Endocrinologia Diabetes Y Nutricion最新文献

{"title":"New lipid-lowering drugs on the horizon. A range of possibilities","authors":"Rosa M. Sánchez-Hernández , Manuel Antonio Botana López","doi":"10.1016/j.endien.2026.501807","DOIUrl":"10.1016/j.endien.2026.501807","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501807"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myostatin in the pituitary–muscle axis: Roles in health and disease","authors":"Pedro Iglesias","doi":"10.1016/j.endien.2026.501757","DOIUrl":"10.1016/j.endien.2026.501757","url":null,"abstract":"<div><div>Myostatin (GDF-8), a TGF-β family myokine, regulates skeletal muscle growth and systemic metabolism and influences pituitary development and hormone secretion. This review summarizes experimental, translational, and clinical data linking myostatin to pituitary biology, including recent mouse evidence identifying muscle-derived myostatin as an endocrine driver of FSH synthesis via activin-type II/TGFBR1 signaling, with human confirmation pending. We analyze how pituitary disorders – growth hormone deficiency, acromegaly, hypercortisolism, central thyroid disease, central hypogonadism, and hypopituitarism – modify myostatin signaling, contributing to sarcopenia, anabolic resistance, and metabolic dysfunction. Across these conditions, human evidence remains limited and confounded by assay heterogeneity and comorbidities, as circulating myostatin often fails to mirror intramuscular changes. We propose an evidence framework emphasizing standardized assays (mature vs latent forms), longitudinal clinical cohorts, and integration of hormonal and functional endpoints. Myostatin remains a promising yet unvalidated biomarker and therapeutic target in endocrine-related muscle disease.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501757"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HbA1c and hemoglobin “La Desirade” are they compatible for monitoring patients with diabetes? Contribution of a clinical case","authors":"Alba Barreiro Lusquiños,&nbsp;Ramiro Antonio Torrado Carrión,&nbsp;Carmen Blanco Barros","doi":"10.1016/j.endien.2026.501731","DOIUrl":"10.1016/j.endien.2026.501731","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501731"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of malnutrition, sarcopenia, and sarcopenic obesity in patients with heart failure","authors":"M. Carmen Dameto Pons,&nbsp;Elena González Arnáiz,&nbsp;María Antequera González,&nbsp;María Casado Rodríguez,&nbsp;Diana García Sastre,&nbsp;María García Duque,&nbsp;Javier Castañón Alonso,&nbsp;Diana Ariadel Cobo,&nbsp;María D. Ballesteros Pomar","doi":"10.1016/j.endien.2026.501718","DOIUrl":"10.1016/j.endien.2026.501718","url":null,"abstract":"<div><h3>Introduction</h3><div>Malnutrition, sarcopenia and sarcopenic obesity have a significant impact on patients with heart failure. Therefore, it is important to perform nutritional assessment in this group of patients. The aim of this study is to determine the prevalence of malnutrition, sarcopenia and sarcopenic obesity in patients with heart failure, assess their quality of life, and eventually reassess their nutritional status.</div></div><div><h3>Methodology</h3><div>We conducted an observational study of patients with heart failure randomly referred by thecCardiology department and examined from 2021 through 2022 in the Nutrition department and then re-evaluated in 2024. The diagnosis of malnutrition was established using the GLIM criteria; sarcopenia was diagnosed according to EWGSOP2, and sarcopenic obesity according to the ESPEN/EASO criteria.</div></div><div><h3>Results</h3><div>A total of 41 patients were evaluated between 2021 and 2022, of whom 23 were re-evaluated in 2024. A total of 82.6% were men (mean age, 64 yeras [SD, 10.6]). Initially the prevalence of malnutrition was 21.7%; sarcopenia, 8.7%; and sarcopenic obesity, 4.3%. Caloric and protein requirements were not reached in 63.2% and 47.4%, respectively. A total of 26.1% of patients had a low calf circumference (CC) value; 100% had low lower limb strength, 90.9% had low gait speed, and 50% had low stability. All patients (100%) had a good quality of life as assessed by the MLHFQ questionnaire. At reassessment, the prevalence of malnutrition was 21.7%; sarcopenia, 17.4%; and sarcopenic obesity, 8.7%. Caloric and protein requirements were not reached in 60.9% and 78.3%, respectively. Furthermore, 52.2% had low CC value, 100% had low lower limb strength, 91.3% had low speed and 43.5% had low stability. A total of 91.3% had a good quality of life as assessed by the MLHFQ questionnaire.