Endocrinologia Diabetes Y Nutricion最新文献

{"title":"Functional structure of a high resolution thyroid nodule unit. Economic impact and results of its implementation in an Endocrinology department","authors":"Javier Bodoque Cubas ,&nbsp;José Fernández Sáez ,&nbsp;Sergio Martínez Hervás ,&nbsp;José Vicente Gil Boix ,&nbsp;Juan José Salazar González ,&nbsp;Raquel María Pallarés Gasulla ,&nbsp;Marcella Miret Llauradó ,&nbsp;Iñaki Argüelles Jiménez ,&nbsp;Santiago Tofé Povedano","doi":"10.1016/j.endien.2024.04.004","DOIUrl":"10.1016/j.endien.2024.04.004","url":null,"abstract":"<div><h3>Background and objective</h3><p>The high incidence of nodular thyroid pathology has led to growing concern about the economic impact that this pathology represents on the healthcare system. There are conclusive data about the cost-effectiveness of high-resolution units for nodular thyroid pathology; however, their implementation is not homogeneous in the Endocrinology and Nutrition services of our country. The objective of the present study was to evaluate the economic impact of the implementation of the high-resolution thyroid nodule unit (HRTNU) in our center.</p></div><div><h3>Patients and methods</h3><p>The present work is a prospective, observational and descriptive study carried out in 1314 patients (82% women, mean age 58 years ds = 11) evaluated at the HRTNU during the period of August 2022–August 2023. Demographic data (age and sex) were analyzed, referral center and consultation type, number of total consultations and neck ultrasound performed, number of fine needle aspiration (FNAB) performed, and cytology results were analyzed.</p></div><div><h3>Results</h3><p>In the period from August 2022 to August 2023, a total of 1314 patients were evaluated (neck ultrasound and clinical consultation) and a total of 133 FNAB were performed, of which only 2.26% were non-diagnostic. Compared to the percentage of unsatisfactory FNAB from the previous year August 2021–July 2022 of 25%, a mean saving of 9931.43 euros was estimated. 84.47% of the patients evaluated for the first time by the HRTNU were discharged, estimating a mean saving of 133,200 euros.</p></div><div><h3>Conclusions</h3><p>The implementation of a HRTNU at the Endocrinology and Nutrition departments, coordinated with primary and specialized care, is a cost-effectiveness alternative, as it reduces the number of medical consultations and is accompanied by a higher rate of diagnostic FNAB.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 7","pages":"Pages 290-297"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of oral supplementation with whey protein on muscle mass in adults with type 2 diabetes mellitus: a systematic review of randomized controlled trials","authors":"David López-Daza ,&nbsp;Natalia López-Ucrós ,&nbsp;Cristina Posada-Álvarez ,&nbsp;Patricia Savino-Lloreda","doi":"10.1016/j.endien.2024.07.002","DOIUrl":"10.1016/j.endien.2024.07.002","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the overall effect of whey protein supplementation on skeletal muscle mass in adults with type 2 diabetes mellitus (T2DM).</p></div><div><h3>Methods</h3><p>Systematic review of reports on corporal muscle mass from clinical trials that assessed the use of whey protein supplementation by means of validated techniques in patients with T2DM. PubMed, SCOPUS, Web of Science, LILACS, and SciELO databases were searched up to April 2022. Risk of bias was assessed by the Cochrane Collaboration Risk of Bias tool. We conducted a qualitative synthesis of information.</p></div><div><h3>Results</h3><p>Four studies (424 participants) that met the selection criteria were identified out of 1,787 records. Of these, 3 studies assessed the total muscle mass using dual-energy X-ray absorptiometry (DXA), and 1 reported changes to the transverse diameter of the vastus lateralis muscle with ultrasound imaging. In the intervention groups, DXA assessments demonstrated an increase in total muscle mass in 3 studies and in the appendicular muscle mass in 2. Changes to the proportion of muscle mass were not seen in the DXA studies and only a discrete difference was seen in the comparative groups studied by ultrasound imaging.</p></div><div><h3>Conclusion</h3><p>Following the administration of whey protein supplementation in patients with T2DM, a partially positive effect was seen in skeletal muscle mass gain with a moderate certainty of evidence.