Endocrinologia Diabetes Y Nutricion最新文献

{"title":"Executive summary of the OSEOSEENconsensus document on the diagnosis and management of rare bone diseases","authors":"Beatriz García-Fontana,&nbsp;Cristina García-Fontana,&nbsp;María Dolores López Robles,&nbsp;Verónica Ávila-Rubio,&nbsp;Guillermo Martínez Díaz-Guerra,&nbsp;Pilar Rodríguez Ortega,&nbsp;Mariela Varsavsky,&nbsp;María Rosa Alhambra Expósito,&nbsp;Antonia García-Martín,&nbsp;María Cortés-Berdonces,&nbsp;Fernando Marín Díez,&nbsp;Isabel Huguet,&nbsp;Esteban Jódar-Gimeno,&nbsp;Manuel Muñoz-Torres","doi":"10.1016/j.endien.2026.501803","DOIUrl":"10.1016/j.endien.2026.501803","url":null,"abstract":"<div><div>Rare bone diseases comprise a heterogeneous group of low-prevalence disorders affecting the development, remodeling, or structural integrity of bone tissue. Despite their individual rarity, their clinical, functional, and psychosocial impact is substantial, particularly due to the diagnostic delay that frequently accompanies these conditions. In order to provide a practical and up-to-date clinical tool to improve the identification, diagnostic approach, and management of these entities, an expert consensus document has been developed. The full and extended version is available in the consensus documents section of the manual of the Spanish Society of Endocrinology and Nutrition (SEEN).</div><div>This executive summary condenses the essential contents of the document, offering an overview of the diseases addressed, their main clinical and diagnostic features, and the recommended therapeutic strategies. It also includes a final table that comparatively summarizes the most relevant aspects of each entity.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 8","pages":"Article 501803"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and diabetes: When glycaemic management is no longer the primary objective","authors":"Josep Franch-Nadal,&nbsp;Didac Mauricio,&nbsp;Giuseppe Maltese","doi":"10.1016/j.endien.2026.501908","DOIUrl":"10.1016/j.endien.2026.501908","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 8","pages":"Article 501908"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of bioelectrical impedance analysis for clinical outcomes in older adults at nutritional risk admitted to an intermediate care convalescent unit","authors":"Jéssica Martínez Rodríguez,&nbsp;Mateu Serra-Prat,&nbsp;Elisabet Palomera Fanegas","doi":"10.1016/j.endien.2026.501775","DOIUrl":"10.1016/j.endien.2026.501775","url":null,"abstract":"<div><h3>Background</h3><div>Bioelectrical impedance analysis (BIA) is a widely used technique in clinical practice, especially in the field of nutrition. Some of its parameters have been associated with an increased risk of malnutrition, sarcopenia, and mortality.</div></div><div><h3>Aim</h3><div>To evaluate the prognostic value of BIA parameters in elderly people at risk of malnutrition admitted to a convalescent unit.</div></div><div><h3>Methods</h3><div>We conducted an observational and prospective study of older adults at nutritional risk admitted to a convalescent unit, followed from admission to hospital discharge. All of them underwent BIA within the first week of admission. The main outcome measures were in-hospital complications, in-hospital mortality, and length of stay. Nutritional status (GLIM criteria), sarcopenia (EWGSOP2 criteria), and frailty (Frail-VIG criteria) were assessed as well.</div></div><div><h3>Results</h3><div>142 patients (62% men, mean age of 82.5 years (SD, 7.58) were recruited. A total of 57.7% exhibited complications during admission; the mean length of stay was 45.0 days (SD, 24.1), and the in-hospital mortality rate, 11.3%. In women, in-hospital complications and mortality were associated with a lower Phase Angle (PhA) and a higher total body water/fat free mass and extracellular water/intracellular water ratios. Survival was significantly lower when PhA on admission was &lt;4.5 ° in men and &lt;4.0 ° in women, as well as when the intracellular water/fat free mass ratio was &lt;0.33 in both sexes.</div></div><div><h3>Conclusions</h3><div>PhA and an imbalance between extracellular and intracellular water are indicators of poor prognosis in elderly patients admitted to a convalescent unit.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 8","pages":"Article 501775"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From storm to stability: The role of plasmapheresis in the stabilization of patients with high-risk thyrotoxicosis","authors":"Agueda María Comisario,&nbsp;Javier Giunta,&nbsp;Teresa Mabel Canteros,&nbsp;Diego Mario Santoro,&nbsp;Sebastian Antelo,&nbsp;María del Pilar Tartaglia,&nbsp;Federico Norberto Cedola,&nbsp;Ivana Leticia Esteban,&nbsp;María Fabiana Russo Picasso","doi":"10.1016/j.endien.2026.501826","DOIUrl":"10.1016/j.endien.2026.501826","url":null,"abstract":"<div><h3>Introduction</h3><div>Thyrotoxicosis in high-risk patients is a severe condition requiring prompt management, although conventional therapeutic approaches often present limitations. Therapeutic plasmapheresis has emerged as a potential option to achieve rapid clinical stabilization and facilitate a safe transition to definitive treatment by effectively reducing circulating thyroid hormone levels. The objective of this study was to evaluate the safety and efficacy profile of plasmapheresis in patients with high-risk thyrotoxicosis.