Endocrinologia Diabetes Y Nutricion最新文献

{"title":"Acute pancreatitis in an infant, a rare diagnosis","authors":"Fátima Pareja Marín, María Pilar Valverde Viu, Sara Vicent Martí, Violeta Martí Enrique","doi":"10.1016/j.endien.2025.501660","DOIUrl":"10.1016/j.endien.2025.501660","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 1","pages":"Article 501660"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Executive summary of the consensus document for the management of severe Cushing's syndrome: Consensus document of the Neuroendocrinology Focus Group of the Spanish Society of Endocrinology and Nutrition (SEEN)","authors":"Marta Araujo-Castro ,&nbsp;Rogelio García-Centeno ,&nbsp;Javier Aller ,&nbsp;Mónica Marazuela ,&nbsp;Alfonso Soto ,&nbsp;María Ángeles Gálvez ,&nbsp;Rosa Cámara ,&nbsp;Elena Valassi ,&nbsp;Ignacio Bernabeu ,&nbsp;Rocío Villar-Taibo ,&nbsp;Felicia A. Hanzu","doi":"10.1016/j.endien.2025.501654","DOIUrl":"10.1016/j.endien.2025.501654","url":null,"abstract":"<div><div>Severe Cushing's syndrome (SCS) is usually defined as a CS with urinary free cortisol (UFC) levels above five times the upper limit of normal or associated with severe complications of hypercortisolism. Combination therapy with ketoconazole and metyrapone is a useful option for these patients. Osilodrostat is the most potent and effective oral drug in monotherapy for the treatment of SCS. For cases with very severe hypercortisolism and/or oral intolerance, etomidate is the most effective and rapid drug for reducing cortisol levels. Bilateral adrenalectomy may be indicated in cases of life-threatening severe hypercortisolism, but UFC should be reduced before surgery to reduce the perioperative morbimortality. Prompt treatment of comorbidities and thrombo- and infection prophylaxis are recommended. In conclusion, a rapid control of hypercortisolism is vital in SCS, and for this purpose combination therapy or potent drugs with a rapid onset of action such as etomidate or osilodrostat are indicated.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501654"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of microscopic extrathyroidal extension on the prognosis of medullary thyroid carcinoma: A multicenter cohort study","authors":"Beyza Olcay Ozturk ,&nbsp;Umran Keskin ,&nbsp;Serhat Uysal ,&nbsp;Aysa Hacioglu ,&nbsp;Seda Karsli ,&nbsp;Burak Andac ,&nbsp;Umit Nur Ozbay ,&nbsp;Hulyanur Sodan ,&nbsp;Sebnem Burhan ,&nbsp;Coskun Ates ,&nbsp;Ugur Avci ,&nbsp;Faruk Kilinc ,&nbsp;Selvinaz Erol ,&nbsp;Merve Catak ,&nbsp;Zafer Pekkolay ,&nbsp;Gulhan Akbaba ,&nbsp;Goknur Yorulmaz ,&nbsp;Sakin Tekin ,&nbsp;Birol Topcu ,&nbsp;Mazhar Muslum Tuna ,&nbsp;Sayid Shafi Zuhur","doi":"10.1016/j.endien.2025.501633","DOIUrl":"10.1016/j.endien.2025.501633","url":null,"abstract":"<div><h3>Purpose</h3><div>Despite several factors are associated with worse disease-free survival (DFS) and prognosis in medullary thyroid carcinoma (MTC) patients, the effect of microscopic extrathyroidal extension (mETE) on the prognosis and DFS is not well understood. This study aims to evaluate the impact of mETE on DFS and prognosis in patients with MTC.</div></div><div><h3>Methods</h3><div>This multicenter study included 208 patients with MTC (17.8% with hereditary disease). Patients with mETE were compared to those without mETE in terms of clinical and histopathological variables.</div></div><div><h3>Results</h3><div>Among the 208 patients, 16.3% (<em>n</em> <!-->=<!--> <!-->34) had mETE on histopathological analysis. Patients with mETE were more likely to have larger tumors, higher serum calcitonin (CTN) levels before and after surgery, increased rates of neck lymph node (LN) and distant metastasis, multifocal disease, and advanced disease stage. Kaplan–Meier analysis showed a significantly lower DFS in patients with mETE than those without mETE (14.7% vs. 71.3%, log-rank <em>p</em> <!-->&lt;<!--> <!-->0.001). However, mETE was not an independent contributing factor for persistent/recurrent disease, whereas neck LN involvement was the strongest independent contributing factor for persistent/recurrent disease (HR: 1.1; 95% CI 0.4–1.8, <em>p</em> <!-->=<!--> <!-->0.76 and HR: 9.6; 95% CI 1.21–76.9, <em>p</em> <!-->=<!--> <!-->0.03, respectively).</div></div><div><h3>Conclusion</h3><div>mETE in patients with MTC is associated with a lower DFS, larger tumor sizes, a higher likelihood of neck LN and distant metastasis, advanced stage, higher serum CTN levels, multifocality, and persistent/recurrent disease. However, mETE was not an independent predictor of persistent/recurrent disease. Further studies with a larger number of patients with mETE could further clarify the impact of mETE on the prognosis of MTC.