Yale Journal of Biology and Medicine最新文献_第2页

Correlation Between Pain, Disease Activity, and Rheumatoid Factor Positivity in Patients with Chikungunya Arthritis. 基孔肯雅关节炎患者的疼痛、疾病活动和类风湿因子阳性之间的相关性

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-12-19 eCollection Date: 2024-12-01 DOI: 10.59249/HGXW4816

José Kennedy Amaral, Robert Taylor Schoen, Clifton O Bingham, Paulo Renato Alves Firmino, Estelita Lima Cândido

{"title":"Correlation Between Pain, Disease Activity, and Rheumatoid Factor Positivity in Patients with Chikungunya Arthritis.","authors":"José Kennedy Amaral, Robert Taylor Schoen, Clifton O Bingham, Paulo Renato Alves Firmino, Estelita Lima Cândido","doi":"10.59249/HGXW4816","DOIUrl":"10.59249/HGXW4816","url":null,"abstract":"Chikungunya fever (CHIKF) is an acute viral disease caused by the chikungunya virus (CHIKV) transmitted by Aedes mosquitoes. The acute phase presents with limited symptoms and low mortality, but approximately half of cases progress to more chronic illness with persistent and disabling joint symptoms. To better characterize the burden of chronic disease, we analyzed the relationship between pain intensity, the Disease Activity Index by DAS28-ESR, rheumatoid factor (RF) positivity, sex, and age in a retrospective cohort of 133 patients with chikungunya arthritis (CHIKA). We assessed all subjects by clinical evaluations, and laboratory testing, including the Pain Visual Analog Scale (VAS), the Disease Activity Score (DAS28-ESR), and RF measurement. We observed that pain intensity increased significantly with disease activity (ρ = 0.416 and p-value < 0.05) and with age (ρ = 0.259 and p-value = 0.003). Despite a predominance of women in our cohort, sex/gender was not associated with increased pain risk. Our study demonstrated a strong correlation between pain and disease activity, but assessment of these variables in a larger, prospective cohort should be undertaken to further characterize risk variables and improve therapy for patients with CHIKA.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 4","pages":"417-422"},"PeriodicalIF":2.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral Myocarditis. 病毒性心肌炎。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-12-19 eCollection Date: 2024-12-01 DOI: 10.59249/BSHH8575

Cai Ying

引用次数: 0

The Intestine in Acute and Long COVID: Pathophysiological Insights and Key Lessons. 急性和长期 COVID 中的肠道：病理生理学见解和重要经验。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-12-19 eCollection Date: 2024-12-01 DOI: 10.59249/PMIE8461

Andreas Zollner, Moritz Meyer, Almina Jukic, Timon Adolph, Herbert Tilg

{"title":"The Intestine in Acute and Long COVID: Pathophysiological Insights and Key Lessons.","authors":"Andreas Zollner, Moritz Meyer, Almina Jukic, Timon Adolph, Herbert Tilg","doi":"10.59249/PMIE8461","DOIUrl":"10.59249/PMIE8461","url":null,"abstract":"Post-Acute Sequelae of SARS-CoV-2 infection (PASC), commonly known as Long COVID, represents a significant and complex health challenge with a wide range of symptoms affecting multiple organ systems. This review examines the emerging evidence suggesting a critical role of the gut and gut-brain axis in the pathophysiology of Long COVID. It explores how changes in the gut microbiome, disruption of gut barrier integrity, and the persistence of SARS-CoV-2 antigens within the gastrointestinal tract may contribute to the prolonged and varied symptoms seen in Long COVID, including chronic inflammation and neuropsychiatric disturbances. The review also summarizes key insights gained about Long COVID, highlighting its multifactorial nature, which involves immune dysregulation, microvascular damage, and autonomic nervous system dysfunction, with the gut playing a central role in these processes. While progress has been made in understanding these mechanisms, current evidence remains inconclusive. The challenges of establishing causality, standardizing research methodologies, and addressing individual variations in the microbiome are discussed, emphasizing the need for further longitudinal studies and more comprehensive approaches to enhance our understanding of these complex interactions. This review underscores the importance of personalized approaches in developing effective diagnostic and therapeutic strategies for Long COVID, while also acknowledging the significant gaps in our current understanding. Future research should aim to further unravel the complex interplay between the gut and Long COVID, ultimately improving outcomes for those affected by this condition.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 4","pages":"447-462"},"PeriodicalIF":2.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Endogenous Retroviruses Expression in Autoimmunity. 人类内源性逆转录病毒在自身免疫中的表达

