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Transgender women and competitive sports: Considerations from Endocrinology
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.101539
Laura Cuadrado Clemente , María Miguélez González , Patricia Cabrera García , Mercedes Noval Font , Élida Alfaro Gandarillas , Marcelino Gómez Balaguer , Nieves Palacios Gil de Antuñano
{"title":"Transgender women and competitive sports: Considerations from Endocrinology","authors":"Laura Cuadrado Clemente ,&nbsp;María Miguélez González ,&nbsp;Patricia Cabrera García ,&nbsp;Mercedes Noval Font ,&nbsp;Élida Alfaro Gandarillas ,&nbsp;Marcelino Gómez Balaguer ,&nbsp;Nieves Palacios Gil de Antuñano","doi":"10.1016/j.endien.2025.101539","DOIUrl":"10.1016/j.endien.2025.101539","url":null,"abstract":"<div><h3>Introduction</h3><div>The participation of transgender women (TW) in high-level competitive sports increases every year, as does the interest of sports organizations in finding solutions that allow their inclusion without compromising the principle of equity governing high-level sports. However, the binary categorization of sports, influenced by the impact of sex hormone on physical performance, creates challenges for the inclusion of TW in the female category. This study aimed to understand the impact of gender-affirming hormone therapy (GAHT) on various athletic performance variables and to compare results with those obtained in cisgender populations.</div></div><div><h3>Methods</h3><div>Review of cross-sectional and longitudinal studies that included TW (preferably athletes) undergoing GAHT.</div></div><div><h3>Results</h3><div>Significant decreases in hematocrit, total serum testosterone, lean body mass, strength, and muscle area were observed after 12 mo of GAHT, with increases in fat mass. Grip strength was higher in TW compared to cisgender females (CW) in the long term. TW showed better performance in sports involving the upper body.</div></div><div><h3>Conclusions</h3><div>At least 2 years of postpubertal GAHT are necessary to achieve a significant reduction in the effects of male hormones on various physiological parameters. The scientific evidence regarding the impact of GAHT on physical performance is insufficient. Long-term studies are needed, incorporating new biomarkers and morphofunctional parameters, to allow for comparisons of athletic performance across different disciplines between TW and CW.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 4","pages":"Article 101539"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trans and cis women in sport: Citius, altius, fortius, sed aequitas
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.501547
Óscar Moreno-Perez , Inés Modrego-Pardo
{"title":"Trans and cis women in sport: Citius, altius, fortius, sed aequitas","authors":"Óscar Moreno-Perez ,&nbsp;Inés Modrego-Pardo","doi":"10.1016/j.endien.2025.501547","DOIUrl":"10.1016/j.endien.2025.501547","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 4","pages":"Article 501547"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical characteristics and management of type 2 diabetes in primary care in Spain. SED2 Study
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.501543
Violeta Antonio-Arques , Berta Fernandez Camins , Bogdan Vlacho , Joan Barrot , Jorge Navarro Pérez , Edelmiro Menéndez Torre , Didac Mauricio , Josep Franch-Nadal
{"title":"Clinical characteristics and management of type 2 diabetes in primary care in Spain. SED2 Study","authors":"Violeta Antonio-Arques ,&nbsp;Berta Fernandez Camins ,&nbsp;Bogdan Vlacho ,&nbsp;Joan Barrot ,&nbsp;Jorge Navarro Pérez ,&nbsp;Edelmiro Menéndez Torre ,&nbsp;Didac Mauricio ,&nbsp;Josep Franch-Nadal","doi":"10.1016/j.endien.2025.501543","DOIUrl":"10.1016/j.endien.2025.501543","url":null,"abstract":"<div><h3>Introduction</h3><div>Type 2 diabetes mellitus (DM2) is a prevalent chronic disease with major complications. Primary care (PC) plays a crucial role in the management of this disease.</div></div><div><h3>Objectives</h3><div>To evaluate the organization and resources available in PC for the care of patients with DM2 in Spain.</div></div><div><h3>Material and methods</h3><div>Descriptive, cross-sectional, observational study in 65 health centers (HC) selected by opportunistic sampling. Data were collected through a structured survey.</div></div><div><h3>Results</h3><div>Half of the HCs have a diabetes referent, two thirds have specific protocols and almost 90% involve nurses in diabetes education. Access to non-mydriatic retinography is limited (38.5%) and its interpretation varies. Diabetic foot examination is mainly performed by nurses (47.7%) and there is the possibility of referral to vascular surgery or specialized units in most cases. The most frequent analytical tests are the HbA1c every 6 mo (67.7%). 63.1% of the HCs can perform telematic consultations to hospital specialists and most of them have access to patients’ medical records at the hospital. Significant variations are observed in some aspects between autonomous communities.</div></div><div><h3>Conclusions</h3><div>Care for patients with DM2 in PC in Spain is uneven and presents opportunities for improvement. Comprehensive diabetes care in PC needs to be strengthened, including the training of professionals, the implementation of protocols and the provision of adequate resources. Measures are needed to reduce variations in care between autonomous communities.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 4","pages":"Article 501543"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alterations in MORC2 gene and DIGFAN syndrome: A rare cause of short stature MORC2 基因的改变与 DIGFAN 综合征：导致身材矮小的罕见病因
