Socioeconomic factors and COVID-19 mortality in immune-mediated rheumatic diseases patients: regional analysis from Argentina, Mexico and Brazil.

IF 2 4区医学 Q3 RHEUMATOLOGY

Advances in Rheumatology Pub Date : 2024-10-09 DOI:10.1186/s42358-024-00418-3

Marco Ulises Martinez-Martinez, Carolina Ayelen Isnardi, Deshiré Alpizar-Rodriguez, Guillermo Javier Pons-Estel, Belén María Virasoro, María Agustina Alfaro, Ingrid Petkovic, Rosana Quintana, Guillermo Berbotto, María Jezabel Haye Salinas, Sofía Ornella, Mariana Pera, Iris Jazmín Colunga-Pedraza, Fedra Irazoque-Palazuelos, Greta Reyes-Cordero, Tatiana S Rodriguez-Reyna, Jose Antonio Veloz-Aranda, Cassandra Michele Skinner-Taylor, Ingrid Maribel Juárez-Mora, Luis H Silveira, Claudia Diniz Lopes Marques, Ricardo Machado Xavier, Adriana Maria Kakehasi, Ana Paula Gomides, Edgard Torres Dos Reis-Neto, Gecilmara Salviato Pileggi, Gilda Aparecida Ferreira, Licia Maria Henrique da Mota, Marcelo Medeiros Pinheiro, Débora Cerqueira Calderaro

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引用次数: 0

Abstract

Background: SARS-CoV-2 infection has become a major international issue, not only from a medical point of view, but also social, economic and political. Most of the available information comes from the United States, Europe, and China, where the population and the socioeconomic status are very different from Latin American countries. This study evaluates the effect of regional socioeconomic characteristics on mortality due SARS-CoV-2 infection in patients with immune-mediated rheumatic diseases (IMRD) from Argentina, Mexico and Brazil.

Methods: Data from three national registries, SAR-COVID (Argentina), CMR-COVID (Mexico) and ReumaCoV-Brasil (Brazil), were combined. Adult IMRD patients with SARS-CoV-2 infection were recruited. National data for each province/state, including population density, number of physicians per inhabitant, income, unemployment, GINI index, Municipal Human Development Index (MHDI), stringency index, vaccination rate and most frequent viral strains per period were assessed as risk factors for mortality due to COVID-19.

Results: A total of 4744 patients were included, 2534 (53.4%) from SAR-COVID, 1166 (24.6%) from CMRCOVID and 1044 (22.0%) from ReumaCoV-Brasil. Mortality due to COVID-19 was 5.4%. In the multivariable analysis, higher number of physicians per 1000 inhabitants and being infected during the vaccination period of each country were associated with lower mortality. After adjustment for socioeconomic factors, there was no association with country of residence and mortality.

Conclusion: These findings corroborate the complex interplay between socioeconomic factors, rheumatic disease activity, and regional disparities as determinants of death due to COVID-19 in Argentina, Brazil and Mexico. Thus, this research provides valuable insights for guiding public health policies and clinical practice in the ongoing fight against the COVID-19 pandemic.

查看原文本刊更多论文

免疫介导的风湿病患者的社会经济因素和 COVID-19 死亡率：阿根廷、墨西哥和巴西的地区分析。

背景：SARS-CoV-2 感染已成为一个重大的国际问题，不仅从医学角度看是如此，从社会、经济和政治角度看也是如此。现有资料大多来自美国、欧洲和中国，而这些国家的人口和社会经济状况与拉丁美洲国家大相径庭。本研究评估了地区社会经济特征对阿根廷、墨西哥和巴西免疫介导风湿病（IMRD）患者感染 SARS-CoV-2 死亡率的影响：方法：合并来自 SAR-COVID（阿根廷）、CMR-COVID（墨西哥）和 ReumaCoV-Brasil（巴西）三个国家登记处的数据。招募了感染 SARS-CoV-2 的成年 IMRD 患者。评估了各省/州的国家数据，包括人口密度、居民人均医生数量、收入、失业率、GINI 指数、城市人类发展指数 (MHDI)、严格指数、疫苗接种率和每个时期最常见的病毒株，作为 COVID-19 导致死亡的风险因素：共纳入了 4744 名患者，其中 2534 人（53.4%）来自 SAR-COVID，1166 人（24.6%）来自 CMRCOVID，1044 人（22.0%）来自 ReumaCoV-Brasil。COVID-19导致的死亡率为5.4%。在多变量分析中，每个国家每 1000 名居民中医生人数较多以及在疫苗接种期间受感染与较低的死亡率有关。在对社会经济因素进行调整后，居住国与死亡率没有关联：这些研究结果证实，在阿根廷、巴西和墨西哥，社会经济因素、风湿病活动和地区差异之间存在复杂的相互作用，是导致 COVID-19 死亡的决定因素。因此，这项研究为指导公共卫生政策和临床实践提供了有价值的见解，有助于持续抗击 COVID-19 大流行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Rheumatology Medicine-Rheumatology

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

53 weeks

期刊介绍： Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.