Yale Journal of Biology and Medicine最新文献_第10页

Inhaled Bacteriophage Therapy for Multi-Drug Resistant Achromobacter. 吸入噬菌体治疗多重耐药无色杆菌。

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2022-12-01

Franziska Winzig, Shiv Gandhi, Alina Lee, Silvia Würstle, Gail L Stanley, Isabella Capuano, Isabel Neuringer, Jonathan L Koff, Paul E Turner, Benjamin K Chan

{"title":"Inhaled Bacteriophage Therapy for Multi-Drug Resistant Achromobacter.","authors":"Franziska Winzig, Shiv Gandhi, Alina Lee, Silvia Würstle, Gail L Stanley, Isabella Capuano, Isabel Neuringer, Jonathan L Koff, Paul E Turner, Benjamin K Chan","doi":"","DOIUrl":"","url":null,"abstract":"The rise of antimicrobial resistant (AMR) bacteria is a global public health threat. AMR Achromobacter bacteria pose a challenging clinical problem, particularly for those with cystic fibrosis (CF) who are predisposed to chronic bacterial lung infections. Lytic bacteriophages (phages) offer a potential alternative to treat AMR infections, with the possible benefit that phage selection for resistance in target bacteria might coincide with reduced pathogenicity. The result is a genetic \"trade-off,\" such as increased sensitivity to chemical antibiotics, and/or decreased virulence of surviving bacteria that are phage resistant. Here, we show that two newly discovered lytic phages against Achromobacter were associated with stabilization of respiratory status when deployed to treat a chronic pulmonary infection in a CF patient using inhaled (nebulized) phage therapy. The two phages demonstrate traits that could be generally useful in their development as therapeutics, especially the possibility that the phages can select for clinically useful trade-offs if bacteria evolve phage resistance following therapy. We discuss the limitations of the current study and suggest further work that should explore whether the phages could be generally useful in targeting pulmonary or other Achromobacter infections in CF patients.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"95 4","pages":"413-427"},"PeriodicalIF":2.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/57/yjbm_95_4_413.PMC9765334.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9515996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Intriguing Carbapenemases of Pseudomonas aeruginosa: Current Status, Genetic Profile, and Global Epidemiology. 铜绿假单胞菌的碳青霉烯酶:现状、遗传特征和全球流行病学。

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2022-12-01

Dalal Hammoudi Halat, Carole Ayoub Moubareck

{"title":"The Intriguing Carbapenemases of Pseudomonas aeruginosa: Current Status, Genetic Profile, and Global Epidemiology.","authors":"Dalal Hammoudi Halat, Carole Ayoub Moubareck","doi":"","DOIUrl":"","url":null,"abstract":"Worldwide, Pseudomonas aeruginosa remains a leading nosocomial pathogen that is difficult to treat and constitutes a challenging menace to healthcare systems. P. aeruginosa shows increased and alarming resistance to carbapenems, long acknowledged as last-resort antibiotics for treatment of resistant infections. Varied and recalcitrant pathways of resistance to carbapenems can simultaneously occur in P. aeruginosa, including the production of carbapenemases, broadest spectrum types of β-lactamases that hydrolyze virtually almost all β-lactams, including carbapenems. The organism can produce chromosomal, plasmid-encoded, and integron- or transposon-mediated carbapenemases from different molecular classes. These include Ambler class A (KPC and some types of GES enzymes), class B (different metallo-β-lactamases such as IMP, VIM, and NDM), and class D (oxacillinases with carbapenem-hydrolyzing capacity like OXA-198) enzymes. Additionally, derepression of chromosomal AmpC cephalosporinases in P. aeruginosa contributes to carbapenem resistance in the presence of other concomitant mechanisms such as impermeability or efflux overexpression. Epidemiologic and molecular evidence of carbapenemases in P. aeruginosa has been long accumulating, and reports of their existence in different geographical areas of the world currently exist. Such reports are continuously being updated and reveal emerging varieties of carbapenemases and/or new genetic environments. This review summarizes carbapenemases of importance in P. aeruginosa, highlights their genetic profile, and presents current knowledge about their global epidemiology.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"95 4","pages":"507-515"},"PeriodicalIF":2.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9c/94/yjbm_95_4_507.PMC9765337.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9123915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Know your Microbe Foes: The Role of Surveillance in Combatting Antimicrobial Resistance. 了解你的微生物敌人:监测在对抗抗菌素耐药性中的作用。

