Endocrinologia Diabetes Y Nutricion最新文献

{"title":"Quality of life of patients with thyroid cancer in Colombia","authors":"Oscar Gómez ,&nbsp;Alvaro Sanabria","doi":"10.1016/j.endien.2024.03.007","DOIUrl":"https://doi.org/10.1016/j.endien.2024.03.007","url":null,"abstract":"<div><h3>Introduction</h3><p>Quality of life (QoL) in thyroid cancer patients is comparable to patients with other tumours with worse prognosis. The aim was to evaluate QoL in Colombian patients with thyroid carcinoma and to explore the association of QoL scores with patient features.</p></div><div><h3>Methods</h3><p>This is a cross-sectional study. The present research was carried out from data obtained for the validation study of the Spanish version of the THYCA-QoL. Adult patients with thyroid carcinoma who underwent total or partial thyroidectomy were included and asked to complete the Spanish-validated versions of the THYCA-QoL and EORTC QLQ-C30 questionnaires. The scores of each domain and single items underwent linear transformation to values of 0–100. Comparisons of scale scores with clinical variables were performed.</p></div><div><h3>Results</h3><p>We included 293 patients. The global EORTC QLQ-C30 score was 73.2<!--> <!-->±<!--> <!-->22.1 and the domains with poorer values were emotional and cognitive and the symptoms with poorer values were insomnia and fatigue. The global THYCA-QOL score was 28.4<!--> <!-->±<!--> <!-->17.8. The domains with poorer values were neuromuscular and psychological and the single items with poorer values were headaches and tingling hands/feet.</p></div><div><h3>Conclusion</h3><p>Colombian patients with thyroid cancer have a good prognosis, but they experience important problems related to QoL. QoL was influenced by demographic and clinical factors such as age, sex functional status and clinical stage.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 2","pages":"Pages 61-70"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet low in fodmaps: fundamentals, evidence and controversies","authors":"Ana Zugasti Murillo","doi":"10.1016/j.endien.2024.03.002","DOIUrl":"10.1016/j.endien.2024.03.002","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 2","pages":"Pages 41-43"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors associated with glomerular filtration rate in Mexican adults with type 2 diabetes mellitus","authors":"Gloria Mendoza López ,&nbsp;Alva Belen Morales Villar ,&nbsp;Andrea Patricia Tejada Bueno ,&nbsp;Jessica Lozada Hernández ,&nbsp;Luis Rey García Cortes ,&nbsp;Jorge Maldonado Hernández","doi":"10.1016/j.endien.2024.03.003","DOIUrl":"10.1016/j.endien.2024.03.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Type 2 diabetes mellitus (T2DM) is related to glomerular filtration rate (GFR) impairment, which is one of the main causes of chronic kidney disease. The objective of this study was to identify the risk factors related to GFR in Mexican adults with T2DM, using a validated multiple linear regression model (MLRM), with emphasis in body adiposity, glycemic control, duration of the diabetes and other relevant risk factors.</p></div><div><h3>Materials and methods</h3><p>A cross-sectional, analytical, and observational study was carried out in 252 adults with a previous diagnosis of T2DM. Body mass index (BMI) and waist circumference (WC) were determined and a fasting blood sample was collected for glucose, creatinine and HbA1c determinations. GFR was calculated with the Cockcroft–Gault equation adjusted for body surface area. Four MLRM were performed to determine the factors related to the GFR; it was evaluated whether these models complied with the statistical assumptions of the linear regression model.</p></div><div><h3>Results</h3><p>The average age of the participants was 60 ± 12 years, 62.3% of them were women. GFR correlated with BMI and WC; age and duration of the diabetes were associated inversely. Model 4 of the MLRM reported a coefficient of determination of 53.5% where the variables BMI (<em>β</em> = 1.31), male sex (<em>β</em> = −6.01), duration of T2DM (<em>β</em> = −0.57), arterial hypertension (<em>β</em> = −6.53) and age (<em>β</em> = −1.45) were simultaneously and significantly related to the GFR.</p></div><div><h3>Conclusions</h3><p>Older age, male sex, longer duration of T2DM and the presence of arterial hypertension were associated with a decrease in the GFR; BMI and WC were directly associated. No effect of glucose and HbA1c on GFR was observed.