</div></div><div><h3>Materials and methods</h3><div>We conducted a retrospective multicenter study with a cohort of 13 patients with high-risk thyrotoxicosis who underwent plasmapheresis due to clinical instability, adverse effects related to antithyroid drugs, or significant cardiovascular comorbidities. Therapeutic success was assessed based on objective clinical improvement and restoration of euthyroidism, determined by hormonal measurements. Adverse events were systematically recorded to evaluate the procedural safety profile.</div></div><div><h3>Results</h3><div>The median age was 50 years, and 84.6% of patients were women. The median number of plasmapheresis sessions was 3. Normalization of T3 and free T4 levels was achieved in 92.3% of patients. Mild adverse events occurred in 30.8% of cases, none of which required treatment discontinuation. Definitive therapy following plasmapheresis was performed in 76.9% of patients, most commonly total thyroidectomy.</div></div><div><h3>Discussion</h3><div>Plasmapheresis appears to be a safe and effective therapeutic option in patients with high-risk thyrotoxicosis, particularly in those with absolute contraindications to conventional treatments or severe cardiovascular comorbidities, facilitating stabilization and transition to definitive therapy.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 8","pages":"Article 501826"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth hormone therapy in Turner syndrome: Do cytogenetic subtypes influence outcomes?","authors":"Ingrid-Ioana Herșcovici,&nbsp;Monica Cristina Pânzaru,&nbsp;Georgiana Constantinescu,&nbsp;Letiția Leuștean,&nbsp;Maria-Christina Ungureanu,&nbsp;Cristina Preda,&nbsp;Cristina Rusu","doi":"10.1016/j.endien.2026.501821","DOIUrl":"10.1016/j.endien.2026.501821","url":null,"abstract":"<div><div>Turner syndrome (TS) is a chromosomal disorder caused by complete or partial loss of one X chromosome, occurring in approximately 1 in 2500 live female births. Short stature, resulting from haploinsufficiency of the short stature homeobox-containing (SHOX) gene, absence of a pubertal growth spurt, and ovarian insufficiency are hallmark features. Recombinant human growth hormone (GH) therapy remains the mainstay of management, increasing adult height by approximately 5–8<!--> <!-->cm. This review examines how cytogenetic subtypes influence GH response, focusing on 45,X monosomy, mosaicism, and structural abnormalities such as isochromosome Xq and ring X. Patients with 45,X monosomy often show a favorable initial response but a more rapid decline in growth velocity, whereas mosaic patients maintain better long-term outcomes. Structural variants involving Xp loss exhibit similarly attenuated responses. Overall, differences between cytogenetic subtypes tend to diminish over time, with age at therapy initiation, treatment duration, and timing of pubertal induction exerting a greater influence on final height outcomes.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 8","pages":"Article 501821"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of pregnancy outcomes in women with type 1 vs type 2 diabetes mellitus: A 10-year retrospective study","authors":"Inês Meira,&nbsp;Juliana Gonçalves,&nbsp;João Menino,&nbsp;Ana Luísa Barbosa,&nbsp;Mafalda Costa,&nbsp;Helena Urbano Ferreira,&nbsp;Sílvia Monteiro,&nbsp;Cristina Gamboa,&nbsp;Gabriela Namora,&nbsp;Sandra Belo,&nbsp;Joana Queirós","doi":"10.1016/j.endien.2026.501805","DOIUrl":"10.1016/j.endien.2026.501805","url":null,"abstract":"<div><h3>Background</h3><div>With the global rise in diabetes mellitus (DM), pregnancies in women with preexisting DM are becoming increasingly common and are associated with a higher risk of adverse outcomes. However, the relative impact of type 1 diabetes mellitus (T1DM) vs type 2 diabetes mellitus (T2DM) remains unclear.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included pregnant women with preexisting DM followed between 2014 and 2024. Demographic, clinical, biochemical, and obstetric data were compared according to DM type. Primary outcomes included maternal complications, fetal growth, and neonatal morbidity.</div></div><div><h3>Results</h3><div>Among 169 pregnancies, 114 (67.5%) involved T1DM and 55 (32.5%), T2DM. Compared with women with T2DM, those with T1DM were younger, had lower body mass index, longer diabetes duration, and a higher prevalence of diabetic retinopathy. They also had higher preconception HbA1c levels and greater gestational weight gain. T1DM was associated with higher odds of retinopathy progression, large-for-gestational-age neonates, and neonatal intensive care unit (NICU) admission, but lower odds of labor dystocia. Rates of miscarriage, preterm birth, hypertensive disorders of pregnancy, and cesarean delivery were similar between groups. Among women with T1DM, excessive gestational weight gain and higher late-pregnancy HbA1c levels were strongly associated with adverse neonatal outcomes.