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Correction: Brazilian recommendations for the management of tuberculosis infection in immune-mediated inflammatory diseases. 更正:巴西关于免疫介导的炎症性疾病中结核感染管理的建议。
IF 2 4区 医学
Advances in Rheumatology Pub Date : 2025-07-21 DOI: 10.1186/s42358-025-00466-3
Viviane Angelina de Souza, Ana Luiza Mendes Amorim Caparroz, Virginia Fernandes Moça Trevisani, Anna Carolina Faria Moreira Gomes Tavares, Ana Karla Guedes de Melo, Anete Trajman, Ana Cristina de Medeiros-Ribeiro, Marcelo de Medeiros Pinheiro, Ricardo Machado Xavier, Odirlei Andre Monticielo, Maria Fernanda Brandão de Resende Guimarães, Flavio Sztajnbok, Sidney Bombarda, Liliana Andrade Chebli, Adriana Maria Kakehasi, Ana Luiza Bierrenbach, Ana Paula Monteiro Gomides Reis, Blanca Elena Rios Gomes Bica, Claudia Diniz Lopes Marques, Cristina Flores, Denise Silva Rodrigues, Eduardo Dos Santos Paiva, Eliana Dias Matos, Fernanda Dockhorn Costa Johansen, Helio Arthur Bacha, Joana Starling de Carvalho, José Roberto Provenza, Ketty Lysie Libardi Lira Machado, Licia Maria Henrique da Mota, Lilian David de Azevedo Valadares, Marco Antônio Araújo da Rocha Loures, Margareth Maria Pretti Dalcolmo, Maria Cecilia de Carvalho Bortoletto, Max Igor Banks Ferreira Lopes, Rejane Maria Rodrigues de Abreu Vieira, Ricardo Romiti, Rogerio Saad-Hossne, Rozana Mesquita Ciconelli, Valderilio Feijó Azevedo, Valéria Maria Augusto, Vitor Alves Cruz, Gecilmara Cristina Salviato Pileggi
{"title":"Correction: Brazilian recommendations for the management of tuberculosis infection in immune-mediated inflammatory diseases.","authors":"Viviane Angelina de Souza, Ana Luiza Mendes Amorim Caparroz, Virginia Fernandes Moça Trevisani, Anna Carolina Faria Moreira Gomes Tavares, Ana Karla Guedes de Melo, Anete Trajman, Ana Cristina de Medeiros-Ribeiro, Marcelo de Medeiros Pinheiro, Ricardo Machado Xavier, Odirlei Andre Monticielo, Maria Fernanda Brandão de Resende Guimarães, Flavio Sztajnbok, Sidney Bombarda, Liliana Andrade Chebli, Adriana Maria Kakehasi, Ana Luiza Bierrenbach, Ana Paula Monteiro Gomides Reis, Blanca Elena Rios Gomes Bica, Claudia Diniz Lopes Marques, Cristina Flores, Denise Silva Rodrigues, Eduardo Dos Santos Paiva, Eliana Dias Matos, Fernanda Dockhorn Costa Johansen, Helio Arthur Bacha, Joana Starling de Carvalho, José Roberto Provenza, Ketty Lysie Libardi Lira Machado, Licia Maria Henrique da Mota, Lilian David de Azevedo Valadares, Marco Antônio Araújo da Rocha Loures, Margareth Maria Pretti Dalcolmo, Maria Cecilia de Carvalho Bortoletto, Max Igor Banks Ferreira Lopes, Rejane Maria Rodrigues de Abreu Vieira, Ricardo Romiti, Rogerio Saad-Hossne, Rozana Mesquita Ciconelli, Valderilio Feijó Azevedo, Valéria Maria Augusto, Vitor Alves Cruz, Gecilmara Cristina Salviato Pileggi","doi":"10.1186/s42358-025-00466-3","DOIUrl":"https://doi.org/10.1186/s42358-025-00466-3","url":null,"abstract":"","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"33"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of rheumatologists' knowledge of biosimilars. 风湿病学家对生物仿制药知识的评估。
IF 2 4区 医学
Advances in Rheumatology Pub Date : 2025-07-17 DOI: 10.1186/s42358-025-00465-4
Thayane Furtado Rolim Lima, Lia Poti Gomes Cordeiro, Kirla Wagner Poti Gomes, Carlos Ewerton Maia Rodrigues
{"title":"Evaluation of rheumatologists' knowledge of biosimilars.","authors":"Thayane Furtado Rolim Lima, Lia Poti Gomes Cordeiro, Kirla Wagner Poti Gomes, Carlos Ewerton Maia Rodrigues","doi":"10.1186/s42358-025-00465-4","DOIUrl":"https://doi.org/10.1186/s42358-025-00465-4","url":null,"abstract":"<p><strong>Introduction: </strong>Biosimilars reduce the cost of biologic therapy without compromising safety and effectiveness. In this study we evaluated Brazilian rheumatologists' knowledge and perceptions of biosimilars.</p><p><strong>Methods: </strong>Cross-sectional and descriptive study based on a questionnaire containing 17 items on familiarity, knowledge and perceptions of biosimilars.