Endocrinologia Diabetes Y Nutricion最新文献

{"title":"Comparison of carbohydrate assessment metrics for predicting fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus","authors":"Qianqian Tian ,&nbsp;Qing Jiang ,&nbsp;Shanshan Ma ,&nbsp;Fangyi Yu ,&nbsp;Xiaohan Tan ,&nbsp;Bin Liu ,&nbsp;Jifang Zhu ,&nbsp;Xiaohua Wang","doi":"10.1016/j.endien.2026.501742","DOIUrl":"10.1016/j.endien.2026.501742","url":null,"abstract":"<div><h3>Background</h3><div>Fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) are critical short-term indicators of glycemic control in type 2 diabetes mellitus (T2DM). Although carbohydrate assessment metrics – carbohydrate (g/d), carbohydrate portion, carbohydrate (%), low carbohydrate diet (LCD) score, carbohydrate to fiber ratio (CFR), and dietary fiber (DF) – may differ in predicting FPG and PPG, their comparative efficacy is unclear. This study aims to identify the most predictive carbohydrate assessment metrics for FPG and PPG, facilitating timely dietary interventions to optimize glycemic management in patients with T2DM.</div></div><div><h3>Methods</h3><div>This cross-sectional study assessed six carbohydrate metrics in 238 patients with T2DM. FPG and PPG were measured (uncontrolled: FPG ≥7.0<!--> <!-->mmol/L, PPG ≥10.0<!--> <!-->mmol/L). Multiple logistic regression and the receiver operating characteristic curve (ROC) analyses evaluated predictive performance.</div></div><div><h3>Results</h3><div>Carbohydrate (%) and LCD score were the strongest predictors of FPG and PPG. Higher carbohydrate (%) was significantly associated with poorer FPG (OR, 0.942, 95%CI, 0.907–0.979, <em>P</em> <!-->&lt;<!--> <!-->0.01) and PPG control (OR, 0.920, 95%CI, 0.875–0.968, <em>P</em> <!-->&lt;<!--> <!-->0.01), while higher LCD score improved odds of control (FPG: OR, 1.073; PPG: OR, 1.128, both <em>P</em> <!-->&lt;<!--> <!-->0.01). ROC analysis identified carbohydrate (%) as the optimal predictor for PPG (AUC, 0.7201, cutoff &gt;51.50%; sensitivity, 80.77%) and FPG (AUC, 0.6751, cutoff &gt;55.50%; sensitivity, 66.47%), followed by LCD score (PPG AUC, 0.7153; FPG AUC, 0.6689).</div></div><div><h3>Conclusion</h3><div>Carbohydrate (%) and LCD score most effectively predict short-term glycemic control in T2DM. Limiting carbohydrate intake to ≤51.5% (PPG) or ≤55.5% (FPG) of energy and achieving LCD scores &gt;23.5 (PPG) or &gt;16.5 may optimize outcomes, guiding personalized dietary interventions.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 5","pages":"Article 501742"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147865392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemoglobin Yanase can lead to inaccurate diabetes diagnoses when using HbA1c measurement by HPLC","authors":"Pedro Moral Parras ,&nbsp;Alba Martínez Chamorro ,&nbsp;Luis Romero Reyes ,&nbsp;Paloma Ropero Gradilla ,&nbsp;Antonio Fernández Suárez","doi":"10.1016/j.endien.2026.501716","DOIUrl":"10.1016/j.endien.2026.501716","url":null,"abstract":"<div><div>Glycated hemoglobin (HbA1c) is essential for diagnosing and monitoring diabetes mellitus (DM). However, hemoglobin (Hb) variants can alter its measurement using high-performance liquid chromatography (HPLC), compromising the patients’ diagnosis and follow-up. The limited information in databases such as HbVar and IthaNet makes it difficult to interpret and classify these variants.</div><div>HbA1c levels in the patient group were uninterpretable when measured using ion-exchange HPLC (Tosoh G8), suggesting possible assay interference. By using alternative methods of immunoassay and capillary electrophoresis, normal HbA1c concentrations were obtained. Genetic testing in all patients confirmed the presence of a variant in the Hb α2 gene, Hb-Yanase.</div><div>Hb-Yanase is a poorly documented variant globally, which could be underestimated in Spain. Its phenotype and degree of pathogenicity are uncertain due to the small number reported and the existence of outdated databases. In the described group, no patient showed variant-related pathophysiological alterations.