Biology-Basel最新文献

{"title":"Soil Moisture Is the Key Factor Facilitating Giant Ragweed Invasions in Grasslands of the Yili Vally, China.","authors":"Xinyi Chen, Zhanli Song, Baoxiong Chen, Wanli Yu, Hegan Dong","doi":"10.3390/biology14030249","DOIUrl":"10.3390/biology14030249","url":null,"abstract":"<p><p>Giant ragweed (GR; <i>Ambrosia trifida</i> L.), an invasive alien species, causes significant harm to grassland ecosystems and farmlands in some areas but is challenging to control. GR has invaded the hilly grasslands of Yili Valley, China, since 2013, and preliminary observations have shown that GR populations on the lower slopes of hills are more successful than those on the middle or upper slopes. To clarify the factors determining GR's invasion success, we compared GR population distributions among slope positions and the relationship between non-biotic factors and the invasion of GR. Of the soil physicochemical properties, only soil moisture differed significantly among slope positions, with the wettest soils found on the lower slopes. GR biomass increased with the soil water content, irrespective of native plant diversity. In our experiment, when the annual average soil volume moisture content exceeded 20.3% and 25.3%, GR could reduce the biomass of native herbs by more than 50% and 80%. Therefore, water is the determining factor of a successful GR invasion in the grasslands of the Yili Valley. On a global scale, it was discovered for the first time that GR can invade temperate grasslands, but also has risks of invading other grasslands that share similar conditions. So, GR invasions of temperate grasslands must be closely monitored, particularly in low-lying areas or those with increasing precipitation.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"14 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gut Microbiota and Colorectal Cancer: Understanding the Link and Exploring Therapeutic Interventions.","authors":"Imen Zalila-Kolsi, Dhoha Dhieb, Hussam A Osman, Hadjer Mekideche","doi":"10.3390/biology14030251","DOIUrl":"10.3390/biology14030251","url":null,"abstract":"<p><p>CRC remains a significant public health challenge due to its high prevalence and mortality rates. Emerging evidence highlights the critical role of the gut microbiota in both the pathogenesis of CRC and the efficacy of treatment strategies, including chemotherapy and immunotherapy. Dysbiosis, characterized by imbalances in microbial communities, has been implicated in CRC progression and therapeutic outcomes. This review examines the intricate relationship between gut microbiota composition and CRC, emphasizing the potential for microbial profiles to serve as biomarkers for early detection and prognosis. Various interventions, such as prebiotics, probiotics, postbiotics, fecal microbiota transplantation, and dietary modifications, aim to restore microbiota balance and shift dysbiosis toward eubiosis, thereby improving health outcomes. Additionally, the integration of microbial profiling into clinical practice could enhance diagnostic capabilities and personalize treatment strategies, advancing the field of oncology. The study of intratumoral microbiota offers new diagnostic and prognostic tools that, combined with artificial intelligence algorithms, could predict treatment responses and assess the risk of adverse effects. Given the growing understanding of the gut microbiome-cancer axis, developing microbiota-oriented strategies for CRC prevention and treatment holds promise for improving patient care and clinical outcomes.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"14 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predatory Behavior of <i>Coccinella septempunctata</i> on Two Different Aphid Species via Functional Response at Two Different Temperatures.","authors":"Muhammad Usama Altaf, Adeel Mukhtar, Muazzama Batool, Syed Muhammad Zaka, Rashid Azad, Yasir Hameed, Alia Tajdar, Asad Ali, Waqar Jaleel","doi":"10.3390/biology14030245","DOIUrl":"10.3390/biology14030245","url":null,"abstract":"<p><p><i>Coccinella septempunctata</i> (Linnaeus, 1758) is a voracious predator all over the world where aphids have found a niche. Behavioral studies of <i>C. septempunctata</i> are very important to make them effective bio-controllers. Therefore, this study explains the functional response of <i>C. septempunctata</i> praying on two distinct aphid species, examined in this work at two different temperatures. Six different prey densities (4, 8, 16, 32, 64, and 128 aphids) and two different temperatures (15 and 25 °C) were used in the experiment. All of the development stages of the predator were used to perform the experiment. Every experiment was replicated five times. The type and parameters of functional response were ascertained by the application of Roger's random predator models and logistic regression. Results showed that <i>C. septempunctata</i> adults and larvae both had a type II functional reaction against the tested aphids in both temperatures. When comparing the fourth instar to other predatory stages, the attack rate against both aphids was shown to be greater. As the temperature rose, so did the attack rate. Fourth instar larvae exhibited attack rates of 1.314 h^-1 on <i>Aphis nerii</i> Fonscolombe, 1758 (Hemiptera: Aphididae) and 1.959 h^-1 on <i>Lipaphis erysimi</i> Kaltenbach, 1843 (Hemiptera: Aphididae) at 15 °C, while at 25 °C, the rates were 1.747 h^-1 and 1.321 h^-1, respectively. Handling time was influenced by both temperature and predator stage. As the temperature increased, the handling time of the later predatory stages decreased. This study suggests that later predatory stages of <i>C. septempunctatas</i> actively hunt aphids at higher temperatures.