Endocrinologia Diabetes Y Nutricion最新文献

{"title":"Study of the prevalence of obesity and sedentary lifestyle among school-aged children in the Health Area of Jerez, Northwest Coast and Sierra de Cádiz","authors":"Josefa Rojas Villegas , Lourdes Garcia Garcia-Doncel , Maria Angeles Santos Mata , Yolanda Quirós López , Isabel Morón Rubio","doi":"10.1016/j.endien.2026.501691","DOIUrl":"10.1016/j.endien.2026.501691","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 3","pages":"Article 501691"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaplastic thyroid cancer that responds to treatment with RET inhibitor","authors":"Carlos Ríos Gómez , Alicia Macías Batista , Ignacio García Puente , Laura Esther Guerrero Casanova , Miguel Carnero Gregorio","doi":"10.1016/j.endien.2026.501690","DOIUrl":"10.1016/j.endien.2026.501690","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 3","pages":"Article 501690"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the transtubular potassium gradient: Alternative urinary markers for diagnosing hypoaldosteronism","authors":"Jorge Gabriel Ruiz-Sánchez ,&nbsp;Alfonso Luis Calle-Pascual ,&nbsp;Miguel Ángel Rubio-Herrera ,&nbsp;María Paz De Miguel Novoa ,&nbsp;Emilia Gómez-Hoyos ,&nbsp;Isabelle Runkle","doi":"10.1016/j.endien.2026.501686","DOIUrl":"10.1016/j.endien.2026.501686","url":null,"abstract":"<div><h3>Background</h3><div>The transtubular potassium gradient (TTKG) is a widely accepted tool for assessing mineralocorticoid activity in hyperkalemia. However, its clinical utility is often limited due to the unavailability of urine osmolality. Identifying alternative, more accessible urinary indices could improve diagnostic performance in suspected hypoaldosteronism.</div></div><div><h3>Methods</h3><div>We conducted a retrospective observational study including 106 hyperkalemic patients with hypoaldosteronism referred to Endocrinology Department. Through correlation analyses using Spearman's <em>ρ</em> and Pearson's <em>r</em>, we assessed the relationship between TTKG values and the urinary potassium-to-serum potassium ratio (UK⁺/SK⁺), the urinary potassium-to-creatinine ratio (UK⁺/creatinine), the fractional excretion of potassium (FEK), and the urinary sodium-to-potassium ratio (UNa⁺/UK).</div></div><div><h3>Results</h3><div>Mean age, 74<!--> <!-->±<!--> <!-->12 years; mean TTKG, 3.8<!--> <!-->±<!--> <!-->1.2, and UK⁺/creatinine, 62<!--> <!-->±<!--> <!-->28<!--> <!-->mmol/g. Median UNa⁺/UK⁺, 2.78 [1.81–3.72]; UK⁺/SK⁺, 5.1 [4–6.8]; FEK, 12.9% [7–18.9]. TTKG showed a strong positive correlation with UK⁺/SK⁺ (<em>ρ</em> <!-->=<!--> <!-->0.706; <em>p</em> <!-->&lt;<!--> <!-->0.001) and FEK (<em>ρ</em> <!-->=<!--> <!-->0.585; <em>p</em> <!-->&lt;<!--> <!-->0.001), and a moderate correlation with UK⁺/creatinine (<em>r</em> <!-->=<!--> <!-->0.352; <em>p</em> <!-->=<!--> <!-->0.011). An inverse strong correlation was observed with UNa⁺/UK⁺ (<em>ρ</em> <!-->=<!--> <!-->−0.655; <em>p</em> <!-->&lt;<!--> <!-->0.001).</div></div><div><h3>Conclusions</h3><div>UK⁺/SK, UK⁺/creatinine, FEK, and UNa⁺/UK⁺ seem to be practical alternatives for assessing renal potassium excretion in hyperkalemia associated with hypoaldosteronism. Further studies are warranted to validate these findings in larger and diverse cohorts.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 3","pages":"Article 501686"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Satisfaction associated with gender-affirming hormone therapy","authors":"Lucía Estévez Asensio ,&nbsp;Esther Delgado García ,&nbsp;Marina Gómez Andrés ,&nbsp;María Samaniego Montoro ,&nbsp;Antonia Maniega Rubio ,&nbsp;Carmen Fernández Rodríguez ,&nbsp;Ruth González Collantes ,&nbsp;María José Bartolomé Albistegui ,&nbsp;Marta Alonso Mesonero ,&nbsp;Ana Belén Casas Marcos ,&nbsp;Daniel A. de Luis Román ,&nbsp;Emilia Gómez Hoyos","doi":"10.1016/j.endien.2026.501688","DOIUrl":"10.1016/j.endien.2026.501688","url":null,"abstract":"<div><h3>Introduction</h3><div>Gender Affirming Hormone Therapy (GAHT) improves psychological well-being and certain quality-of-life parameters. Nevertheless, the satisfaction perceived by individuals undergoing this treatment remains unclear. The aim of this study was to assess such satisfaction using the Spanish adaptation of the received treatment satisfaction scale (CRES-4).