Biology-Basel最新文献

{"title":"Quantifying the Ecological Performance of Migratory Bird Conservation: Evidence from Poyang Lake Wetlands in China.","authors":"Zhenjiang Song, Shichao Gao, Mingni Leng, Bo Zhou, Baoshu Wu","doi":"10.3390/biology13100786","DOIUrl":"https://doi.org/10.3390/biology13100786","url":null,"abstract":"<p><p>Protected areas are essential for the conservation of biodiversity. However, the rapid expansion of urbanization and the intensification of human activities have significantly disrupted environmental integrity, leading to a continuous deterioration in both the quantity and quality of large ecological patches. This has further diminished the connectivity among ecological patches, leading to significant consequences for regional biodiversity conservation. Taking Poyang Lake as a case study, which serves as a crucial wintering habitat for migratory birds along the East Asia-Australasia flyway, this research employs ArcMap technology. It considers various factors including land use type, slope, and elevation to evaluate habitat quality and degradation through the application of the InVEST model. Additionally, the study utilizes the minimum cumulative resistance (MCR) model alongside circuit theory to delineate ecological corridors within the area and to establish a comprehensive ecological network system. The research results in this paper are as follows. (i) During the period from 2000 to 2020, there was an overall decline in habitat quality within the study area, indicating a clear trend of habitat degradation. However, it is worth noting that there was an increase in habitat quality in certain local areas within the protected area. (ii) The ecological resistance values in the core area of the migratory bird reserve in Poyang Lake are generally low. However, the ecological resistance values of the habitats have shown a consistent increase from 2000 to 2020. Additionally, there has been a significant decrease in the density of ecological corridors during this time period. (iii) Over the period from 2000 to 2020, both the number and connectivity of ecological corridors decreased and their integrity and functionality degraded. Consequently, this weakened role of the ecological network has had implications for maintaining regional biodiversity and ecosystem service functions. The findings indicate two conclusions. (i) Ecological connectivity is essential for the conservation of migratory bird habitats. Strengthening control measures aimed at expanding ecological corridors can effectively safeguard flagship and umbrella species, thereby promoting biodiversity conservation. (ii) The establishment of ecological corridors can help reconcile conflicts between conservation efforts and development objectives. This reconciliation carries significant theoretical implications for fostering a harmonious coexistence between humans and birds in Poyang Lake's migratory bird sanctuary.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Cell RNA Sequencing and Combinatorial Approaches for Understanding Heart Biology and Disease.","authors":"Le Wang, Bo Jin","doi":"10.3390/biology13100783","DOIUrl":"https://doi.org/10.3390/biology13100783","url":null,"abstract":"<p><p>By directly measuring multiple molecular features in hundreds to millions of single cells, single-cell techniques allow for comprehensive characterization of the diversity of cells in the heart. These single-cell transcriptome and multi-omic studies are transforming our understanding of heart development and disease. Compared with single-dimensional inspections, the combination of transcriptomes with spatial dimensions and other omics can provide a comprehensive understanding of single-cell functions, microenvironment, dynamic processes, and their interrelationships. In this review, we will introduce the latest advances in cardiac health and disease at single-cell resolution; single-cell detection methods that can be used for transcriptome, genome, epigenome, and proteome analysis; single-cell multi-omics; as well as their future application prospects.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crop Improvement of <i>Moringa oleifera</i> L. through Genotype Screening for the Development of Clonal Propagation Techniques of High-Yielding Clones in Malaysia.","authors":"Sures Kumar Muniandi, Farah Fazwa Md Ariff, Mazura Md Pisar, Samsuri Toh Harun, Mohd Zaki Abdullah, Fauziah Abdullah, Siti Nur Aisyah Mohd Hashim, Syafiqah Nabilah Samsul Bahari, Norhayati Saffie","doi":"10.3390/biology13100785","DOIUrl":"https://doi.org/10.3390/biology13100785","url":null,"abstract":"<p><p><i>Moringa oleifera</i> L. is a valuable multipurpose tree species widely planted for centuries due to its high medicinal value and antifungal, antiviral, antidepressant, and anti-inflammatory properties in the food industry. However, its cultivation is hindered by production constraints such as the unavailability of planting material