Bio-Design and Manufacturing最新文献_第3页

Jetting-based bioprinting: process, dispense physics, and applications 基于喷射的生物打印：工艺、点胶物理和应用

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2024-07-12 DOI: 10.1007/s42242-024-00285-3

Wei Long Ng, Viktor Shkolnikov

{"title":"Jetting-based bioprinting: process, dispense physics, and applications","authors":"Wei Long Ng, Viktor Shkolnikov","doi":"10.1007/s42242-024-00285-3","DOIUrl":"https://doi.org/10.1007/s42242-024-00285-3","url":null,"abstract":"<p>Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells, growth factors, drugs, and biomaterials in a highly automated layer-by-layer fabrication approach. Due to its immense versatility, jetting-based bioprinting has been used for various applications, including tissue engineering and regenerative medicine, wound healing, and drug development. A lack of in-depth understanding exists in the processes that occur during jetting-based bioprinting. This review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based bioprinting. We first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting, laser-induced forward transfer bioprinting, electrohydrodynamic jet bioprinting, acoustic bioprinting and microvalve bioprinting. Next, we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition, print chamber design, droplet formation and droplet impact. Finally, we highlight recent accomplishments in jetting-based bioprinting. We present the advantages and challenges of each method, discuss considerations relating to cell viability and protein stability, and conclude by providing insights into future directions of jetting-based bioprinting.</p><h3 data-test=\"abstract-sub-heading\">Graphic abstract</h3>\u0000","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":null,"pages":null},"PeriodicalIF":7.9,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141610236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A drug-loaded flexible substrate improves the performance of conformal cortical electrodes 载药柔性基底可提高保形皮层电极的性能

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2024-07-12 DOI: 10.1007/s42242-024-00299-x

Rongrong Qin, Tian Li, Yifu Tan, Fanqi Sun, Yuhao Zhou, Ronghao Lv, Xiaoli You, Bowen Ji, Peng Li, Wei Huang

引用次数: 0

Enhanced wear resistance, antibacterial performance, and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro 利用含有纳米银的纳米管和体外生物陶瓷增强耐磨性、抗菌性能和生物相容性

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2024-07-11 DOI: 10.1007/s42242-024-00279-1

Qingge Wang, Jia Liu, Hong Wu, Jingbo Liu, Yaojia Ren, Luxin Liang, Xinxin Yan, Ian Baker, Shifeng Liu, V. V. Uglov, Chengliang Yang, Liqiang Wang

{"title":"Enhanced wear resistance, antibacterial performance, and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro","authors":"Qingge Wang, Jia Liu, Hong Wu, Jingbo Liu, Yaojia Ren, Luxin Liang, Xinxin Yan, Ian Baker, Shifeng Liu, V. V. Uglov, Chengliang Yang, Liqiang Wang","doi":"10.1007/s42242-024-00279-1","DOIUrl":"https://doi.org/10.1007/s42242-024-00279-1","url":null,"abstract":"<p>理想的钛基关节植入物应避免力屏蔽, 且具有良好的生物活性和抗感染性能。为满足这些要求, 研究人员以低弹性模量合金Ti–35Nb–2Ta–3Zr为基底, 采用阳极化、沉积和旋涂等方法制备含有生物陶瓷和银离子的功能涂层, 并将其涂覆在TiO<sub>2</sub>纳米管 ((80 ± 20) nm 和(150 ± 40) nm) 表面。研究了生物陶瓷 (nano-β-TCP, micro-HA, meso-CaSiO<sub>3</sub>) 和Ag纳米颗粒 ((50 ± 20) nm) 对纳米管的抗菌活性、摩擦、腐蚀和早期体外成骨行为的影响。摩擦和腐蚀结果表明, 磨损率和腐蚀速率与纳米管表面形貌密切相关。由于粘着磨损和磨粒磨损, 生物陶瓷micro-HA 表现出优异的耐磨性, 磨损率为(1.26 ± 0.06)×10<sup>–3</sup> mm<sup>3</sup>/(N m)。生物陶瓷meso-CaSiO<sub>3</sub>显示出良好的细胞粘附、增殖能力和碱性磷酸酶活性。含有纳米银的涂层具有良好的抗菌活性, 对大肠杆菌的抗菌率 ≥ 89.5%。研究结果表明, 该功能涂层具有加速成骨的潜力。</p>","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":null,"pages":null},"PeriodicalIF":7.9,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141610234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A crosstalk-free dual-mode sweat sensing system for naked-eye sweat loss quantification via changes in structural reflectance 无串扰双模汗液传感系统，通过结构反射率的变化进行裸眼汗液损失量化

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2024-07-11 DOI: 10.1007/s42242-024-00294-2