</div></div><div><h3>Conclusions</h3><div>Approximately 20% of patients with heart failure exhibit malnutrition at initial assessment and during follow-up. A high percentage of patients do not achieve nutritional requirements, presenting deterioration in functional tests and worsening quality of life. It is therefore advisable to establish early and sustained nutritional screening and assessment strategies in these patients, establishing the appropriate nutritional medical treatment.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501718"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between benefit and risk: The role of dietary supplements in endocrinology","authors":"Cristina Tejera-Pérez","doi":"10.1016/j.endien.2026.501711","DOIUrl":"10.1016/j.endien.2026.501711","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501711"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopathological aspects of EDs in adolescents with type 1 diabetes: Findings from the DEPS-R and clinical outcomes","authors":"Meliha Esra Bilici ,&nbsp;Hümeyra Altıntaş ,&nbsp;Elif Özsu ,&nbsp;Zeynep Şıklar ,&nbsp;Merih Berberoğlu ,&nbsp;Zehra Aycan","doi":"10.1016/j.endien.2026.501719","DOIUrl":"10.1016/j.endien.2026.501719","url":null,"abstract":"<div><h3>Objective</h3><div>Adolescence is marked by significant physiological and psychological changes that can lead to body image dissatisfaction and eating disorders (ED). Adolescents with type 1 diabetes mellitus (T1DM) may engage in restrictive dieting or insulin manipulation to control weight, risking severe complications. This study aims to identify adolescents with T1DM at risk for diabetes-specific eating behaviors using the Diabetes-Specific Eating Problems Scale-Revised (DEPS-R) and assess associated psychopathological factors, including diabulimia.</div></div><div><h3>Methods</h3><div>Adolescents (10–18 years) with T1DM who were under follow-up in our clinic within the past year were included. Patients were categorized into 3 metabolic control groups according to HbA1c levels: good (&lt;7%), moderate (7–9%), and poor (&gt;9%) based on the cumulative glycemic index that was calculated from the average HbA1c values over the past year. Eating behaviors were assessed using the DEPS-R scale, with scores<!--> <!-->≥<!--> <!-->20 indicating risk for ED. Individuals with high DEPS-R scores (at-risk group) were referred for psychiatric evaluation.</div></div><div><h3>Results</h3><div>A total of 11.2% our of 80 adolescents, were identified as at risk for EDs. The mean DEPS-R score of the at-risk group was significantly higher vs the other group (25.8<!--> <!-->±<!--> <!-->3.5 vs 10.0<!--> <!-->±<!--> <!-->4.6, <em>p</em> <!-->&lt;<!--> <!-->0.001). No significant differences were observed for age, gender, height SDS, and relative BMI. Although the at-risk group had a higher cumulative glycemic index and longer diabetes duration, there was no statistical significance (<em>p</em> <!-->=<!--> <!-->0.29, 0.28, respectively). Logistic regression analysis, adjusted for age, sex, diabetes duration, and comorbidities, did not identify statistically significant predictors of high DEPS-R scores. A weak positive correlation was found between high DEPS-R scores and basal-bolus insulin therapy (<em>r</em> <!-->=<!--> <!-->0.09, <em>p</em> <!-->=<!--> <!-->0.03). Psychopathology was observed in 55% of high-risk adolescents, with a higher prevalence in the poor metabolic control subgroup.</div></div><div><h3>Conclusion</h3><div>Although the DEPS-R scale is a valuable tool for identifying not only EDs but also early changes in eating behaviors in adolescents with T1DM, psychiatric evaluation is essential for confirming underlying psychopathology. Psychological factors play a key role in shaping eating behaviors, highlighting the need for integrated care combining diabetes management with psychological support.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501719"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sternoclavicular osteomyelitis and secondary mediastinitis in patients with diabetes: A case series from a Mexican tertiary referral center","authors":"Alejandro Hernández-Solís,&nbsp;Pablo Álvarez-Maldonado,&nbsp;Diego A. Vidales-Torres,&nbsp;Kevin H. Arizmendi-Venegas,&nbsp;Francisco Navarro-Reynoso","doi":"10.1016/j.endien.2026.501712","DOIUrl":"10.1016/j.endien.2026.501712","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501712"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Web-based application for the interpretation of adrenal vein sampling results","authors":"Marta Gallach Martínez,&nbsp;José Joaquín Alfaro Martínez,&nbsp;Silvia Aznar Rodríguez,&nbsp;Cristina Lamas Oliveira,&nbsp;César Gonzalvo