and the inadequate number of high-yielding clones. Thus, a study was initiated to select high-yielding clones in terms of growth and chemical content for the mass propagation of superior moringa trees. Screening on high-yielding clones with high astragalin content was conducted through the high-performance liquid chromatography (HPLC) analysis of moringa leaf extract. Selected genotypes were evaluated for their anti-inflammatory potential through in vitro bioactivity assays of leaf methanol extract. The effects of the rooting hormone, rooting substrates, and size of the cutting on the rooting response of branch cuttings of moringa were investigated. Results found that samples collected from different ecological zones of Peninsular Malaysia show significant variation in terms of astragalin content. The extracts were observed to show considerable variation in biological activity against the pro-inflammatory enzymes. The size of the cuttings had significant effects on the rooting of the cuttings as longer cuttings with bigger diameters rooted better than shorter cuttings with smaller diameters. Several genotypes of <i>M. oleifera</i> with superior phenotypic characteristics and bioactive compounds have been identified. Factors affecting the rooting efficiency and optimal conditions of rooting are suggested, which provides valuable information for the propagation of the superior planting material of moringa. This effort will ensure the sustainable production and supply of good quality raw materials for the production of quality end-products for the food and pharmaceutical industry.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Codes between Poles: Linking Transcriptomic Insights into the Neurobiology of Bipolar Disorder.","authors":"Jon Patrick T Garcia, Lemmuel L Tayo","doi":"10.3390/biology13100787","DOIUrl":"https://doi.org/10.3390/biology13100787","url":null,"abstract":"<p><p>Bipolar disorder (BPD) is a serious psychiatric condition that is characterized by the frequent shifting of mood patterns, ranging from manic to depressive episodes. Although there are already treatment strategies that aim at regulating the manifestations of this disorder, its etiology remains unclear and continues to be a question of interest within the scientific community. The development of RNA sequencing techniques has provided newer and better approaches to studying disorders at the transcriptomic level. Hence, using RNA-seq data, we employed intramodular connectivity analysis and network pharmacology assessment of disease-associated variants to elucidate the biological pathways underlying the complex nature of BPD. This study was intended to characterize the expression profiles obtained from three regions in the brain, which are the nucleus accumbens (nAcc), the anterior cingulate cortex (AnCg), and the dorsolateral prefrontal cortex (DLPFC), provide insights into the specific roles of these regions in the onset of the disorder, and present potential targets for drug design and development. The nAcc was found to be highly associated with genes responsible for the deregulated transcription of neurotransmitters, while the DLPFC was greatly correlated with genes involved in the impairment of components crucial in neurotransmission. The AnCg did show association with some of the expressions, but the relationship was not as strong as the other two regions. Furthermore, disease-associated variants or single nucleotide polymorphisms (SNPs) were identified among the significant genes in BPD, which suggests the genetic interrelatedness of such a disorder and other mental illnesses. <i>DRD2</i>, <i>GFRA2</i>, and <i>DCBLD1</i> were the genes with disease-associated variants expressed in the nAcc; <i>ST8SIA2</i> and <i>ADAMTS16</i> were the genes with disease-associated variants expressed in the AnCg; and <i>FOXO3</i>, <i>ITGA9</i>, <i>CUBN</i>, <i>PLCB4</i>, and <i>RORB</i> were the genes with disease-associated variants expressed in the DLPFC. Aside from unraveling the molecular and cellular mechanisms behind the expression of BPD, this investigation was envisioned to propose a new research pipeline in studying the transcriptome of psychiatric disorders to support and improve existing studies.