Endocrinologia Diabetes Y Nutricion最新文献

{"title":"ATA 2025: Less is more—Practical implications for the management of differentiated thyroid cancer","authors":"Garcilaso Riesco Eizaguirre , Emma Anda Apiñániz , Cecilia Sánchez Ragnarsson , Jordi Lluis Reverter Calatayud , Carles Zafon","doi":"10.1016/j.endien.2026.501760","DOIUrl":"10.1016/j.endien.2026.501760","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 2","pages":"Article 501760"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of cervical ultrasound and related techniques in endocrinology and nutrition services in Spain. ECOSEEN 2025 study","authors":"Jordi L. Reverter ,&nbsp;Gonzalo Díaz Soto ,&nbsp;Tomás Martin ,&nbsp;Manuel Gargallo ,&nbsp;Marcel Sambo ,&nbsp;Iñaki Argüelles ,&nbsp;Imaging and Associated Techniques Group of the Spanish Society of Endocrinology and Nutrition","doi":"10.1016/j.endien.2025.501659","DOIUrl":"10.1016/j.endien.2025.501659","url":null,"abstract":"<div><h3>Introduction</h3><div>Before 2014, few Endocrinology and Nutrition Departments nationwide routinely used cervical ultrasound. Following the training activities promoted by the Thyroid Pathology Imaging Group, it is important to evaluate the current level of implementation of ultrasound and ultrasound-guided techniques in clinical practice.</div></div><div><h3>Material and methods</h3><div>A structured, self-administered survey was designed and sent electronically to hospitals throughout the country.</div></div><div><h3>Results</h3><div>Responses were received from a total of 101 hospitals. Ninety-three percent of the departments surveyed reported routine use of ultrasound in clinical practice, with specialized consultations in 71% of cases. Sixty percent performed fine-needle aspiration cytology, and 55% performed staging and follow-up of differentiated thyroid cancer. Among minimally invasive techniques (MIT), 42% of centers perform enolization of thyroid cysts and 12% offer thermal ablation techniques, with radiofrequency being the most commonly used modality. Eighty-six% of professionals have received training through the Applied Imaging Techniques for Thyroid Pathology Group of the SEEN (National Institute of Endocrinology and Nutrition). Currently, 56 centers offer specific ultrasound training for medical residents in the specialty.</div></div><div><h3>Conclusion</h3><div>Over the last decade, ultrasound has been widely implemented in the Endocrinology and Nutrition Departments affiliated with the SEEN, including the incorporation of ultrasound-guided techniques into routine practice. However, the use of MIT such as thermal ablation is still limited, so it is considered necessary to strengthen both specific training and institutional support to promote its maximum implementation.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 1","pages":"Article 501659"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymorphisms in TLR4 and IL6 and their association with obesity and insulin resistance in a Venezuelan population","authors":"Stefani Hernández Osorio ,&nbsp;María Fátima Garcés ,&nbsp;Eva Salazar Alcalá ,&nbsp;José Manuel Pestana ,&nbsp;Mercedes Fernández Mestre","doi":"10.1016/j.endien.2025.501657","DOIUrl":"10.1016/j.endien.2025.501657","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the association between genetic polymorphisms in the <em>TLR4</em> (rs4986790 and rs4986791) and <em>IL6</em> (rs1800795) genes with obesity in a Venezuelan population.</div></div><div><h3>Methods</h3><div>We conducted a retrospective case-control study with 207 unrelated Venezuelans (137 obese, 70 normal weight). Blood samples were obtained to measure glucose, cholesterol, triglycerides, HDL, insulin, and insulin resistance (HOMA-IR ≥ 2.6) and genotype the <em>TLR4</em> (rs4986790 and rs4986791) and <em>IL6</em> (rs1800795) polymorphisms using PCR-SSP. Statistical tests: Student's <em>t</em>-test, Pearson correlation coefficient, chi-square test, odds ratio (OR) with 95%CI were used.</div></div><div><h3>Results</h3><div>The relationship between obesity and insulin resistance (IR) was confirmed. Heterozygous genotypes A/G (<em>TLR4</em> rs4986790, <em>P</em> = .012) and C/T (<em>TLR4</em> rs4986791, <em>P</em> = .005) were more frequent in normal-weight individuals, while homozygous genotypes A/A (<em>TLR4</em> rs4986790, <em>P</em> = .012) and C/C (<em>TLR4</em> rs4986791, <em>P</em> = .005) were more frequent in obese individuals. The C allele and CC genotype of <em>IL6</em> rs1800795 (<em>P</em> = .007) were associated with obesity. The <em>IL6</em> C/C genotype was associated with higher insulin and HOMA in obese individuals. In obese individuals with IR, the CC genotype (<em>TLR4</em> rs4986791, <em>P</em> = .03) was more common, as opposted to CT, which was less common (<em>P</em> = .03). The C/C genotype of <em>IL6</em> rs1800795 was more frequent in obese individuals with IR (<em>P</em> &lt; .0001). Obese individuals with IR and the AA genotype of <em>TLR4</em> rs4986790 had higher BMI, HOMA-IR, and glucose.