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 5","pages":"Article 501716"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147865418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and treatment of solitary fibrous tumors of the thyroid gland: the importance of an appropriate diagnostic approach","authors":"Maria Teresa Soriano Palao ,&nbsp;Miriam Abellán Lucas ,&nbsp;Juan José Ruiz Manzanera ,&nbsp;Álvaro Cerezuela Fernández de Palencia ,&nbsp;Beatriz Febrero Sánchez ,&nbsp;José Manuel Rodríguez González","doi":"10.1016/j.endien.2026.501744","DOIUrl":"10.1016/j.endien.2026.501744","url":null,"abstract":"<div><div>Solitary fibrous tumor (SFT) is a type of fibroblastic neoplasm with characteristic histological features, typically showing cytoplasmic expression of CD34 and nuclear expression of STAT6, associated with NAB2-STAT6 gene fusion. Thyroid localization is exceptionally rare, with only 51 cases reported worldwide to date. Its behavior in the thyroid is generally benign, although it may exhibit rapid growth, and its treatment is primarily surgical. The NAB2-STAT6 gene fusion, detected by immunohistochemistry, is pathognomonic for SFT. As exemplified in the present case, core needle biopsy (CNB) is more likely to provide sufficient material for microscopic, immunohistochemical, and other diagnostic techniques.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 5","pages":"Article 501744"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The echo of a question, ten years later: Letter to Amanda and Jesús","authors":"Camila Milad ,&nbsp;Alex Mesa","doi":"10.1016/j.endien.2026.501772","DOIUrl":"10.1016/j.endien.2026.501772","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 5","pages":"Article 501772"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panhypopituitarism and hypothalamic obesity in pediatric patients due to Langerhans cell histiocytosis: An aggressive and rare condition","authors":"Ignacio Jiménez Hernando,&nbsp;Marta Pérez Noguero,&nbsp;Mónica Gómez-Gordo Hernanz,&nbsp;Rogelio García Centeno","doi":"10.1016/j.endien.2026.501725","DOIUrl":"10.1016/j.endien.2026.501725","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 5","pages":"Article 501725"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147865371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ambient air pollution exposure and pubertal development: An ecological study","authors":"Diego Rivas-Otero ,&nbsp;Tomás González-Vidal ,&nbsp;Cristina Rodríguez-Dehli ,&nbsp;Alicia Pérez-Pérez ,&nbsp;Pablo Agüeria-Cabal ,&nbsp;Aroa Alonso-Alonso ,&nbsp;Miguel García-Villarino ,&nbsp;Elías Delgado-Álvarez ,&nbsp;Edelmiro Menéndez-Torre ,&nbsp;Isolina Riaño-Galán","doi":"10.1016/j.endien.2026.501740","DOIUrl":"10.1016/j.endien.2026.501740","url":null,"abstract":"<div><h3>Background</h3><div>The incidence rate of precocious puberty (PP) is rising, and ambient air pollutants may influence pubertal timing. This study explores the association between air pollution and PP and normal variants of puberty (NVP) in a Spanish pediatric population.</div></div><div><h3>Methods</h3><div>We conducted a retrospective ecological study in Asturias, Spain. Children ≤9 years diagnosed with PP or NVP between 2021 and 2024 were included. Data on pollutants (PM₁₀, PM_2.5, SO₂, NO₂, CO, O₃, NO, NO_<em>x</em>) from the 2 years prior to diagnosis were obtained from the nearest monitoring stations. The region was divided into 12 zones, yielding 48 zone-years across the 4-year study period. Incidence rates and mean pollutant levels were calculated for each zone. Each zone-year was classified as having high or low exposure according to the median pollutant concentration.</div></div><div><h3>Results</h3><div>A total of 96 children were diagnosed with central PP (<em>n</em> <!