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 2","pages":"Pages 44-52"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe hypertriglyceridaemia and hypervitaminosis D secondary to multiple myeloma","authors":"Luis Francisco de Miguel-Rodríguez ,&nbsp;Carla Francés-Artigas ,&nbsp;María Paz Ribas-García ,&nbsp;Laura Pérez-Sanchez ,&nbsp;Carlos Morillas-Ariño","doi":"10.1016/j.endien.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.endien.2024.03.001","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 2","pages":"Pages 88-90"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, glycometric features and treatment in a family with monogenic diabetes due to a new mutation in the insulin gene","authors":"Paloma Pérez López ,&nbsp;Pilar Bahillo Curieses ,&nbsp;Pablo Fernández ,&nbsp;Rosa Martínez ,&nbsp;Esther Delgado ,&nbsp;Ana Ortolá ,&nbsp;Daniel de Luis ,&nbsp;Gonzalo Díaz-Soto","doi":"10.1016/j.endien.2024.03.006","DOIUrl":"https://doi.org/10.1016/j.endien.2024.03.006","url":null,"abstract":"<div><p>Monogenic diabetes caused by changes in the gene that encodes insulin (INS) is a very rare form of monogenic diabetes (&lt;1%). The aim of this work is to describe the clinical and glycaemic control characteristics over time from four members of a family diagnosed with monogenic diabetes with the novel mutation: c.206del,p.(Gly69Aalfs*62) located in exon 3 of the gene INS. 75% are females, with debut in adolescence and negative autoimmunity. In all cases, C-peptide is detectable decades after diagnosis (&gt;0.6<!--> <!-->ng/ml). Currently, patients are being treated either with insulin in a bolus-basal regimen, oral antidiabetics or hybrid closed loop system. Monogenic diabetes due to mutation in the INS is an entity with heterogeneous presentation, whose diagnosis requires high suspicion and presents an important clinical impact. Given the lack of standards in this regard, therapy must be individualized, although insulin therapy could help preserve beta cell functionality in these subjects.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 2","pages":"Pages 77-82"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early nutritional risk detection and intervention in COVID-19 hospitalized patients through the implementation of electronic automatized alarms","authors":"Analía Ramos ,&nbsp;Clara Joaquin ,&nbsp;Mireia Ros ,&nbsp;Mariona Martin ,&nbsp;Montserrat Cachero ,&nbsp;María Sospedra ,&nbsp;Eva Martínez ,&nbsp;Guillem Socies ,&nbsp;Alejandra Pérez-Montes de Oca ,&nbsp;Maria José Sendrós ,&nbsp;Jose Manuel Sánchez-Migallón ,&nbsp;Nuria Alonso ,&nbsp;Manel Puig-Domingo","doi":"10.1016/j.endien.2024.03.008","DOIUrl":"https://doi.org/10.1016/j.endien.2024.03.008","url":null,"abstract":"<div><h3>Introduction</h3><p>Hospitalized COVID-19 patients may present acute malnutrition which could influence morbidity and mortality. In the first wave of the pandemic severe weight loss was observed in many hospitalized patients. This pilot study evaluates the usefulness of an electronic automatized alarm for the early quantification of a low food intake as a predictor of the risk of malnutrition using COVID-19 disease as a model of severe illness.</p></div><div><h3>Methods</h3><p>Observational prospective nutritional screening with a daily automatized warning message to the Endocrinology and Nutrition Service provided by the Information Systems. All adult patients admitted for COVID-19 from November 2020 to February 2021 were included. When diet intake was &lt;50% during consecutive 48<!--> <!-->h, an automated message was generated identifying the patient as “at nutritional risk (NR)” and additional specialist nutritional evaluation and therapy was performed within the next 24<!--> <!-->h.</p></div><div><h3>Results</h3><p>205 patients out of 1176 (17.4%) were detected by automatized alarm and were considered as presenting high NR; 100% were concordant by the validated nutritional screening SNAQ. Nutritional support after detection was: 77.6% dietary adaptation<!--> <!-->+<!--> <!-->oral supplements; 9.3% enteral nutrition (EN); 1.5% parenteral nutrition (PN); 1% EN<!--> <!-->+<!--> <!-->PN and 10.7% no intervention is performed due to an end-of-life situation. Median weight loss during admission was 2.5<!--> <!-->kg (<em>p</em>25 0.25–p75: 6<!--> <!-->kg). Global mortality was 6.7% while in those detected by automatized alarm was 31.5%.</p></div><div><h3>Conclusions</h3><p>The implementation of an electronic NR screening tool was feasible and allowed the early nutritional assessment and intervention in COVID-19 hospitalized patients and can be useful in patients hospitalized for other pathologies.