Predictive value of total CSVD burden scores in cognitive impairment among SLE patients on the basis of MRI evaluation.

IF 2 4区医学 Q3 RHEUMATOLOGY

Advances in Rheumatology Pub Date : 2025-07-03 DOI:10.1186/s42358-025-00463-6

Lei Wang, Guimin Zheng, Xiuchuan Jia, Yingmin Chen

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引用次数: 0

Abstract

Background: Cognitive impairment (CI) is a significant problem in systemic lupus erythematosus (SLE) patients. In recent years, total cerebral small vessel disease (CSVD) burden scores have had substantial value in predicting cognitive impairment. However, its application in treating concurrent cognitive impairment in SLE patients is unclear. To explore the relationship between total CSVD burden scores and cognitive dysfunction in SLE patients and to analyze its predictive value.

Methods: The Montreal Cognitive Assessment (MoCA) score was used to evaluate the cognitive function of 50 patients with SLE, and the total load score of patients with CSVD was analyzed via magnetic resonance imaging (MRI). Multivariate regression was used to evaluate the relationship between total CSVD burden scores and cognitive dysfunction, and the predictive value of total CSVD burden scores was assessed.

Results: Multivariate logistic regression analysis revealed that years of education (OR = 0.975, 95% CI [0.952-0.998], P = 0.035), neuropsychiatric systemic lupus erythematosus (NPSLE) (OR = 4.152, 95% CI [2.158-7.990], P < 0.001), and the CSVD total burden score (OR = 3.884, 95% CI [0.840-0.928], P < 0.001) were independently associated with cognitive impairment in SLE patients. The results of the ROC curve analysis revealed that the area under the curve (AUC) of the CSVD total burden score for the prediction of cognitive impairment in SLE patients was 0.885.

Conclusions: Years of education, NPSLE score, and total CSVD burden score are closely related to the occurrence of cognitive impairment in SLE patients. In particular, the total CSVD burden score is beneficial for the prediction of cognitive impairment.

Clinical trial number: Not applicable.

Trial registration: Not applicable.

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基于MRI评价的SLE患者认知障碍CSVD总负担评分的预测价值

背景：认知障碍（CI）是系统性红斑狼疮（SLE）患者的一个重要问题。近年来，总脑血管病（CSVD）负担评分在预测认知障碍方面具有重要价值。然而，其在SLE患者并发认知功能障碍治疗中的应用尚不清楚。探讨SLE患者CSVD总负担评分与认知功能障碍的关系，并分析其预测价值。方法：采用蒙特利尔认知评估（MoCA）评分对50例SLE患者的认知功能进行评估，并通过磁共振成像（MRI）分析CSVD患者的总负荷评分。采用多变量回归评估CSVD总负担评分与认知功能障碍的关系，并评估CSVD总负担评分的预测价值。结果：多因素logistic回归分析显示，受教育年限（OR = 0.975, 95% CI [0.952-0.998], P = 0.035）、神经精神系统性红斑狼疮（NPSLE） (OR = 4.152, 95% CI [2.158-7.990]， P结论：受教育年限、NPSLE评分、CSVD总负担评分与SLE患者认知功能障碍的发生密切相关。特别是，CSVD总负担评分有利于预测认知功能障碍。临床试验号：不适用。试验注册：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Rheumatology Medicine-Rheumatology

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

53 weeks

期刊介绍： Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.