Bowen Zhong, Hao Xu, Xiaokun Qin, Lingchen Liu, Hailong Wang, Lili Wang

{"title":"A crosstalk-free dual-mode sweat sensing system for naked-eye sweat loss quantification via changes in structural reflectance","authors":"Bowen Zhong, Hao Xu, Xiaokun Qin, Lingchen Liu, Hailong Wang, Lili Wang","doi":"10.1007/s42242-024-00294-2","DOIUrl":"https://doi.org/10.1007/s42242-024-00294-2","url":null,"abstract":"<p>Sweat loss monitoring is important for understanding the body’s thermoregulation and hydration status, as well as for comprehensive sweat analysis. Despite recent advances, developing a low-cost, scalable, and universal method for the fabrication of colorimetric microfluidics designed for sweat loss monitoring remains challenging. In this study, we propose a novel laser-engraved surface roughening strategy for various flexible substrates. This process permits the construction of microchannels that show distinct structural reflectance changes before and after sweat filling. By leveraging these unique optical properties, we have developed a fully laser-engraved microfluidic device for the quantification of naked-eye sweat loss. This sweat loss sensor is capable of a volume resolution of 0.5 μL and a total volume capacity of 11 μL, and can be customized to meet different performance requirements. Moreover, we report the development of a crosstalk-free dual-mode sweat microfluidic system that integrates an Ag/AgCl chloride sensor and a matching wireless measurement flexible printed circuit board. This integrated system enables the real-time monitoring of colorimetric sweat loss signals and potential ion concentration signals without crosstalk. Finally, we demonstrate the potential practical use of this microfluidic sweat loss sensor and its integrated system for sports medicine via on-body studies.</p><h3 data-test=\"abstract-sub-heading\">Graphic abstract</h3>\u0000","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":null,"pages":null},"PeriodicalIF":7.9,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mixed-coordination electron trapping-enabled high-precision touch-sensitive screen for wearable devices 用于可穿戴设备的混合配位电子陷阱式高精度触摸屏

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2024-07-10 DOI: 10.1007/s42242-024-00293-3

Xi Zhang, Junchi Ma, Hualin Deng, Jinming Zhong, Kaichen Xu, Qiang Wu, Bo Wen, Dongfeng Diao

{"title":"A mixed-coordination electron trapping-enabled high-precision touch-sensitive screen for wearable devices","authors":"Xi Zhang, Junchi Ma, Hualin Deng, Jinming Zhong, Kaichen Xu, Qiang Wu, Bo Wen, Dongfeng Diao","doi":"10.1007/s42242-024-00293-3","DOIUrl":"https://doi.org/10.1007/s42242-024-00293-3","url":null,"abstract":"<p>Touch-sensitive screens are crucial components of wearable devices. Materials such as reduced graphene oxide (rGO), carbon nanotubes (CNTs), and graphene offer promising solutions for flexible touch-sensitive screens. However, when stacked with flexible substrates to form multilayered capacitive touching sensors, these materials often suffer from substrate delamination in response to deformation; this is due to the materials having different Young’s modulus values. Delamination results in failure to offer accurate touch screen recognition. In this work, we demonstrate an induced charge-based mutual capacitive touching sensor capable of high-precision touch sensing. This is enabled by electron trapping and polarization effects related to mixed-coordinated bonding between copper nanoparticles and vertically grown graphene nanosheets. Here, we used an electron cyclotron resonance system to directly fabricate graphene–metal nanofilms (GMNFs) using carbon and copper, which are firmly adhered to flexible substrates. After being subjected to 3000 bending actions, we observed almost no change in touch sensitivity. The screen interaction system, which has a signal-to-noise ratio of 41.16 dB and resolution of 650 dpi, was tested using a handwritten Chinese character recognition trial and achieved an accuracy of 94.82%. Taken together, these results show the promise of touch-sensitive screens that use directly fabricated GMNFs for wearable devices.</p><h3 data-test=\"abstract-sub-heading\">Graphic abstract</h3>","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":null,"pages":null},"PeriodicalIF":7.9,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nacre-inspired MXene-based film for highly sensitive piezoresistive sensing over a broad sensing range 在宽传感范围内实现高灵敏度压阻传感的珍珠层启发型 MXene 基薄膜

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2024-07-02 DOI: 10.1007/s42242-024-00292-4