</p><p><strong>Results: </strong>Answers were received from 135 rheumatologists, of whom 97.8% were familiar with biosimilars and 92.5% had at some time prescribed them, but only 47.7% felt comfortable prescribing them to stable patients and 62.2% strongly disagreed with automatic substitution. In addition, 51.9% preferred naive patients when starting treatment with biosimilars.</p><p><strong>Conclusion: </strong>Despite the growing acceptance of biosimilars, many physicians remain reluctant. Evidence-based continuing education is essential to clarify these issues.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"32"},"PeriodicalIF":2.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of metabolic syndrome in low-income childhood-onset systemic lupus erythematosus patients. 低收入儿童期系统性红斑狼疮患者代谢综合征的患病率。
IF 2 4区 医学
Advances in Rheumatology Pub Date : 2025-07-07 DOI: 10.1186/s42358-025-00464-5
Natalia Gomes Iannini, Carlos Ewerton Maia Rodrigues
{"title":"Prevalence of metabolic syndrome in low-income childhood-onset systemic lupus erythematosus patients.","authors":"Natalia Gomes Iannini, Carlos Ewerton Maia Rodrigues","doi":"10.1186/s42358-025-00464-5","DOIUrl":"https://doi.org/10.1186/s42358-025-00464-5","url":null,"abstract":"<p><strong>Objective: </strong>To determine the prevalence of metabolic syndrome (MetS) in patients with childhood onset Systemic Lupus Erithematosus (cSLE) and controls from Northeastern Brazil and to verify its association with specific SLE parameters and cardiovascular risk factors.</p><p><strong>Methods: </strong>The prevalence of MetS was assessed cross-sectionally in 58 patients with cSLE and 33 age -matched controls. Information was collected by clinical examination and standardized questionnaires, investigating personal and family history of cardiovascular disease and obesity and socioeconomic and demographic characteristics.</p><p><strong>Results: </strong>The prevalence of MetS was higher in cSLE patients than in controls according to both ABRAN criteria (8.6% vs. 0%; p = 0.083) and IDF criteria (10,3% vs. 3.0%; p = 0.208), but without statistical significance. Importantly, 91.4% of patients were from a low-income household. Patients with MetS according to ABRAN also had lower ESR levels (p = 0.039), higher total cholesterol (p = 0.013), HDL-c (p = 0.007) and triglycerides (p = 0.001) and a lower albumin level (p = 0.016). Patients with MetS according to IDF had higher SDI scores (p = 0.039) and higher C3 and C4 levels (p < 0.001 and p < 0.001, respectively). The multivariate logistic regression identified higher levels C4 (OR = 32.6; 95% CI = 1.0-544.0; p = 0.015) and increase in the number of leukocytes (OR = 1.9, 95%CI = 1.1-3.2; p = 0.022) as independent risk factors for MetS in patients with cSLE.</p><p><strong>Conclusion: </strong>The prevalence of Mets in the patients with cSLE seems to be low in this population. There was association of MetS with higher cumulative damage indices and levels of complement. We did not observe any association with clinical manifestations, autoantibody profile and dose of corticosteroids.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"31"},"PeriodicalIF":2.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive value of total CSVD burden scores in cognitive impairment among SLE patients on the basis of MRI evaluation. 基于MRI评价的SLE患者认知障碍CSVD总负担评分的预测价值
IF 2 4区 医学
Advances in Rheumatology Pub Date : 2025-07-03 DOI: 10.1186/s42358-025-00463-6
Lei Wang, Guimin Zheng, Xiuchuan Jia, Yingmin Chen
{"title":"Predictive value of total CSVD burden scores in cognitive impairment among SLE patients on the basis of MRI evaluation.","authors":"Lei Wang, Guimin Zheng, Xiuchuan Jia, Yingmin Chen","doi":"10.1186/s42358-025-00463-6","DOIUrl":"https://doi.org/10.1186/s42358-025-00463-6","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment (CI) is a significant problem in systemic lupus erythematosus (SLE) patients. In recent years, total cerebral small vessel disease (CSVD) burden scores have had substantial value in predicting cognitive impairment. However, its application in treating concurrent cognitive impairment in SLE patients is unclear. To explore the relationship between total CSVD burden scores and cognitive dysfunction in SLE patients and to analyze its predictive value.