Endocrinologia Diabetes Y Nutricion最新文献

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Prevalence of chronic kidney disease in patients treated in Endocrinology, Diabetes and Nutrition outpatient clinics: A single-center, cross-sectional, retrospective, descriptive study 在内分泌、糖尿病和营养门诊治疗的患者中慢性肾病的患病率:一项单中心、横断面、回顾性、描述性研究
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-07-30 DOI: 10.1016/j.endien.2025.501612
Noel Roig-Marín , Javier Torres Hernández , Cristina Delicado Hernández , Laura Navarro Casado , Pedro J. Pinés Corrales
{"title":"Prevalence of chronic kidney disease in patients treated in Endocrinology, Diabetes and Nutrition outpatient clinics: A single-center, cross-sectional, retrospective, descriptive study","authors":"Noel Roig-Marín , Javier Torres Hernández , Cristina Delicado Hernández , Laura Navarro Casado , Pedro J. Pinés Corrales","doi":"10.1016/j.endien.2025.501612","DOIUrl":"10.1016/j.endien.2025.501612","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 7","pages":"Article 501612"},"PeriodicalIF":1.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trans-signaling through the agonistic sIL-6R and an imbalanced inflammatory response are associated with increased susceptibility to Graves’ disease 通过激动性sIL-6R的反式信号传导和不平衡的炎症反应与格雷夫斯病易感性增加有关
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-07-30 DOI: 10.1016/j.endien.2025.501598
Zulvikar Syambani Ulhaq , Zulkarnain Zulkarnain , Lola Ayu Istifiani , Syafrizal Aji Pamungkas , Susiati , Djoko Wahono Soeatmadji , Aulanni’am Aulanni’am
{"title":"Trans-signaling through the agonistic sIL-6R and an imbalanced inflammatory response are associated with increased susceptibility to Graves’ disease","authors":"Zulvikar Syambani Ulhaq ,&nbsp;Zulkarnain Zulkarnain ,&nbsp;Lola Ayu Istifiani ,&nbsp;Syafrizal Aji Pamungkas ,&nbsp;Susiati ,&nbsp;Djoko Wahono Soeatmadji ,&nbsp;Aulanni’am Aulanni’am","doi":"10.1016/j.endien.2025.501598","DOIUrl":"10.1016/j.endien.2025.501598","url":null,"abstract":"<div><h3>Background</h3><div>Excessive inflammatory cytokines are known to impact immune response and autoimmunity. In this study, we quantified the level of interleukin (IL)-6, soluble IL-6 receptor (sIL-6R), glycoprotein 130 (sgp130) and IL-10 to determine their involvement in the pathogenesis of Graves’ disease (GD), in addition to the assessment serum cytokines IL-6, sIL-6R, sgp130, and IL-10 performance as biomarkers for the diagnosis of GD.</div></div><div><h3>Methods</h3><div>A total of 20 patients with GD and 21 healthy individuals from the Indonesian population were enrolled. The serum concentrations of the selected cytokines were quantified using the ELISA method. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), and TSH receptor antibody (TSHR-Ab) were also evaluated. Comparative analysis was performed in addition to the assessment of the diagnostic performance of cytokines using receiver-operating-curve (ROC) analysis. Pearson's correlation coefficient was used to assess the relationship between 2 quantitative variables.</div></div><div><h3>Results</h3><div>Patients with GD had a higher IL-6, sIL-6R, and IL-6/IL-10 ratio but a lower sgp130/sIL-6R/IL-6 ratio vs controls. The ROC curve analysis showed that the sgp130/sIL-6R/IL-6 ratio exhibited better performance than IL-6, sIL-6R, and IL-6/IL-10 ratio in diagnosing GD. In addition, serum levels of IL-6, sIL-6, and IL-10 were associated with thyroid parameters, including TSHR-antibody (Ab) levels.</div></div><div><h3>Conclusion</h3><div>IL-6 trans-signaling and imbalance of inflammatory response could be prominent factors in the pathogenesis of GD.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 7","pages":"Article 501598"},"PeriodicalIF":1.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Broadening perspectives on hypoglycemia diagnosis in non-diabetic patients 拓宽非糖尿病患者低血糖诊断的视角
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-07-30 DOI: 10.1016/j.endien.2025.501599
Beatriz Rodríguez Jiménez , Ignacio Jiménez Varo , Fernando-Francisco Ortega Ortega , Mariola Méndez Muros , Félix Sánchez Fernández , María Asunción Martínez-Brocca