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2022-12-01

Rachel E Bosserman, Jennie H Kwon

引用次数: 0

Antimicrobial Peptides Therapy: An Emerging Alternative for Treating Drug-Resistant Bacteria. 抗菌肽疗法:治疗耐药细菌的新选择。

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2022-12-01

Ifeanyi Elibe Mba, Emeka Innocent Nweze

{"title":"Antimicrobial Peptides Therapy: An Emerging Alternative for Treating Drug-Resistant Bacteria.","authors":"Ifeanyi Elibe Mba, Emeka Innocent Nweze","doi":"","DOIUrl":"","url":null,"abstract":"Microbial resistance to antibiotics is an ancient and dynamic issue that has brought a situation reminiscent of the pre-antibiotic era to the limelight. Currently, antibiotic resistance and the associated infections are widespread and pose significant global health and economic burden. Thus, the misuse of antibiotics, which has increased resistance, has necessitated the search for alternative therapeutic agents for combating resistant pathogens. Antimicrobial peptides (AMPs) hold promise as a viable therapeutic approach against drug-resistant pathogens. AMPs are oligopeptides with low molecular weight. They have broad-spectrum antimicrobial activities against pathogenic microorganisms. AMPs are nonspecific and target components of microbes that facilitate immune response by acting as the first-line defense mechanisms against invading pathogenic microbes. The diversity and potency of AMPs make them good candidates for alternative use. They could be used alone or in combination with several other biomaterials for improved therapeutic activity. They can also be employed in vaccine production targeting drug-resistant pathogens. This review covers the opportunities and advances in AMP discovery and development targeting antimicrobial resistance (AMR) bacteria. Briefly, it presents an overview of the global burden of the antimicrobial resistance crisis, portraying the global magnitude, challenges, and consequences. After that, it critically and comprehensively evaluates the potential roles of AMPs in addressing the AMR crisis, highlighting the major potentials and prospects.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"95 4","pages":"445-463"},"PeriodicalIF":2.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/6a/yjbm_95_4_445.PMC9765339.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10628416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research status and development trend of altruism in the biological field - knowledge graph analysis based on CiteSpace 生物领域利他主义的研究现状与发展趋势——基于CiteSpace的知识图谱分析

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2022-12-01 DOI: 10.17352/jbm.000034

Jia Li, Zhu Xianglei, X. Guoliang

{"title":"Research status and development trend of altruism in the biological field - knowledge graph analysis based on CiteSpace","authors":"Jia Li, Zhu Xianglei, X. Guoliang","doi":"10.17352/jbm.000034","DOIUrl":"https://doi.org/10.17352/jbm.000034","url":null,"abstract":"Based on the visualization analysis of foreign literature on altruistic behavior in recent ten years (2012-2022) by CiteSpace, it is found that the research on altruistic behavior in the field of biology abroad has experienced the initial exploratory stage, the outbreak stage, and now enters the stable and deepening stage. The discipline distribution is mainly behavioral ecology, supplemented by evolutionary biology, biomathematics, and genetics. The author has three main cooperative groups, and a relatively tight cooperative network has been formed locally in related fields. From the perspective of cooperation degree, the cooperation density of major research institutions is high, and relevant research has been relatively mature. Judging from the period calculated in the software, altruism, cooperation, kin Selection, reciprocity, and inclusive fitness emerged earlier. In recent years, constitutive theory, density dependence, and Habitat construction have emerged, which may become a new direction for future research. Therefore, future research can expand the scope of disciplines, strengthen the cooperation between authors and units, and explore other research hotspots.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"84 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90987692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Microbiota Modulation and Prevention of Dysbiosis as an Alternative Approach to Antimicrobial Resistance: A Narrative Review. 肠道菌群调节和预防失调作为抗微生物药物耐药性的另一种途径:叙述性综述。