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Candidate Genes for Cold Tolerance at Seedling Stage by GWAS in Rice (<i>Oryza sativa</i> L.).","authors":"Huimin Shi, Wenyu Zhang, Huimin Cao, Laiyuan Zhai, Qingxin Song, Jianlong Xu","doi":"10.3390/biology13100784","DOIUrl":"https://doi.org/10.3390/biology13100784","url":null,"abstract":"<p><p>Due to global climate change, cold temperatures have significantly impacted rice production, resulting in reduced yield and quality. In this study, we investigated two traits related to the cold tolerance (CT) of 1992 diverse rice accessions at the seedling stage. <i>Geng</i> accessions exhibited higher levels of CT compared to <i>xian</i> accessions, with the GJ-tmp subgroup displaying the strongest CT. However, extreme CT accessions were also identified within the <i>xian</i> subspecies. Through GWAS analysis based on the survival rate (SR) and leaf score of cold tolerance (SCT), a total of 29 QTLs associated with CT at the seedling stage were identified, among which four QTLs (<i>qSR3.1a</i>, <i>qSR4.1a</i>, <i>qSR11.1x</i>, and <i>qSR12.1a</i>) were found to be important. Furthermore, five candidate genes (<i>LOC_Os03g44760</i>, <i>LOC_Os04g06900</i>, <i>LOC_Os04g07260</i>, <i>LOC_Os11g40610</i>, and <i>LOC_Os12g10710</i>) along with their favorable haplotypes were identified through gene function annotation and haplotype analysis. Pyramiding multiple favorable haplotypes resulted in a significant improvement in CT performance. Subsequently, three selected accessions (CX534, B236, and IRIS_313-8565), carrying different superior alleles for CT, were selected and recommended for molecular breeding for CT using marker-assisted selection (MAS). The findings from this study provide valuable resources for enhancing rice's ability for CT while laying a foundation for the future cloning of novel genes involved in conferring CT.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the Diet of an Invasive Predatory Crab, <i>Chionoecetes opilio</i>, in the Degrading Benthic Community of an Arctic Fjord.","authors":"Alexander D Kiselev, Anna K Zalota","doi":"10.3390/biology13100781","DOIUrl":"https://doi.org/10.3390/biology13100781","url":null,"abstract":"<p><p>The introduction of a new species can lead to substantial changes in a new ecosystem. Local and introduced species' survival depends on their ability to adapt to the new environment. Studying such adaptations is often hindered by multiple factors affecting the ecosystem. The introduction of a large predatory snow crab, <i>Chionoecetes opilio</i>, into the Kara Sea, is a unique invasive species affecting an otherwise undisturbed ecosystem. The crab has caused drastic changes in the macro- and megabenthic taxonomic structure, abundance, and biomass of the most common species in an Arctic fjord, Blagopoluchiya Bay. Stomach content and stable isotope analysis were applied to study crabs' feeding habits. As the abundance of the most common prey items diminished, the crabs switched to other less accessible food. Prior to substantial changes in benthic communities, the diet of the snow crabs was similar to that of other invaded and native areas, where animal food predominates. However, with the degradation of the ecosystem, detritus contribution has substantially increased. The changes in prey items did not change the crab's trophic status, and they continued to feed within the same trophic niche. In the depleted benthic communities of Blagopoluchiya Bay, the snow crab is forced to use all available food sources.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Sex Estimation Accuracy with Cranial Angle Measurements and Machine Learning.","authors":"Diana Toneva, Silviya Nikolova, Gennady Agre, Stanislav Harizanov, Nevena Fileva, Georgi Milenov, Dora Zlatareva","doi":"10.3390/biology13100780","DOIUrl":"https://doi.org/10.3390/biology13100780","url":null,"abstract":"<p><p>The development of current sexing methods largely depends on the use of adequate sources of data and adjustable classification techniques. Most sex estimation methods have been based on linear measurements, while the angles have been largely ignored, potentially leading to the loss of valuable information for sex discrimination. This study aims to evaluate the usefulness of cranial angles for sex estimation and to differentiate the most dimorphic ones by training machine learning algorithms. Computed tomography images of 154 males and 180 females were used to derive data of 36 cranial angles. The classification models were created by support vector machines, naïve Bayes, logistic regression, and the rule-induction algorithm CN2. A series of cranial angle subsets was arranged by an attribute selection scheme. The algorithms achieved the highest accuracy on subsets of cranial angles, most of which correspond to well-known features for sex discrimination. Angles characterizing the lower forehead and upper midface were included in the best-performing models of all algorithms. The accuracy results showed the considerable classification potential of the cranial angles. The study demonstrates the value of the cranial angles as sex indicators and the possibility to enhance the sex estimation accuracy by using them.