Yale Journal of Biology and Medicine最新文献_第3页

Suppressor of Cytokine Signaling Proteins 3 and 5 Potentially Delineate Polarization of Th cells in Chronic Rhinosinusitis. 细胞因子信号转导抑制蛋白 3 和 5 有可能划定慢性鼻炎 Th 细胞的极化。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI: 10.59249/HZFN2950

Babak Ghalehbaghi, Hossein Aazami, Majid Khoshmirsafa, Alireza Mohebbi, Pegah Babaheidarian, Nesa Rashidi, Kobra Mokhtarian, Reza Ahmadi, Monireh Kamali, Majid Ponour, Ayda Sanaei, Farhad Seif, Maryam Jalessi

{"title":"Suppressor of Cytokine Signaling Proteins 3 and 5 Potentially Delineate Polarization of Th cells in Chronic Rhinosinusitis.","authors":"Babak Ghalehbaghi, Hossein Aazami, Majid Khoshmirsafa, Alireza Mohebbi, Pegah Babaheidarian, Nesa Rashidi, Kobra Mokhtarian, Reza Ahmadi, Monireh Kamali, Majid Ponour, Ayda Sanaei, Farhad Seif, Maryam Jalessi","doi":"10.59249/HZFN2950","DOIUrl":"10.59249/HZFN2950","url":null,"abstract":"Background: Chronic rhinosinusitis (CRS) is an inflammatory condition classified into chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP). Th cells manage inflammatory cells in CRS. Suppressor of Cytokine Signaling (SOCS) proteins regulate Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway in Th cells by polarizing toward Th1, Th2, and Th17 cells. This study evaluated the levels of SOCS1,3,5 in CRS patients to find associations with Th cells. Methods: In this cross-sectional study, 20 CRSwNP patients, 12 CRSsNP patients, and 12 controls participated. The infiltration of CD4+ T cells was determined using immunohistochemistry. The expression of specific transcription factors and SOCS proteins was assessed using real-time PCR. Cytokine levels were evaluated using ELISA. SOCS protein levels were investigated using western blot analysis. Results: The expression of SOCS3 increased in the CRSwNP group compared to CRSsNP and control groups (p <0.001). SOCS3 protein levels increased in the CRSwNP group compared to CRSsNP (p <0.05) and control (p <0.001) groups. Although there was a significant difference in SOCS5 expression between CRSsNP and control groups, SOCS5 protein levels were significantly different between CRSsNP and control (p <0.001) and CRSwNP (p <0.05) groups. Conclusions: Targeted therapies may be suggested for CRS by modulating SOCS3 and SOCS5 proteins that are responsible for polarization of Th cells toward Th2 or Th1 cells, respectively. JAK-STAT pathway targeting, which encompasses numerous cells, can be limited to SOCS proteins to more effectively orchestrate Th cell differentiation.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer to Cataracts: The Mechanistic Impact of Aldo-Keto Reductases in Chronic Diseases. 从癌症到白内障：慢性疾病中醛酮还原酶的机理影响。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI: 10.59249/VTBV6559

Anirudh P Shanbhag, Purnendu Bhowmik

引用次数: 0

Causes and Effects of COVID-19 Vaccine Hesitancy Among Pregnant Women and its Association with Adverse Maternal, Placental, and Perinatal Outcomes. 孕妇不接种 COVID-19 疫苗的原因和影响及其与孕产妇、胎盘和围产期不良结果的关联。

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/LPOQ5146

Kristen Lee Moriarty, Roselyn O Oyenuga, Olatoyosi Olafuyi, David A Schwartz

引用次数: 0

Effect of Prenatal Care on Perinatal Outcomes of Pregnant Women with Diabetes Mellitus: A Systematic Review. 产前护理对糖尿病孕妇围产期结果的影响：系统回顾

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/WPTY4075

Letícia B G da Silva, Lenita Zajdenverg, Elisa Keating, Manoela Pereira Smith Silvestre, Beatriz M B Dos Santos, Cláudia Saunders

