Endocrinologia Diabetes Y Nutricion最新文献

{"title":"Evaluation of serum placenta-specific gene 8 protein, total antioxidant capacity, interleukin-10, interleukin-17A, interleukin-21 and interleukin-33 levels in Turkish women with gestational diabetes mellitus","authors":"Enver Ciraci ,&nbsp;Tugba Elgun ,&nbsp;Asiye Gok Yurttas ,&nbsp;Hazel Cagin Kuzey ,&nbsp;Yagmur Ekenoglu Merdan ,&nbsp;Muhammed Sait Toprak ,&nbsp;Sermin Tetik","doi":"10.1016/j.endien.2024.02.002","DOIUrl":"https://doi.org/10.1016/j.endien.2024.02.002","url":null,"abstract":"<div><h3>Purpose</h3><p>Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that begins or is diagnosed during pregnancy. Our study aimed to establish a correlation between proinflammatory and anti-inflammatory response in order to be able to develop treatment strategies and determine early diagnosis biomarkers in the sera of cases diagnosed with GDM. Moreover, we aimed to investigate interleukin (IL), placenta-specific gene 8 protein (PLAC8) and total antioxidant capacity (TAC) in patients with GDM.</p></div><div><h3>Methods</h3><p>A total of 121 patients were included in the study. These were divided into four patient groups: pregnant and diagnosed with DM (P-GDM, <em>n</em> <!-->=<!--> <!-->30); pregnant and not diagnosed with DM (P-NGDM, <em>n</em> <!-->=<!--> <!-->32); non-pregnant diagnosed with DM (NP-DM, <em>n</em> <!-->=<!--> <!-->29) and non-pregnant and not diagnosed with DM (NPNDM, <em>n</em> <!-->=<!--> <!-->30). IL-10, IL-17A, IL-21, IL-33, PLAC8 and TAC determinations from patients were evaluated by ELISA (Enzyme-Linked ImmunoSorbent Assay) method.</p></div><div><h3>Results</h3><p>IL-10 and IL-33 concentrations were found to be significantly higher in P-GDM and NP-DM patient groups compared to P-NGDM and NP-NDM groups (<em>p</em> <!-->&lt;<!--> <!-->0.001). The PLAC8 level in the P-GDM patient group (20.38<!--> <!-->±<!--> <!-->5.37) was determined to be significantly higher than in the P-NGDM patient group (3.41<!--> <!-->±<!--> <!-->2.17, <em>p</em> <!-->&lt;<!--> <!-->0.001). TAC in the P-NGDM and NP-NDM groups (12.42<!--> <!-->±<!--> <!-->2.31 vs. 12.96<!--> <!-->±<!--> <!-->3.78, <em>p</em> <!-->&lt;<!--> <!-->0.001) was determined to be significantly higher than in the P-GDM and NP-DM groups (4.8<!--> <!-->±<!--> <!-->0.52 vs. 2.21<!--> <!-->±<!--> <!-->0.71, <em>p</em> <!-->&lt;<!--> <!-->0.001).</p></div><div><h3>Discussion</h3><p>The fact that the importance of PLAC8 level and TAC in the diagnosis and follow-up of GDM in pregnancy is demonstrated for the first time in this study shows that it is unique.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 1","pages":"Pages 12-18"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139908506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concern about hypoglycaemia is mainly nocturnal: An infodemiology study","authors":"Tomás González-Vidal ,&nbsp;Elías Delgado Álvarez ,&nbsp;Edelmiro Menéndez Torre","doi":"10.1016/j.endien.2024.02.003","DOIUrl":"https://doi.org/10.1016/j.endien.2024.02.003","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 1","pages":"Pages 32-35"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139908507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Routine consumption of iodized salt in a sample of patients with thyroid nodules","authors":"Estefanía Chumbiauca ,&nbsp;Juan C. Galofré","doi":"10.1016/j.endien.2024.01.005","DOIUrl":"10.1016/j.endien.2024.01.005","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 1","pages":"Pages 38-39"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypercalcemia as the first finding of late recurrence of a PTHrP neuroendocrine tumor of the pancreas","authors":"Beatriz Febrero ,&nbsp;Beatriz Gómez ,&nbsp;Juan José Ruiz-Manzanera ,&nbsp;Inmaculada Ros-Madrid ,&nbsp;José M. Rodríguez","doi":"10.1016/j.endien.2024.01.002","DOIUrl":"10.1016/j.endien.2024.01.002","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 1","pages":"Pages 31-32"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid pseudoaneurysms after endoscopic transsphenoidal surgery for acromegaly","authors":"Catalina Vivancos Sánchez ,&nbsp;Pedro Navia Álvarez ,&nbsp;Carolina Alfonso Carrillo ,&nbsp;Paola Parra Ramírez ,&nbsp;Carlos Pérez López","doi":"10.1016/j.endien.2024.01.004","DOIUrl":"10.1016/j.endien.2024.01.004","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 