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-12-19 eCollection Date: 2024-12-01 DOI: 10.59249/OIKF8301

Christophe Viret, Margaret S Bynoe

引用次数: 0

Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future Directions. 眼部基因治疗：病毒载体、免疫反应和未来方向综述。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-12-19 eCollection Date: 2024-12-01 DOI: 10.59249/HWID7537

Lamprini Banou, Soshian Sarrafpour, Christopher C Teng, Ji Liu

{"title":"Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future Directions.","authors":"Lamprini Banou, Soshian Sarrafpour, Christopher C Teng, Ji Liu","doi":"10.59249/HWID7537","DOIUrl":"10.59249/HWID7537","url":null,"abstract":"Ocular gene therapy has rapidly advanced from proof-of-concept studies to clinical trials by exploiting the unique advantages of the eye, including its easy accessibility, relative immune privilege, and the ability to use the contralateral eye as a control. An important step forward was achieved with the Food and Drug Administration (FDA) approval of voretigene neparvovec (Luxturna) for the treatment of biallelic RPE65-mutation-associated retinal dystrophies in 2017. Gene therapy is a promising field aimed at treating various inherited and acquired eye diseases. Viral vectors such as adeno-associated virus (AAV) are mainly used to efficiently deliver genes. Despite the immune-privileged status of the eye, viral vector-based therapies can induce immune responses, potentially leading to gene therapy-associated uveitis. Future directions include developing strategies to reduce immune responses while maintaining therapeutic efficacy, optimizing vector selection, and improving delivery techniques. Continued advances in the field of viral vectors, particularly AAV, are expanding the potential applications of gene therapy to treat a variety of ocular diseases. To fully realize the potential of ocular gene therapy, more research and clinical trials are needed to improve these methods, ensure safe and efficient treatments, and ultimately overcome existing obstacles.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 4","pages":"491-503"},"PeriodicalIF":2.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological Sequelae of SARS-CoV-2: A Review for Clinicians. SARS-CoV-2的病理后遗症：临床研究综述

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-12-19 eCollection Date: 2024-12-01 DOI: 10.59249/DQJH2274

Joseph Asuam Nyarko, Patience Mawuena Dogbe, Lawrencia Ami Emefa Ativi, Jennifer Wutsika, Emmanuel Boateng Agyenim, Aaron Awere-Duodu, Anthony Twumasi Botaeng, Nana Afia Asante Ntim

{"title":"Pathological Sequelae of SARS-CoV-2: A Review for Clinicians.","authors":"Joseph Asuam Nyarko, Patience Mawuena Dogbe, Lawrencia Ami Emefa Ativi, Jennifer Wutsika, Emmanuel Boateng Agyenim, Aaron Awere-Duodu, Anthony Twumasi Botaeng, Nana Afia Asante Ntim","doi":"10.59249/DQJH2274","DOIUrl":"10.59249/DQJH2274","url":null,"abstract":"The Coronavirus Disease 2019 (COVID-19) pandemic, driven by the novel coronavirus and its variants, has caused over 518 million infections and 6.25 million deaths globally, leading to a significant health crisis. Beyond its primary respiratory impact, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been implicated in various extra-pulmonary complications. Research studies reveal that the virus affects multiple organs, including the kidneys, liver, pancreas, and central nervous system (CNS), largely due to the widespread expression of Angiotensin Converting Enzyme-2 (ACE-2) receptors. Clinical evidence shows that the virus can induce diabetes by disrupting pancreatic and liver functions as well as cause acute kidney injury. Additionally, neurological complications, including cognitive impairments and neuroinflammation, have been observed in a significant number of COVID-19 patients. This review discusses the mechanisms linking SARS-CoV-2 to acute kidney injury, Type 1 and Type 2 Diabetes Mellitus (T1DM and T2DM), emphasizing its effects on pancreatic beta cells, insulin resistance, and the regulation of gluconeogenesis. We also explore how SARS-CoV-2 induces neurological complications, detailing the intricate pathways of neuro-invasion and the potential to trigger conditions such as Alzheimer's disease (AD). By elucidating the metabolic and neurological manifestations of COVID-19 and the underlying pathogenic mechanisms, this review underscores the imperative for continued research and the development of effective therapeutic interventions to mitigate the long-term and short-term impacts of SARS-CoV-2 infection.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 4","pages":"431-445"},"PeriodicalIF":2.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Potential of Saffron as a Therapeutic Agent in Depression Treatment: A Comparative Review. 探索藏红花作为抑郁症治疗剂的潜力：比较综述。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-09-30 eCollection Date: 2024-09-01 DOI: 10.59249/XURF4540

