Advances in Rheumatology最新文献

{"title":"Exercises plus intra-articular injection for knee osteoarthritis: a systematic review with meta-analysis.","authors":"Christine Brumini, Jamil Natour, Sandra Mara Meireles Adolph, Rita Nely Vilar Furtado, Anamaria Jones","doi":"10.1186/s42358-025-00458-3","DOIUrl":"10.1186/s42358-025-00458-3","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether the combination of exercise and intra-articular injection (IAI) effectively improves pain, function, and quality of life in patients with knee osteoarthritis (OA) compared to any control group in the short, medium, and long term through a systematic review.</p><p><strong>Methods: </strong>A comprehensive search strategy was applied in the databases Embase, PubMed, MEDLINE, CENTRAL, CINAHL, and PEDro. Inclusion criteria focused on randomized controlled trials examining the effects of exercise combined with IAI in patients with knee OA, with outcomes assessed at short-, medium-, and long-term follow-ups. The primary outcomes were pain and function. The quality of the evidence was evaluated using the GRADE system.</p><p><strong>Results: </strong>Eleven studies, comprising 802 participants, were included. All studies investigated the combination of IAI and exercise. A statistically significant difference in pain was observed: in the short and medium term, the Botulinum toxin IAI group demonstrated superior pain reduction compared to the Hyaluronic acid IAI group (MD -1.32, 95% CI -2.20 to -0.44 and MD -9.09, 95% CI -13.16 to -5.01, respectively). In the medium term, Saline IAI was more effective than Corticosteroid IAI (MD 1.99, 95% CI 0.49 to 1.90). Regarding function, Saline IAI outperformed IAI with any medication in the short term (MD 0.50, 95% CI 0.20 to 0.79). In terms of quality of life, the Corticosteroid IAI group demonstrated superior physical function and mental health outcomes compared to the Saline IAI group in the medium term (MD -0.43, 95% CI -0.77 to -0.08 and MD -0.38, 95% CI -0.76 to -0.01, respectively). In the long term, physical function improved more with IAI combined with exercise compared to exercise alone.</p><p><strong>Conclusion: </strong>Given the very low quality of the evidence, it is not possible to definitively conclude that the combination of IAI and exercise is more effective than IAI or exercise alone in patients with knee OA. Further high-quality studies are needed to establish more definitive conclusions.</p><p><strong>Registration: </strong>The International Prospective Register of Systematic Reviews (PROSPERO): CRD42021277729.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":" ","pages":"5"},"PeriodicalIF":2.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperinflammatory status associated with COVID-19: clinical features of a pediatric series.","authors":"Douglas Squizatto Leite, Lucas Silva Cortes, Maria Aparecida Custódio Domingues, Claudia Saad Magalhaes, Taciana de Albuquerque Pedrosa Fernandes","doi":"10.1186/s42358-025-00504-0","DOIUrl":"10.1186/s42358-025-00504-0","url":null,"abstract":"<p><p>OBJECTIVE: Explore clinical features, atypical manifestations and rare autoimmune complications of pediatric hyperinflammatory manifestations associated to SARS-CoV-2, observed during the COVID-19 pandemic, and the relationship of Multisystemic Inflammatory Syndrome of Childhood (MIS-C) with other manifestations, such as macrophage activation syndrome, vasculitis and vasculopathy. METHODS: A protocol with detailed socio-demographic and clinical features, SARS-CoV-2 exposure and morbidity was conducted in a public tertiary hospital as part of a multicentric international protocol. Cases were selected and enrolled in a single centre from 2020 to 2022, recording all the organ and systems manifestations, standard treatment and outcome. RESULTS: Of the 23 suspicious cases, 21 met the inclusion criteria of MIS-C. Gastrointestinal manifestations were frequent, and three out of 21 had acute abdomen, one with documented histiocytic necrotizing mesenteric lymphadenopathy (Kikuchi-Fujimoto), 3 had macrophage activation syndrome (MAS), and one case, with previous enthesitis related arthritis evolved into type V Takayasu arteritis and malignant