Endocrinologia Diabetes Y Nutricion最新文献

{"title":"Advanced follicular thyroid carcinoma: Multidisciplinary approach to rare metastases","authors":"Lucía Menéndez Muros, Nuria Birruezo Hernández, María Angustias Muros de Fuentes","doi":"10.1016/j.endien.2026.501823","DOIUrl":"10.1016/j.endien.2026.501823","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 7","pages":"Article 501823"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal toxicity in the treatment of hematological tumors. Influence on nutritional status","authors":"Teresa Alonso Domínguez,&nbsp;Miguel Civera Andrés,&nbsp;Katherine García Malpartida,&nbsp;José González Medina,&nbsp;María José Serna Muñoz,&nbsp;Williana M. Torres Jiménez,&nbsp;Bolívar Luis Díaz Jordán,&nbsp;Francisco Botella Romero","doi":"10.1016/j.endien.2026.501777","DOIUrl":"10.1016/j.endien.2026.501777","url":null,"abstract":"<div><h3>Introduction</h3><div>Hematologic neoplasms (lymphomas, leukemias, and myelomas) represent approximately 10% of all tumors. Antineoplastic treatments, including chemotherapy, targeted therapies, and immunotherapy, generate gastrointestinal toxicity that impacts therapeutic efficacy and nutritional status, establishing a vicious cycle of malnutrition and toxicity.</div></div><div><h3>Materials and methods</h3><div>A narrative review was conducted using a literature search of the electronic databases PubMed, Embase, UpToDate, and Medscape for chemotherapy, targeted therapies, and immunotherapy used in lymphomas, leukemias, and multiple myeloma. The frequencies of gastrointestinal adverse effects (diarrhea, nausea/vomiting, mucositis), as well as those of grade ≥3, were analyzed.</div></div><div><h3>Results</h3><div>The results are presented in tables showing the commonly used drugs along with the probability of experiencing gastrointestinal adverse effects. In acute lymphoblastic leukemia, therapies such as Tisa-Cel and Brexu-Cel, with or without cytotoxic agents, cause gastrointestinal toxicity in almost all patients. In acute myeloid leukemia, most drugs produce nausea and vomiting, while diarrhea and mucositis are less frequent (30%). In chronic lymphocytic leukemia, diarrhea is prominent with targeted therapies (ibrutinib [42%], idelalisib [47%]). In chronic myeloid leukemia, bosutinib causes the highest rate of gastrointestinal intolerance (68%). In non-Hodgkin lymphoma, most combinations induce nausea/vomiting (&gt;90%). Regarding multiple myeloma, gastrointestinal effects are generally low, with the exception of some immunotherapies (selinexor, elranatamab, elotuzumab).</div></div><div><h3>Discussion</h3><div>Diarrhea, nausea, vomiting, and mucositis are common complications, with diverse mechanisms depending on the drug. These toxicities directly impact nutritional status and quality of life, potentially requiring modifications to treatments.</div></div><div><h3>Conclusions</h3><div>Understanding the frequency and severity of gastrointestinal side effects of drugs used to treat hematological malignancies can facilitate early diagnosis and medical-nutritional management, which can be key to reducing malnutrition and improving clinical outcomes in hematological tumors.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 7","pages":"Article 501777"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and fetal outcomes associated with flash glucose monitoring metrics in women with type 1 diabetes: A cohort study","authors":"Gema López-Gallardo,&nbsp;Ana Piñar-Gutiérrez,&nbsp;Celia Hernández-Reina,&nbsp;Sandra Amuedo,&nbsp;Noelia Gros-Herguido,&nbsp;Pablo J. Remón-Ruiz,&nbsp;Virginia Bellido,&nbsp;Pilar Santa Cruz-Álvarez,&nbsp;Lucas Cerrillo,&nbsp;Alfonso Soto-Moreno","doi":"10.1016/j.endien.2026.501804","DOIUrl":"10.1016/j.endien.2026.501804","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the association between flash glucose monitoring (FGM) metrics and perinatal outcomes in pregnant women with type 1 diabetes (T1DM).</div></div><div><h3>Research design and methods</h3><div>This retrospective cohort study included pregnant women with T1DM who used FGM. The primary outcome was a composite endpoint including fetal or neonatal mortality, large-for-gestational-age (LGA) birth weight, neonatal intensive care unit (NICU) admission, or neonatal hypoglycemia. Glycated hemoglobin (HbA1c) levels were assessed together with time in range (TIR), time below range (TBR), and time above range (TAR) within pregnancy-specific glucose targets, as well as glucose variability.