</div></div><div><h3>Material and methods</h3><div>Cross-sectional observational study among transgender individuals who had been receiving GAHT for &gt;1 year and had not undergone genital reassignment surgery. Participants were recruited from a Transgender Medicine Unit between January 2014 and January 2023. Demographic and clinical data were collected, along with responses to the CRES-4 scale. Statistical analysis performed using SPSS-V-23.</div></div><div><h3>Results</h3><div>Out of the 83 subjects included, 52 (62.7%) were identified as transgender men and 31 (37.3%) as transgender women. The median age at initiation of GAHT was 19 [17–25] years, with a median treatment duration of 3 [1.75–4] years at the time of evaluation. 95% of participants reported being satisfied with GAHT and 75% noted an improvement in the “perceived problem solution” domain. Emotional well-being improved markedly, with 68% reporting an acceptable emotional state after GAHT, compared to 9% before starting treatment. Satisfaction was not significantly associated with treatment duration, psychological comorbidity, age at initiation, non-genital gender-affirming surgeries or type of hormone therapy (feminizing vs. masculinizing).</div></div><div><h3>Conclusions</h3><div>Most transgender individuals reported high levels of satisfaction with GAHT when provided as part of comprehensive biopsychosocial care. The therapy improved emotional well-being and enhanced perceptions of problem resolution.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 3","pages":"Article 501688"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary apoplexy: lessons from the Spanish registry for clinical stratification supported by advanced imaging","authors":"Betina Biagetti","doi":"10.1016/j.endien.2026.501779","DOIUrl":"10.1016/j.endien.2026.501779","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 3","pages":"Article 501779"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health care resource utilization among individuals with diabetes in Spain: Trends from population-based surveys, 2014–2020","authors":"Luyi Zeng-Zhang ,&nbsp;Natividad Cuadrado-Corrales ,&nbsp;Rodrigo Jiménez-García ,&nbsp;Ana López-de-Andrés ,&nbsp;Zichen Ji ,&nbsp;Jose J. Zamorano-León ,&nbsp;Andrés Bodas-Pinedo ,&nbsp;Ana Jiménez-Sierra ,&nbsp;Elena Labajo-Gonzalez ,&nbsp;Javier de Miguel-Diez","doi":"10.1016/j.endien.2026.501684","DOIUrl":"10.1016/j.endien.2026.501684","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus (DM) has a high health care burden. Understanding health care resource use in DM is essential for optimizing services. This study examines health care utilization among individuals with DM in Spain, comparing them to individuals without DM.</div></div><div><h3>Methods</h3><div>This study analyzed data from the 2014 and 2020 European Interview Health Survey for Spain (EHISS). Participants who reported a diagnosis of DM were classified as cases and matched to controls without DM by sex, age, EHISS edition and place of residence. The dependent variables studied were hospitalizations and emergency department visits during the 12 months. Independent variables included sociodemographics, lifestyle, and comorbidity factors.</div></div><div><h3>Results</h3><div>The study included a total of 7854 participants (3927 cases and 3927 controls). A comparison between 2014 and 2020 showed fewer hospitalizations (19.0% vs 16.1%, <em>p</em> <!-->=<!--> <!-->0.018) and emergency department visits (36.2% vs 28.7%, <em>p</em> <!-->&lt;<!--> <!-->0.001) among individuals with DM. Individuals with DM had significantly higher rates of hospitalization (17.5% vs 11.1%; <em>p</em> <!