hypertension. All patients were treated with either intravenous immunoglobulin (IVIG), high dose glucocorticoids or both, five were under intensive care treatment with respiratory and cardio-circulatory support. All had full recovery during acute phase. Description the lymphonode histopathology showed proliferation of small lymphocytes and macrophage infiltrates with microthrombi and lymph nodes germinal centers necrosis. CONCLUSION: Post-infectious hyperinflammatory states associated with COVID-19 manifestations may cause not only to transient inflammatory features, but also autoimmunity, vasculitis and vasculopathy manifestations that require prompt treatment. </p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":" ","pages":"4"},"PeriodicalIF":2.8,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening tools for obstructive sleep apnea in patients with systemic lupus erythematosus.","authors":"Lia Belchior Mendes Bezerra, Manoel Alves Sobreira Neto, Juliana Arcanjo Lino, Adriana Lima Araújo, Carlos Ewerton Maia Rodrigues","doi":"10.1186/s42358-025-00503-1","DOIUrl":"10.1186/s42358-025-00503-1","url":null,"abstract":"<p><p>BACKGROUND: Obstructive sleep apnea (OSA) seems to be an important comorbidity in systemic lupus erythematosus (SLE) but studies on prevalence have inconsistent results. Moreover, uncertainty exists as to the reliability of questionnaires that could predict who should be considered for sleep testing. We aimed to determine the prevalence OSA in SLE patients and in healthy controls, and to evaluate the performance of two widely used OSA screening tools (STOP-Bang; NoSAS). METHODS: Selected patients underwent a home sleep apnea testing (HSAT), or type III polysomnography, using a portable ApneaLinkTM Air device (ResMed®), Martinsried, Germany. OSA was defined as apnea-hypopnea index ≥5 events/h. The probability of OSA was evaluated with two questionnaires: STOP-Bang and NoSAS. The ability of these questionnaries to diagnose apnea in SLE patients was analyzed with ROC curves, determining the area under the ROC curve (AUC-ROC) and the respective 95% confidence intervals. RESULTS: The final sample included 19 SLE patients (women: 89.5%; mean age: 35.6 ± 10.3 years; mean BMI: 27.87 ± 6.87 kg/m2) and 20 controls. The prevalence of OSA was 26.4% for SLE patients and 35% for controls (p = 0.360). OSA patients had higher BMI (p = 0.043). STOP-Bang scores were higher for patients with OSA than for patients without OSA (3 [2; 3] vs. 1 [0; 2], p = 0.001). The same was observed for NoSAS scores (7 [7; 9] vs. 2 [0; 3], p < 0.005). The area under the ROC curve (AUC) was greater for NoSAS than for STOP-Bang (0.957, 95%CI: 0.710–1.000, p = 0.003) vs. (0.914, 95%CI 0.786–1.000, p = 0.003), respectively. CONCLUSION: SLE patients and controls had a similar frequency of OSA in this study. Both OSA screening tools (NoSAS and STOP-Bang scores) detected OSA with reasonable accuracy in this population but at cut-offs lower than the usual. </p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":" ","pages":"1"},"PeriodicalIF":2.8,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between body mass index and disease activity in patients with systemic lupus erythematosus from China.","authors":"Hanchao Li, Xinru Du, Xiaohong Lv, Zhiming Hao, Lan He","doi":"10.1186/s42358-025-00502-2","DOIUrl":"10.1186/s42358-025-00502-2","url":null,"abstract":"<p><strong>Objective: </strong>To assess the association between clinical indicators (primarily Body Mass Index, BMI) and disease activity in systemic lupus erythematosus (SLE) populations in a large population-based cohort.</p><p><strong>Methods: </strong>Consecutive patients with SLE were enrolled to investigate the relationships among clinical features, inflammatory and biochemical indicators, and disease activity parameters. Significance values were adjusted by Bonferroni correction for multiple tests, then differences between continuous variables were analyzed by Kruskal Wallis tests. Associations were assessed using multiple linear regression to adjust for potential confounders, including glucocorticoid use, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and lipid levels.