{"title":"Broadening perspectives on hypoglycemia diagnosis in non-diabetic patients","authors":"Beatriz Rodríguez Jiménez ,&nbsp;Ignacio Jiménez Varo ,&nbsp;Fernando-Francisco Ortega Ortega ,&nbsp;Mariola Méndez Muros ,&nbsp;Félix Sánchez Fernández ,&nbsp;María Asunción Martínez-Brocca","doi":"10.1016/j.endien.2025.501599","DOIUrl":"10.1016/j.endien.2025.501599","url":null,"abstract":"<div><div>A 51-year-old man with a past medical history of chronic alcoholism was admitted for a planned fasting test due to suspected hypoglycemia. Despite previous evaluations by cardiology and neurology revealing no evident etiology, his syncopal episodes were suspected be associated with inconsistent hypoglycemic episodes. During his hospital admission, the patient experienced several syncopal episodes with associated seizures, which, at the time, were not related to hypoglycemia. This led to further investigation, including the exclusion of other causes, such as a possible autonomic dysfunction. Neurology consequently expanded the assessment, identifying subtle signs of mild parkinsonism and symptoms suggestive of a REM sleep disorder, which shifted the diagnostic suspicion.</div><div>This case underscores the importance of considering other clinical conditions when evaluating hypoglycemia, especially when classic symptoms are absent or inconsistently presented, and an endocrinological origin has been ruled out.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 7","pages":"Article 501599"},"PeriodicalIF":1.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical, diagnostic and therapeutic aspects of Mauriac syndrome, a complication of type 1 diabetes mellitus: A systematic review 1型糖尿病并发症莫里亚克综合征的临床、诊断和治疗:系统综述
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-07-30 DOI: 10.1016/j.endien.2025.501611
André Saad Cleto, João Matheus Schirlo, Mayara Beltrame, Victor Hugo Oliveira Gomes, Janete Machozeki, Camila Marinelli Martins
{"title":"Clinical, diagnostic and therapeutic aspects of Mauriac syndrome, a complication of type 1 diabetes mellitus: A systematic review","authors":"André Saad Cleto,&nbsp;João Matheus Schirlo,&nbsp;Mayara Beltrame,&nbsp;Victor Hugo Oliveira Gomes,&nbsp;Janete Machozeki,&nbsp;Camila Marinelli Martins","doi":"10.1016/j.endien.2025.501611","DOIUrl":"10.1016/j.endien.2025.501611","url":null,"abstract":"<div><div>This systematic review aimed to present the main clinical, diagnostic and therapeutic aspects of Mauriac syndrome, which is a rare syndrome that mainly affects children and adolescents with uncontrolled type 1 diabetes mellitus. This review was carried out in accordance with PRISMA and registered in PROSPERO (CRD42024531249). The following databases were used in our search: PubMed, Lilacs and Scielo, on 04/02/2024. Studies that presented any data on patients with Mauriac syndrome were included, however, review studies, letters to the editor and animal studies were excluded. The risk of bias was assessed using a specific method for case reports. To analyze the results, the general, clinical, diagnostic and therapeutic characteristics were analyzed using a qualitative analysis. A total of 24 studies were included, 18 case reports and 6 case series. The patients’ mean age was 16.26 years, and the mean glycated hemoglobin was 12.93%. The main signs and symptoms reported were hepatomegaly (88%), short stature (52%), cushingoid features (35%) and abdominal discomfort (26%). The means of AST, ALT, GGT, alkaline phosphatase, total cholesterol, triglycerides and lactate were above the reference value. Some studies used abdominal ultrasound (US), abdominal computed tomography (CT) or liver biopsy to make the diagnosis. CT and US showed hepatomegaly, while liver biopsies showed glycogen accumulation in hepatocytes. Treatment in most studies was based on improving blood glucose levels and diet. Therefore, Mauriac syndrome has diverse symptoms. Lab test and imaging modalities can be useful to establish diagnosis.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 7","pages":"Article 501611"},"PeriodicalIF":1.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimation of the incidence and prevalence of type 1 diabetes mellitus in children under 15 years of age in Spain 西班牙15岁以下儿童1型糖尿病发病率和患病率的估计
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-07-10 DOI: 10.1016/j.endien.2025.501591
Santiago Conde Barreiro , Beatriz González Pelegrín , Bárbara Quevedo Beneyto , Cristina Feja Solana , Carmen Malo Aznar , Gemma Rojo-Martínez , Edelmiro Menéndez Torre , Fernando Gómez Peralta