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"14 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of Rodent-Specific <i>Probasin</i> Gene Reveals Its Evolutionary Origin in Pseudoautosomal Region and Provides Novel Insights into Rodent Phylogeny.","authors":"Stephan Maxeiner, Lukas Walter, Samuel Luca Zeitz, Gabriela Krasteva-Christ","doi":"10.3390/biology14030239","DOIUrl":"10.3390/biology14030239","url":null,"abstract":"<p><p>Probasin protein was originally identified as a basic protein present in rat prostate epithelium. So far, its physiological role, its origin, and its presence in other species including humans remain largely elusive. With the ever-growing number of genome assemblies, thus far, <i>probasin</i> genes (<i>Pbsn</i>/<i>PBSN</i>) have only been predicted in a subset of rodent genomes. In this study, we addressed the phylogeny of <i>probasin</i> genes and found them to be exclusively present in members of the superfamily Muroidea. It first emerged in the so-called pseudoautosomal region, a subtelomeric gene cluster of both mammalian sex chromosomes. During evolution of the Muroidea lineages, <i>probasin</i> recombined to the X-specific region of the X-chromosome in mice and hamster species. This event likely saved the gene from events that other pseudoautosomal genes suffered, namely displaying an increase in G and C nucleotide composition or accumulation of repetitive elements. We observed changes to its coding region, e.g., sequence insertions in exon 6, which challenge the current understanding of rodent phylogeny, in particular regarding the evolutionary history of tribe formation within the subfamily Murinae. Analyzing the evolution of <i>probasin</i> genes in Muroidea allows fostering understanding of phylogenetic relationships in one of the largest groups of mammalian species.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"14 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the Tumor-Associated Microbiota: From Origins to Nanomedicine Applications in Cancer Therapy.","authors":"Ruiqi Wang, Weizheng Li, Hongqian Cao, Lei Zhang","doi":"10.3390/biology14030243","DOIUrl":"10.3390/biology14030243","url":null,"abstract":"<p><p>Growing evidence reveals that the tumor microbiome-comprising distinct microbial communities within neoplastic tissues-exerts a profound influence on cancer initiation, progression, and therapeutic response. These microbes actively reshape the tumor microenvironment (TME) through metabolite secretion, the modulation of immune pathways, and direct interactions with host cells, thereby affecting tumor biology and therapeutic outcomes. Despite substantial heterogeneity among cancer types, recent insights underscore the tumor microbiome's potential as both a diagnostic/prognostic biomarker and a targetable component for innovative treatments. In this review, we synthesize emerging knowledge on the mechanistic roles of tumor-associated microbiota in shaping the TME, with a focus on how these discoveries can guide novel therapeutic strategies. We further explore interdisciplinary advances, including the convergence of microbiomics and nanotechnology, to enhance drug delivery, circumvent resistance, and foster TME remodeling. By highlighting these cutting-edge developments, our review underscores the transformative potential of integrating tumor microbiome research into precision oncology and advancing more personalized cancer therapies.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"14 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fading into Obscurity: Impact of Climate Change on Suitable Habitats for Two Lesser-Known Giant Flying Squirrels (Sciuridae: <i>Petaurista</i>) in Northeastern India.","authors":"Imon Abedin, Manokaran Kamalakannan, Tanoy Mukherjee, Anwaruddin Choudhury, Hilloljyoti Singha, Joynal Abedin, Dhriti Banerjee, Hyun-Woo Kim, Shantanu Kundu","doi":"10.3390/biology14030242","DOIUrl":"10.3390/biology14030242","url":null,"abstract":"<p><p>In recent years, global warming has become a major driver of biodiversity loss, significantly impacting various vertebrate species, including mammals. Consequently, numerous smaller species face extinction risks due to anthropogenic factors as well as inadequate assessments and conservation planning. Thus, this study focuses on two recently described endemic giant flying squirrel species under the <i>Petaurista</i> genus-<i>Petaurista