Satendra Chauhan, Aarohi Tiwari, Ashish Verma, Pratyush Kumar Padhan, Shivam Verma, Prakash Chandra Gupta

{"title":"Exploring the Potential of Saffron as a Therapeutic Agent in Depression Treatment: A Comparative Review.","authors":"Satendra Chauhan, Aarohi Tiwari, Ashish Verma, Pratyush Kumar Padhan, Shivam Verma, Prakash Chandra Gupta","doi":"10.59249/XURF4540","DOIUrl":"10.59249/XURF4540","url":null,"abstract":"Depression is a significant mental health challenge globally. While traditional antidepressants are effective, they often have unwanted side effects. Saffron, a natural spice derived from Crocus sativus L., has emerged as a potential alternative therapy for depression. Researchers have found that its components such as crocin, crocetin, and safranal have been found to mitigate depressive symptoms through neurotransmitter regulation, anti-inflammatory effects, and neuroprotection. Clinical trials suggest that the effectiveness of saffron in treating mild to moderate depression is comparable to that of standard medications, and animal studies support these results, showing behavioral improvements with saffron treatment. Saffron is particularly appealing due to its safety and lower incidence of side effects, making it suitable for those sensitive to conventional drugs. Additionally, its antioxidant properties may offer further health benefits. However, challenges such as determining the appropriate dosage, prohibitive cost, and the limited availability of quality saffron need to be addressed. Most research on saffron's efficacy is short-term; thus, long-term studies are essential to understand its full therapeutic potential and ongoing antidepressant effects. While saffron is safe in terms of its culinary value, higher therapeutic doses require careful monitoring for drug interactions and side effects. In summary, saffron represents a promising direction in depression treatment, with benefits potentially matching those of standard treatments and a better safety profile. However, further research is necessary to establish clear guidelines for its use, optimize dosing, and assess long-term outcomes. Saffron offers a natural treatment path for depression, but its use must be controlled and supported by scientific evidence.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 3","pages":"365-381"},"PeriodicalIF":2.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local and Systemic Peptide Therapies for Soft Tissue Regeneration: A Narrative Review. 用于软组织再生的局部和全身肽疗法：叙述性综述。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-09-30 eCollection Date: 2024-09-01 DOI: 10.59249/TKNM3388

Caroline J Cushman, Andrew F Ibrahim, Alexander D Smith, Evan J Hernandez, Brendan MacKay, Mimi Zumwalt