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.101537
Enrique Palomo Atance , Prado Sánchez Ruiz , Elena Reyzábal Ereño , Paola Sánchez Tudela , Laura Acero García de la Santa
{"title":"Alterations in MORC2 gene and DIGFAN syndrome: A rare cause of short stature","authors":"Enrique Palomo Atance ,&nbsp;Prado Sánchez Ruiz ,&nbsp;Elena Reyzábal Ereño ,&nbsp;Paola Sánchez Tudela ,&nbsp;Laura Acero García de la Santa","doi":"10.1016/j.endien.2025.101537","DOIUrl":"10.1016/j.endien.2025.101537","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 4","pages":"Article 101537"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined adalimumab and etonogestrel/ethinylestradiol therapy associated with hypertriglyceridemia-induced pancreatitis in a young woman with hidradenitis suppurativa
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.101536
Darko Siuka , Matej Rakusa
{"title":"Combined adalimumab and etonogestrel/ethinylestradiol therapy associated with hypertriglyceridemia-induced pancreatitis in a young woman with hidradenitis suppurativa","authors":"Darko Siuka ,&nbsp;Matej Rakusa","doi":"10.1016/j.endien.2025.101536","DOIUrl":"10.1016/j.endien.2025.101536","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 4","pages":"Article 101536"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering deleterious missense variants in the MC4R gene in the pathogenesis of obesity
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.501559
Meriem El Fessikh , Hanaa Skhoun , Zohra Ouzzif , Jamila El Baghdadi
{"title":"Deciphering deleterious missense variants in the MC4R gene in the pathogenesis of obesity","authors":"Meriem El Fessikh ,&nbsp;Hanaa Skhoun ,&nbsp;Zohra Ouzzif ,&nbsp;Jamila El Baghdadi","doi":"10.1016/j.endien.2025.501559","DOIUrl":"10.1016/j.endien.2025.501559","url":null,"abstract":"<div><div>The <em>MC4R</em> gene plays a critical role in regulating food intake, making it an important model for studying genetic mutations that impact the protein function. This study aimed to identify the most deleterious functional and structural variants in individuals with obesity by analyzing SNPs from the NCBI dbSNP database and selecting pathogenic variants from ClinVar. Bioinformatics tools were employed to predict deleterious SNPs, and conservation analysis was performed using ConSurf. Stability predictions were made with MUpro, I-Mutant2.0, and iStable. The 3D structure of the MC4R protein was examined using YASARA view. A total of 20 out of 348 missense mutations were associated with obesity. Fifteen of these variants were predicted to be the most deleterious. Eight variants located in conserved regions were found to significantly reduce protein stability and cause structural changes (S58C, E61K, N62S, I69R, D90N, R165Q, P299H, and I316S), indicating their potential as obesity biomarkers and therapeutic targets.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 4","pages":"Article 501559"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperglycemia-related risk factors in enteral nutrition in non-critically ill patients
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-03-01 DOI: 10.1016/j.endien.2025.101534
Esther Delgado-García , Juan José López-Gómez , Rebeca Jiménez-Sahagún , Emilia Gómez-Hoyos , Ana Ortolá-Buigues , Paloma Pérez-López , Beatriz Torres-Torres , Daniel A. De Luis-Román
{"title":"Hyperglycemia-related risk factors in enteral nutrition in non-critically ill patients","authors":"Esther Delgado-García ,&nbsp;Juan José López-Gómez ,&nbsp;Rebeca Jiménez-Sahagún ,&nbsp;Emilia Gómez-Hoyos ,&nbsp;Ana Ortolá-Buigues ,&nbsp;Paloma Pérez-López ,&nbsp;Beatriz Torres-Torres ,&nbsp;Daniel A. De Luis-Román","doi":"10.1016/j.endien.2025.101534","DOIUrl":"10.1016/j.endien.2025.101534","url":null,"abstract":"<div><h3>Introduction</h3><div>Carbohydrate metabolism can change in hospitalized patients due to stress, or the use of enteral nutrition (EN). The aim of this study was to determine the risk factors triggering these changes.</div></div><div><h3>Material and Methods</h3><div>We conducted a retrospective observational study in non-diabetic patients with low levels of stress on EN. Five groups were categorized based on changes to the metabolism of hydrocarbons produced before or after EN: plasma glycemia prior to EN &gt;126<!--> <!-->mg/dL (stress hyperglycemia – SH) (35.1%); plasma glycaemia prior to EN &lt;126<!--> <!-->mg/dL (non-HE) (64.89%). Hyperglycemia with EN (HyperEN): at least, two capillary blood glucose readings &gt;140<!