</div></div><div><h3>Conclusion</h3><div>These findings suggest that genetic variations in the <em>TLR4</em> and <em>IL6</em> genes may predispose to obesity and its metabolic complications in the Venezuelan population.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 1","pages":"Article 501657"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3, 2, 1! From GLP-2 to GLP-1 analog over a 10-year journey","authors":"María Sara Tapia-Sanchiz,&nbsp;Miguel Antonio Sampedro-Núñez,&nbsp;Sara Jiménez-Blanco,&nbsp;Begoña Molina-Baena","doi":"10.1016/j.endien.2025.501662","DOIUrl":"10.1016/j.endien.2025.501662","url":null,"abstract":"<div><div>Short bowel syndrome (SBS) represents one of the central conditions in clinical nutrition, with a complex and challenging management. Teduglutide, an analog of human glucagon-like peptide-2 (GLP-2), is the first approved long-term, non-symptomatic treatment for SBS. We present the case of a 62-year-old woman with SBS who required prolonged home parenteral nutrition (HPN). Following clinical stabilization, teduglutide was initiated, leading to significant clinical and nutritional improvement, including spontaneous closure of enterocutaneous fistulas and a 70% reduction in parenteral nutrition requirements. This allowed for a surgical reconstruction, after which she achieved full enteral autonomy, later developing grade 1 obesity. This case highlights the therapeutic potential of teduglutide as a bridging therapy and the remaining uncertainties regarding its long-term management.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 1","pages":"Article 501662"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145640914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing levothyroxine dosing accuracy post-total thyroidectomy using body fat percentage","authors":"Ana M. Díaz Abram ,&nbsp;Federico Volpi ,&nbsp;Estefanía Chumbiauca ,&nbsp;Marta García Goñi ,&nbsp;Juan C. Galofré","doi":"10.1016/j.endien.2025.501645","DOIUrl":"10.1016/j.endien.2025.501645","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 1","pages":"Article 501645"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuity of care in obesity clinical care","authors":"Irene Bretón ,&nbsp;José Manuel Fernández García ,&nbsp;Nuria Vilarrasa ,&nbsp;Violeta Ramírez Arroyo ,&nbsp;Ani de Hollanda ,&nbsp;Guadalupe Blay Cortés ,&nbsp;María D. Ballesteros-Pomar ,&nbsp;on behalf of SEEN, SEMERGEN, semFYC and SEMG","doi":"10.1016/j.endien.2025.501658","DOIUrl":"10.1016/j.endien.2025.501658","url":null,"abstract":"<div><div>Obesity is a chronic, multifactorial and relapsing disease with a great impact on public health. Due to its high prevalence and complications, it is essential to coordinate clinical care in different health care settings in order to improve the clinical evaluation and treatment of people with obesity and to optimize the use of health care resources. This document, prepared by experts from the Spanish Society of Endocrinology and Nutrition (SEEN), the Spanish Society of Primary Care Physicians (SEMERGEN), the Spanish Society of Family and Community Medicine (semFYC) and the Spanish Society of General Practitioners (SEMG) proposes a comprehensive clinical approach to obesity, based on effective coordination between Primary Care and Endocrinology and Nutrition Departments.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 1","pages":"Article 501658"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond vectorial bioelectrical impedance: Assessing body composition changes with novel electrical parameters in obese osteoarthritis patients on a meal-replacement diet","authors":"José-Joaquín Alfaro-Martínez ,&nbsp;David Primo-Martín ,&nbsp;César Gonzalvo-Díaz ,&nbsp;Olatz Izaola-Jauregui ,&nbsp;Marina Jara-Vidal ,&nbsp;Lourdes García-Blasco ,&nbsp;Beatriz Ramos-Bachiller ,&nbsp;Diego Bellido-Guerrero ,&nbsp;Daniel A. De Luis-Román ,&nbsp;Juan José López-Gómez","doi":"10.1016/j.endien.2025.501644","DOIUrl":"10.1016/j.endien.2025.501644","url":null,"abstract":"<div><h3>Background</h3><div>Rapid weight loss with restricted diets can cause muscle mass decline. The aim of this work is to evaluate a new method for representing the raw electrical values obtained in the bioelectrical impedance analysis (BIA) in patients with obesity and osteoarthritis undergoing a meal-replacement diet.