-->=<!--> <!-->53), peripheral PP (<em>n</em> <!-->=<!--> <!-->3) or NVP (<em>n</em> <!-->=<!--> <!-->40). Overall PP incidence (either central or peripheral PP) was positively correlated with CO (rho<!--> <!-->=<!--> <!-->0.479, <em>p</em> <!-->=<!--> <!-->0.024) and NO_<em>x</em> (rho<!--> <!-->=<!--> <!-->0.391, <em>p</em> <!-->=<!--> <!-->0.033) concentrations. We found no statistically significant associations between the incidence of central PP and any air pollutant. However, there was a trend toward a positive correlation between central PP incidence and CO exposure (rho<!--> <!-->=<!--> <!-->0.389; <em>p</em> <!-->=<!--> <!-->0.074). In addition, central PP incidence was higher in high-exposure areas for all pollutants, although these differences were not statistically significant (<em>p</em> <!-->&gt;<!--> <!-->0.05).</div></div><div><h3>Conclusions</h3><div>The findings of our study suggest a possible environmental influence on PP that needs to be explored in larger, longitudinal studies.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 5","pages":"Article 501740"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147865394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional dentition and chronic noncommunicable diseases among adults in Brazil","authors":"Galileu Bottermund Galli ,&nbsp;Milene Rossi ,&nbsp;Pedro Bohlke Barcellos ,&nbsp;Luísa Casarin Rickes ,&nbsp;Jivago da Fonseca Lopes ,&nbsp;Eduardo Ribes Kohn ,&nbsp;Maristela Bohlke","doi":"10.1016/j.endien.2026.501770","DOIUrl":"10.1016/j.endien.2026.501770","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the association between functional dentition and a prior diagnosis of diabetes mellitus (DM) and/or chronic kidney disease (CKD) in a nationally representative sample of the Brazilian population.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis using data from the 2019 Brazilian National Health Survey (PNS). The PNS is representative of the Brazilian population. The associations between self-reported diagnoses of DM and/or CKD and the absence of functional dentition were assessed using multilevel logistic regression models, adjusted for sociodemographic and behavioral variables, such as age, sex, skin color, income, education, and smoking status.</div></div><div><h3>Results</h3><div>Functional dentition was absent in 9.3% of the sample (95%CI, 8.9–9.7). Additionally, 8.8% (95%CI, 8.5–9.0) reported a previous diagnosis of DM, and 1.4% (95%CI, 1.3–1.5) a prior diagnosis of CKD. The proportion of individuals with both CKD and DM was 0.29% (95%CI, 0.27–0.32). In adjusted models, DM was significantly associated with the absence of functional dentition (OR, 1.16; 95%CI, 1.07; 1.23, <em>p</em> <!-->&lt;<!--> <!-->0.001). No significant association was observed for CKD (OR, 1.06; 95%CI, 0.89; 1.26, <em>p</em> <!-->=<!--> <!-->0.48) or for individuals with both DM and CKD (OR, 1.08; 95%CI, 0.74; 1.57, <em>p</em> <!-->=<!--> <!-->0.66).</div></div><div><h3>Conclusion</h3><div>Diabetes is associated with a higher risk of functional dentition loss in the Brazilian population. Promoting collaboration between dental and medical professionals is essential to improve the prevention and management of tooth loss, particularly among individuals with diabetes, ultimately contributing to better overall health outcomes.