</p><p><strong>Results: </strong>A total of 400 SLE patients (375 women and 25 men) were included. Among them, 61 patients (15.25%) were classified into the low BMI group (BMI < 18.5 kg/m²), 267 patients (66.75%) into the normal BMI group (18.5 kg/m² ≤ BMI < 25 kg/m²), and 72 patients (18.00%) into the high BMI group (BMI ≥ 25 kg/m²). BMI was negatively correlated with SLE disease activity index (SLEDAI) score (ρ = -0.11, P = 0.02). This inverse association remained significant in multivariate linear regression after adjusting for potential confounders, including glucocorticoid use, CRP, ESR, and lipid levels. Patients in the low BMI group exhibited higher mean SLEDAI scores and a greater proportion of moderate to severe disease activity (SLEDAI ≥ 10) compared with the normal and high BMI groups. Additionally, anti-dsDNA, complement component 3, white blood cell count, alanine aminotransferase, neutrophil count, and hemoglobin were significantly different between the low BMI group and the other two groups.</p><p><strong>Conclusions: </strong>These findings indicate an association between low BMI and higher SLE disease activity. However, further investigation, particularly through prospective studies, is needed to determine whether low BMI exerts a detrimental effect on disease activity.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":" ","pages":"3"},"PeriodicalIF":2.8,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring somatosensory temporal discrimination deficits in rheumatoid arthritis: associations with disease activity and functionality.","authors":"Banu Gokcen Baydogan Tan, Hasan Kilinc, Zafer Gunendi, Sefa Tan, Feride Nur Gogus","doi":"10.1186/s42358-025-00497-w","DOIUrl":"10.1186/s42358-025-00497-w","url":null,"abstract":"<p><p>Objective- Somatosensory deficits in rheumatoid arthritis (RA) have not been adequately investigated, despite their potential impact on an individual's functioning. This study aims to evaluate the central processing of sensory stimuli in RA patients using the Somatosensory Temporal Discrimination (STD) test and to investigate any possible associations between sensory status, self-reported disability, and disease activity. Methods- The study included twenty patients with RA and twenty healthy subjects. RA disease activity was assessed using the Disease Activity Score 28-joint count Erythrocyte Sedimentation Rate (DAS28-ESR). The Health Assessment Questionnaire Disability Index (HAQ) was used to assess self-reported disability. A constant current stimulator was employed to measure minimal detection stimulus intensity (MDSI) and Somatosensory Temporal Discrimination Thresholds (STDT) from the dorsum of the participant's hands. Results- The STDTs for the right (114.50 ± 28.41 ms) and left hands (112.62 ± 20.89 ms) in RA patients were significantly higher compared to those of healthy subjects (right hand: 80.00 ± 35.16 ms; left hand: 80.39 ± 37.34 ms) (right hand: p = 0.021; left hand: p = 0.034). The mean MDSIs for the right (3.17 ± 0.62 mA) and left hands (3.24 ± 0.80 mA) of RA patients were higher than those of the control group (right hand: 2.91 ± 1.00 mA; left hand: 2.81 ± 0.98 mA), although these differences were not statistically significant (right hand: p = 0.353; left hand: p = 0.145). No significant correlations were found between STDTs, MDSIs, DAS28-ESR and its components, and HAQ in the RA group (p > 0.05). Conclusions- Our study provides novel insights into how sensory information is processed centrally in RA, highlighting changes in sensory processing not fully captured by traditional sensory function measures. Clinically, prolonged STDT indicates impaired temporal discrimination capacity, reflecting deficits in central sensory integration. Although STD impairment does not directly correlate with current disease activity or functional disability scores, the findings underscore the need for targeted rehabilitation strategies to address sensory processing deficits.