PTH levels and establishment of reference intervals: Impact of vitamin D and renal function

IF 1.8 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Luis Agustín Ramírez Stieben , María Lorena Brance , Marina Verónica Belardinelli , Diamela Bolzán , Estefanía Pustilnik , Rodolfo Néstor Feldman , Lucas Ricardo Brun
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引用次数: 0

Abstract

Introduction

Parathyroid hormone (PTH) and vitamin D are essential components in mineral metabolism. Our aims were to estimate the thresholds of 25-hydroxyvitamin D [25(OH)D] and estimated glomerular filtration rate (eGFR) that inhibit PTH, establish PTH reference intervals (RIs), and the stratify need based on age and gender.

Materials and methods

We conducted a cross-sectional study on participants older than 18 years. Segmented regressions (SR) were performed to determine the thresholds of 25(OH)D and eGFR in relation to PTH levels. Multivariate regression was used to evaluate the associations between PTH and 25(OH)D, gender, age, eGFR, and season. To establish the PTH RIs, extreme percentiles were calculated.

Results

A total of 2794 subjects were analyzed (women, 77.56%). Multivariate regression indicated that age, gender, 25(OH)D, and eGFR explained PTH variation. SR demonstrated that PTH stabilized when eGFR > 46.64 mL/min/1.73 m2, and PTH increased when 25(OH)D was <15.8 ng/mL. Stratification by gender and age revealed different RIs, with women and over 70 years showing higher limits.

Conclusion

Our study suggests a stabilization point in PTH with an eGFR > 46.64 mL/min/1.73 m2, indicating a significant interaction between renal function and PTH regulation. Additionally, the significant increase in PTH in individuals with 25(OH)D < 15.8 ng/mL emphasizes the importance of vitamin D in regulation. An association between age and PTH was also evident, particularly a substantial increase after the age of 70. Finally, we established the need to define partitioned RIs for PTH based on age and gender.
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来源期刊
CiteScore
2.10
自引率
10.50%
发文量
99
期刊介绍: Endocrinología, Diabetes y Nutrición is the official journal of the Spanish Society of Endocrinology and Nutrition (Sociedad Española de Endocrinología y Nutrición, SEEN) and the Spanish Society of Diabetes (Sociedad Española de Diabetes, SED), and was founded in 1954. The aim of the journal is to improve knowledge and be a useful tool in practice for clinical and laboratory specialists, trainee physicians, researchers, and nurses interested in endocrinology, diabetes, nutrition and related disciplines. It is an international journal published in Spanish (print and online) and English (online), covering different fields of endocrinology and metabolism, including diabetes, obesity, and nutrition disorders, as well as the most relevant research produced mainly in Spanish language territories. The quality of the contents is ensured by a prestigious national and international board, and by a selected panel of specialists involved in a rigorous peer review. The result is that only manuscripts containing high quality research and with utmost interest for clinicians and professionals related in the field are published. The Journal publishes Original clinical and research articles, Reviews, Special articles, Clinical Guidelines, Position Statements from both societies and Letters to the editor. Endocrinología, Diabetes y Nutrición can be found at Science Citation Index Expanded, Medline/PubMed and SCOPUS.
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