</div></div><div><h3>Conclusions</h3><div>Pregnancies complicated by T1DM showed a higher burden of adverse outcomes than those complicated by T2DM. Glycemic control and gestational weight gain emerged as key modifiable risk factors, underscoring the need for tailored management strategies.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 8","pages":"Article 501805"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical diabetes and familial partial lipodystrophy in carriers of COL3A1 and PAX4 variants: Description of a family","authors":"Gema Villa López,&nbsp;Clara Marijuan Sánchez,&nbsp;Elena García Fernández,&nbsp;Celestino Rodríguez Jiménez,&nbsp;Miguel León Sanz","doi":"10.1016/j.endien.2026.501778","DOIUrl":"10.1016/j.endien.2026.501778","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 8","pages":"Article 501778"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peroneal nerve palsy, an unusual complication after bariatric surgery: Experience of a series of clinical cases","authors":"Laura Martínez Suero,&nbsp;Noelia Sánchez-Maroto García,&nbsp;Sara Mera Carreiro,&nbsp;Celia López Nevado,&nbsp;Miguel A. Rubio-Herrera","doi":"10.1016/j.endien.2026.501824","DOIUrl":"10.1016/j.endien.2026.501824","url":null,"abstract":"<div><div>Bariatric and metabolic surgery (BMS) can be associated with neurological complications, including common peroneal nerve palsy, which usually arises from a combination of rapid weight loss, a decrease in the fatty tissue that protects the nerve, and sustained postures, such as crossing the legs, which promote compression at the fibular neck. This complication is uncommon among patients undergoing BMS, occurring in less than 1% of all surgical procedures. We present a series of six clinical cases of foot drop syndrome, the clinical manifestation of peroneal nerve motor palsy, that occurred after BMS over the last 25 years of experience at our hospital. A description of the cases is provided, along with an analysis of potential triggering causes and different types of treatment.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 8","pages":"Article 501824"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoid heart disease in gastroenteropancreatic neuroendocrine tumors: clinical case series and real-world experience","authors":"Francisco Javier Albacete Zapata,&nbsp;Pedro Iglesias","doi":"10.1016/j.endien.2026.501802","DOIUrl":"10.1016/j.endien.2026.501802","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 8","pages":"Article 501802"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status of women with anorexia nervosa. Morphofunctional assessment","authors":"Abel González-González,&nbsp;Marta Ventosa-Viña,&nbsp;Encarnación Arranz-Sinovas,&nbsp;Isabel Domínguez-Osorio,&nbsp;Cristina Urrios-Gómez,&nbsp;Fernándo García Urruzola,&nbsp;Jose María Palacio-Mures,&nbsp;Luis Cuéllar-Olmedo","doi":"10.1016/j.endien.2026.501776","DOIUrl":"10.1016/j.endien.2026.501776","url":null,"abstract":"<div><h3>Objective</h3><div>To provide a descriptive analysis of the nutritional status of a sample of women with anorexia nervosa (AN).</div></div><div><h3>Materials and methods</h3><div>Descriptive observational study of women attending an outpatient clinic for AN.</div></div><div><h3>Results</h3><div>Thirty-five patients were evaluated, with a mean age of 23.6 ± 10.7 years and a body mass index of 18.3 ± 3.53 kg/m². A total of 73.52% were malnourished (40 % with severe malnutrition). Muscle strength was 24.3 ± 3.53 kg; 16 patients (55.88%) showed strength below the 20th percentile, but only 3 fell below the cutoff defining sarcopenia.</div><div>Muscle mass variables assessed included: appendicular skeletal muscle mass, 14.7 ± 2.47 kg/m²; fat-free mass index, 14.8 ± 1.47 kg/m²; appendicular skeletal muscle mass index, 5.52 ± 0.629 kg/m²; anteroposterior diameter of the rectus femoris muscle (Y-axis), 1.18 ± 0.32 cm; and cross-sectional area of the same muscle, 3.54 ± 1.29 cm². The ratio of the lateral diameter of the rectus femoris (X-axis) to the Y-axis, used as an index of muscle quality, was 3.09 ± 1.17.</div><div>Patients with severe malnutrition had lower adipose tissue content and reduced appendicular skeletal muscle mass compared with the rest of the cohort.</div><div>Phase angle was 5.85 ± 0.77°, and standardized phase angle was −0.92 ± 0.89. Both showed a good positive correlation with body cell mass.</div></div><div><h3>Conclusions</h3><div>Malnutrition is extremely prevalent among patients with AN; however, sarcopenia—according to conventional criteria—is not. Morphofunctional differences were observed according to nutritional status.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 8","pages":"Article 501776"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}