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501633"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastroileal bypass reversal as a treatment for iatrogenic hyperparathyroidism and refractory hypocalcemia","authors":"Bryan-Josué Flores-Robles ,&nbsp;Juan Antonio López Martín ,&nbsp;María Jesús Chinchetru Ranedo ,&nbsp;José Miguel Lázaro Guevara ,&nbsp;José Fernando Marín Díez ,&nbsp;Núria Guañabens","doi":"10.1016/j.endien.2025.501632","DOIUrl":"10.1016/j.endien.2025.501632","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501632"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delphi Consensus of the Nutrition Area of ​​the SEEN (NutriSEEN) on the use of enteral tube nutrition in people with advanced dementia","authors":"Francisco Pita Gutiérrez ,&nbsp;Irene Breton Lesmes ,&nbsp;Julia Álvarez Hernández ,&nbsp;María D. Ballesteros-Pomar ,&nbsp;Rocío Campos del Portillo ,&nbsp;Ana Hernández Moreno ,&nbsp;Francisco Botella Romero","doi":"10.1016/j.endien.2025.501640","DOIUrl":"10.1016/j.endien.2025.501640","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite the available scientific evidence, the use of enteral tube feeding in people with advanced dementia is currently controversial. Given this situation, and following the position paper promoted by the SEEN (Spanish Society of Endocrinology and Nutrition), a consensus is sought to contribute to improving the management of this condition.</div></div><div><h3>Material and methods</h3><div>A Delphi consultation was conducted, a formal and systematic method for obtaining consensus. The project was developed in the following stages: (1) questionnaire development by the Scientific Committee; (2) first round of Delphi consultation; (3) second round of Delphi consultation, and; (4) a meeting to present the results.</div></div><div><h3>Results</h3><div>A total of 340 expert members of the SEEN Nutrition Department were invited to participate through the society itself. Of these, 128 panellists completed the questionnaire in the first round (response rate of 38%) and 53 in the second round (response rate of 41%, compared to the first round). Of the 24 statements initially proposed, 14 (58%) reached consensus. Of these, 13 achieved this goal in the first round and one in the second.</div></div><div><h3>Conclusions</h3><div>Advanced dementia represents a significant challenge for both healthcare professionals and patients' families, raising ethical and practical dilemmas regarding appropriate treatment and management to improve the quality of life of those affected. This paper draws several key conclusions that can guide the care and attention of these patients.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501640"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pembrolizumab-induced dual endocrine disruption: A case report","authors":"María Carmen Dameto Pons,&nbsp;Elena González Arnáiz,&nbsp;María Antequera González,&nbsp;Xavier F. Pérez Candel,&nbsp;Diana Ariadel Cobo,&nbsp;Javier Castañón Alonso,&nbsp;María D. Ballesteros Pomar","doi":"10.1016/j.endien.2025.501630","DOIUrl":"10.1016/j.endien.2025.501630","url":null,"abstract":"<div><div>Immunotherapy is an increasingly used treatment for different types of cancer. The most widely used are cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitors, PD-1 ligand (PD-L1) inhibitors and PD-1 receptor inhibitors. All of them can produce endocrine autoimmune side effects in multiple organs. The most frequent are thyroid disorders and hypophysitis although, less frequently, they can also cause autoimmune adrenalitis and autoimmune diabetes. Thyroid involvement is usually transient but can become chronic in the form of hypothyroidism in more than 50% of cases. Diabetes is due to autoimmune destruction of pancreatic β-cells, in many cases abrupt and irreversible. The 2 entities occur more frequently with PD-1 or PD-L1 inhibitors. This is the case of a patient with cutaneous melanoma on pembrolizumab who simultaneously developed thyroiditis and fulminant autoimmune diabetes.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501630"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of iodisation in pregnant women in Asturias, Spain","authors":"Carmen Sánchez Blanco ,&nbsp;Marina García Cancelo ,&nbsp;Cristina González Martínez ,&nbsp;Leire Cardo González ,&nbsp;Marta Diéguez Felechosa","doi":"10.1016/j.endien.2025.501646","DOIUrl":"10.1016/j.endien.2025.501646","url":null,"abstract":"<div><h3>Introduction</h3><div>Although former studies indicated that Asturias (Spain) is an iodine-sufficient region, preliminary data suggest this trend may be changing.</div></div><div><h3>Objective</h3><div>To determine the prevalence of iodine deficiency in pregnant women in Asturias.