</p><p><strong>Methods: </strong>The Montreal Cognitive Assessment (MoCA) score was used to evaluate the cognitive function of 50 patients with SLE, and the total load score of patients with CSVD was analyzed via magnetic resonance imaging (MRI). Multivariate regression was used to evaluate the relationship between total CSVD burden scores and cognitive dysfunction, and the predictive value of total CSVD burden scores was assessed.</p><p><strong>Results: </strong>Multivariate logistic regression analysis revealed that years of education (OR = 0.975, 95% CI [0.952-0.998], P = 0.035), neuropsychiatric systemic lupus erythematosus (NPSLE) (OR = 4.152, 95% CI [2.158-7.990], P < 0.001), and the CSVD total burden score (OR = 3.884, 95% CI [0.840-0.928], P < 0.001) were independently associated with cognitive impairment in SLE patients. The results of the ROC curve analysis revealed that the area under the curve (AUC) of the CSVD total burden score for the prediction of cognitive impairment in SLE patients was 0.885.</p><p><strong>Conclusions: </strong>Years of education, NPSLE score, and total CSVD burden score are closely related to the occurrence of cognitive impairment in SLE patients. In particular, the total CSVD burden score is beneficial for the prediction of cognitive impairment.</p><p><strong>Clinical trial number: </strong>Not applicable.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"30"},"PeriodicalIF":2.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brazilian guidelines for the management of tuberculosis infection in immune-mediated inflammatory diseases: is retesting in latent tuberculosis screening appropriate and Safe? 巴西免疫介导的炎症性疾病结核病感染管理指南:潜伏性结核病筛查重新检测是否适当和安全?
IF 2 4区 医学
Advances in Rheumatology Pub Date : 2025-07-01 DOI: 10.1186/s42358-025-00462-7
Carlos Brito, Rita Moraes de Brito
{"title":"Brazilian guidelines for the management of tuberculosis infection in immune-mediated inflammatory diseases: is retesting in latent tuberculosis screening appropriate and Safe?","authors":"Carlos Brito, Rita Moraes de Brito","doi":"10.1186/s42358-025-00462-7","DOIUrl":"10.1186/s42358-025-00462-7","url":null,"abstract":"<p><p>The article \"Brazilian Recommendations for the Management of Tuberculosis Infection in Immune-Mediated Inflammatory Diseases\" by Viviane de Souza et al. presents important discussions on the subject; however, the recommendation for annual repetition of the TST/IGRA test for three years and after medication changes raises considerable concerns. This approach may lead to overdiagnosis and overtreatment of latent tuberculosis infection (LTBI). Frequent false-positive results in retests can result in unnecessary antibiotic use, contributing to bacterial resistance, a problem of global significance. The recommendation, considered to have a moderate level of evidence, is subject to criticism. Arguments used to support retesting, such as high conversion rates of tests after one year, reports of tuberculosis cases despite negative screenings being attributed to false negatives, and reliance on other sources with lower levels of evidence, do not constitute sufficient evidence to confirm tuberculosis infection or justify the recommendation. On the other hand, there is evidence that has not been considered in the discussion against the recommendation for retesting, indicating that this practice may increase the risk of diagnosing false-positive infections, leading to overtreatment without clinically proven benefits. Potentially harmful interventions should not be implemented without solid evidence to support them. In this letter to the editor, we briefly discuss this recommendation and the arguments against its implementation, highlighting its associated risks.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"29"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of myocardial fibrosis in patients with immune-mediated inflammatory diseases. 免疫介导的炎症性疾病患者心肌纤维化的决定因素