{"title":"Effect of Prenatal Care on Perinatal Outcomes of Pregnant Women with Diabetes Mellitus: A Systematic Review.","authors":"Letícia B G da Silva, Lenita Zajdenverg, Elisa Keating, Manoela Pereira Smith Silvestre, Beatriz M B Dos Santos, Cláudia Saunders","doi":"10.59249/WPTY4075","DOIUrl":"10.59249/WPTY4075","url":null,"abstract":"Objective: to evaluate the effect of prenatal care (PC) on perinatal outcomes of pregnant women with diabetes mellitus (DM). Methods: systematic review developed according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines and conducted through the population, intervention, control, and outcomes (PICO) strategy. Clinical trials and observational studies were selected, with adult pregnant women, single-fetus pregnancy, diagnosis of DM, or gestational DM and who had received PC and/or nutritional therapy (NT). The search was carried out in PubMed, Scopus, and BIREME databases. The quality of the studies was evaluated using the tools of the National Heart, Lung and Blood Institute-National Institutes of Health (NHLBI-NIH). Results: We identified 5972 records, of which 15 (n=47 420 pregnant women) met the eligibility criteria. The most recurrent outcomes were glycemic control (14 studies; n=9096 participants), hypertensive disorders of pregnancy (2; n=39 282), prematurity (6; n=40 163), large for gestational age newborns (4; n=1556), fetal macrosomia (birth weight >4kg) (6; n=2980) and intensive care unit admission (4; n=2022). Conclusions: The findings suggest that PC interferes with the perinatal outcome, being able to reduce the risks of complications associated with this comorbidity through early intervention, especially when the NT is an integral part of this assistance.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Open Conversation About Postpartum Psychosis: An Interview with Jessie Hunt: Communications Lead, Advocate, and Expert by Experience. 关于产后精神病的公开对话：采访杰西-亨特（Jessie Hunt）：沟通领导者、倡导者和经验专家。

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/PWXZ3821

Udita Iyengar, Jessie Hunt

引用次数: 0

External Disruption of Ocular Development in Utero. 胎儿眼部发育的外部干扰

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/RRMM8911

Hyun Sue Kim, Soshian Sarrafpour, Christopher C Teng, Ji Liu

{"title":"External Disruption of Ocular Development in Utero.","authors":"Hyun Sue Kim, Soshian Sarrafpour, Christopher C Teng, Ji Liu","doi":"10.59249/RRMM8911","DOIUrl":"10.59249/RRMM8911","url":null,"abstract":"The intricate steps of human ocular embryology are impacted by cellular and genetic signaling pathways and a myriad of external elements that can affect pregnancy, such as environmental, metabolic, hormonal factors, medications, and intrauterine infections. This review focuses on presenting some of these factors to recognize the multifactorial nature of ocular development and highlight their clinical significance. This review is based on English-language articles sourced from PubMed, Web of Science, and Google Scholar; keywords searched included \"ocular development in pregnancy,\" \"ocular embryology,\" \"maternal nutrition,\" \"ophthalmic change,\" and \"visual system development.\" While some animal models show the disruption of ocular embryology from these external factors, there are limited post-birth assessments in human studies. Much remains unknown about the precise mechanisms of how these external factors can disrupt normal ocular development in utero, and more significant research is needed to understand the pathophysiology of these disruptive effects further. Findings in this review emphasize the importance of additional research in understanding the dynamic association between factors impacting gestation and neonatal ocular development, particularly in the setting of limited resources.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of Genetic and Artificial Intelligence approaches to improving Gestational Diabetes Mellitus Screening and Diagnosis in sub-Saharan Africa. 审查改进撒哈拉以南非洲妊娠糖尿病筛查和诊断的遗传和人工智能方法。

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/ZBSC2656

Vansh V Gadhia, Jaspreet Loyal

{"title":"Review of Genetic and Artificial Intelligence approaches to improving Gestational Diabetes Mellitus Screening and Diagnosis in sub-Saharan Africa.","authors":"Vansh V Gadhia, Jaspreet Loyal","doi":"10.59249/ZBSC2656","DOIUrl":"10.59249/ZBSC2656","url":null,"abstract":"Background: Adverse outcomes from gestational diabetes mellitus (GDM) in the mother and newborn are well established. Genetic variants may predict GDM and Artificial Intelligence (AI) can potentially assist with improved screening and early identification in lower resource settings. There is limited information on genetic variants associated with GDM in sub-Saharan Africa and the implementation of AI in GDM screening in sub-Saharan Africa is largely unknown. Methods: We reviewed the literature on what is known about genetic predictors of GDM in sub-Saharan African women. We searched PubMed and Google Scholar for single nucleotide polymorphisms (SNPs) involved in GDM predisposition in a sub-Saharan African population. We report on barriers that limit the implementation of AI that could assist with GDM screening and offer possible solutions. Results: In a Black South African cohort, the minor allele of the SNP rs4581569 existing in the PDX1 gene was significantly associated with GDM. We were not able to find any published literature on the implementation of AI to identify women at risk of GDM before second trimester of pregnancy in sub-Saharan Africa. Barriers to successful integration of AI into healthcare systems are broad but solutions exist. Conclusions: More research is needed to identify SNPs associated with GDM in sub-Saharan Africa. The implementation of AI and its applications in the field of healthcare in the sub-Saharan African region is a significant opportunity to positively impact early identification of GDM.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Physiological Changes During Pregnancy. 孕期的自然生理变化