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"63"},"PeriodicalIF":2.8,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VII Brazilian Consensus guidelines for the detection and interpretation of anti-cell autoantibodies on HEp-2 cells.","authors":"Wilson de Melo Cruvinel, Paulo Luiz Carvalho Francescantônio, Wilton Ferreira Silva Santos, Fabiano de Almeida Brito, Sandra Gofinet Pasoto, Andressa Mathias, Carlos David Araújo Bichara, Diana Landoni, Trischna Martins Berger, Eliane Aparecida Rosseto Welter, Cristóvão Luis Pitangueira Mangueira, Eloisa Bonfá, Henrique Ataíde Mariz, Jozelia Rego, Lisiane Maria Enriconi Dos Anjos, Valeria Valim, Antônio Carlos Ximenes, Luis Eduardo Coelho Andrade","doi":"10.1186/s42358-025-00493-0","DOIUrl":"10.1186/s42358-025-00493-0","url":null,"abstract":"<p><p>BACKGROUND: The VII Brazilian Consensus on Autoantibodies against HEp-2 Cells (BCA/HEp-2), dedicated to the identification of autoantibodies targeting cellular constituents in HEp-2 cells, was held on October 5–6, 2023, in Goiânia (GO, Brazil), as part of the 40th Brazilian Congress of Rheumatology. MAIN BODY: Nineteen researchers and experts from universities and clinical laboratories participated in this meeting, which resulted in important advancements. Among the key updates, two new nuclear patterns were incorporated into the Brazilian classification tree: the nuclear fine speckled with mitotic plate (AC-30) and the myriad discrete speckled pattern strongly associated with antibodies to SS-A/Ro60, previously categorized as AC-4a and now recognized as AC-31. Additionally, the mitotic pattern AC-28 (mitotic chromosomal), characterized by punctate staining of chromosomes in pro- and metaphase stages without interphase cell staining, was included. Adjustments to the classification tree were made to redistribute patterns based on morphological characteristics, harmonize composite pattern designations with ICAP nomenclature, and incorporate the AC-XX group into the classification structure. Guidance was also provided to laboratory analysts on the limitations of identifying patterns with weak reactivity, recommending that reports in such cases be issued according to the appropriate level of analytical competency. CONCLUSION: The recommendations aimed to establish clear guidelines for laboratories and clinicians, building upon those from the V and VI Consensuses while further aligning with ICAP recommendations. This consensus marks a significant step forward in adapting ICAP guidelines to the Brazilian context, refining the classification tree and addressing practical challenges faced by the scientific and clinical community. </p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"61"},"PeriodicalIF":2.8,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of conventional and novel inflammatory biomarkers in Familial Mediterranean fever during attack-free periods.","authors":"Aleksandra Klisic, Ana Ninic, Bayram Kizilkaya, Osman Cure, Vesna Ćeriman Krstić, Filiz Mercantepe","doi":"10.1186/s42358-025-00491-2","DOIUrl":"10.1186/s42358-025-00491-2","url":null,"abstract":"<p><strong>Background: </strong>Familial Mediterranean fever (FMF) is a monogenic autoinflammatory condition accompanied with periodic attacks of fever. The clinical utility of some novel inflammatory parameters has not been well explored in FMF. Hence, the aim of this study was to explore the accuracy of a variety of inflammatory indexes in patients with an FMF-attack-free period and without a complication of amyloidosis.</p><p><strong>Methods: </strong>This cross-sectional study included a total of 114 patients with FMF (of them, 43.8% were men) and 97 controls (of them, 43.3% were men). Complete blood count, albumin, fibrinogen, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and serum amyloid A (SAA) were measured. Other parameters were calculated [i.e., platelet-albumin ratio (PAR), HALP score, systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV)]. Receiver operating characteristic (ROC) curve analysis was used to test the discriminative ability of each marker between patients with FMF and those without FMF.</p><p><strong>Results: </strong>The area under the ROC curve for fibrinogen [AUC = 0.710, 95% CI (0.644-0.770)], CRP [AUC = 0.780 (0.718-0.834)], fibrinogen/albumin [AUC = 0.722 (0.657-0.782)], and CRP/albumin [AUC = 0.782 (0.720-0.836)] indicated satisfactory clinical accuracy. The AUCs for SAA [AUC = 0.844 (0.788-0.890)], SAA/albumin [AUC = 0.856 (0.801-0.900)], and PLT/SAA [AUC = 0.810 (0.750-0.861)] indicated good clinical accuracy. There was no difference between AUCs for SAA and SAA/albumin (P = 0.073), whereas the AUCs for these 2 parameters were significantly higher than the AUC for PLT/SAA (P = 0.033 and P = 0.005, respectively).