IF 2 4区 医学
Advances in Rheumatology Pub Date : 2025-06-14 DOI: 10.1186/s42358-025-00451-w
Nicholas Black, Joshua Bradley, Fardad Soltani, John P Farrant, Josephine H Naish, Matthias Schmitt, Maya H Buch, Christopher A Miller
{"title":"Determinants of myocardial fibrosis in patients with immune-mediated inflammatory diseases.","authors":"Nicholas Black, Joshua Bradley, Fardad Soltani, John P Farrant, Josephine H Naish, Matthias Schmitt, Maya H Buch, Christopher A Miller","doi":"10.1186/s42358-025-00451-w","DOIUrl":"10.1186/s42358-025-00451-w","url":null,"abstract":"<p><strong>Background: </strong>Myocardial fibrosis is an important adverse prognostic marker, however; determinants of myocardial fibrosis in immune-mediated inflammatory diseases (IMIDs) remain poorly defined. We aimed to identify determinants of myocardial fibrosis in patients with IMIDs, as measured by cardiovascular magnetic resonance (CMR) extracellular volume (ECV).</p><p><strong>Methods: </strong>Cross-sectional study of 116 patients with IMIDs undergoing clinical CMR at Manchester University NHS Foundation Trust. IMIDs included rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis (SSc), ankylosing spondylitis, psoriatic arthritis and vasculitis. CMR included pre- and post-contrast T1 mapping to measure myocardial ECV, with same day blood sampling. Determinants of ECV were investigated with univariable and multivariable linear regression.</p><p><strong>Results: </strong>ECV varied significantly according to IMID diagnosis (ANOVA F statistic 2.80, P = 0.015); ECV was higher in patients with SSc compared to other IMIDs. Major determinants of ECV as a continuous variable were SSc, smoking and body mass index (BMI); regression coefficients 3.33 (95% confidence interval 0.82-5.84), 3.08 (0.73-5.43), and - 0.19 (-0.29 - -0.09) respectively, P < 0.01 (SSc, smoking and lower BMI were associated with increased ECV). Approximately a quarter of the variability in ECV could be explained by these predictors (optimism adjusted R<sup>2</sup> 0.265).</p><p><strong>Conclusion: </strong>SSc is associated with a higher burden of myocardial fibrosis compared to other IMIDs. In patients with IMIDs, independent determinants of myocardial fibrosis were presence of SSc, smoking and BMI. Importantly, participants underwent CMR for clinical indications and may not be representative of IMID populations in the community.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"28"},"PeriodicalIF":2.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibromyalgia with concomitant immune-mediated rheumatic diseases: an evaluation of clinical characteristics, diagnostic criteria and multimodal treatment outcomes. 纤维肌痛伴发免疫介导的风湿性疾病:临床特征、诊断标准和多模式治疗结果的评估
IF 2 4区 医学
Advances in Rheumatology Pub Date : 2025-06-12 DOI: 10.1186/s42358-025-00457-4
Johanna Mettler, Pedro Ming-Azevedo, Thomas Hügle
{"title":"Fibromyalgia with concomitant immune-mediated rheumatic diseases: an evaluation of clinical characteristics, diagnostic criteria and multimodal treatment outcomes.","authors":"Johanna Mettler, Pedro Ming-Azevedo, Thomas Hügle","doi":"10.1186/s42358-025-00457-4","DOIUrl":"https://doi.org/10.1186/s42358-025-00457-4","url":null,"abstract":"<p><strong>Objectives: </strong>Fibromyalgia (FM) is a relevant comorbidity in immune-mediated rheumatic diseases (IMRD). Immune mechanisms have been postulated to trigger FM, potentially leading to distinct clinical features compared to FM occurring without IMRDs. This study aims to provide a comprehensive comparison of FM characteristics in patients with and without concomitant IMRD and to evaluate the differences in diagnostic FM criteria between the two groups.