Sonsoles Gutiérrez Medina , Elena Sánchez Campayo , Sonsoles Guadalix , Javier Escalada
{"title":"Super response to liraglutide in people with obesity: A case report and literature review","authors":"Sonsoles Gutiérrez Medina , Elena Sánchez Campayo , Sonsoles Guadalix , Javier Escalada","doi":"10.1016/j.endien.2024.11.012","DOIUrl":"10.1016/j.endien.2024.11.012","url":null,"abstract":"<div><div>GLP1 receptor agonists (GLP1-RAs) are currently the most widely used pharmacological option to treat obesity. However, considerable heterogeneity in weight loss response has been observed with different anti-obesity drugs and response predictors to these drugs still remain ambiguous. Furthermore, very few published data have been available on cases of high-responders to treatment with GLP1-RAs. In this article, we present the case of a patient with grade 4 obesity (initial body mass index, 50.2<!--> <!-->kg/m<sup>2</sup>) with associated mechanical and metabolic complications who achieved an initial weight loss of 40% at 1 year with hygienic-dietary measures and drug treatment with liraglutide. We also review the available literature on factors potentially contributing to variations in weight loss with GLP1-RAs in general and liraglutide, in particular.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 10","pages":"Pages 447-453"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antelm Pujol , Pilar Sanchis , María I. Tamayo , Lluís Masmiquel
{"title":"Are we underdiagnosing cognitive impairment in patients with type 2 diabetes mellitus?","authors":"Antelm Pujol , Pilar Sanchis , María I. Tamayo , Lluís Masmiquel","doi":"10.1016/j.endien.2024.11.009","DOIUrl":"10.1016/j.endien.2024.11.009","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 10","pages":"Pages 454-455"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patricia Enes Romero , María Güemes , Blanca Guijo , Gabriel Á. Martos-Moreno , Jesús Pozo Román , Jesús Argente
{"title":"Automated insulin delivery systems in the treatment of diabetes: Benefits, challenges, and practical considerations in pediatric patients","authors":"Patricia Enes Romero , María Güemes , Blanca Guijo , Gabriel Á. Martos-Moreno , Jesús Pozo Román , Jesús Argente","doi":"10.1016/j.endien.2024.11.010","DOIUrl":"10.1016/j.endien.2024.11.010","url":null,"abstract":"<div><div>At present, the majority of patients with type 1 diabetes mellitus do not achieve the recommended glycemic control goals to reduce the risk of acute and chronic complications. Hybrid closed-loop systems or automated insulin infusion systems emerged as an opportunity to improve metabolic control, quality of life and reduce the psychosocial impact of type 1 diabetes. This article analyzes the evidence regarding their effectiveness and safety, the challenges they pose and best practices to optimize results when implemented in clinical practice.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 10","pages":"Pages 436-446"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberto Sánchez Medina , Alejandro de Arriba Fernández , Ángela Gutiérrez Pérez , José Luis Alonso Bilbao
{"title":"Association between the economic situation and diabetes mellitus, metabolic control and the use of health services in a Spanish region","authors":"Roberto Sánchez Medina , Alejandro de Arriba Fernández , Ángela Gutiérrez Pérez , José Luis Alonso Bilbao","doi":"10.1016/j.endien.2024.11.008","DOIUrl":"10.1016/j.endien.2024.11.008","url":null,"abstract":"<div><h3>Introduction</h3><div>The prevalence of diabetes mellitus (DM) has increased in low- and middle-income countries and in marginal areas of developed countries<sub>.</sub> In Spain, it grew by 3.42% from 1993 to 2020. In the Canary Islands, the increase was even greater.</div></div><div><h3>Objectives</h3><div>The main one was to evaluate the possible relationship of the income level with DM, different markers of metabolic control and the use of Primary Care services, in Las Palmas de Gran Canaria (LPGC). Secondary ones are to determine the prevalence of DM in the city of LPGC, to describe the sociodemographic characteristics, the use of Primary Care services of the population with DM, the level of registry of variables related to metabolic control and the main process indicators and intermediate results of the metabolic control in the population with DM in the city of LPGC.</div></div><div><h3>Material and method</h3><div>All patients with DM over 14 years of age, living in LPGC as of 12/31/22 were included. Data were collected from the electronic medical records of the Canarian Primary Care Service, the National Institute of Statistics and the National Tax Agency.