</div></div><div><h3>Results</h3><div>A total of 70 women were included, with a median age of 36 years (IQR, 31–38), body mass index (BMI) 27<!--> <!-->±<!--> <!-->5<!--> <!-->kg/m², diabetes duration 20<!--> <!-->±<!--> <!-->8 years, and pregestational HbA1c 7.3<!--> <!-->±<!--> <!-->1.4%. Among them, 21.7% were smokers, 4.5% had hypertension, 10.1% had dyslipidemia, and 41.2% had diabetic retinopathy. Women who experienced the composite endpoint exhibited significantly lower TIR and higher TAR across all trimesters, greater glycemic variability (CV) during the first (1T) and third trimesters (3T), and a higher glucose management indicator (GMI) in the third trimester. Logistic regression analysis showed that a TIR<!--> <!-->&lt;<!--> <!-->69.5% during the second trimester (2T) increased the risk of the composite endpoint by 10.56-fold (<em>P</em> <!-->=<!--> <!-->.015). Similarly, CV<!--> <!-->≥<!--> <!-->31.85% during the first trimester was associated with a 6.42-fold increased risk (<em>P</em> <!-->=<!--> <!-->.039). A model combining these 2 variables achieved a sensitivity of 94.3% and a specificity of 50%.</div></div><div><h3>Conclusions</h3><div>Glycemic control assessed through FGM metrics, particularly TIR during the second trimester and CV during the first trimester, is associated with adverse maternal–fetal outcomes in pregnant women with T1DM.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 7","pages":"Article 501804"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroendocrine tumor of the gallbladder: An unusual location","authors":"María José Vallejo Herrera,&nbsp;Verónica Vallejo Herrera,&nbsp;Félix Serrano Puche","doi":"10.1016/j.endien.2026.501797","DOIUrl":"10.1016/j.endien.2026.501797","url":null,"abstract":"<div><div>Neuroendocrine tumors of the gallbladder are included among neuroendocrine tumors of uncommon location. Because they are non-functioning tumors, they usually do not produce symptoms and are often discovered at advanced stages. Their main differential diagnosis, due to gallbladder wall thickening, is acute cholecystitis. If imaging findings do not improve despite appropriate treatment, this entity should be considered in the differential diagnosis to achieve early treatment. Histopathological examination is the key to diagnosis. Small-cell neuroendocrine tumors with a high Ki-67 index have a poor prognosis and high short-term morbidity and mortality.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 7","pages":"Article 501797"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe neonatal hypercalcemia secondary to intra-abdominal paniculitis","authors":"Pedro Agudo-Montore,&nbsp;Elena Merchante,&nbsp;Marisa Rosso,&nbsp;Emilio García-García","doi":"10.1016/j.endien.2026.501822","DOIUrl":"10.1016/j.endien.2026.501822","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 7","pages":"Article 501822"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MEDEA study: Organizational models for the care of type 2 diabetes mellitus in Andalusia — The endocrinologist’s contribution","authors":"Pablo Jesús Remon-Ruiz,&nbsp;Román Villegas-Portero,&nbsp;Fernando Losada Viñau,&nbsp;Miguel Ángel Mangas Cruz,&nbsp;Alfonso Pumar Lopez,&nbsp;Josefa Mayoral Sánchez,&nbsp;María del Mar Muñoz García,&nbsp;Alfonso Soto Moreno","doi":"10.1016/j.endien.2026.501819","DOIUrl":"10.1016/j.endien.2026.501819","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Diabetes mellitus is currently a major health care priority due to its high prevalence, complexity, and associated morbidity and mortality. The organization of care for type 2 diabetes mellitus (T2DM) is essential to deliver high-quality care aimed at optimizing clinical outcomes. However, the effectiveness of different health care delivery models remains under evaluation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;The MEDEA project was a multicenter, quasi-experimental study that assessed three different models of care for T2DM. The comparison groups consisted of an intensive intervention group, a moderate intervention group, and the remainder of the health care system as a control group. The groups differed according to the degree of hospital-based specialist involvement in primary care.