</p><p><strong>Methods: </strong>A comprehensive dataset of clinical, psychosocial, and sleep variables, along with validated questionnaires, was prospectively collected from 341 patients with chronic musculoskeletal pain syndromes who participated in a rheumatology-led, two-week multimodal inpatient program at the University Hospital of Lausanne between 2018 and 2024. Participants were included if they met either the Fibromyalgia Rapid Screening Tool (FiRST) or the American College of Rheumatology (ACR) 2010 criteria for FM. The disease activity of the underlying IMRD was assessed by two rheumatologists. Data were separately analyzed in two cohorts: one fulfilling the FiRST criteria and the other fulfilling the ACR 2010 criteria.</p><p><strong>Results: </strong>Among the participants, 153 patients met the FiRST criteria, of whom 34 also had a history of clinically diagnosed IMRD. Similarly, 149 patients fulfilled the ACR 2010 criteria, with 32 of them also having IMRD. The most common IMRDs were HLA-B27-negative spondyloarthritis (53%), Sjögren's syndrome (16%), HLA-B27-positive spondyloarthritis (9%), psoriatic arthritis (9%), seronegative rheumatoid arthritis (9%), and seropositive rheumatoid arthritis (3%). In 88% of patients with IMRD, the disease was considered inactive. No significant clinical or epidemiological differences were found between FM patients with or without IMRD in either the FiRST or ACR 2010 cohorts, except for a higher prevalence of enthesopathies and childhood pain in patients with concomitant IMRD. FM patients with IMRD had slightly lower FiRST scores, and FiRST-positive IMRD patients showed a better short-term response to the multimodal program, particularly in FABQ-work, BPI-interference, and Pain Catastrophizing Scale scores. However, no significant difference was observed in the Pain Disability Index (PDI) three months post-program.</p><p><strong>Conclusion: </strong>HLA-B27-negative spondyloarthritis and Sjögren's syndrome were the most common concomitant IMRDs in this FM cohort. FM patients with and without IMRD exhibited similar clinical and epidemiological features, suggesting a common pathophysiological background. The FiRST criteria, which emphasize central hypersensitization rather than diffuse pain, appear to be a suitable tool for detecting FM in IMRD patients. This may be particularly useful in cases where enthesial pain might interfere with FM diagnosis, and vice versa.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"27"},"PeriodicalIF":2.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A real-life study of juvenile idiopathic arthritis from two Brazilian referral centers for pediatric rheumatology. 来自两个巴西儿童风湿病转诊中心的青少年特发性关节炎的现实生活研究。
IF 2 4区 医学
Advances in Rheumatology Pub Date : 2025-06-11 DOI: 10.1186/s42358-025-00459-2
Ana María Loroño Terrazas, Raúl Gutiérrez Suárez, Reinan Tavares Campos, Claudio Arnaldo Len, Nadia Emi Aikawa, Jade Dib Fernandez, Mayra Lisyer Dantas, Clóvis Artur Silva, Gleice Clemente, Maria Teresa Terreri
{"title":"A real-life study of juvenile idiopathic arthritis from two Brazilian referral centers for pediatric rheumatology.","authors":"Ana María Loroño Terrazas, Raúl Gutiérrez Suárez, Reinan Tavares Campos, Claudio Arnaldo Len, Nadia Emi Aikawa, Jade Dib Fernandez, Mayra Lisyer Dantas, Clóvis Artur Silva, Gleice Clemente, Maria Teresa Terreri","doi":"10.1186/s42358-025-00459-2","DOIUrl":"10.1186/s42358-025-00459-2","url":null,"abstract":"<p><strong>Background: </strong>Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood, but its outcomes are still difficult to determine. We aimed to obtain outcome measurements of disease activity, functional capacity, disease damage, and therapeutic response, at one-year follow-up study on a real-life basis.</p><p><strong>Methods: </strong>An observational JIA cohort from two referral centers for pediatric rheumatology in Brazil Pediatric Rheumatology Centers was carried out over a period of one year. Clinimetric validated outcome measurements were applied over four visits. Multivariable logistic regression was performed to evaluate baseline variables associated with the following outcomes after one year of follow-up: disease activity, Minimal Disease Activity (MDA), disease flare, remission on medication and remission off medication.