用于软组织再生的局部和全身肽疗法:叙述性综述。

IF 2.5 3区 工程技术 Q2 BIOLOGY
Yale Journal of Biology and Medicine Pub Date : 2024-09-30 eCollection Date: 2024-09-01 DOI:10.59249/TKNM3388
Caroline J Cushman, Andrew F Ibrahim, Alexander D Smith, Evan J Hernandez, Brendan MacKay, Mimi Zumwalt
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引用次数: 0

摘要

背景:肌肉骨骼系统因其固有的结构和功能,容易导致关节疼痛,无论是类风湿性关节炎等炎症性疾病、骨关节炎等退行性疾病,还是外伤导致的软组织损伤都是如此。使用肽来治疗关节疼痛或炎症是一种新兴疗法,旨在提供治疗效果,同时保持安全和相对非侵入性。研究目的:本研究旨在回顾现有口服多肽制剂、关节内多肽制剂以及人体试验中新开发药物的文献,以评估软组织再生方面的给药途径(RoA)。研究设计:叙述性综述。研究方法:使用 PubMed 数据库进行了全面的文献检索。检索包括与肽疗法、软组织再生和RoA相关的医学主题词(MeSH)。纳入标准包括关注肽的作用机制、临床或生化结果的文章以及综述文章。排除标准包括文献不足或不符合设定证据级别的研究。结论该综述确定了在软组织修复方面具有疗效的各种肽。口服肽和关节内肽在软组织再生方面表现出明显的优势,关节内途径可产生局部效果,而口服途径则可产生全身效果。不过,这两种途径在生物利用度和吸收方面都有局限性。新出现的多肽仍处于起步阶段,在广泛使用之前,有必要对其特性和功效进行进一步的调查/研究。作为手术干预前的一种可行替代方法,肽疗法有望在软组织再生方面取得积极成果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Local and Systemic Peptide Therapies for Soft Tissue Regeneration: A Narrative Review.

Background: The musculoskeletal system, due to inherent structure and function, lends itself to contributing toward joint pain, whether from inflammatory disorders such as rheumatoid arthritis, degenerative diseases such as osteoarthritis, or trauma causing soft tissue injury. Administration of peptides for treatment of joint pain or inflammation is an emerging line of therapy that seeks to offer therapeutic benefits while remaining safe and relatively non-invasive. Purpose: The purpose of this study is to review the current literature on existing oral peptide agents, intra-articular peptide agents, and new developments in human trials to assess route of administration (RoA) for drug delivery in terms of soft tissue regeneration. Study Design: Narrative Review. Methods: A comprehensive literature search was conducted using the PubMed database. The search included medical subject headings (MeSH) terms related to peptide therapy, soft tissue regeneration, and RoA. Inclusion criteria comprised articles focusing on the mechanisms of action of peptides, clinical or biochemical outcomes, and review articles. Exclusion criteria included insufficient literature or studies not meeting the set evidence level. Conclusion: The review identified various peptides demonstrating efficacy in soft tissue repair. Oral and intra-articular peptides showed distinct advantages in soft tissue regeneration, with intra-articular routes providing localized effects and oral routes offering systemic benefits. However, both routes have limitations in bioavailability and absorption. Still in their infancy, further inquiries/research into the properties and efficacy of emerging peptides will be necessary before widespread use. As a viable alternative prior to surgical intervention, peptide treatments present as promising candidates for positive outcomes in soft tissue regeneration.

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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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