-->&lt;<!--> <!-->0.001) and emergency department visits (32.3% vs 24.6%; <em>p</em> <!-->&lt;<!--> <!-->0.001) vs those without DM. The identified common predictors of hospitalization and emergency department visits were poor self-rated health and cardiac ischemia.</div></div><div><h3>Conclusion</h3><div>We observed a higher health care utilization among individuals with DM and a downward trend from 2014 to 2020. Identifying predictors of health care use may facilitate the development of interventions to reduce health care costs. The results should be interpreted with caution due to limitations, particularly the lack of data on DM type and glycemic control.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 3","pages":"Article 501684"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudomotor dysfunction in type 1 diabetes: A case report","authors":"Juan A. García-Arnés ,&nbsp;Lidia Fernández-Díaz ,&nbsp;Fatima Herrera-Pérez ,&nbsp;Natalia García-Casares ,&nbsp;Marc S. Dawid-Milner","doi":"10.1016/j.endien.2026.501715","DOIUrl":"10.1016/j.endien.2026.501715","url":null,"abstract":"<div><div>Sudomotor dysfunction is a frequent and early sign of diabetic neuropathy. It is a disorder of the autonomic nervous system that involves small fibers and is usually underdiagnosed despite the impact it has on the patients’ quality of life. Its study is recommended as a strategy for early detection as an indicator of dysautonomic dysfunction and management of later complications. Although it can be highly disabling, it often goes unnoticed, as it is considered less alarming than other dysautonomic symptoms. We present the case of a diabetic patient with sudomotor disfunction who underwent a comprehensive autonomic nervous system evaluation. Unlike most related studies, this case highlights a combination of compensatory hyperhidrosis and distal anhidrosis, underscoring the variability in clinical signs of sudomotor dysfunction. Additionally, it demonstrates the importance of autonomic testing in differential diagnosis and emphasizes the need for further research into its pathophysiological mechanisms and effective therapeutic strategies.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 3","pages":"Article 501715"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Looking into the future: The updated Endocrinology and Nutrition residency training program in Spain","authors":"María D. Ballesteros-Pomar ,&nbsp;María Antequera ,&nbsp;Manuel Antonio Botana-López ,&nbsp;Pilar Beato-Víbora ,&nbsp;Luis Eduardo Lander ,&nbsp;Paloma Moreno-Moreno ,&nbsp;Juan Francisco Merino-Torres ,&nbsp;Joana Nicolau ,&nbsp;Luis Vázquez ,&nbsp;Manel Puig-Domingo","doi":"10.1016/j.endien.2026.501714","DOIUrl":"10.1016/j.endien.2026.501714","url":null,"abstract":"<div><h3>Background</h3><div>Endocrinology and Nutrition residency training in Spain (MIR program) is undergoing a major update for the first time since 2006, reflecting rapid advances in endocrine science, technology, and educational standards. Internationally, the European Society of Endocrinology (ESE) has introduced a unified curriculum to harmonize specialist training across Europe, highlighting core competencies and the need for longer training. This article outlines the renewed Spanish Endocrinology-Nutrition MIR program proposal, detailing its modernized curriculum, innovative assessment methods, and the debate on extending training duration.</div></div><div><h3>Advances in modern endocrinology</h3><div>The updated program highlights emerging areas such as molecular endocrinology, technology-enhanced diabetes care, diagnosis and prevention of arteriosclerotic vascular disease, metabolism and rare endocrine disorders, multidisciplinary obesity management, and the central role of nutrition in patient care. These priorities reflect current trends in clinical practice and the forefront of endocrine research.