</p><p><strong>Conclusion: </strong>SAA and SAA/albumin ratio are the most reliable biomarkers in discriminating patients with FMF from healthy individuals.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"62"},"PeriodicalIF":2.8,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the influence of sagittal imbalance on spinal mobility, function and quality of life in axial spondyloarthritis: a novel comprehensive compensatory mechanism of adaptation.","authors":"Thauana Luiza de Oliveira, Flávio Duarte Silva, Alípio Gomes Ormond Filho, Marcelo Astolfi Caetano Nico, Artur da Rocha Correa Fernandes, Sofia Ramiro, Marcelo de Medeiros Pinheiro","doi":"10.1186/s42358-025-00495-y","DOIUrl":"10.1186/s42358-025-00495-y","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate whether sagittal imbalance, defined by sagittal vertical axis (SVA) using EOS^® imaging, is associated with spinal mobility, function, and quality of life in patients with axial spondyloarthritis (axSpA).</p><p><strong>Methods: </strong>Patients with axSpA were cross-sectionally assessed for sagittal imbalance (SVA ≥ 50 mm). Spinal mobility (BASMI), function (BASFI) and quality of life (ASQoL) were compared between patients with and without sagittal imbalance. Multivariable analyses examined the associations between SVA and the above-mentioned disease outcomes, adjusted for confounders. Mediation analysis explored whether sagittal alignment mediated the relationship between spinal mobility and structural damage.</p><p><strong>Results: </strong>Among 117 patients (mean age 51 (SD 11) years, 68% males), 44 (38%) had sagittal imbalance. SVA was only independently and significantly associated with BASMI but not with BASFI or ASQoL. SVA minimally mediated the relationship between mSASSS and BASMI. The optimal BASMI cutoff to identify patients with sagittal imbalance was 5.2 with 80% of correct classification.</p><p><strong>Conclusions: </strong>Sagittal imbalance is associated with impaired spinal mobility but not with impaired function or quality of life. These findings may reflect compensatory mechanisms for sagittal balance in long-term axSpA patients. Impaired spinal mobility can be used to identify patients with sagittal imbalance who may benefit from physiotherapy or rehabilitation.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"60"},"PeriodicalIF":2.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145597345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the immunogenicity and safety among COVID-19 vaccines ChadOx-1, CoronaVac and BNT162b2 in systemic lupus erythematosus (SLE) patients: a prospective cohort.","authors":"Priscila Dias Cardoso Ribeiro, Flavia Maria Matos Melo Campos Peixoto, Edgard Torres Dos Reis-Neto, Gecilmara Salviato Pileggi, Nancy Cristina Junqueira Bellei, Marcelo de Medeiros Pinheiro, Vanessa de Oliveira Magalhães, Erika Biegelmeyer, André Gustavo Cunha Trolese, Alexandre Wagner Silva de Souza, Cristiane Kayser, Valéria Valim, Ketty Lysie Libardi Lira Machado, Maressa Barbosa Beloni Lirio, Juliana Ribeiro de Oliveira, Andrea Teixeira de Carvalho, Rodrigo Poubel Vieira de Rezende, Ana Karla Guedes de Melo, Rejane Maria Rodrigues de Abreu Vieira, Vitor Alve Cruz, Viviane Angelina de Souza, Gilda Aparecida Ferreira, Sandra Lúcia Euzébio Ribeiro, Odirlei Monticielo, Ricardo Machado Xavier, Natalia Sarzi Sartori, Emilia Inoue Sato","doi":"10.1186/s42358-025-00498-9","DOIUrl":"10.1186/s42358-025-00498-9","url":null,"abstract":"<p><strong>Background: </strong>The immune response and safety using different COVID-19 vaccine platforms in patients with immune mediated rheumatic diseases is still uncertain. The objective of this study is to compare the immunogenicity and safety after two doses of BNT162b2, CoronaVac and ChadOx-1 in SLE patients.