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 7","pages":"Pages 308-316"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing the management of diabetes: The promise of connected insulin pens and caps","authors":"Fernando Gómez-Peralta,&nbsp;Cristina Abreu","doi":"10.1016/j.endien.2024.04.005","DOIUrl":"10.1016/j.endien.2024.04.005","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 7","pages":"Pages 275-277"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posthemithyroidectomy hypothyroidism. Prevalence and predictive markers. Comparison between patients with euthyroid and hyperthyroid nodular goitre","authors":"Luis García Pascual ,&nbsp;Carlos Puig-Jové ,&nbsp;Andreu Simó-Servat ,&nbsp;Lluís García-González","doi":"10.1016/j.endien.2024.05.003","DOIUrl":"10.1016/j.endien.2024.05.003","url":null,"abstract":"<div><h3>Background and objective</h3><p>Posthemithyroidectomy hypothyroidism (PHH) is a relatively common complication (22%–30%) for which we have no published information from our country. The objective of the study is to determine the prevalence of PHH and evaluate its predictive markers by comparing patients who had euthyroidism with those who had hyperthyroidism before hemithyroidectomy.</p></div><div><h3>Patients and method</h3><p>Retrospective observational cross-sectional study on 106 patients, 88 euthyroid before hemithyroidectomy and 18 hyperthyroid.</p></div><div><h3>Results</h3><p>Prevalence of PHH in euthyroid patients 42% (89.2% subclinical hypothyroidism; 10.8% manifest hypothyroidism) and in hyperthyroid patients 50% (77.8% subclinical hypothyroidism; 22.2% manifest hypothyroidism). Predictive markers in euthyroid patients: preoperative thyrotropin ≥ 2.2 mIU/L (OR: 4.278, 95% CI: 1.689−10.833; sensitivity: 54.1%, 95% CI: 38%–70.1%; specificity: 78.4%, 95% CI: 67.1%–89.7%), age ≥50 years (OR: 3.509, 95% CI: 1.438–8.563; sensitivity: 64.9%, 95% CI: 49.5%–80.3%; specificity: 64.7%, 95% CI: 51.6%–77.8%) and percentage of remainder lobe ≤ 19.6% (OR: 1.024, 95%: 1.002–1.046; sensitivity: 70.2%, 95% CI: 55.5%–84.9%; specificity: 48.6%, 95% CI: 34.9%–62.3%). Predictive marker in hyperthyroid patients: weight &gt;70 kg (OR: 28, 95% CI: 2.067–379.247; sensitivity: 88.9%, 95% CI: 68.4%–100%; specificity: 88.9%, 95% CI: 68.4%–100%).</p></div><div><h3>Conclusions</h3><p>This is the first study in our country that demonstrates a prevalence of PHH above the average in euthyroid patients, which is slightly higher and more intense in hyperthyroid patients, and that recognizes the classic predictive markers in euthyroid patients but highlights a novel predictive marker marker in hyperthyroid patients, useful to assess a different risk of PHH when indicating hemithyroidectomy and to establish closer control of postoperative hormonal evolution.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 7","pages":"Pages 298-307"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective observational study on real world use of the Minimed™ 780G automated insulin delivery system: Impact of the settings on autocorrection and omitted meal boluses","authors":"Fidel Jesús Enciso Izquierdo,&nbsp;María José Amaya García,&nbsp;Ana Alejandra Cordero Vaquero,&nbsp;Jose Antonio Lucas Gamero,&nbsp;Paula Gomez-Barrado Turégano,&nbsp;María Luengo Andrada,&nbsp;Andrea Cordero Pearson,&nbsp;Rocío Jazmín Grau Figueredo","doi":"10.1016/j.endien.2024.03.019","DOIUrl":"10.1016/j.endien.2024.03.019","url":null,"abstract":"<div><h3>Introduction</h3><p>The Medtronic MiniMed™ 780G (MM780G) system uses an algorithm that includes autocorrection bolus (AB) delivery. This study evaluates the impact of omitted meal boluses and the system settings, glucose target and active insulin time (AIT), on the AB.</p></div><div><h3>Method</h3><p>Retrospective observational study on data uploaded by all MiniMed 780G users in our healthcare area, obtained through the remote monitoring platform Care Connect, from April to August 2023. Downloads with a sensor usage time &lt;95% were excluded.</p></div><div><h3>Results</h3><p>235 downloads belonging to 235 users were analysed. AB delivery was significantly higher at 2 h AIT (36.08 ± 13.17%) compared to the rest of settings (2.25–4 h) (26.43 ± 13.2%) (p &lt; 0.001). AB differences based on the glucose target were not found.