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 5","pages":"Article 501770"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147865417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the experience of women living with obesity and reproductive pathology","authors":"Alba Andreu ,&nbsp;Jessica Farré ,&nbsp;Eva Palou ,&nbsp;Gemma Casals ,&nbsp;Olga Rubio ,&nbsp;Violeta Moizé ,&nbsp;Dolors Manau ,&nbsp;Lilliam Flores ,&nbsp;Eva Antúnez ,&nbsp;Miriam Redondo ,&nbsp;Josep Vidal ,&nbsp;Joan Escarrabill","doi":"10.1016/j.endien.2026.501746","DOIUrl":"10.1016/j.endien.2026.501746","url":null,"abstract":"<div><h3>Introduction</h3><div>Obesity in women of reproductive age is a significant risk factor for infertility. Current treatment strategies primarily focus on weight reduction through lifestyle modifications, pharmacological interventions, or surgical procedures. However, there is still a lack of consensus on the most effective approach. Moreover, such interventions have limited effectiveness in maintaining WL and optimizing assisted reproduction results following assisted reproductive techniques, which may lead to stigmatization and negative experiences for patients.</div><div>Although qualitative evidence regarding preconception and gestational stages has increased, literature specifically addressing women who simultaneously present obesity and infertility, as well as the impact of these conditions on their physical and emotional well-being, remains limited.</div></div><div><h3>Aim</h3><div>To explore the care trajectory of women with obesity and infertility.</div></div><div><h3>Methods</h3><div>We designed a mixed-methods study involving 10 health care professionals, a focus group and a co-creation workshop with 6 and 8 patients respectively, and an online survey was administered and completed by 33 out of a total of 150 women with obesity and reproductive pathology who were invited to participate (response rate 22%).</div></div><div><h3>Results</h3><div>While some aspects of preconception care were positively evaluated, the overall patient journey is complex. We identified four areas for improvement: providing personalized information, offering stigma-free emotional support, ensuring efficient time management, and promoting shared decision-making.</div></div><div><h3>Conclusions</h3><div>A comprehensive, multidisciplinary approach emerges as a key element to optimize care and enhance the experience of these women.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 5","pages":"Article 501746"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of arterial stiffness and plasma FGF23 levels in patients with hypoparathyroidism","authors":"Irene Berges-Raso ,&nbsp;Ismael Capel ,&nbsp;Albert Cano ,&nbsp;Rocío Pareja ,&nbsp;Jaume Almirall ,&nbsp;Ruth Cano ,&nbsp;Assumpta Caixàs ,&nbsp;Mercedes Rigla","doi":"10.1016/j.endien.2026.501724","DOIUrl":"10.1016/j.endien.2026.501724","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with hypoparathyroidism are at a higher cardiovascular risk (CVR) due to mechanisms that are not yet well understood. In patients with renal failure, fibroblast growth factor 23 (FGF23) has been associated with an increased calcification and arterial stiffness (AS), leading to an increased CVR. In hypoparathyroidism—due to the situation of hyperphosphatemia—an increase in FGF23 is also probable. There is a paucity of research examining the relationship between FGF23 levels and AS in patients with hypoparathyroidism. The present study aims to assess AS, by measuring aortic pulse wave velocity (aPWV), and FGF23 levels in patients with hypoparathyroidism vs age and sex matched healthy controls.</div></div><div><h3>Material and methods</h3><div>We conducted a cross-sectional descriptive study, and collected demographical data of patients and treatment characteristics (calcium and vitamin D doses). Furthermore, we measured aPWV using the SphygmoCorXCEL® device and assessed FGF23 and all other parameters of calcium–phosphorus metabolism in a blood and 24<!--> <!-->h-urine samples.</div></div><div><h3>Results and discussion</h3><div>A total of 20 subjects with hypoparathyroidism (85% postoperative) and 16 healthy matched controls were included. The mean age was 58.6 years (SD, 12.2). The mean course of the disease was 16.31 years (3–44). Regarding the general characteristics, the most remarkable finding was that patients had an estimated glomerular filtration rate (eGFR) significantly lower than controls (72.5 [SD, 21.25] vs 95.3 [SD, 12.21]<!