</div></div><div><h3>Assessment innovation</h3><div>New evaluation methods focus on competency-based training, with progressive responsibility, portfolios, workplace-based assessments and entrustable professional activities (EPAs) to ensure trainees attain defined skills. Formal examinations and objective assessments are introduced to standardize certification.</div></div><div><h3>Training duration</h3><div>A pivotal discussion is whether to extend the residency from 4 to 5 years. Given the breadth of endocrinology and ESE recommendations of a 6-year combined internal medicine–endocrinology training, Spanish experts argue a 5th year is “reasonable” to accommodate new technologies and growing complexity although no consensus has been attained so far.</div></div><div><h3>Conclusion</h3><div>The renewed program aligns with international standards and future-proofs endocrinologist training. It balances broad endocrine-nutrition competencies with specialized skills, modern assessment, and potentially longer training to produce experts equipped for evolving healthcare needs.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 3","pages":"Article 501714"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory hypothyroidism and treatment with subcutaneous levothyroxine: a case report","authors":"Isabella Mattei,&nbsp;María Calatayud Gutiérrez,&nbsp;Carla Jimena Santiváñez Pérez","doi":"10.1016/j.endien.2026.501689","DOIUrl":"10.1016/j.endien.2026.501689","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 3","pages":"Article 501689"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of oral semaglutide on quality of life and metabolic parameters in patients with type 2 diabetes mellitus: A multicenter observational study","authors":"Javier Lago Garma ,&nbsp;Cristina Gil Mouce ,&nbsp;Nazareth Rodríguez Novo ,&nbsp;Olaia Díaz Trastoy ,&nbsp;Alicia Santamaría Nieto ,&nbsp;Patricia Pérez Castro ,&nbsp;Carmen Díaz Ortega ,&nbsp;Eva Fernández Rodríguez ,&nbsp;Regina Palmeiro Carballeira ,&nbsp;Iria Pinal Osorio ,&nbsp;Alma Prieto Tenreiro ,&nbsp;Paula Sánchez Sobrino ,&nbsp;Cristina Tejera Pérez ,&nbsp;Francisco Pita Gutiérrez ,&nbsp;Rocío Villar Taibo ,&nbsp;Alfonso Vidal Casariego","doi":"10.1016/j.endien.2026.501713","DOIUrl":"10.1016/j.endien.2026.501713","url":null,"abstract":"<div><h3>Introduction</h3><div>Type 2 diabetes mellitus (T2DM) significantly impacts the patients' quality of life due to chronic complications and associated comorbidities. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated benefits in glycemic control. This study evaluates the effect of oral semaglutide on quality of life, metabolic parameters, and treatment adherence of T2DM patients.</div></div><div><h3>Patients and methods</h3><div>We conducted a multicenter prospective observational study Galicia (Spain). A total of 43 adult T2DM patients on oral semaglutide were evaluated at baseline and 3–6 months later using validated questionnaires (DTSQ and EuroQol), anthropometric measures, and metabolic parameters. Changes in quality of life, HbA1c, weight, lipid profile, and insulin dose were analyzed.</div></div><div><h3>Results</h3><div>Oral semaglutide significantly improved quality of life according to the visual analog scale (from 62.8 to 72.6 points; <em>p</em> &lt; 0.001) and DTSQ questionnaire (from 28.2 to 33.0 points; <em>p</em> &lt; 0.001). Significant reductions were observed in HbA1c (8.3% to 7.2%; <em>p</em> &lt; 0.001) and body weight (−4.9%; <em>p</em> = 0.018). The most common adverse effects were nausea and vomiting, reported by 39.5% of patients, with no impact on the overall quality of life.</div></div><div><h3>Conclusion</h3><div>Oral semaglutide significantly improves quality of life and metabolic parameters in T2DM patients, with good tolerance and low discontinuation rates. These findings support its utility in the comprehensive management of T2DM.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 3","pages":"Article 501713"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}