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Pressure Loading on Heel Skin Temperature and Moisture in Healthy Volunteers: Preliminary Results.","authors":"Érica de Carvalho, Leticia Costa Marostica, Gabriela Fagundes Trento, Julia Scalco Marcolina, Fernanda Ceolin Teló, Rhea Silvia de Avila Soares, Lidiana Batista Teixeira Dutra Silveira, Suzinara Beatriz Soares de Lima, Paulo Jorge Pereira Alves, Thaís Dresch Eberhardt","doi":"10.3390/biology13100782","DOIUrl":"https://doi.org/10.3390/biology13100782","url":null,"abstract":"<p><p>Recent studies emphasize the significance of skin microclimate in the prevention of pressure injuries (PI). The objective was to evaluate the effect of pressure loading on skin temperature and moisture in the heels of healthy adults. This is a before-and-after study performed at Brazil, in October 2022. Skin temperature (°C) was measured by an infrared digital thermometer, and skin moisture (%) using electrical bioimpedance. Ten individuals/twenty heels were evaluated. The average temperature of the right and left heel was the same at baseline (27.2 °C). It was recognized that after 30 min of pressure loading on the heels, there was a decrease in temperature, and after 15 min of pressure offloading, the temperature decreased again. It was found that at t0, the moisture of the right heel (12.6%) was lower than the left heel (15.6%). The median moisture in the right heel increased from t0 to t1 and decreased in t2, while in the left heel, there was a small variation of the median from t0 to t1, as well as to t2. The pressure loading leads to a decrease in temperature and changes the skin moisture of the heels of healthy individuals.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the Power of Fermented Tea to Improve Gut Microbiota and Combat Obesity Epidemic.","authors":"Ruyi Zhang, Qiling Li, Yuxuan Gu, Wenli Liao","doi":"10.3390/biology13100779","DOIUrl":"https://doi.org/10.3390/biology13100779","url":null,"abstract":"<p><p>The global rise in obesity rates has prompted a thorough evaluation of dietary strategies that may alleviate this metabolic issue. Fermented tea, a beverage rich in polyphenols and catechins, has emerged as a viable therapeutic option for obesity management. This review discusses the role of fermented tea in modulating the gut microbiome, a critical factor in energy regulation and obesity. We explore how the bioactive components in fermented tea influence gut health and their implications for metabolic health. Fermented tea may inhibit weight gain and fat accumulation in obese animal models, likely by promoting beneficial bacteria and suppressing harmful species. Changes in the production of short-chain fatty acids and improvements in gut barrier integrity are linked to enhanced insulin sensitivity and reduced inflammatory markers, essential for effective obesity management. However, barriers remain in applying these findings in clinical settings, such as the need for standardized fermentation techniques and accurate dosage assessments. This review underscores the therapeutic potential of fermented tea in obesity treatment and advocates for further research to enhance its integration with public health initiatives.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemistry and Evaluation of the Anti-Inflammatory Activity of the Hydroethanolic Extract of <i>Virola elongata</i> (Benth.) Warb. Stem Bark.","authors":"Bruna Fioravante Di Serio, Jessica de Araujo Isaias Muller, Marcelo José Dias Silva, Fabiana de Freitas Figueiredo, Domingos Tabajara de Oliveira Martins","doi":"10.3390/biology13100776","DOIUrl":"https://doi.org/10.3390/biology13100776","url":null,"abstract":"<p><strong>Background: </strong>Previous studies of the hydroethanolic extract of <i>Virola elongata</i> inner stem bark (HEVe) have demonstrated its antioxidant, gastroprotective, and antiulcer properties, but have not evaluated its anti-inflammatory potential.</p><p><strong>Methods: </strong>HEVe was obtained by maceration and phytochemically analyzed. Its systemic anti-inflammatory activity was assessed by its effect on lipopolysaccharide (LPS)-induced peritonitis in mice. HEVe gel (HEgVe) was employed to evaluate topical anti-inflammatory activity by measuring the ear edema resulting from croton-oil-induced dermatitis in mice. A cell viability assay was conducted to determine the non-cytotoxic concentrations of the HEVe. RAW 264.7 cells were stimulated by LPS to determinate cytokine and nitric oxide production.</p><p><strong>Results: </strong>A phytochemical analysis of the HEVe revealed the presence of phenolic acids, neolignans, flavonoids, and monomeric catechins. The oral treatment of acute peritonitis with HEVe reduced the total leukocytes, neutrophils, TNF-α, and IL-1β and elevated IL-10 levels. The application of the HEgVe reduced local edema. The HEVe on the RAW 264.7 cells exhibited no cytotoxicity, and the cells with HEVe displayed reduced TNF-α, IL-1β, and NO levels and increased IL-13 levels.</p><p><strong>Conclusions: </strong>HEVe demonstrated systemic and topical multitarget anti-inflammatory activity, likely due to the combined effects of secondary metabolites. HEVe emerges as a promising herbal remedy for inflammation with minimal cytotoxicity, emphasizing its potential therapeutic significance.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}