mishmiensis</i> and <i>Petaurista mechukaensis</i>-found in Arunachal Pradesh, India. Using an ensemble species distribution model (SDM), this research delineates suitable habitats for these lesser-known species and evaluates the effects of climate change and habitat fragmentation on these areas. This analysis aims to inform a comprehensive management plan for their conservation. The ensemble model identified suitable habitat patches for the two species, extending beyond their current IUCN-designated ranges in Arunachal Pradesh. Under present conditions, <i>P. mishmiensis</i> has the largest predicted suitable area (9213 sq. km), followed by <i>P. mechukaensis</i> (6754 sq. km). However, future projections reveal alarming habitat losses ranging from 13.45% to 55.86% across the study area. This study also highlights severe habitat fragmentation throughout the state as viable patches for <i>P. mishmiensis</i> are drastically reduced in size, resulting in many being completely lost and the remaining areas being closer together. However, the <i>P. mechukaensis</i> experiences significant disintegration, resulting in numerous smaller, more dispersed patches within Arunachal Pradesh. Hence, to address these challenges, this study recommends several actions such as genetic assessments to confirm evolutionary relationships, evaluations of corridor connectivity, and comprehensive field studies. Furthermore, establishing joint forest conservation committees involving local communities, forest personnel, defense forces, naturalists, and scientists are also encouraged. Ultimately, this research provides critical insights for guiding future field studies across Arunachal Pradesh's vast landscapes and supports the development of detailed species management plans to protect these endemic flying squirrels.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"14 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shape and Size Variability of the Gynostemium in <i>Epipactis helleborine</i> (L.) Crantz (Orchidaceae).","authors":"Zbigniew Łobas, Anna Jakubska-Busse","doi":"10.3390/biology14030241","DOIUrl":"10.3390/biology14030241","url":null,"abstract":"<p><p><i>Epipactis helleborine</i> (L.) Crantz is considered a challenging and phenotypically difficult species to identify due to its wide range of morphological variability. This variability is mainly observed in the perianth parts but also extends to the gynostemium structure, which has so far been considered one of the most useful diagnostic characteristics. As a result, a simple graphic illustrating the structural pattern of gynostemium morphology has appeared in 10 different forms in available European taxonomic keys, which significantly complicates the identification of this species. A total of 122 flowers of <i>E</i>. <i>helleborine</i> were collected from four natural populations in the Lower Silesia region (Poland) between 2017 and 2019 and analysed for gynostemium morphological variation. Geometric morphometric analyses, including Procrustes ANOVA, PCA, and CVA, were used to examine gynostemium shape, with statistical tests assessing variation in size and stigma inclination angle among populations, individual plants (ramets), and years of research. Statistical analysis revealed significant positive correlations between gynostemium width and height, with significant variation in size and angle of stigma inclination, primarily driven by population, while ramet and year of research had a lesser impact. Geometric morphometric analyses indicated significant population-level variation in gynostemium shape, with principal component analysis identifying the ventral view as the most informative for discriminating these differences. The first two principal components explained the major shape variation, and canonical variate analysis confirmed that this view is most important for species identification.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"14 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Vesicles and Pregnancy-Related Hypertensive Disorders: A Descriptive Review on the Possible Implications \"From Bench to Bedside\".","authors":"Elena Grossini, Daniela Surico, Sakthipriyan Venkatesan, Mohammad Mostafa Ola Pour, Carmen Imma Aquino, Valentino Remorgida","doi":"10.3390/biology14030240","DOIUrl":"10.3390/biology14030240","url":null,"abstract":"<p><p>Pregnancy involves extracellular vesicles (EVs) through mechanisms that are poorly understood to date. Furthermore, it is not surprising that EVs may also be involved in the pathophysiology of pre-eclampsia (PE) and gestational hypertension, two clinical conditions with high morbidity and mortality, given their capacity to mediate intracellular communications and regulate inflammation and angiogenesis. We searched major online scientific search engines (PubMed, Google Scholar, Scopus, WES, Embase, etc.) using the terms \"Preeclampsia\", \"Pregnancy\", \"Hypertension\", \"Pregnancy-related hypertension\", \"Extracellular vesicles\", \"Biomarkers\", \"Gestation\" AND \"Obstetrics\". Finding potential