1","pages":"Pages 35-37"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of probiotics as treatment in irritable bowel syndrome","authors":"Cristina Ruiz-Sánchez,&nbsp;Blanca Escudero-López,&nbsp;María-Soledad Fernández-Pachón","doi":"10.1016/j.endien.2024.01.003","DOIUrl":"10.1016/j.endien.2024.01.003","url":null,"abstract":"<div><p>Irritable bowel syndrome (IBS) is a gastrointestinal functional disorder mainly characterised by abdominal pain, bloating and altered bowel habits. Dysbiosis might seem to be involved in the pathogenesis of the disease. Probiotics represent a potential treatment, since these could favour the functional microbiota and improve symptoms. The aim was to review the effectiveness of the use of probiotics in IBS symptomatology, analysing the influence of duration and dose. 18 articles were included. At the individual level, <em>Lactobacillus, Bifidobacterium</em> and <em>Bacillus</em> could be useful in the treatment of symptoms. <em>Bifidobacterium bifidum</em> reported the best results (1 × 10⁹ CFU/day for 4 weeks). The most effective combination was 2 <em>Lactobacillus</em> strains, one of <em>Bifidobacterium</em> and one of <em>Streptococcus</em> (4 × 10⁹ CFU/day for 4 weeks). Future clinical trials should confirm these results and analyse the difference between individual and combined treatments.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 1","pages":"Pages 19-30"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2530018024000039/pdfft?md5=6378cfbf6737fa4eb193548ad5fcbd06&pid=1-s2.0-S2530018024000039-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second radioiodine treatment in patients with differentiated thyroid carcinoma: Causes and effects","authors":"María de las Nieves Sicilia Pozo ,&nbsp;Francisco José Pena Pardo ,&nbsp;Mariano Amo Salas ,&nbsp;Marcos Cruz Montijano ,&nbsp;Javier Torres Hernández ,&nbsp;Amanda Padilla Bermejo ,&nbsp;Cristina Montalbán Méndez ,&nbsp;María Zhao Montero ,&nbsp;Ángel Soriano Castrejón ,&nbsp;Ana María García Vicente","doi":"10.1016/j.endien.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.endien.2024.02.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Patients with incomplete response to initial therapy of thyroid cancer can be managed with ongoing observation or potentially additional therapies.</p><p>Our aim was to assess the effect of a second radioactive iodine treatment (RAIT) and its relationship with causes and clinical variables.</p></div><div><h3>Material and methods</h3><p>Patients undergoing a second RAIT for biochemical or structural incomplete response to initial therapy of DTC were retrospectively included (<em>n</em> <!-->=<!--> <!-->120). They were categorised based on the American Thyroid Association (ATA) classification of response to initial therapy.</p><p>Patients were reclassified in the following 6–18 months after second RAIT based on imaging findings and measurements of thyroglobulin and antithyroglobulin antibody levels.</p><p>The associations of a downgrading of response category and progression-free survival (PFS), and the related variables, were evaluated.</p></div><div><h3>Results</h3><p>Sixty-six patients (55%) had a downgrading on ATA response category after second RAIT. A significant interdependence of causes for second RAIT and outcomes was found (<em>χ</em>² <!-->=<!--> <!-->29.400, <em>p</em> <!-->=<!--> <!-->0.001), with patients with neck reoperation showing a higher rate of indeterminate or excellent responses.</p><p>A significant association between ATA response to second RAIT and absence of structural progression was found (<em>χ</em>² <!-->=<!--> <!-->44.914, <em>p</em> <!-->&lt;<!--> <!-->0.001), with less structural progression in patients with downgrading on ATA response (<em>χ</em>² <!-->=<!--> <!-->30.914, <em>p</em> <!-->&lt;<!--> <!-->0.001). There was also significant interdependence to some clinical variables, such as AJCC stage (<em>χ</em>² <!-->=<!--> <!-->8.460, <em>p</em> <!-->=<!--> <!-->0.015), ATA risk classification (<em>χ</em>² <!-->=<!--> <!-->10.694, <em>p</em> <!-->=<!--> <!-->0.005) and initial N stage (<em>χ</em>² <!-->=<!--> <!-->8.485, <em>p</em> <!-->=<!--> <!-->0.004).</p></div><div><h3>Conclusions</h3><p>In selected cases, a second RAIT could lead to more robust responses with a potential improvement in prognosis in patients with incomplete response to initial DTC treatment.