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2022-12-01

Rafail Matzaras, Anna Nikopoulou, Efthimia Protonotariou, Eirini Christaki

{"title":"Gut Microbiota Modulation and Prevention of Dysbiosis as an Alternative Approach to Antimicrobial Resistance: A Narrative Review.","authors":"Rafail Matzaras, Anna Nikopoulou, Efthimia Protonotariou, Eirini Christaki","doi":"","DOIUrl":"","url":null,"abstract":"Background: The importance of gut microbiota in human health is being increasingly studied. Imbalances in gut microbiota have been associated with infection, inflammation, and obesity. Antibiotic use is the most common and significant cause of major alterations in the composition and function of the gut microbiota and can result in colonization with multidrug-resistant bacteria. Methods: The purpose of this review is to present existing evidence on how microbiota modulation and prevention of gut dysbiosis can serve as tools to combat antimicrobial resistance. Results: While the spread of antibiotic-resistant pathogens requires antibiotics with novel mechanisms of action, the number of newly discovered antimicrobial classes remains very low. For this reason, the application of alternative modalities to combat antimicrobial resistance is necessary. Diet, probiotics/prebiotics, selective oropharyngeal or digestive decontamination, and especially fecal microbiota transplantation (FMT) are under investigation with FMT being the most studied. But, as prevention is better than cure, the implementation of antimicrobial stewardship programs and strict infection control measures along with newly developed chelating agents could also play a crucial role in decreasing colonization with multidrug resistant organisms. Conclusion: New alternative tools to fight antimicrobial resistance via gut microbiota modulation, seem to be effective and should remain the focus of further research and development.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"95 4","pages":"479-494"},"PeriodicalIF":2.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b7/36/yjbm_95_4_479.PMC9765331.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9123920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotics and Antimicrobial Resistance in Acne: Epidemiological Trends and Clinical Practice Considerations. 痤疮的抗生素和抗菌素耐药性:流行病学趋势和临床实践考虑。

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2022-12-01

Clio Dessinioti, Andreas Katsambas

{"title":"Antibiotics and Antimicrobial Resistance in Acne: Epidemiological Trends and Clinical Practice Considerations.","authors":"Clio Dessinioti, Andreas Katsambas","doi":"","DOIUrl":"","url":null,"abstract":"Antimicrobial resistance is an increasing public health problem worldwide. The interest of a focus on antimicrobial resistance in acne lies on the facts that acne vulgaris (acne) is the most common skin disease worldwide, that the bacterium Cutibacterium acnes (C. acnes, formerly Propionibacterium acnes) plays a key role in the pathogenesis of acne, while at the same time being part of the skin flora, and that antibiotics are commonly recommended for acne treatment. The overuse of topical and/or systemic antibiotics, the long treatment courses used for acne, and the availability of over-the-counter antibiotic preparations, have led to the worldwide emergence of resistant strains in acne patients. In this review, we discuss the epidemiological trends of antimicrobial resistance in acne, the need to avoid the perturbation of the skin microbiome caused by anti-acne antibiotics, and the clinical practice considerations related to the emergence of resistant strains in acne patients. In light of the increasing risk of antimicrobial resistance, raising concerns over the misuse of antibiotics, prescribing patterns can be a critical target for antibiotic stewardship efforts. Also, the selection of non-antibiotic therapies for acne, whenever possible, may offer significant advantages.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"95 4","pages":"429-443"},"PeriodicalIF":2.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/3e/yjbm_95_4_429.PMC9765333.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9123917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain Abscess Caused by Nocardia asteroides in a Diabetic Patient: A Rare Case Report. 糖尿病诺卡菌致脑脓肿1例报告。

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2022-12-01

Hossein Ali Rahdar, Hamid Heidari, Morteza Karami-Zarandi, Tahereh Soori, Parisa Asadollahi, Hossein Kazemian