early biomarkers of risk or illness progression would be essential for the optimum care of expectant mothers with the aforementioned conditions. Nevertheless, none of the various screening assays that have been discovered recently have shown high predictive values. The analysis of EVs in the peripheral blood starting from the first trimester of pregnancy may hold great promise for the possible correlation with gestational hypertension problems and represent a marker of the early stages of the disease. EVs use may be a novel therapeutic approach for the management of various illnesses, as well. In order to define EVs' function in the physiopathology of pregnancy-associated hypertension and PE, as well as their potential as early biomarkers and therapeutic tools, we have compiled the most recent data in this review.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"14 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitric Oxide Donor Metallodrug: Single-Inhaler Proposal for Rescue in Acute Allergic Asthma Crises.","authors":"Paula Priscila Correia Costa, Stefanie Bressan Waller, Hálef Herbet Ramos, Belarmino Eugênio Lopes Neto, Wesley Lyeverton Correia Ribeiro","doi":"10.3390/biology14030244","DOIUrl":"10.3390/biology14030244","url":null,"abstract":"<p><p>Allergic asthma is characterized by chronic airway inflammation and recurrent bronchial hyperreactivity, highlighting the need for rapid therapeutic interventions during acute crises. This study aimed to assess the potential of a single-dose administration of the ruthenium nitrosyl complex <i>cis</i>-[Ru(bpy)₂(2-MIM)(NO)](PG₆)₃ (named as FOR811A) as a fast-acting treatment in a murine model of allergic asthma. Female Swiss mice were sensitized with ovalbumin for the induction of asthma and subjected to inhalation challenges. The experimental groups included controls and ovalbumin-sensitized mice receiving FOR811A (0.75 mg/kg) or saline (NaCl 0.9%), both by gavage. Lung tissues were collected for analyses of oxidative damage (nitrite/nitrate and GSH), inflammatory markers (myeloperoxidase, IL-1β, and IL-4), and histological assessment. The results showed that, while FOR811A did not significantly reduce oxidative damage or overall inflammation, it effectively decreased IL-4 levels, indicating a modulation of the Th2 immune response without affecting IL-1β levels (Th1 response). These findings suggest that a single-dose administration of FOR811A may provide a rapid therapeutic effect in allergic asthma crises by promoting smooth muscle relaxation and modulating immune responses. Further research is warranted to explore its clinical utility as a fast-acting rescue medication for acute asthma management.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"14 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Neurophysiological, Perceptual, and Cognitive Mechanisms in Misophonia.","authors":"Chhayakanta Patro, Emma Wasko, Prashanth Prabhu, Nirmal Kumar Srinivasan","doi":"10.3390/biology14030238","DOIUrl":"10.3390/biology14030238","url":null,"abstract":"<p><p>Misophonia is a condition characterized by intense, involuntary distress or anger in response to specific sounds, often leading to irritation or aggression. While the condition is recognized for its emotional and behavioral impacts, little is known about its physiological and perceptual effects. The current study aimed to explore the physiological correlates and perceptual consequences of misophonia through a combination of electrophysiological, perceptual, and cognitive assessments. Seventeen individuals with misophonia and sixteen control participants without the condition were compared. Participants completed a comprehensive battery of tests, including (a) cortical event-related potentials (ERPs) to assess neural responses to standard and deviant auditory stimuli, (b) the spatial release from the speech-on-speech masking (SRM) paradigm to evaluate speech segregation in background noise, and (c) the flanker task to measure selective attention and cognitive control. The results revealed that individuals with misophonia exhibited significantly smaller mean peak amplitudes of the N1 and N2 components in response to oddball tones compared to controls. This suggests a potential underlying neurobiological deficit in misophonia patients, as these components are associated with early auditory processing. However, no significant differences between each group were observed in the P1 and P2 components regarding oddball tones or in any ERP components in response to standard tones. Despite these altered neural responses, the misophonia group did not show differences in hearing thresholds, speech perception abilities, or cognitive function compared to the controls. These findings suggest that while misophonia may involve distinct neurophysiological changes, particularly in early auditory processing, it does not necessarily lead to perceptual deficits in speech perception or cognitive function.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"14 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}