Prevalence of hypogonadism in men with and without chronic obstructive pulmonary disease: A cross-sectional study

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion Pub Date : 2024-10-01 DOI:10.1016/j.endien.2024.09.006

Horacio Matías Castro , Pablo Knoblovits , Joaquin Maritano Furcada , Eduardo Luis De Vito , Sebastían Matias Suarez , Pablo Rene Costanzo

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引用次数: 0

Abstract

Background

Hypogonadism is a common finding of chronic obstructive pulmonary disease (COPD). However, the prevalence of hypogonadism in COPD varies among studies. The aim of this study was to determine and compare the prevalence of hypogonadism in men with and without COPD.

Methods

We conducted a cross-sectional study with 134 patients with stable COPD and 70 age-matched men with non-COPD. Hypogonadism was defined by the presence of symptoms according to the Androgen Deficiency in Aging Males questionnaire, along with total testosterone deficiency (<300 ng/dL).

Results

Patients had a mean age of 68 years (SD, 6), a body mass index of 28 kg/m² (SD, 6), and 17% were current smokers. The prevalence of hypogonadism was 41.8% in COPD men (N = 56, 95%CI, 33–51) and 10.0% in non-COPD men (N = 7, 95%CI, 4–20), with a prevalence ratio of 4.2 (95%CI, 2.0–8.7, p < 0.001). The prevalence of low total testosterone concentrations (<300 ng/dL) were significantly higher in COPD patients vs the control group (47.0% vs 15.7%, p = <0.001). In the COPD group, 89.3% of patients had hypogonadotropic hypogonadism and 10.7%, hypergonadotropic hypogonadism. The prevalence of hypogonadism was higher in severe vs non-severe COPD patients (55.8% vs 35.2%; p = 0.024).

Conclusions

The prevalence of hypogonadism was high and greater in COPD vs non-COPD men. This study suggests that COPD patients should be screened for hypogonadism.

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患有和未患有慢性阻塞性肺病的男性性腺功能减退症的患病率：一项横断面研究。

背景：性腺功能减退症是慢性阻塞性肺病（COPD）的常见病因。然而，慢性阻塞性肺病患者性腺功能减退症的发病率在不同研究中存在差异。本研究旨在确定并比较患有和未患有慢性阻塞性肺病的男性性腺功能减退症的患病率：我们对 134 名稳定期慢性阻塞性肺病患者和 70 名年龄匹配的非慢性阻塞性肺病男性患者进行了横断面研究。根据 "老年男性雄激素缺乏症 "问卷调查，性腺功能低下的定义是存在症状以及总睾酮缺乏：患者的平均年龄为 68 岁（SD，6），体重指数为 28kg/m2（SD，6），17% 的患者目前吸烟。慢性阻塞性肺病男性的性腺功能减退症患病率为41.8%（N=56，95%CI，33-51），非慢性阻塞性肺病男性的患病率为10.0%（N=7，95%CI，4-20），患病率比为4.2（95%CI，2.0-8.7，p结论：慢性阻塞性肺病男性与非慢性阻塞性肺病男性相比，性腺功能减退症的患病率更高。本研究建议对慢性阻塞性肺病患者进行性腺功能减退症筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrinologia Diabetes Y Nutricion Multiple-

CiteScore

2.10

自引率

10.50%

发文量

期刊介绍： Endocrinología, Diabetes y Nutrición is the official journal of the Spanish Society of Endocrinology and Nutrition (Sociedad Española de Endocrinología y Nutrición, SEEN) and the Spanish Society of Diabetes (Sociedad Española de Diabetes, SED), and was founded in 1954. The aim of the journal is to improve knowledge and be a useful tool in practice for clinical and laboratory specialists, trainee physicians, researchers, and nurses interested in endocrinology, diabetes, nutrition and related disciplines. It is an international journal published in Spanish (print and online) and English (online), covering different fields of endocrinology and metabolism, including diabetes, obesity, and nutrition disorders, as well as the most relevant research produced mainly in Spanish language territories. The quality of the contents is ensured by a prestigious national and international board, and by a selected panel of specialists involved in a rigorous peer review. The result is that only manuscripts containing high quality research and with utmost interest for clinicians and professionals related in the field are published. The Journal publishes Original clinical and research articles, Reviews, Special articles, Clinical Guidelines, Position Statements from both societies and Letters to the editor. Endocrinología, Diabetes y Nutrición can be found at Science Citation Index Expanded, Medline/PubMed and SCOPUS.