{"title":"Brain Abscess Caused by Nocardia asteroides in a Diabetic Patient: A Rare Case Report.","authors":"Hossein Ali Rahdar, Hamid Heidari, Morteza Karami-Zarandi, Tahereh Soori, Parisa Asadollahi, Hossein Kazemian","doi":"","DOIUrl":"","url":null,"abstract":"Nocardial brain abscess is usually associated with immunodeficiency, but can sometimes emerge in healthy individuals. This infection can be acquired through inhalation or direct inoculation of the bacteria, followed by dissemination to various organs, including the brain, through blood circulation. Mortality rate due to nocardial cerebral abscess is three times higher than that associated with cerebral abscess caused by other types of bacteria. Moreover, patients with Nocardia asteroides-associated brain abscess show poorer prognosis compared to patients with brain abscess caused by other Nocardia species, which is probably due to the high tendency of N. asteroides to become resistant to numerous antibiotics. It is, therefore, of paramount importance to diagnose and treat N. asteroides cerebral abscess in patients as soon as possible. The current paper is a rare report of a brain abscess caused by N. asteroides in a diabetic patient who failed to respond to multiple antibiotics (trimethoprim/sulfamethoxazole and amikacin), but improved by receiving imipenem and linezolid, and was finally successfully treated by surgical operation and long-term antibiotic therapy (imipenem and linezolid).","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"95 4","pages":"407-411"},"PeriodicalIF":2.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/7e/yjbm_95_4_407.PMC9765341.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9123921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pandemic panic and the culture of complacency 流行病恐慌和自满文化

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2022-11-10 DOI: 10.17352/jbm.000033

Ford Brian J

引用次数: 0

Bacteriological pattern of urinary tract infection in men with symptomatic benign prostatic hyperplasia at a tertiary hospital in Nigeria 尼日利亚一家三级医院男性症状性良性前列腺增生患者尿路感染的细菌学模式

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2022-10-29 DOI: 10.17352/jbm.000032

P. Ngwu, IE Ihedoro, EI Kalu

{"title":"Bacteriological pattern of urinary tract infection in men with symptomatic benign prostatic hyperplasia at a tertiary hospital in Nigeria","authors":"P. Ngwu, IE Ihedoro, EI Kalu","doi":"10.17352/jbm.000032","DOIUrl":"https://doi.org/10.17352/jbm.000032","url":null,"abstract":"Introduction/Background: Benign Prostatic Hyperplasia (BPH) is characterized by narrowing of the prostatic urethra with resultant difficulty in passing urine, stasis, and a predisposition to urinary tract infection. The objective of this study is to identify the prevalence of urinary tract infections, common organisms isolated, their antimicrobial sensitivity pattern, and the relationship of co-morbidities with urinary tract infection in this population. Materials and methods: All patients who presented to our urology team with bladder outlet obstruction secondary to benign prostatic hyperplasia between January 2020 and January 2021 were included. Information on age, occupation, co-morbid conditions, urine microscopy, culture, and sensitivity patterns were obtained and analyzed using SPSS version 25. Midstream urine samples were collected from 172 BPH patients. Microscopy, culture, and antibiotic susceptibility tests were carried out. Results: From our study, the prevalence of bacteriuria was 67.9% with the 65-74 and 45-54 age groups having the highest and the least prevalence of bacteriuria (88.9% and 33.3% respectively). The most common organisms cultured from their urine were Pseudomonas (17.9%), E. coli (14.3%), Coliforms (10.7%), and Klebsiella (10.7%). Sensitivity patterns of these microorganisms revealed the highest sensitivity to the fluoroquinolones (25.9%) followed by Nitrofurantoin (14.8%) and Ceftriaxone and Cefoxitin (7.4%). The least sensitivity was to Augmentin and Gentamycin. Conclusion: Bacteriuria is common in patients with BPH. Pseudomonas spp was the commonest isolated organism in our study and most isolated organisms were susceptible to the fluoroquinolones.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":"27 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91165887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0