Díaz","doi":"10.1016/j.endien.2026.501723","DOIUrl":"10.1016/j.endien.2026.501723","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501723"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency and depression in diabetes mellitus: A systematic review and meta-analysis","authors":"Miriam Hernández-López ,&nbsp;Mónica Grande-Alonso ,&nbsp;Soledad Aguado-Henche ,&nbsp;Rafael Ramírez-Carracedo ,&nbsp;Alba Sebastián-Martín ,&nbsp;Rafael Moreno-Gómez-Toledano","doi":"10.1016/j.endien.2026.501743","DOIUrl":"10.1016/j.endien.2026.501743","url":null,"abstract":"<div><div>Diabetes mellitus (DM) is a major global health concern with rising prevalence and significant comorbidities. Among modifiable risk factors, vitamin D (VD) deficiency has been increasingly associated with both the development of DM and the presence of depressive symptoms. Given the relevance of psychological health in diabetes management, exploring the interrelationship between VD, depression, and diabetes is of growing scientific interest. To investigate this triad, we conducted a systematic review of human cohort studies across PubMed and Web of Science, focusing on the relationship between VD status and depression in diabetic patients. Meta-analyses were performed with Review Manager (RevMan 5.3, Cochrane, London, United Kingdom) using the inverse variance method, and funnel plots assessed publication bias. Despite the limited and heterogeneous literature, pooled analyses revealed a significant inverse association between VD levels and depression in diabetes (OR, 0.90, 95%CI, 0.84–0.96). Future longitudinal and interventional studies are needed to clarify causal pathways, considering sex differences and body composition. Confirming this relationship could inform preventive strategies that improve the quality of life of diabetic patients through targeted nutritional and vitamin-based interventions.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501743"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RECALSEEN 2024. Resources and quality in the endocrinology and nutrition units of the National Health System of Spain","authors":"M. Julia Ocón Bretón ,&nbsp;Juan José Díez ,&nbsp;Gabriel Olveira Fuster ,&nbsp;Alberto Fernández Martínez ,&nbsp;Alba Galdón Sanz-Pastor ,&nbsp;Nuria Vilarrasa García ,&nbsp;Beatriz Lardies Sánchez ,&nbsp;Emma Anda Apiñaniz ,&nbsp;Francisco Pita Gutiérrez ,&nbsp;Manuel Gahete Ortiz ,&nbsp;Juan José López Gómez ,&nbsp;Rosa Casañ Fernández ,&nbsp;Miguel Ángel Rubio Herrera ,&nbsp;Náyade del Prado ,&nbsp;Javier Escalada San Martín ,&nbsp;Francisco Javier Elola Somoza ,&nbsp;Ignacio Bernabeu Morón","doi":"10.1016/j.endien.2026.501729","DOIUrl":"10.1016/j.endien.2026.501729","url":null,"abstract":"<div><h3>Objectives</h3><div>RECALSEEN analyses the structure, activity and results of the Endocrinology and Nutrition Services and Units (S-U_EyN) of the Spanish National Health System (SNHS). This article presents data collected from the 2024 survey, as well as activity and outcome indicators from the SNHS Minimum Basic Data Set (CMBD) for 2007–2022.</div></div><div><h3>Material and methods</h3><div>Descriptive cross-sectional study of S-U_EyN in general acute care hospitals of the SNHS. Data obtained through an ad hoc survey referring to data from 2023 and discharges from S-U_EyN recorded in the CMBD (2022) were used.</div></div><div><h3>Results</h3><div>A total of 116 responses were obtained from S-U_EyN of 160 general acute care hospitals in the SNHS (72%). Fifty-six per cent of the S-U_EyN respondents were services or clinical management units. The average number of endocrinologists per S-U_EyN department was 8.4 (5.4), with an estimated rate of 2.9 endocrinologists per 100,000 inhabitants. In 74% of hospitals there is a Clinical Nutrition Unit (dependent on the S-U_EyN in 93% of cases) and 39% of S-U_EyNs have a day hospital. The portfolio of services offered by S-U_EyN is closely related to the complexity of the hospital. There is a significant trend to decline in hospitalisations for endocrine and nutritional diseases. Notable differences were found in resources, activity and outcomes between hospitals and autonomous communities. In relation to quality management and the implementation of good practices, there was still considerable room for improvement. The trend to worsening of short- and long-term complication indicators for diabetes mellitus in the period 2016–2022 should be analysed.</div></div><div><h3>Conclusions</h3><div>RECALSEEN provides relevant information on S-U_EyN and the evolution of endocrinology and nutrition care in the SNHS.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501729"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}