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 2","pages":"Pages 71-76"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes and jaundice in young patients. The importance of extrapancreatic manifestations in the typing of diabetes mellitus","authors":"Víctor José Simón Frapolli,&nbsp;Miguel Damas Fuentes,&nbsp;María José Picón César,&nbsp;Andrea Fernández Valero,&nbsp;Francisco José Tinahones Madueño","doi":"10.1016/j.endien.2024.03.004","DOIUrl":"10.1016/j.endien.2024.03.004","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 2","pages":"Pages 90-91"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of semaglutide on weight loss and glycaemic control in patients with Prader–Willi Syndrome and type 2 diabetes","authors":"Olga Giménez-Palop ,&nbsp;Ana Romero ,&nbsp;Laia Casamitjana ,&nbsp;Rocio Pareja ,&nbsp;Mercedes Rigla ,&nbsp;Assumpta Caixàs","doi":"10.1016/j.endien.2023.12.001","DOIUrl":"https://doi.org/10.1016/j.endien.2023.12.001","url":null,"abstract":"<div><p>Prader–Willi Syndrome (PWS) is the most common genetic cause of obesity, occurring in approximately 1 in 15,000 newborns. It results from the lack of expression of genes on the paternal allele of the chromosomal region 15q-11q13 (65–75% due to type 1 or type 2 deletion). Individuals with PWS experience associated symptoms such as hypotonia, hyperphagia, and early-onset obesity (before 5 years of age). Around 20% of adults with PWS also develop type 2 diabetes. Previous studies have shown the beneficial effects of GLP1-RA medications, such as exenatide and liraglutide, in treating type 2 diabetes in PWS. However, there is limited information available on the use of semaglutide in PWS. This study aimed to evaluate the effects of semaglutide on weight loss and glycaemic control in four patients with PWS and type 2 diabetes associated with obesity. The patients were started on weekly subcutaneous progressive doses of semaglutide.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 2","pages":"Pages 83-87"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the COVID-19 pandemic on gestational diabetes in Castilla-La Mancha (Spain)","authors":"Dulce M.ª Calderón Vicente ,&nbsp;Amparo Marco Martínez ,&nbsp;Inés Gómez García ,&nbsp;Rosa Quílez Toboso ,&nbsp;Iván Quiroga López ,&nbsp;Manolo Delgado Rey ,&nbsp;Javier Gargallo Vaamonde ,&nbsp;María Olmos Alemán ,&nbsp;Raquel Miralles Moragrega ,&nbsp;César Gonzalvo Díaz ,&nbsp;Javier González López ,&nbsp;on behalf of the SCAMEND Group for the Study of Gestational Diabetes during the COVID-19 pandemic","doi":"10.1016/j.endien.2024.03.005","DOIUrl":"10.1016/j.endien.2024.03.005","url":null,"abstract":"<div><h3>Subject-matter</h3><p>To assess the effect of the 2019 coronavirus (COVID-19) pandemic on gestational diabetes (GDM).</p></div><div><h3>Material and methods</h3><p>In this retrospective, multicentre, non-interventional study carried out in Castilla-La Mancha, Spain, we compared 663 women with GDM exposed to the pandemic (pandemic group), with 622 women with GDM seen one year earlier (pre-pandemic group). The primary endpoint was a Large for Gestational Age (LGA) newborn as an indicator of poor GDM control. Secondary endpoints included obstetric and neonatal complications.</p></div><div><h3>Results</h3><p>During the pandemic, the gestational week at diagnosis (24.2 ± 7.4 vs 22.9 ± 7.7, p = 0.0016) and first visit to Endocrinology (26.6 ± 7.2 vs 25.3 ± 7.6, p = 0.0014) were earlier. Face-to-face consultations were maintained in most cases (80.3%). The new diagnostic criteria for GDM were used in only 3% of cases. However, in the pandemic group, the final HbA1c was higher (5.2 ± 0.48 vs 5.29 ± 0.44%, p = 0.047) and there were more LGA newborns (8.5% vs 12.8%, p = 0.015). There were no differences in perinatal complications.</p></div><div><h3>Conclusions</h3><p>Care for GDM in our Public Health System did not significantly deteriorate during the COVID-19 pandemic. However, this did not prevent a higher number of LGA newborns.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 2","pages":"Pages 53-60"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undergraduate and postgraduate training in Endocrinology and Nutrition","authors":"Pedro José Pinés Corrales","doi":"10.1016/j.endien.2024.01.001","DOIUrl":"10.1016/j.endien.2024.01.001","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 1","pages":"Pages 1-3"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}