&lt;/div&gt;&lt;div&gt;Based on electronic health record data, at-risk patients were identified according to predefined criteria: poor metabolic control (HbA1c &gt;8%), inadequate lipid control (LDL &gt; 100 mg/dL), and risk of hypoglycemia in older adults (patients older than 75 years with HbA1c &lt;7% receiving potentially hypoglycemia-inducing treatments). Outcomes were measured as the percentage of patients achieving targets across these three domains.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;No significant differences were observed in mean HbA1c at baseline and at the end of the study among the three intervention groups. However, the proportion of patients achieving HbA1c &lt;8% increased significantly in the intensive intervention group (17.9%) compared with the moderate intervention and control groups. A total of 3,513 patients were included in the intensive intervention group. In the centers belonging to this group (CS1 and CS2), the target HbA1c &lt;8% was achieved in 56.9% and 68.02% of patients, respectively. Regarding deprescribing, pharmacological withdrawal was achieved in 41.9% and 26.9% of eligible patients in CS1 and CS2, respectively. There was a significant increase in the number of patients treated with more than one oral antidiabetic drug (P &lt; 0.001), with increased use of DPP-4 inhibitors (P = 0.000) and SGLT2 inhibitors (P = 0.002). A reduction in basal–bolus insulin therapy was observed (P = 0.01), alongside an increase in the proportion of patients treated with basal insulin analogs (P = 0.01).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Intensive intervention leads to improved health outcomes in patients with diabetes and is clearly superior to on-demand intervention, which does not demonstrate improvements compared with routine clinical practice. Centralized data more closely reflect the reality of individual centers and enable the identification of at-risk patient groups; however, health records lack specificity and require individualized validation, data cleaning, and clinical contextualization to ensure that analyses accurately represent real-world practice.&lt;/div&gt;&lt;div&gt;Mean HbA1c may not be an optimal parameter","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 7","pages":"Article 501819"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations for defining incident overweight and obesity in EHR-based cohorts: Response from the authors","authors":"Irene Bretón,&nbsp;Igotz Aranbarri,&nbsp;Anastasia Lampropoulou,&nbsp;Jennifer Redondo-Antón,&nbsp;Javier Ágreda,&nbsp;Atif Adame,&nbsp;Esther Artime","doi":"10.1016/j.endien.2026.501848","DOIUrl":"10.1016/j.endien.2026.501848","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 7","pages":"Article 501848"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of diabetes and its complications on nutritional assessment in disease-related malnutrition: A cross-sectional study","authors":"Jaime González-Gutiérrez,&nbsp;Juan José López-Gómez,&nbsp;Paloma Pérez-López,&nbsp;Ángela Cebriá,&nbsp;Olatz Izaola-Jáuregui,&nbsp;Lucía Estévez-Asensio,&nbsp;David Primo-Martín,&nbsp;Eduardo Jorge Godoy,&nbsp;Daniel A. De Luis-Román","doi":"10.1016/j.endien.2026.501720","DOIUrl":"10.1016/j.endien.2026.501720","url":null,"abstract":"<div><h3>Background/Objectives</h3><div>This study seeks to assess the influence of type 2 diabetes mellitus (T2DM) and its complications on the deterioration of muscle mass and function in patients with disease-related malnutrition (DRM).</div></div><div><h3>Methods</h3><div>We conducted a descriptive cross-sectional study in a sample of 206 patients (57.6% women) with DRM. Patients were compared based on the presence or absence of diabetes mellitus (DM). Differences were also observed based on the duration of DM and the presence of complications. Age, gender, body mass index (BMI), bioimpedanciometry (BIA) parameters, ultrasonography parameters and the diagnosis of dynapenia or sarcopenia were recorded.</div></div><div><h3>Results</h3><div>A total of 46 (22.33%) patients had DM, which was associated with higher values of skeletal muscle index (SMI) (DM, 7.73 (1.98)<!--> <!-->kg/m² vs NoDM, 6.75 (1.34)<!--> <!-->kg/m², <em>p</em> <!-->&lt;<!--> <!-->0.01) in BIA analysis. Furthermore, it was associated with lower values of rectus femoris muscle thickness (RFMT) (DM, 0.85 (0.25) vs NoDM, 0.94 (0.29), <em>p</em> <!-->&lt;<!--> <!-->0.05). Long-standing DM was associated with lower values of SMI (DM<!--> <!-->&gt;10 years: 7.25 (1.46)<!--> <!-->kg/m² vs DM<!--> <!-->&lt;<!--> <!-->10 years: 8.18 (2.30)<!--> <!