</div></div><div><h3>Results and conclusion</h3><div>The overall prevalence of DM was 11.39%. The mean age of participants was 67.06 years (SD<!--> <!-->=<!--> <!-->13.86), lower in men than in women. The groups with low or moderate income accounted for more than 40% of the prevalence each, while those with high income barely accounted for 10%. Higher income levels corresponded to lower use of health resources and registration of metabolic variables, while decreasing income levels were associated to higher prevalence of overweight/obesity, worse lipid and glycemic profiles and higher risk of diabetic foot. The middle-income group showed the highest prevalence of pathological/uncertain diabetic retinopathy, lower glomerular filtration and higher LDL levels.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 10","pages":"Pages 427-435"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natalia R. Iglesias , Romina Ceccomancini , María del Pilar Jaime , Ayla Gerk , Delfina Mendiola , Jorgelina Stegmann
{"title":"Distortion of body image perception in the Prader-Willi syndrome: Relationship with the perceptual reasoning index","authors":"Natalia R. Iglesias , Romina Ceccomancini , María del Pilar Jaime , Ayla Gerk , Delfina Mendiola , Jorgelina Stegmann","doi":"10.1016/j.endien.2024.11.011","DOIUrl":"10.1016/j.endien.2024.11.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Self-perception of body image has been scarcely evaluated in people with Prader-Willi syndrome (PWS), who, in addition to intellectual disability, are often obese. Therefore, we explored whether people with PWS can accurately identify their true image and how this self-perception is impacted by their neuropsychological profile.</div></div><div><h3>Methodology</h3><div>This observational study included patients with PWS with regular attendance to transdisciplinary treatment at a center specialized in the management of rare diseases. All patients were evaluated with the Stunkard scale (including silhouettes ranging from extremely skinny to extremely obese) and the WISC-IV and WAIS-III questionnaires, specifically the perceptual reasoning index (PRI).</div></div><div><h3>Results</h3><div>Among the 21 participants, 62% misperceived their body image, most underestimating their body dimensions (actual BMI 28.0<!--> <!-->±<!--> <!-->8.3<!--> <!-->kg/m<sup>2</sup> vs self-perceived BMI 23.2<!--> <!-->±<!--> <!-->4.7<!--> <!-->kg/m<sup>2</sup>, <em>p</em> <!-->=<!--> <!-->0.03). While BMI differences between accurate and inaccurate body image perception were nonsignificant (accurate 26.6<!--> <!-->±<!--> <!-->8.8<!--> <!-->kg/m<sup>2</sup> vs inaccurate 28.9<!--> <!-->±<!--> <!-->8.1<!--> <!-->kg/m<sup>2</sup>, <em>p</em> <!-->=<!--> <!-->0.56), individuals with accurate perception showed both higher PRI scores (accurate 67.6<!--> <!-->±<!--> <!-->8.2 vs inaccurate 60.2<!--> <!-->±<!--> <!-->7.2, <em>p</em> <!-->=<!--> <!-->0.043) and, to a lesser extent, intelligence quotients (IQ) (accurate 60.0<!--> <!-->±<!--> <!-->4.9 vs inaccurate 55.0<!--> <!-->±<!--> <!-->7.5, <em>p</em> <!-->=<!--> <!-->0.079).</div></div><div><h3>Conclusion</h3><div>In this study, we identified distortion of body image perception as a very common finding among PWS patients, in most cases as underestimation, and influenced by the neuropsychological profile.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 10","pages":"Pages 415-420"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emilio García García , Mercedes L. Llempén López , María Molina Mata , Rosa Cabello Laureano , Suset Dueñas Disotuar
{"title":"Early thyroid carcinoma in PTEN syndrome. Importance of immediate ultrasound screening","authors":"Emilio García García , Mercedes L. Llempén López , María Molina Mata , Rosa Cabello Laureano , Suset Dueñas Disotuar","doi":"10.1016/j.endien.2024.11.006","DOIUrl":"10.1016/j.endien.2024.11.006","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 9","pages":"Pages 407-408"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor Perez de Arenaza Pozo, Jersy Cárdenas Salas, Clotilde Vázquez Martínez
{"title":"Potential of insulin deprescription adding a GLP-1 receptor agonist as a therapeutic strategy to improve the metabolic profiles of patients with type 2 diabetes mellitus","authors":"Victor Perez de Arenaza Pozo, Jersy Cárdenas Salas, Clotilde Vázquez Martínez","doi":"10.1016/j.endien.2024.11.007","DOIUrl":"10.1016/j.endien.2024.11.007","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"71 9","pages":"Pages 405-407"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}