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/JTIV4138

Mahesh Chandra, Ansar Ahmad Paray

引用次数: 0

Assessing the Efficacy of Large Language Models in Health Literacy: A Comprehensive Cross-Sectional Study. 评估大语言模型在健康扫盲中的功效：综合横断面研究

IF 2.5 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/ZTOZ1966

Kanhai S Amin, Linda C Mayes, Pavan Khosla, Rushabh H Doshi

{"title":"Assessing the Efficacy of Large Language Models in Health Literacy: A Comprehensive Cross-Sectional Study.","authors":"Kanhai S Amin, Linda C Mayes, Pavan Khosla, Rushabh H Doshi","doi":"10.59249/ZTOZ1966","DOIUrl":"10.59249/ZTOZ1966","url":null,"abstract":"Enhanced health literacy in children has been empirically linked to better health outcomes over the long term; however, few interventions have been shown to improve health literacy. In this context, we investigate whether large language models (LLMs) can serve as a medium to improve health literacy in children. We tested pediatric conditions using 26 different prompts in ChatGPT-3.5, ChatGPT-4, Microsoft Bing, and Google Bard (now known as Google Gemini). The primary outcome measurement was the reading grade level (RGL) of output as assessed by Gunning Fog, Flesch-Kincaid Grade Level, Automated Readability Index, and Coleman-Liau indices. Word counts were also assessed. Across all models, output for basic prompts such as \"Explain\" and \"What is (are),\" were at, or exceeded, the tenth-grade RGL. When prompts were specified to explain conditions from the first- to twelfth-grade level, we found that LLMs had varying abilities to tailor responses based on grade level. ChatGPT-3.5 provided responses that ranged from the seventh-grade to college freshmen RGL while ChatGPT-4 outputted responses from the tenth-grade to the college senior RGL. Microsoft Bing provided responses from the ninth- to eleventh-grade RGL while Google Bard provided responses from the seventh- to tenth-grade RGL. LLMs face challenges in crafting outputs below a sixth-grade RGL. However, their capability to modify outputs above this threshold, provides a potential mechanism for adolescents to explore, understand, and engage with information regarding their health conditions, spanning from simple to complex terms. Future studies are needed to verify the accuracy and efficacy of these tools.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Social Support in Perinatal Mental Health and Psychosocial Stimulation. 社会支持在围产期心理健康和社会心理刺激中的作用。

IF 2.7 3区工程技术

Yale Journal of Biology and Medicine Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI: 10.59249/WMGE9032

Tatjana L Kay, Margaret C Moulson, Simone N Vigod, Nour Schoueri-Mychasiw, Daisy R Singla

{"title":"The Role of Social Support in Perinatal Mental Health and Psychosocial Stimulation.","authors":"Tatjana L Kay, Margaret C Moulson, Simone N Vigod, Nour Schoueri-Mychasiw, Daisy R Singla","doi":"10.59249/WMGE9032","DOIUrl":"10.59249/WMGE9032","url":null,"abstract":"Social support refers to the help someone receives emotionally or instrumentally from their social network. Poor social support in the perinatal period has been associated with increased risk for symptoms of common mental disorders, including depression and posttraumatic stress symptoms (PTS), which may impact parenting behavior. Whether social support impacts parenting behaviors, independent of mental health symptomatology, remains unclear. Among N=309 participants of the Scaling Up Maternal Mental healthcare by Increasing access to Treatment (SUMMIT Trial), a large perinatal depression and anxiety treatment trial, we explored the relations between perceived social support, perinatal depressive and PTS symptoms, and psychosocial stimulation provided by the parent in their home environment. Social support was measured at baseline using the Multidimensional Scale of Perceived Social Support (MSPSS). Perinatal depressive symptoms were measured by the Edinburgh Postnatal Depression Scale (EPDS) and PTS symptoms were measured by the Abbreviated PTSD Checklist (PCL-6) at baseline, 3-, and 6-months post-randomization. Psychosocial stimulation was assessed by the Home Observation Measurement of the Environment (HOME) when the infant was between 6 to 24 months. Using stepwise hierarchical regressions, we found: (1) perceived social support at baseline significantly predicted both depressive and PTS symptoms at 3-months post-randomization, even when controlling for baseline depressive and PTS symptoms; and (2) while neither depressive nor PTS symptoms were significantly associated with psychosocial stimulation, perceived social support at baseline was a significant predictor. Clinical implications regarding treatment of perinatal patients are discussed.","PeriodicalId":48617,"journal":{"name":"Yale Journal of Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0