</div></div><div><h3>Material and methods</h3><div>We designed an observational, prospective, multicenter study. The urinary iodine concentration (UIC) of 371 pregnant women was analyzed between November 2021 and March 2023. Participants were recruited from the three central areas of the Principality of Asturias (Areas III, IV, and V). The project received approval from the Research Ethics Committee of the Principality of Asturias (RECPA).</div></div><div><h3>Results</h3><div>A total of 52% of pregnant women had urinary iodine levels indicative of iodine deficiency (&lt; 150 μg/L). The average UIC in our cohort was 146 μg/L. We compared thyroid-stimulating hormone (TSH) levels between pregnant women with iodine deficiency and those with sufficient iodine, but found no statistically significant differences in TSH levels between the two groups. We also couldn't establish statistically significant links between iodine deficiency status and body mass index (BMI), number of previous births, nationality, or age. Furthermore, iodine deficiency did not show a significant link to obstetric complications such such as hypertension during pregnancy or premature birth.</div></div><div><h3>Conclusions</h3><div>These findings support the hypothesis of an increase in iodine deficiency during the first trimester of pregnancy in our population. This highlights the urgent need to review our supplementation strategies and nutritional education programs.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501646"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unavoidable decision for medical societies: Commercial drift or integrity","authors":"Ildefonso Hernández-Aguado ,&nbsp;Elisa Chilet-Rosell","doi":"10.1016/j.endien.2025.501730","DOIUrl":"10.1016/j.endien.2025.501730","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501730"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish-eye disease. Altered HDL cholesterol metabolism and corneal involvement: A case report","authors":"Ana Álvarez ODogherty ,&nbsp;Carmen Rodríguez Jiménez ,&nbsp;Amaya Belanger-Quintana ,&nbsp;Sonia Rodríguez Novoa ,&nbsp;Francisco Arrieta Blanco","doi":"10.1016/j.endien.2025.501638","DOIUrl":"10.1016/j.endien.2025.501638","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501638"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The overweight and obesity landscape in Spain: Data from the Spanish cohort of the multi-country IMPACT-O study","authors":"Irene Breton ,&nbsp;Igotz Aranbarri ,&nbsp;Anastasia Lampropoulou ,&nbsp;Jennifer Redondo-Antón ,&nbsp;Javier Ágreda ,&nbsp;Atif Adam ,&nbsp;Esther Artime","doi":"10.1016/j.endien.2025.501643","DOIUrl":"10.1016/j.endien.2025.501643","url":null,"abstract":"<div><h3>Introduction</h3><div>The epIdeMiology landscape PAtient Care paThways of Obesity (IMPACT-O) study was a multi-country, retrospective cohort study that utilised healthcare databases to determine the landscape/impact of overweight and obesity. Here we describe the sociodemographic, clinical and treatment characteristics of adults with a first record of overweight/obesity or obesity in Spain between 2018 and 2022.</div></div><div><h3>Materials and methods</h3><div>The IQVIA longitudinal patient database in Spain was used to identify individuals with a first record of overweight/obesity, as determined by diagnosis codes and/or body mass index (BMI) measurements (overweight/obesity cohort: BMI ≥25<!--> <!-->kg/m²; obesity cohort: BMI ≥30<!--> <!-->kg/m²), in the years 2018–2022. Demographic and clinical parameters, including obesity-related complications (ORCs), as recorded by primary care providers and specialists contributing to the database, were described.</div></div><div><h3>Results</h3><div>The overweight/obesity cohort included 25,016 individuals, and the obesity cohort 13,441 individuals. Most individuals with overweight/obesity (60.1%) and obesity (63.6%) presented with ≥1 ORCs. The most frequent ORCs among people with obesity were hypertension (25.3%), dyslipidaemia (19.8%), anxiety (19.0%), osteoarthritis (14.3%), low-back pain (10.9%) and depression (10.9%). The proportion of individuals receiving pharmacological therapies with an effect on weight was &lt;1%. There were no records of lifestyle interventions or bariatric surgery in the database for this population.</div></div><div><h3>Conclusions</h3><div>This study highlights the high ORC burden at first documented diagnosis of overweight/obesity. Very few individuals with obesity in Spain receive pharmacological treatment with an effect on weight. Patient management could be improved by systematically recording all interventions in this population.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501643"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}