--> <!-->mg/dL or 1 &gt;180<!--> <!-->mg/dL during EN (71%); non-HyperEN: capillary blood glucose readings with EN &lt;140<!--> <!-->mg/dL (29%).</div></div><div><h3>Results</h3><div>A total of 131 patients were included (45.8% men) with a median age of 81 (71–87) years. A total of 52 patients exceeded 180<!--> <!-->mg/dL at one measurement, and 24 patients required insulin detemir with a median of 16 (12–27) IU per day. Risk factors for HyperEN were identified as patient age (OR, 1.186; 95% CI, 1.051–1.341; <em>p</em> <!-->&lt;<!--> <!-->0.01) and duration of nutritional treatment (OR, 1.320; 95% CI, 1.086–1.605; <em>p</em> <!-->&lt;<!--> <!-->0.01).</div></div><div><h3>Conclusions</h3><div>Our study shows a high prevalence of carbohydrate metabolism disorders in hospitalized patients on total EN, with age and duration of nutritional treatment being the main risk factors.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 3","pages":"Article 101534"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short bowel syndrome and d-lactic acidosis: A case report with supplemental home parenteral nutrition and teduglutide
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-03-01 DOI: 10.1016/j.endien.2025.101535
Elena Carrillo-López, Maria Sara Tapia-Sanchiz, Sara Jiménez-Blanco, Begoña Molina-Baena
{"title":"Short bowel syndrome and d-lactic acidosis: A case report with supplemental home parenteral nutrition and teduglutide","authors":"Elena Carrillo-López,&nbsp;Maria Sara Tapia-Sanchiz,&nbsp;Sara Jiménez-Blanco,&nbsp;Begoña Molina-Baena","doi":"10.1016/j.endien.2025.101535","DOIUrl":"10.1016/j.endien.2025.101535","url":null,"abstract":"<div><div><span>d</span>-Lactic acidosis is an uncommon cause of acidosis that occurs in patients with short bowel syndrome (SBS). Reduced intestinal absorption surface leads to carbohydrate malabsorption, fermented by abnormal colonic bacterial flora, resulting in elevated <span>d</span>-lactate levels. It should be suspected in SBS patients who exhibit typical neurological symptoms without other apparent causes, along with metabolic acidosis with normal <span>l</span>-lactate levels. Treatment involves correcting acidosis and managing bacterial overgrowth with non-absorbable antibiotics.</div><div>This report presents a case of a patient on teduglutide for SBS who experienced an episode of <span>d</span>-lactic acidosis. To date, there are no documented cases in the literature of similar episodes in adult patients undergoing therapy with GLP2 analogs.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 3","pages":"Article 101535"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New drugs in pituitary diseases
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-03-01 DOI: 10.1016/j.endien.2025.501546
Fernando Cordido , Pedro Iglesias
{"title":"New drugs in pituitary diseases","authors":"Fernando Cordido ,&nbsp;Pedro Iglesias","doi":"10.1016/j.endien.2025.501546","DOIUrl":"10.1016/j.endien.2025.501546","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 3","pages":"Article 501546"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recommendations of the Spanish Society of Endocrinology and Nutrition (SEEN) on “what not to do” in clinical practice
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-03-01 DOI: 10.1016/j.endien.2025.101531
Juan José Díez , Emma Anda , Irene Bretón , Cintia González-Blanco , María Miguélez , Ana Zugasti , Alberto Fernández , on behalf of the Sociedad Española de Endocrinología y Nutrición
{"title":"Recommendations of the Spanish Society of Endocrinology and Nutrition (SEEN) on “what not to do” in clinical practice","authors":"Juan José Díez ,&nbsp;Emma Anda ,&nbsp;Irene Bretón ,&nbsp;Cintia González-Blanco ,&nbsp;María Miguélez ,&nbsp;Ana Zugasti ,&nbsp;Alberto Fernández ,&nbsp;on behalf of the Sociedad Española de Endocrinología y Nutrición","doi":"10.1016/j.endien.2025.101531","DOIUrl":"10.1016/j.endien.2025.101531","url":null,"abstract":"<div><div>Quality healthcare should be grounded on clinical practice with the highest benefit-risk ratio and cost-effectiveness according to the available scientific evidence. The overuse of unproven diagnostic or therapeutic procedures is common in our setting and leads to increased healthcare spending and even iatrogenic harm. Previous cost-effectiveness initiatives have proposed identifying diagnostic and therapeutic measures that are better 'not done' in certain clinical contexts under the lens of the available scientific evidence. In this regard, the Spanish Society of Endocrinology and Nutrition (SEEN) has compiled a series of 'not-to-do' recommendations from its various working groups. These recommendations cover common clinical situations classified into the following thematic areas: diabetes, nutrition, pituitary gland, neuroendocrine tumors, thyroid, and hormone replacement therapy in postmenopausal women.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 3","pages":"Article 101531"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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