-->kg/m², <em>p</em> <!-->&lt;<!--> <!-->0.01) and with complicated DM (complicated DM, 7.57 (2.40)<!--> <!-->kg/m² vs non-complicated DM, 7.90 (1.48)<!--> <!-->kg/m², <em>p</em> <!-->&lt;<!--> <!-->0.01). Moreover, these conditions were associated with lower values of RFMT (DM<!--> <!-->&gt;<!--> <!-->10 years: 0.76 (0.18)<!--> <!-->cm vs DM<!--> <!-->&lt;<!--> <!-->10 years: 0.93 (0.29) cm, <em>p</em> <!-->&lt;<!--> <!-->0.05; Complicated DM, 0.77 (0.17) cm vs Non-complicated DM, 0.94 (0.29)<!--> <!-->cm, <em>p</em> <!-->&lt;<!--> <!-->0.05). DM was a risk factor for the development for dynapenia (OR, 3.56, 95%CI, 1.52–8.29, <em>p</em> <!-->&lt;<!--> <!-->0.01) and sarcopenia (OR, 3.08, 95%CI, 1.35–7.02, <em>p</em> <!-->&lt;<!--> <!-->0.05) adjusted for age, gender, BMI and inflammatory status (determined by CRP). The presence of diabetic complications was a risk factor for dynapenia (OR, 2.08, 95%CI, 1.18–3.66; <em>p</em> <!-->=<!--> <!-->0.01) and sarcopenia (OR, 1.92, 95%CI, 1.12–3.28; <em>p</em> <!-->=<!--> <!-->0.02), after adjusting for gender, age, oncologic condition, BMI and CRP levels.</div></div><div><h3>Conclusions</h3><div>In patients with DRM, poorly controlled T2DM was associated with worse muscle quantity and quality in muscle ultrasound. Long-standing DM and complicated DM were risk factors of dynapenia and sarcopenia. For clinical practice, multidisciplinary management to prevent these events is essential.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 6","pages":"Article 501720"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148273494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common errors in the initial management of hyponatremia","authors":"Jorge Gabriel Ruiz-Sánchez,&nbsp;Yvonne Fernández-Cagigao,&nbsp;Paola Parra-Ramírez,&nbsp;Patricia Martín Rojas-Marcos,&nbsp;Cristina Álvarez-Escolá","doi":"10.1016/j.endien.2026.501768","DOIUrl":"10.1016/j.endien.2026.501768","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 6","pages":"Article 501768"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148273582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 diabetes onset in children and adolescents: Clinical and temporal analysis in a tertiary referral center","authors":"Alicia Pérez Pérez,&nbsp;Rebeca García García,&nbsp;Oihane Salcedo Fresneda,&nbsp;Aroa Alonso Alonso,&nbsp;Ana Cristina Rodríguez Dehli,&nbsp;Isolina Riaño Galán","doi":"10.1016/j.endien.2026.501771","DOIUrl":"10.1016/j.endien.2026.501771","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in pediatric patients with type 1 diabetes mellitus (T1DM). The objectives of this study were to analyze the incidence of DKA at the time of T1DM diagnosis and to evaluate changes in its presentation over recent years. We also assessed whether a family history of T1DM or specific HLA haplotypes influenced the incidence of DKA at diagnosis.</div></div><div><h3>Materials and methods</h3><div>We conducted a descriptive, observational, and retrospective study of all patients younger than 14 years diagnosed with T1DM at a tertiary referral center from from 2017 through 2024. Data collected included age at onset, sex, date of diagnosis, and initial laboratory values. Data were, then, grouped into 2 periods of time (2017–2020; 2020–2024) for comparison purposes.</div></div><div><h3>Results</h3><div>A total of 85 patients were included (41 women), with a mean age at diagnosis of 7.9 years. DKA at disease onset was observed in 29 patients (34.1%), including 15 cases (17.6%) classified as severe. Mean C-peptide level was 0.8 ng/mL, mean plasma glucose level was 423 mg/dL, and mean hemoglobin A1c level was 11.1%.</div><div>Between 2017 and 2020, 37 new diagnoses were established, 37.8% with DKA (13.5% severe) and from 2021 to 2024, 48, 31.2% with DKA (20.8% severe).</div><div>A total of 12 patients had first-degree relatives with T1DM, and 0 exhibited DKA (P &lt; .05). No significant associations were found between HLA haplotypes and the incidence rate of DKA.</div></div><div><h3>Conclusions</h3><div>The prevalence of DKA at diagnosis was similar to that reported in other Spanish studies. Having a family history of T1DM seems to be a protective factor against the development of DKA. No significant association was found between HLA haplotypes and DKA prevalence.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"73 6","pages":"Article 501771"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}