</p><p>Patients with &lt;3 meal boluses per day had higher AB delivery (46.91 ± 19.00% vs 27.53 ± 11.54%) (p &lt; 0.001) and had more unfavourable glucometric parameters (GMI 7.12 ± 0.45%, TIR 67.46 ± 12.89% vs GMI 6.78 ± 0.3%, TIR 76.51 ± 8.37%) (p &lt; 0.001). However, the 2-h AIT group presented similar TAR, TIR and GMI regardless of the number of meal boluses.</p></div><div><h3>Conclusion</h3><p>The fewer user-initiated boluses, the greater the autocorrection received. The active insulin time of 2 h entails a more active autocorrection pattern that makes it possible to more effectively compensate for the omission of meal boluses without increasing hypoglycaemias.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 6","pages":"Pages 229-235"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New approaches to refractory necrobiosis lipoidica with photodynamic therapy: Case report","authors":"A. López Montalbán ,&nbsp;A. López Ávila","doi":"10.1016/j.endien.2024.05.002","DOIUrl":"10.1016/j.endien.2024.05.002","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 6","pages":"Pages 271-273"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of coffee intake on appetite parameters in woman with overweight or obesity: A pilot crossover randomized trial","authors":"Lisset Magaña-de la Vega ,&nbsp;Erika Martínez-López ,&nbsp;Tania Sanchez-Murguia ,&nbsp;Andrea Madrigal-Juárez ,&nbsp;Saraí Citlalic Rodríguez-Reyes ,&nbsp;Ivan Aguilar-Vega ,&nbsp;Nathaly Torres-Castillo","doi":"10.1016/j.endien.2024.03.021","DOIUrl":"10.1016/j.endien.2024.03.021","url":null,"abstract":"<div><h3>Introduction</h3><p>Coffee consumption has demonstrated an effect on the regulation of appetite, causing less hunger and/or greater satiety; however, its effects are not well known in woman with overweight or obesity. Therefore, this study aimed to evaluate the effect of coffee consumption on hunger, satiety, sensory specific desire (SSD), and dietary intake in women with overweight or obesity.</p></div><div><h3>Methodology</h3><p>A randomized crossover clinical trial was realized in 3 sessions: in the first session a clinical history, anthropometric measurements and body composition analysis were performed; in sessions 2 and 3 the participants randomly consumed 240<!--> <!-->mL of coffee with 6<!--> <!-->mg/caffeine/kg of weight or 240<!--> <!-->mL of water along with a standardized breakfast. At fasting and every 30<!--> <!-->min after breakfast for the next 3<!--> <!-->h, appetite sensations and SSD were recorded using visual analog scales. Blood samples were taken at fasting, 30 and 180<!--> <!-->min after breakfast. Dietary intake was recorded in the rest of the intervention days.</p></div><div><h3>Results</h3><p>In the coffee intervention there was an increased desire for sweet foods, higher fructose intake during the rest of the day, and higher triglyceride levels than with the water intervention. No differences were detected in ghrelin or cholecystokinin.</p></div><div><h3>Conclusions</h3><p>Coffee consumption may lead to higher triglycerides and higher intake of simple sugars, mainly fructose, through changes in the SSD.</p><p>Clinical Trial Registration: <span>https://clinicaltrials.gov/</span><svg><path></path></svg> <span>NCT05774119</span><svg><path></path></svg>.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 6","pages":"Pages 236-245"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of socioeconomic factors on glycemic control, therapeutic adherence and quality of life in children and adolescents with type 1 diabetes","authors":"Carmen Yoldi-Vergara ,&nbsp;Ignacio Conget-Donlo ,&nbsp;Roque Cardona-Hernandez ,&nbsp;Marta Ramon-Krauel","doi":"10.1016/j.endien.2024.04.003","DOIUrl":"10.1016/j.endien.2024.04.003","url":null,"abstract":"<div><h3>Objective</h3><p>To stablish the relationship between socioeconomic status of a cohort of children and adolescents with type 1 diabetes (T1D) with glycemic control, therapeutic adherence and diabetes quality of life (DQoL).