--> <!-->ml/min/1.73<!--> <!-->m²; <em>p</em> <!-->&lt;<!--> <!-->0.001). FGF23 levels were clearly elevated in subjects with hypoparathyroidism (255.2 [35.9–1487.4] vs 61.9 [27.8–134.8]<!--> <!-->RU/mL; <em>p</em> <!-->&lt;<!--> <!-->0.05). A trend toward higher AS was observed in subjects with hypoparathyroidism (aPWV 8.4 [5.2–17.3] vs 6.9 [5.1–10.8]<!--> <!-->m/s; <em>p</em> <!-->=<!--> <!-->0.08), as well as a positive correlation between aPWV and time of disease progression (<em>r</em> <!-->=<!--> <!-->0.679; <em>p</em> <!-->&lt;<!--> <!-->0.01). A negative correlation was observed in subjects with hypoparathyroidism between aPWV and eGFR (−0.519; <em>p</em> <!-->&lt;<!--> <!-->0.05). We found no significant correlation between aPWV and FGF23 or with phosphate levels or calcium supplements or calcitriol doses used in replacement treatment.</div></div><div><h3>Conclusions</h3><div>In subjects with hypoparathyroidism there is a marked increase in FGF23 levels and a trend toward a higher AS, which correlates with disease duration. However, these findings may be conditioned by an impaired renal function that this pathological process entails. A causal relationship could not be established between the elevated levels of FGF23 and AS.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501724"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioelectrical impedance analysis-derived phase angle predicts sarcopenia in older adults with type 2 diabetes mellitus","authors":"Tingying Xiao ,&nbsp;Shiyue Zou ,&nbsp;Chunming Yuan ,&nbsp;Lijuan Gou ,&nbsp;Ying Dai ,&nbsp;Fang Chen ,&nbsp;Jing Lai ,&nbsp;Lixi Yang","doi":"10.1016/j.endien.2026.501717","DOIUrl":"10.1016/j.endien.2026.501717","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Sarcopenia is prevalent among older patients with type 2 diabetes mellitus (T2DM). The phase angle (PhA), derived from bioelectrical impedance analysis (BIA), is a potential marker for sarcopenia. This study aimed to explore the relationship between PhA and sarcopenia in older patients with T2DM and determine the PhA threshold for predicting sarcopenia.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study with 263 older patients with T2DM hospitalized at a Chinese tertiary referral center. Participants were categorized into sarcopenia (T2DM-SP) and non-sarcopenia (T2DM-NSP) groups. Logistic regression analysis was used to evaluate the PhA as an independent predictor of sarcopenia after adjusting for confounding factors. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of PhA in sarcopenia.</div></div><div><h3>Results</h3><div>PhA was significantly lower in the T2DM-SP group vs the T2DM-NSP group (4.523<!--> <!-->±<!--> <!-->0.627° vs 4.995<!--> <!-->±<!--> <!-->0.711°; <em>p</em> <!-->&lt;<!--> <!-->0.001). Moreover, the PhA was significantly related to sarcopenia, even after adjusting for age, sex, body mass index (BMI), and other covariates, PhA remained independently associated with sarcopenia (OR, 0.112; <em>p</em> <!-->=<!--> <!-->0.001), low HGS (OR, 0.220; <em>p</em> <!-->=<!--> <!-->0.007), and low ASMI (OR, 0.083; <em>p</em> <!-->&lt;<!--> <!-->0.001). ROC curve analysis determined the optimal PhA cutoff values for diagnosing sarcopenia as 5.35° for men (AUC, 0.717; <em>p</em> <!-->&lt;<!--> <!-->0.001) and 4.55° for women (AUC, 0.745; <em>p</em> <!-->&lt;<!--> <!-->0.001).</div></div><div><h3>Conclusions</h3><div>The study identified a significant relationship between sarcopenia and PhA among older patients with T2DM, which may serve as a valuable marker for predicting sarcopenia in this population. Further prospective studies are required to confirm these findings and clarify the underlying mechanisms.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 4","pages":"Article 501717"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}