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 1","pages":"Pages 4-11"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139907800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the Spanish type 1 diabetes mellitus registry really necessary?","authors":"Javier Escalada ,&nbsp;Antonio Pérez ,&nbsp;Itxaso Rica","doi":"10.1016/j.endien.2023.05.018","DOIUrl":"10.1016/j.endien.2023.05.018","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"70 10","pages":"Pages 617-618"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138435222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum neuregulin 1 in relation to ventricular function and subclinical atherosclerosis in type 2 diabetes patients","authors":"Aya Saad Eldin ,&nbsp;Olfat Fawzy ,&nbsp;Eman Mahmoud ,&nbsp;Ola H. Abd Elaziz ,&nbsp;Alshimaa Ezzat A. Enayet ,&nbsp;Emad Gamil Khidr","doi":"10.1016/j.endien.2023.11.010","DOIUrl":"https://doi.org/10.1016/j.endien.2023.11.010","url":null,"abstract":"<div><h3>Background and aims</h3><p>Neuregulin 1 (NRG-1) is one of the members of the epidermal growth factors proteins. The present study provides novel insights into the relationship between serum levels of NRG-1 and insulin resistance, subclinical atherosclerosis and cardiac dysfunction that occur in type 2 diabetes (T2D).</p></div><div><h3>Methods</h3><p>The study included 50 patients with T2D and 40 healthy age- and gender-matched controls. Serum NRG-1 was measured using ELISA. Glycemic parameters, lipid profile and insulin resistance were assessed. Trans-thoracic echocardiography and carotid intima media thickness (CIMT) were studied for all study subjects.</p></div><div><h3>Results</h3><p><span>T2D patients had significantly lower serum NRG-1 levels than controls. Serum NRG-1 was negatively correlated with age, fasting blood glucose, HbA1c<span>, insulin resistance, blood urea, serum creatinine and LDL-C, and positively correlated with HDL-C, eGFR and CIMT. Regarding echocardiographic variables, serum NRG-1 was found to correlate positively with left ventricular global longitudinal strain and negatively with </span></span><em>E</em>/<em>E</em>_<em>a</em> ratio. NRG-1 was found to predict subclinical atherosclerosis in type 2 diabetes patients at a cut-off value<!--> <!-->&lt;<!--> <!-->108.5<!--> <!-->pg/ml with 78% sensitivity and 80% specificity.</p></div><div><h3>Conclusions</h3><p>A robust relationship was found between serum NRG-1 levels and hyperglycemia, insulin resistance, subclinical atherosclerosis, and cardiac dysfunction in patients with type 2 diabetes. These results shed light on a possible role of NRG-1 as a potential noninvasive biomarker for detection of cardiometabolic risk in T2D.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"70 10","pages":"Pages 619-627"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138549274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary loss of thyroid hormones: An issue to remember","authors":"Ismael Capel ,&nbsp;Loreley Betancourt ,&nbsp;María Florencia Luchtenberg ,&nbsp;Andreea Muntean ,&nbsp;Valeria Arsentales ,&nbsp;Judith Jover ,&nbsp;Mercedes Rigla","doi":"10.1016/j.endien.2023.11.011","DOIUrl":"https://doi.org/10.1016/j.endien.2023.11.011","url":null,"abstract":"<div><p>A 45-year-old woman suffering from primary hypothyroidism, previously well substituted with levothyroxine, was urgently referred from Primary Care to Endocrinology due to very elevated thyrotropin, free thyroxine at low limit of normality, very high cholesterol and generalised oedema. Hypothyroidism was suspected as the main aetiology of this clinical condition. A detailed examination showed nephrotic range proteinuria and the patient was finally diagnosed with lupus nephritis. Urinary loss of thyroid hormones, fundamentally linked to their transport proteins, in patients affected by nephrotic syndrome is sometimes a forgotten phenomenon and one which should be considered in patients with increased levothyroxine requirements. In this report, we present the details of this case and a brief review of the literature on this topic.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"70 10","pages":"Pages 649-653"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138549521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}