{"title":"Estimation of the incidence and prevalence of type 1 diabetes mellitus in children under 15 years of age in Spain","authors":"Santiago Conde Barreiro ,&nbsp;Beatriz González Pelegrín ,&nbsp;Bárbara Quevedo Beneyto ,&nbsp;Cristina Feja Solana ,&nbsp;Carmen Malo Aznar ,&nbsp;Gemma Rojo-Martínez ,&nbsp;Edelmiro Menéndez Torre ,&nbsp;Fernando Gómez Peralta","doi":"10.1016/j.endien.2025.501591","DOIUrl":"10.1016/j.endien.2025.501591","url":null,"abstract":"<div><h3>Introduction</h3><div>Epidemiological studies on type 1 diabetes mellitus (DM1) have been developed in almost all the Spanish geography, but no registry currently provides national incidence and prevalence figures. This study aims to estimate the incidence of DM1 in children under 15 years of age in Spain based on the available studies, and to know the prevalence of diabetes in children under 15 years of age based from the data collected in the Primary Care Clinical Database (BDCAP).</div></div><div><h3>Material and methods</h3><div>Bibliographic review of publications and communications that provided data up to December 2020. Estimation of the average incidence in Spain, based on data from each autonomous community. Estimation of the prevalence of DM1 in children under 15 years of age according to BDCAP.</div></div><div><h3>Results</h3><div>The reported incidences varied from 7.9 cases/100,000 population per year (c/10<sup>5</sup>ppy) in the Balearic Islands to 30.48 c/10<sup>5</sup>ppy in Gran Canaria. Diagnosis in diabetic ketoacidosis (DKA) is found in approximately one third of cases (21-43.7%). The average incidence of DM1 in children under 15 years of age in Spain would be 20.54 c/10<sup>5</sup>ppy, with about 1,398 new cases per year. BDCAP records 12,346 cases of diabetes in children under 15 years of age, with a prevalence of 1.96 cases/1,000 population.</div></div><div><h3>Conclusions</h3><div>There are studies of DM1 incidence in almost all Spanish communities. The incidence of DM1 in children under 15 years of age in Spain is very high according to the WHO classification (&gt; 20 c/10<sup>5</sup>ppy). The proportion of cases diagnosed with CAD is high, suggesting that programs to improve the early diagnosis of DM1 are still needed.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 7","pages":"Article 501591"},"PeriodicalIF":1.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hand dynamometry: Does the device used for measurement matter? 手测力:测量所用的装置重要吗?
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-07-09 DOI: 10.1016/j.endien.2025.501575
Diana García Sastre, Begoña Pintor de la Maza, María López Melgar, María D. Ballesteros Pomar
{"title":"Hand dynamometry: Does the device used for measurement matter?","authors":"Diana García Sastre,&nbsp;Begoña Pintor de la Maza,&nbsp;María López Melgar,&nbsp;María D. Ballesteros Pomar","doi":"10.1016/j.endien.2025.501575","DOIUrl":"10.1016/j.endien.2025.501575","url":null,"abstract":"<div><h3>Introduction</h3><div>Handgrip dynamometers measure muscle strength through the grip strength of the dominant hand. The purpose of this study is to compare the Dynx, Saehan, and Smedlay dynamometers with the Jamar dynamometer (gold standard) by evaluating the correlation and concordance of their measurements to determine if it is indifferent to use different dynamometers.</div></div><div><h3>Material and methods</h3><div>Cross-sectional study conducted between 2020 and 2021.</div><div>We evaluated a group of patients (GP) from the Endocrinology and Nutrition consultations and a control group (CG) of health personnel.</div><div>Dominant hand grip strength was measured with four different dynamometers Jamar, Dynx, Saehan and Smedlay, in random order. Statistical analysis was performed with SPSS using Student's t-test, intraclass correlation coefficient (ICC), and Bland-Altman plots.</div></div><div><h3>Results</h3><div>A total of 124 subjects were included; 91 GP (60.4% women), mean age 54.9 (SD14.2) years. ICC showed the best correlation for Saehan in GP (0.977 p &lt; 0.001) and in GC (0.960 p &lt; 0.001). Dynx correlated better in GP than in GC (0.967 vs. 0.900, p &lt; 0.001) and Smedlay had the worst correlation in GC (0.812 p &lt; 0.001). The dynamometer with the lowest bias (-0.39, SD 3.11) and better limits of agreement (LOA) in both groups (GP -0.39, GC -0.51) was the Saehan</div></div><div><h3>Conclusion</h3><div>Despite good measurement correlation, there is bias and insufficient agreement between different dynamometers, so they should not be used interchangeably.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 7","pages":"Article 501575"},"PeriodicalIF":1.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neglect in the parental care of children and adolescents with type 1 diabetes. Predictors 父母对1型糖尿病儿童和青少年的忽视。预测因子。
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-07-09 DOI: 10.1016/j.endien.2025.501581
Emilio García-García , Juan Gil-Arrones , Antonio J. Molina-Facio , Elena Digón-Fernández , Manuel Sobrino-Toro