</p><p><strong>Results: </strong>A total of 127 patients were included in the study. Eighty-three (65.4%) were females, and median time to diagnosis was 6.0 months. JADAS71 and CHAQ improved during follow-up (mean Vbaseline 7.05 ± 9.3 vs. V52 3.52 ± 8.4; 0 ± 0.5 vs. 0.14 ± 0.4, p < 0.001, respectively) as well as JIA-ACR 30, 50, 70 and 90 (Vbaseline 79.8% vs. V52 88.8%; 71.4% vs. 84.1%; 59.7% vs. 77.6%; 49.6% vs. 69.2%, p < 0.05, respectively). Inactive disease was present in 33% of patients at baseline and in 67.9% at V52 (p < 0.001). Remission on medication, remission off medication and MDA were present in 46%, 11%, and 80.6% of patients at V52, respectively. Extra-articular and articular damage were not common at baseline (0.3 ± 0.7 and 1.1 ± 3.4 respectively) and did not decrease significantly during the period of the study. The presence of active joints 46/101 (45.5%) at baseline reduced the chance of the patient achieving remission off medication at the last visit by 84% (OR = 0.16; CI 95% from 0.03 to 0.91, p = 0.039).</p><p><strong>Conclusion: </strong>This study showed improvement in clinimetric outcome measurements and therapeutic responses in an inception cohort of JIA patients. The presence of active joints at baseline is related to not achieving remission at last visit. Long-term prospective and multicenter studies are needed to better assess the outcome of JIA and the differences among JIA subtypes.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"26"},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2025 Chinese guideline for the imaging diagnosis and evaluation of Takayasu arteritis. 2025中国高须动脉炎影像诊断与评价指南。
IF 2 4区 医学
Advances in Rheumatology Pub Date : 2025-06-03 DOI: 10.1186/s42358-025-00460-9
Yun Liu, Lingying Ma, Zhuoli Zhang, Yan Zhao, Xuerong Deng, Jiang Lin, Jianxing Qiu, Hongcheng Shi, Ke Wang, Zhu Chen, Lie Dai, Lingli Dong, Xuebing Feng, Lan He, Wenhui Huang, Fen Li, Guangtao Li, Qin Li, Ting Li, Yisha Li, Jin Lin, Jinying Lin, Wufang Qi, Haili Shen, Xiaofei Shi, Qiang Shu, Wenfeng Tan, Caihong Wang, Wei Wei, Huaxiang Wu, Lijun Wu, Qibing Xie, Pingting Yang, Liyun Zhang, Ling Zhao, Zhaohui Zheng, Wenjie Zheng, Jing Zhu, Xiaochun Zhu, Xiaoqin Wang, Jun Ying, Lindi Jiang
{"title":"2025 Chinese guideline for the imaging diagnosis and evaluation of Takayasu arteritis.","authors":"Yun Liu, Lingying Ma, Zhuoli Zhang, Yan Zhao, Xuerong Deng, Jiang Lin, Jianxing Qiu, Hongcheng Shi, Ke Wang, Zhu Chen, Lie Dai, Lingli Dong, Xuebing Feng, Lan He, Wenhui Huang, Fen Li, Guangtao Li, Qin Li, Ting Li, Yisha Li, Jin Lin, Jinying Lin, Wufang Qi, Haili Shen, Xiaofei Shi, Qiang Shu, Wenfeng Tan, Caihong Wang, Wei Wei, Huaxiang Wu, Lijun Wu, Qibing Xie, Pingting Yang, Liyun Zhang, Ling Zhao, Zhaohui Zheng, Wenjie Zheng, Jing Zhu, Xiaochun Zhu, Xiaoqin Wang, Jun Ying, Lindi Jiang","doi":"10.1186/s42358-025-00460-9","DOIUrl":"10.1186/s42358-025-00460-9","url":null,"abstract":"<p><strong>Background: </strong>Takayasu arteritis (TAK) presents as systemic vasculitis. Imaging is crucial for the diagnosis and evaluation of TAK, but the rational selection of imaging methods and interpretation of imaging results are major challenges in clinical practice, which can affect treatment decisions. This guideline aims to establish standardized protocols for selecting imaging modalities (as well as interpreting their findings) in TAK.</p><p><strong>Methods: </strong>Relevant clinical questions were formulated by an expert panel. Systematic reviews of evidence published from database establishment to 31 October 2023 were done. The grading system set by the Oxford University Evidence-Based Medicine Center was employed to assess the quality of evidence. Recommendations were developed through consensus using the Delphi method.</p><p><strong>Results: </strong>Seventeen recommendation statements were developed based on evidence summaries and consensus. The first four recommendations focused on overarching principles. Recommendations 5 to 14 covered the advantages and disadvantages of different imaging modalities, as well as the selection of imaging modalities in the diagnosis and evaluation of TAK, including ultrasound (three statements), magnetic resonance angiography (two), computed tomography angiography (two), positron emission tomography/computed tomography (two), and digital subtraction angiography (one). Recommendations 15 to 17 focused on the selection of imaging methods for special populations and organ perfusion.