identified incidentally. Notably, progressive atrophy developed in the distal pancreas, likely secondary to ductal obstruction by the mass. This case highlights the diagnostic challenges of atypical SPNs, emphasizes the importance of careful image interpretation, and provides rare insight into the tumor’s natural history in the absence of treatment.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 2","pages":"Pages 252-255"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which quadruple therapy should be prescribed as first-line treatment for Helicobacter pylori infection? Results of a prospective study comparing concomitant and bismuth therapy","authors":"Omar Bahlaoui ,&nbsp;Sara Darhoua ,&nbsp;Anass Nadi ,&nbsp;Fatima Belabbes ,&nbsp;Hanane Delsa ,&nbsp;Wafaa Khannoussi ,&nbsp;Imane Benelbarhdadi","doi":"10.1016/j.ajg.2026.01.004","DOIUrl":"10.1016/j.ajg.2026.01.004","url":null,"abstract":"<div><h3>Background and aims</h3><div><em>Helicobacter pylori</em> (H. pylori) infection is a major global health concern associated with peptic ulcer disease, chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. Rising antibiotic resistance, particularly to clarithromycin and metronidazole, has reduced the efficacy of standard triple therapy, prompting guidelines to recommend quadruple regimens. This study aimed to compare the efficacy, safety, and patient adherence of concomitant quadruple therapy (QC-14) versus bismuth-based quadruple therapy (QB-10) as first-line treatments in a Moroccan population.</div></div><div><h3>Methods</h3><div>In this prospective, randomized study, 86 adult outpatients with <em>H. pylori</em> infection confirmed by active diagnostic tests (histology, 13C-urea breath test, or stool antigen test) were enrolled between January and June 2024 at two university hospitals in Casablanca, Morocco. Patients initially identified by serology were included only if infection was subsequently confirmed by an active test. Participants were randomized to receive either QC-14 (omeprazole, amoxicillin, clarithromycin, metronidazole for 14 days) or QB-10 (omeprazole, bismuth subsalicylate, tetracycline, metronidazole for 10 days). Eradication was assessed 4–6 weeks post-treatment. Safety, adverse events, and adherence were evaluated.</div></div><div><h3>Results</h3><div>Baseline characteristics were similar between groups. Endoscopy was performed in 69.7 % of patients, revealing erythematous gastritis in 91.6 % and peptic ulcer disease in 8.3 %. Eradication rates were 79.5 % for QB-10 and 76.1 % for QC-14 (p = 0.53). Adverse events occurred in 31.8 % (QB-10) and 23.8 % (QC-14) (p = 0.776); diarrhea was more frequent in QC-14 (15 %), while discolored stools were reported only in QB-10 (18.2 %). Adherence exceeded 93 % in both groups.</div></div><div><h3>Conclusions</h3><div>Both concomitant and bismuth quadruple therapies are effective, safe, and well-tolerated first-line treatments for <em>H. pylori</em> eradication, achieving &gt; 75 % eradication rates. The choice of regimen may depend on local resistance patterns, cost, and patient-specific factors. Further multicenter studies with resistance profiling are warranted.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 2","pages":"Pages 172-175"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capsule endoscopic features in a severe case of eosinophilic enteritis: A case report","authors":"Phu Quang Pham ,&nbsp;Thuan Duc Nghiem ,&nbsp;Nhuong Xuan Duong ,&nbsp;Thuong Hoai Nguyen ,&nbsp;Yen Hai Tran ,&nbsp;Hoa Thi Vu ,&nbsp;Thu Dang Nguyen","doi":"10.1016/j.ajg.2026.02.002","DOIUrl":"10.1016/j.ajg.2026.02.002","url":null,"abstract":"<div><h3>Background</h3><div>Eosinophilic enteritis (EoN) is a rare digestive disorder characterised by eosinophilic infiltration of the small intestine. Diagnosis relies on the recognition of characteristic endoscopic findings and the identification of eosinophilia in gastrointestinal tissues. Capsule endoscopy is particularly useful for detecting lesions in the small intestine, a region that is difficult to assess. However, the endoscopic features of EoN are poorly understood.</div></div><div><h3>Case presentation</h3><div>A 20-year-old Asian man presented with a one-month history of right lower quadrant abdominal pain accompanied by nausea, vomiting, and diarrhea occurring 1–2 times per day. Laboratory tests revealed peripheral blood eosinophilia (665/μL; normal range, 20–400) and elevated C-reactive protein level (28.8 mg/L; normal range, &lt;10 mg/L). Abdominal computed tomography revealed uneven thickening of the ileum and the ileocaecal region. Capsule endoscopy (MC 2000; Intromedic, South Korea) revealed multiple areas of erythema, villous atrophy, erosion, ulceration, and oedema throughout the small intestine. Histopathological examination of a biopsy sample confirmed mucosal infiltration of more than 50 eosinophils per high-power field, leading to the diagnosis of EoN. The patient was administered intravenous methylprednisolone at 40 mg/day, which resulted in significant symptom relief within two weeks. The dose was gradually tapered to 15 mg/day. Follow-up capsule endoscopy performed two months later showed complete resolution of the mucosal lesions in the small intestine.</div></div><div><h3>Conclusion</h3><div>This case highlights the key capsule endoscopy findings in EoN, including multiple areas of erythema, villous atrophy, erosion, ulceration, and oedema throughout the small intestine, which may serve as a diagnostic guide for cases in which small bowel biopsy is not feasible.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 2","pages":"Pages 256-259"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}