</p></div><div><h3>Patients y methods</h3><p>A cross-sectional, observational study with consecutive inclusion was carried out. Participants aged 8–18 years with T1D duration &gt;1 year. Data on family structure, family income, parents’ educational level and parental role on primary diabetes care supervision were registered. Adherence (DMQ-Sp) and DQoL (PedsQl) were analyzed. Linear and logistic regression models adjusted for demographics, family structure and parental role on primary diabetes care responsibility were applied.</p></div><div><h3>Results</h3><p>A total of 323 patients (T1D duration 5,3 ± 3,3 years; HbA1c 7,7 ± 1,0%; age 13,3 ± 2,8 years; 49,8% females) were included. Patients living in a nuclear family and those whose main diabetes care supervision was shared by both parents showed lower HbA1c [adjusted for demographics and family structure (7,06; CI 95% 6,52–7,59); adjusted for demographics and role on primary diabetes care supervision (7,43; CI 95% 6,57–8,28)]. DMQ-Sp score (adjusted for demographics and role on main supervision) was higher in patients whose parents shared the diabetes care supervision (84,56; CI 95% 73,93–95,19). Parents sharing diabetes care supervision showed a significantly higher PedsQl score (both 74,63 ± 12,70 vs mother 68,53 ± 14,59; p = 0,001).</p></div><div><h3>Conclusions</h3><p>Children and adolescents with T1D had lower HbA1c, better therapeutic adherence and better DQoL when lived in a nuclear family, with higher socioeconomic status and the responsibility for supervising diabetes care was shared by both parents.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 6","pages":"Pages 253-262"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum cholesterol levels are inversely associated with the risk of malignancy in subjects with Bethesda category IV thyroid nodules","authors":"Beatriz Montejo-Marcos ,&nbsp;Yaiza López-Plasencia ,&nbsp;Dunia Marrero-Arencibia ,&nbsp;Carlos A. Rodríguez-Pérez ,&nbsp;Mauro Boronat","doi":"10.1016/j.endien.2024.03.022","DOIUrl":"10.1016/j.endien.2024.03.022","url":null,"abstract":"<div><h3>Introduction</h3><p>Some epidemiological data suggest that there may be an inverse relationship between cholesterol levels and the risk of thyroid cancer in the overall population. The present study was aimed to evaluate the lipid profile specifically in subjects with Bethesda category IV thyroid nodules, and compare whether there were any differences between those with benign and malignant nodules.</p></div><div><h3>Methods</h3><p>Single-centre, retrospective study on 204 subjects treated by partial or total thyroidectomy for excision of a Bethesda category IV thyroid nodule, who had undergone a blood lipid profile test in the 12 months prior to surgery. In addition to lipid measures, other demographic, clinical, biochemical and ultrasound data were collected.</p></div><div><h3>Results</h3><p>Seventy-five subjects (36.8%) were diagnosed with thyroid carcinoma in the definitive histopathological examination. Patients with thyroid cancer had lower levels of total cholesterol, LDL-cholesterol and non-HDL-cholesterol than subjects with benign thyroid diseases. There were no differences in HDL-cholesterol, triglycerides or total cholesterol/HDL-cholesterol ratio. There were no differences either between groups in other clinical, biochemical and ultrasound variables, including the use of lipid-lowering drugs. In multivariate analysis, only LDL-cholesterol was independently associated with malignancy. Subjects with follicular carcinoma showed the lowest cholesterol levels, while those with papillary carcinoma had intermediate values between the group with follicular carcinoma and the group with benign thyroid diseases.</p></div><div><h3>Conclusions</h3><p>In subjects with cytologically indeterminate Bethesda category IV thyroid nodules, levels of total cholesterol, non-HDL-cholesterol and, particularly, LDL-cholesterol are lower among those with malignant nodules.</p></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 6","pages":"Pages 246-252"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized medicine in type 1 diabetes: The influence of socioeconomic context","authors":"Fernando Sebastian-Valles","doi":"10.1016/j.endien.2024.05.001","DOIUrl":"10.1016/j.endien.2024.05.001","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 6","pages":"Pages 227-228"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141444119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}