</p><p><strong>Conclusion: </strong>These recommendations could help to standardize the use of imaging modalities by clinicians in the diagnosis and evaluation of TAK.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"25"},"PeriodicalIF":2.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Demographic, clinical, treatment, outcome, and comorbidities of patients with relapsing polychondritis: experience from Brazilian tertiary center, and literature review. 复发性多软骨炎患者的人口学、临床、治疗、结局和合并症:来自巴西三级中心的经验和文献综述。
IF 2 4区 医学
Advances in Rheumatology Pub Date : 2025-05-14 DOI: 10.1186/s42358-025-00456-5
Patricia Pilar Lury Ortale Ueda, Luiz Antonio Leandrini Komati, Samuel Katsuyuki Shinjo
{"title":"Demographic, clinical, treatment, outcome, and comorbidities of patients with relapsing polychondritis: experience from Brazilian tertiary center, and literature review.","authors":"Patricia Pilar Lury Ortale Ueda, Luiz Antonio Leandrini Komati, Samuel Katsuyuki Shinjo","doi":"10.1186/s42358-025-00456-5","DOIUrl":"10.1186/s42358-025-00456-5","url":null,"abstract":"<p><strong>Background: </strong>Due to the rarity of relapsing polychondritis (RP), we described the demographic, clinical, treatment, outcomes, and comorbidities of patients with RP from our tertiary service. Additionally, a literature review was conducted.</p><p><strong>Methods: </strong>A total of 47 Brazilian patients with RP between 2000 and 2024 were analyzed. All patient data were collected from pre-parametrized and pre-standardized electronic medical records. A literature review using PubMed with \"relapsing polychondritis\" as the search term included 25 articles after applying the strict exclusion criteria.</p><p><strong>Results: </strong>A total of 47 patients were evaluated. The median age was 40 (34-51) years, with a female-to-male ratio of 1.4:1, and 89.4% were of white ethnicity. The median time from symptom onset to diagnosis was 39 months and the median follow-up duration was 7 years. Ear cartilage biopsy was performed in 12.8% of cases. The clinical manifestations included auricular chondritis, arthralgia, and ocular involvement. Approximately half of the patients had hypertension and dyslipidemia, one-third had diabetes mellitus, and one-fifth had hypothyroidism. Tracheostomy and cochlear implantation were required in 12.8% and 6.4% of the patients, respectively. Disease outcomes showed that 46.8% of patients were in remission, 29.8% had active disease, and 25.5% were controlled with immunosuppressive therapy. Mortality occurred in 6.4% of the cases. In the literature review, 25 studies were analyzed, most of which originated in Asia. Studies have reported the classical manifestations of RP, such as auricular chondritis, arthritis, and ocular involvement. The median age of the patients with RP was similar across studies, averaging 46.4 years, with a predominance of female patients. A comparison with the literature showed consistency in clinical manifestations, particularly auricular chondritis and septum nasal chondritis, although few studies have explored comorbidities, disease evolution, and outcomes.</p><p><strong>Conclusions: </strong>The reviewed articles described classical clinical manifestations, but few articles reported data on other manifestations and comorbidities that can occur in RP. Our study provided new insights by mapping symptom evaluations, thereby enhancing the understanding of disease evolution. Understanding and characterizing RP will allow for better assistance in its diagnosis and follow-up.</p>","PeriodicalId":48634,"journal":{"name":"Advances in Rheumatology","volume":"65 1","pages":"24"},"PeriodicalIF":2.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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