</p><p><strong>Methods: </strong>Prospective study including SLE patients who received a primary schedule to COVID-19 vaccination between May and August 2021. Immunogenicity, events supposedly attributable to vaccination or immunization (ESAVI) and disease activity were assessed at baseline and after each vaccine dose.</p><p><strong>Results: </strong>121 SLE patients were included in the cohort, 88 in the immunogenicity analysis and 118 in the safety analysis. The groups were homogenous concerning sex, age, and comorbidities. Seropositivity after two doses of vaccines was similar between CoronaVac (68%), ChadOx1 (80,6%) and BNT162b2 (88%) (p=0.231). However, CoronaVac and ChadOx-1 presented lower titers in comparison with BNT162b2.  Regarding ESAVI, the most frequent reported following first and second vaccine doses were, respectively: injection site pain (65.2%/41.1%), headache (50.9%/29.9%) and arthralgia (37.5%/22.5%). Fever and myalgia were more related to ChAdOx1 than CoronaVac (23.3 vs. 5.0%; p=0.025). There was no difference in MEX-SLEDAI between vaccine platforms. No serious ESAVI were reported.</p><p><strong>Conclusion: </strong>After two doses, the three COVID-19 vaccine platforms induced a significant increase in antibody titers against SARS-CoV-2. Patients who received BNT162b2 exhibited a higher serological response compared to the other vaccines. All three vaccine platforms demonstrated a favorable safety profile, with no serious ESAVI or worsening of disease activity.</p><p><strong>Clinical trial number: </strong>The study was registered in The Brazilian Registry of Clinical Trials (ReBEC) in 04/14/2021 with code RBR-108fyykd.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":" ","pages":"67"},"PeriodicalIF":2.8,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile idiopathic inflammatory myopathies assessment by magnetic resonance imaging: a scoping review of protocols, scoring systems, and applications.","authors":"Vitor Tavares Paula, Clarissa Harumi Omori, Samuel Katsuyuki Shinjo, Daniel Brito de Araújo, Jessica Day, Adam Schiffenbauer, Claudia Saad Magalhães, Edoardo Conticini, Edoardo Marrani, Julio Brandão Guimarães, Lisa G Rider, Mickael Essouma, Simone Appenzeller, Andrea Schwarz Doria, Adriana Maluf Elias","doi":"10.1186/s42358-025-00494-z","DOIUrl":"10.1186/s42358-025-00494-z","url":null,"abstract":"<p><p>BACKGROUND: Our review assessed whole body (WB) and dedicated body-part magnetic resonance imaging (DedMRI) techniques, protocols, and inflammatory scoring systems, focusing on their clinimetric properties (reliability, validity, responsiveness) in clinical and research settings of patients with juvenile idiopathic inflammatory myopathies (JIIM). METHODS: A comprehensive search of MEDLINE, EMBASE, and Cochrane databases from 2000 to 2024 identified relevant studies. RESULTS: Sixteen studies enrolling JIIM patients with MRI were reviewed, which showed heterogeneity in objectives, methodologies, and scoring systems. Four (25%) studies used quantitative assessments, while 12 (75%) employed semi-quantitative or qualitative methods in scoring MRI. WB-MRI was performed in 3 (18.7%) studies, and DedMRI in 13 (81.2%). Muscle evaluation included assessments of edema [14 (87.5%) studies], fatty infiltration [4 (25%) studies], and atrophy [6 (37.5%) studies]. T1 images were used in 9 (56.2%) studies for measuring chronic changes, with coronal views reported in 6 (37.5%). Fluid-sensitive sequences (T2 with fat saturation, STIR) were employed in all studies and were obtained in the coronal plane in 9 (56.2%). These sequences were crucial for detecting soft tissue edema related to acute/subacute inflammation. One (6%) study included diffusion and T1 post-contrast sequences. CONCLUSION: There is significant heterogeneity in MRI protocols for evaluating JIIM. Standardized WB-MRI protocols are needed to ensure consistency and comparability across studies and institutions, optimize assessments of disease activity, treatment response, and follow-up in JIIM patients. Standardization should enhance the reliability of MRI for diagnosing and monitoring JIIM in clinical and research settings. </p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":" ","pages":"64"},"PeriodicalIF":2.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12711408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}