</div></div><div><h3>Methods</h3><div>We conducted a 1-group intervention study with meal-replacement diet for 3 months in patients with osteoarthritis prior to orthopedic surgery. Anthropometry and BIA was registered at baseline (B) and 3 months (3M) after the intervention. We have calculated traditional estimations of body composition over the raw electrical parameters of BIA parameters and a new bioelectrical impedance vector analysis (BIVA) based method to detect nutrition (NP), hydration (HP) and fat (FP) parameters without estimation.</div></div><div><h3>Results</h3><div>A total of 272 patients (23.16% men; 76.84% women) were analyzed. There was a correlation between NP and body composition estimates (body cell mass [BCM] standardized by height (BCM/h): men: 0.96; <em>p</em> <!-->&lt;<!--> <!-->0.01; women: 0.88; <em>p</em> <!-->&lt;<!--> <!-->0.01). The correlation coefficient between HP and estimated total body water was 0.769 for men and 0.63 for women (<em>p</em> <!-->&lt;<!--> <!-->0.01 in both cases). The correlation coefficient between FP and estimated fat mass (FM) standardized by height was 0.83 for men and 0.89 for women (<em>p</em> <!-->&lt;<!--> <!-->0.01). There was a significant decrease in body weight (<em>B</em>: 99.33(15.0)<!--> <!-->kg; 3M: 92.03(16.0)<!--> <!-->kg; <em>p</em> <!-->&lt;<!--> <!-->0.01); and FM (<em>B</em>: 49.93(6.67)<!--> <!-->kg; 3M: 44.22(9.08)<!--> <!-->kg). There was no difference in BCM and fat free mass. In new parameters a decrease in NP (<em>B</em>: +0.50(0.31); 3M: +0.42(0.42); <em>p</em> <!-->=<!--> <!-->0.03) and FP (<em>B</em>: +0.49(0.17) was reported; 3M: +0.38(0.16); <em>p</em> <!-->&lt;<!--> <!-->0.01), although there was no difference in HP.</div></div><div><h3>Conclusions</h3><div>The new interpretation of BIVA as NP and HP have a high correlation with the body composition parameters estimated by regression models, and they report changes in body composition after a partial meal-replacement diet such as regression equations.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 1","pages":"Article 501644"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioactive iodine-induced esophagitis: A rare complication","authors":"Ignacio Jiménez Hernando ,&nbsp;Irene Bretón Lesmes ,&nbsp;Arantxa Díaz Gómez ,&nbsp;Miguel Sebastián Casallas Cepeda ,&nbsp;Santiago Salcedo Cortés","doi":"10.1016/j.endien.2025.501656","DOIUrl":"10.1016/j.endien.2025.501656","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 1","pages":"Article 501656"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in pituitary tumors following the 2022 WHO classification","authors":"Ignacio Ruz-Caracuel","doi":"10.1016/j.endien.2026.501747","DOIUrl":"10.1016/j.endien.2026.501747","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 1","pages":"Article 501747"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin K in home parenteral nutrition: Is it really necessary?","authors":"Estrella Diego ,&nbsp;María del Carmen Farnández ,&nbsp;Beatriz de León ,&nbsp;Andoni Monzón ,&nbsp;Leire Isasa ,&nbsp;Beatriz Sordo ,&nbsp;Nuria Valdés","doi":"10.1016/j.endien.2025.501655","DOIUrl":"10.1016/j.endien.2025.501655","url":null,"abstract":"<div><h3>Introduction</h3><div>Multivitamin preparations with added vitamin K in parenteral nutrition (PN) ensure the coverage of this micronutrient in all adults, as indicated by the latest ESPEN clinical practice guidelines on micronutrients.</div></div><div><h3>Objectives</h3><div>To monitor vitamin K levels after adding this multivitamin with vitamin K in patients requiring home parenteral nutrition (HPN) at <em>Hospital Universitario Cruces</em> (Bilbao, Basque County, Spain) from 2021 to 2022.</div></div><div><h3>Materials and methods</h3><div>We analyzed vitamin K levels were collected 6 months into therapy with the multivitamin containing vitamin K in home parenteral nutrition.</div></div><div><h3>Results</h3><div>At our centre, a total of 8 patients required home parenteral nutrition due to intestinal failure type III, 60% of whom were men, with a mean age of 58<!--> <!-->±<!--> <!-->13 years. The cause of intestinal failure was short bowel syndrome (50%), intestinal mucosal disease (38%), and intestinal dysmotility (12%). After adding the multivitamin with vitamin K, 80% (6/8) of patients exhibited elevated vitamin K levels, with a mean of 4.4<!--> <!-->μl/L.</div></div><div><h3>Conclusions</h3><div>After observing vitamin K levels above the upper limit of normal, we reached consensus with the Pharmacy Service to discontinue this multivitamin and restart conventional multivitamin. After this initiative, the vitamin K levels of our patients normalized.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 1","pages":"Article 501655"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}