Gaofeng Wang, Lingxian Meng, Xinyi Ji, Xuying Liu, Jiajie Liang, Shuiren Liu

{"title":"Nacre-inspired MXene-based film for highly sensitive piezoresistive sensing over a broad sensing range","authors":"Gaofeng Wang, Lingxian Meng, Xinyi Ji, Xuying Liu, Jiajie Liang, Shuiren Liu","doi":"10.1007/s42242-024-00292-4","DOIUrl":"https://doi.org/10.1007/s42242-024-00292-4","url":null,"abstract":"<p>As the main component of wearable electronic equipment, flexible pressure sensors have attracted wide attention due to their excellent sensitivity and their promise with respect to applications in health monitoring, electronic skin, and human–computer interactions. However, it remains a significant challenge to achieve epidermal sensing over a wide sensing range, with short response/recovery time and featuring seamless conformability to the skin simultaneously. This is critical since the capture of minute electrophysiological signals is important for health care applications. In this paper, we report the preparation of a nacre-like MXene/sodium carboxymethyl cellulose (CMC) nanocomposite film with a “brick-and-mortar” interior structure using a vacuum-induced self-assembly strategy. The synergistic behavior of the MXene “brick” and flexible CMC “mortar” contributes to attenuating interlamellar self-stacking and creates numerous variable conductive pathways on the sensing film. This resulted in a high sensitivity over a broad pressure range (i.e., 0.03–22.37 kPa: 162.13 kPa<sup>−1</sup>; 22.37–135.71 kPa: 127.88 kPa<sup>−1</sup>; 135.71–286.49 kPa: 100.58 kPa<sup>−1</sup>). This sensor also has a low detection limit (0.85 Pa), short response/recovery time (8.58 ms/34.34 ms), and good stability (2000 cycles). Furthermore, we deployed pressure sensors to distinguish among tiny particles, various physiological signals of the human body, space arrays, robot motion monitoring, and other related applications to demonstrate their feasibility for a variety of health and motion monitoring use cases.</p><h3 data-test=\"abstract-sub-heading\">Graphic abstract</h3>\u0000","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":null,"pages":null},"PeriodicalIF":7.9,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implantable probe with integrated reference electrode for in situ neural signal and calcium ion monitoring 带集成参比电极的植入式探针，用于现场神经信号和钙离子监测

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2024-07-01 DOI: 10.1007/s42242-024-00283-5

Junyu Xiao, Mengfei Xu, Longchun Wang, Bin Yang, Jingquan Liu

引用次数: 0

Flexible, high-density, laminated ECoG electrode array for high spatiotemporal resolution foci diagnostic localization of refractory epilepsy 用于难治性癫痫高时空分辨率病灶诊断定位的灵活、高密度、层叠式心电图电极阵列

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2024-06-17 DOI: 10.1007/s42242-024-00278-2

Yafeng Liu, Zhouheng Wang, Yang Jiao, Ying Chen, Guangyuan Xu, Yinji Ma, Xue Feng

{"title":"Flexible, high-density, laminated ECoG electrode array for high spatiotemporal resolution foci diagnostic localization of refractory epilepsy","authors":"Yafeng Liu, Zhouheng Wang, Yang Jiao, Ying Chen, Guangyuan Xu, Yinji Ma, Xue Feng","doi":"10.1007/s42242-024-00278-2","DOIUrl":"https://doi.org/10.1007/s42242-024-00278-2","url":null,"abstract":"<p>High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization, as the spatial scale of some pathologic signals is at the submillimeter or micrometer level. This entails connecting hundreds or thousands of electrode wires on a limited surface. This study reported a class of flexible, ultrathin, high-density electrocorticogram (ECoG) electrode arrays. The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement. The flexible, ultrathin, high-density ECoG electrode array was conformably attached to the cortex for reliable, high spatial resolution electrophysiologic recordings. The minimum spacing between electrodes was 15 μm, comparable to the diameter of a single neuron. Eight hundred electrodes were prepared with an electrode density of 4444 mm<sup>−2</sup>. In focal epilepsy surgery, the flexible, high-density, laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves in rabbits, improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level. The flexible, high-density, laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.</p>","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":null,"pages":null},"PeriodicalIF":7.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular interplay to 3D in vitro microphysiological disease model: cell patterning microbiota–gut–brain axis 三维体外微生理学疾病模型的细胞相互作用：细胞模式化微生物群-肠-脑轴

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2024-05-21 DOI: 10.1007/s42242-024-00282-6

Kamare Alam, Lakshmi Nair, Souvik Mukherjee, Kulwinder Kaur, Manjari Singh, Santanu Kaity, Velayutham Ravichandiran, Sugato Banerjee, Subhadeep Roy

引用次数: 0

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications 调整表面接枝生物分子密度的简便策略，用于基于熔融挤压的增材制造应用

IF 7.9 1区医学

Bio-Design and Manufacturing Pub Date : 2024-05-20 DOI: 10.1007/s42242-024-00286-2

I. Beeren, G. Dos Santos, P. J. Dijkstra, C. Mota, J. Bauer, H. Ferreira, Rui L. Reis, N. Neves, S. Camarero-Espinosa, M. B. Baker, L. Moroni

引用次数: 0