{"title":"Neglect in the parental care of children and adolescents with type 1 diabetes. Predictors","authors":"Emilio García-García ,&nbsp;Juan Gil-Arrones ,&nbsp;Antonio J. Molina-Facio ,&nbsp;Elena Digón-Fernández ,&nbsp;Manuel Sobrino-Toro","doi":"10.1016/j.endien.2025.501581","DOIUrl":"10.1016/j.endien.2025.501581","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 7","pages":"Article 501581"},"PeriodicalIF":1.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient syndrome of inappropriate antidiuresis due to intracranial hematoma in a patient with partial antidiuretic hormone deficiency and Steinert’s dystrophy 部分抗利尿激素缺乏伴斯泰纳特营养不良患者颅内血肿所致不适当抗利尿的短暂综合征。
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-07-08 DOI: 10.1016/j.endien.2025.501592
Guillermo Ropero-Luis , Viyey Kishore Doulatram-Gamgaram
{"title":"Transient syndrome of inappropriate antidiuresis due to intracranial hematoma in a patient with partial antidiuretic hormone deficiency and Steinert’s dystrophy","authors":"Guillermo Ropero-Luis ,&nbsp;Viyey Kishore Doulatram-Gamgaram","doi":"10.1016/j.endien.2025.501592","DOIUrl":"10.1016/j.endien.2025.501592","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 7","pages":"Article 501592"},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced diagnostic imaging techniques in pituitary pathology 垂体病理的先进诊断成像技术。
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-07-08 DOI: 10.1016/j.endien.2025.501610
Beatriz Brea Álvarez
{"title":"Advanced diagnostic imaging techniques in pituitary pathology","authors":"Beatriz Brea Álvarez","doi":"10.1016/j.endien.2025.501610","DOIUrl":"10.1016/j.endien.2025.501610","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 7","pages":"Article 501610"},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-world evaluation of the efficacy and safety of switching from weekly dulaglutide to weekly semaglutide: The SEMA-SWITCH study 从每周一次的杜拉鲁肽转换为每周一次的西马鲁肽的有效性和安全性的实际评估:SEMA-SWITCH研究。
IF 1.8 4区 医学
Endocrinologia Diabetes Y Nutricion Pub Date : 2025-06-01 DOI: 10.1016/j.endien.2025.501574
Felipe Pardo Lozano , Arantxa Rubio Marcos , Rosa Casañ Fernández , Amparo Bartual Rodrigo , Sergio Martínez-Hervás , Francisco Javier Ampudia-Blasco
{"title":"Real-world evaluation of the efficacy and safety of switching from weekly dulaglutide to weekly semaglutide: The SEMA-SWITCH study","authors":"Felipe Pardo Lozano ,&nbsp;Arantxa Rubio Marcos ,&nbsp;Rosa Casañ Fernández ,&nbsp;Amparo Bartual Rodrigo ,&nbsp;Sergio Martínez-Hervás ,&nbsp;Francisco Javier Ampudia-Blasco","doi":"10.1016/j.endien.2025.501574","DOIUrl":"10.1016/j.endien.2025.501574","url":null,"abstract":"<div><h3>Introduction</h3><div>Dulaglutide and semaglutide are once-weekly administered GLP-1 receptor agonists (GLP-1 RAs) indicated for the treatment of hyperglycemia in individuals with type 2 diabetes mellitus (T2DM) and obesity (BMI ≥ 30 kg/m<sup>2</sup>).</div></div><div><h3>Objective</h3><div>To evaluate the efficacy and safety of switching from subcutaneous (SC) dulaglutide to SC semaglutide, in real-world conditions.</div></div><div><h3>Materials and methods</h3><div>A total of 123 individuals with T2DM on SC dulaglutide, either as monotherapy or with other antihyperglycemic drugs, who switched to SC semaglutide were included. This switch was motivated by insufficient reduction in glycated hemoglobin (HbA1C), the need for greater weight loss, or gastrointestinal intolerance associated with dulaglutide. Changes with semaglutide in HbA1C and weight at 6, 12, 18, and 24 mo, as well as any changes in associated adverse effects. Data are expressed as mean ± standard deviation.</div></div><div><h3>Results</h3><div>Previous treatment with dulaglutide (duration 16.9 ± 13.8 mo) reduced HbA1c by 0.38% (p = 0.003 vs. baseline) and weight by −1.3 kg (p = 0.003 vs. baseline). After switching to semaglutide, an additional reduction in HbA1C levels was observed at 6, 12, 18, and 24 mo (−0.43%, p = 0.000; −0.54%, p = 0.000; −0.38%, p = 0.021; −0.12%, p = 0.622, respectively) and in weight at 6, 12, 18, and 24 mo (−2.7 kg, p = 0.000; −3.7 kg, p = 0.000; −5.4 kg, p = 0.001; −4.2 kg, p = 0.000, respectively) With no significant differences in the frequency of adverse effects after switching to semaglutide.</div></div><div><h3>Conclusions</h3><div>In real-world conditions, switching dulaglutide to semaglutide in obese patients with T2DM is associated with an additional reduction in HbA1C and weight, without notable changes in the frequency of adverse effects.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 6","pages":"Article 501574"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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