{"title":"Local and Systemic Peptide Therapies for Soft Tissue Regeneration: A Narrative Review.","authors":"Caroline J Cushman, Andrew F Ibrahim, Alexander D Smith, Evan J Hernandez, Brendan MacKay, Mimi Zumwalt","doi":"10.59249/TKNM3388","DOIUrl":"10.59249/TKNM3388","url":null,"abstract":"Background: The musculoskeletal system, due to inherent structure and function, lends itself to contributing toward joint pain, whether from inflammatory disorders such as rheumatoid arthritis, degenerative diseases such as osteoarthritis, or trauma causing soft tissue injury. Administration of peptides for treatment of joint pain or inflammation is an emerging line of therapy that seeks to offer therapeutic benefits while remaining safe and relatively non-invasive. Purpose: The purpose of this study is to review the current literature on existing oral peptide agents, intra-articular peptide agents, and new developments in human trials to assess route of administration (RoA) for drug delivery in terms of soft tissue regeneration. Study Design: Narrative Review. Methods: A comprehensive literature search was conducted using the PubMed database. The search included medical subject headings (MeSH) terms related to peptide therapy, soft tissue regeneration, and RoA. Inclusion criteria comprised articles focusing on the mechanisms of action of peptides, clinical or biochemical outcomes, and review articles. Exclusion criteria included insufficient literature or studies not meeting the set evidence level. Conclusion: The review identified various peptides demonstrating efficacy in soft tissue repair. Oral and intra-articular peptides showed distinct advantages in soft tissue regeneration, with intra-articular routes providing localized effects and oral routes offering systemic benefits. However, both routes have limitations in bioavailability and absorption. Still in their infancy, further inquiries/research into the properties and efficacy of emerging peptides will be necessary before widespread use. As a viable alternative prior to surgical intervention, peptide treatments present as promising candidates for positive outcomes in soft tissue regeneration.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 3","pages":"399-413"},"PeriodicalIF":2.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical Ozone as a Therapeutic Option in Musculoskeletal Pain Control: A Critical Review of Clinical Trials Considering Safety and Quality Indicators for Procedures and Devices. 医用臭氧作为控制肌肉骨骼疼痛的治疗选择：考虑程序和设备安全与质量指标的临床试验批判性回顾》。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-09-30 eCollection Date: 2024-09-01 DOI: 10.59249/HGTG9363

Lila T de Araújo, Patricia C da Silva, Marcos Masini

{"title":"Medical Ozone as a Therapeutic Option in Musculoskeletal Pain Control: A Critical Review of Clinical Trials Considering Safety and Quality Indicators for Procedures and Devices.","authors":"Lila T de Araújo, Patricia C da Silva, Marcos Masini","doi":"10.59249/HGTG9363","DOIUrl":"10.59249/HGTG9363","url":null,"abstract":"Background: Drug therapies have been widely applied for pain management, however, there are important side effects such as those related to corticosteroids and opioids. Recent studies demonstrated promising results using medical ozone as a safe, effective, and low-cost intervention for pain control. Objective: to review and critically analyze clinical studies that used ozone therapy for musculoskeletal pain. Methods: a literature search of various databases was performed to identify relevant studies. From a total of 249 records, 27 studies were included. Quality indicators, human and device factors that strongly influence the generation of evidence were considered, such as study design and device safety. We also mitigated biases, considering the safety and efficacy of the intervention itself. Results: Regarding safety, 77 (8%) of studies reported no adverse effects; concerning efficacy outcomes, medical ozone shows to be an effective intervention on musculoskeletal pain control. Important information about used devices were missing. Conclusions: medical ozone shows to be safe and effective; qualification of health professionals as well as the device safety are mandatory. However, there is a lack of requirements to identify the best therapeutic scheme; further longer, clinical and rigorous trials are needed.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 3","pages":"383-398"},"PeriodicalIF":2.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Power of Thought: The Role of Psychological Attentiveness and Emotional Support in Patient Trajectories. 思想的力量：心理关注和情感支持在患者轨迹中的作用。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-09-30 eCollection Date: 2024-09-01 DOI: 10.59249/CPTG1770

Angel D Prabakar

{"title":"The Power of Thought: The Role of Psychological Attentiveness and Emotional Support in Patient Trajectories.","authors":"Angel D Prabakar","doi":"10.59249/CPTG1770","DOIUrl":"10.59249/CPTG1770","url":null,"abstract":"In modern healthcare, the influence of a patient's mindset on health outcomes is an often neglected yet vital component of holistic care. This review explores the significant impact of positive and negative mindsets on disease progression and recovery, emphasizing the need to integrate mental wellness practices into conventional medical care. Drawing from a wide array of studies, it demonstrates how fostering a positive mindset can enhance patient trajectories across various medical specialties. The article advocates for training healthcare providers to adopt a more empathetic and patient-centered approach, bridging the gap between mind and body. By presenting compelling evidence on the correlation between patient mindset and health outcomes, this review highlights the potential benefits of incorporating psychological support and holistic strategies into standard care protocols. Practical strategies for implementing mindset-focused interventions are also proposed, including training programs for healthcare professionals and the development of interdisciplinary treatment plans. Ultimately, this article underscores the need for a paradigm shift in medical practice, advocating for a comprehensive approach that recognizes the power of thought in promoting patient wellness.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"97 3","pages":"335-347"},"PeriodicalIF":2.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0