Journal of Integrative Medicine-Jim最新文献

{"title":"Collision of Chinese medicine and materials science: Interdisciplinary biomaterials’ perspectives","authors":"Wei-kang Luo ,&nbsp;Xiao-hang Guo ,&nbsp;Li-na Cao ,&nbsp;Jun Zheng ,&nbsp;Ming Luo ,&nbsp;Yang Wang","doi":"10.1016/j.joim.2025.11.006","DOIUrl":"10.1016/j.joim.2025.11.006","url":null,"abstract":"<div><div>The integration of materials science and Chinese medicine (CM) has emerged as a significant interdisciplinary field, playing a crucial role in enhancing the pharmacodynamics of CM and its derived small molecules. This field introduces novel concepts, like carrier-based CM delivery systems and carrier-free CM-based material systems, and here we present a detailed exposition of their respective merits and drawbacks. In recent years, there has been an exponential increase in research on carrier-based drug delivery systems for CM, which are designed to optimize administration routes, improve targeted delivery precision, and enable controlled drug release. Nonetheless, these systems face critical challenges including suboptimal drug payloads, prohibitive manufacturing costs, and compromised biocompatibility. The introduction of carrier-free CM-based material system addresses these shortcomings through inherent advantages including exceptional drug-loading capacity, full-bioactive components, and superior biocompatibility. Comparative analyses demonstrate that nanonization of the active components of herbal medicines can significantly improve the permeability, solubility, stability, and targeting of the active components themselves. The intrinsic therapeutic components, eco-friendly attributes, and sustainable regenerative capacity of CM, combined with the adjustable physicochemical properties of advanced materials create unique therapeutic advantages. The advancement and optimization of CM and materials science concept have significantly bolstered the clinical application of drugs, increasingly aligning with the personalized treatment model in clinical practice. We provide an overview of the future obstacles and potential development strategies in the realm of CM-materials science with the aspiration to propel sustainable development in both CM and materials science.</div><div>Please cite this article as: Luo WK, Guo XH, Cao LN, Zheng J, Luo M, Wang Y. Collision of Chinese medicine and materials science: Interdisciplinary biomaterials’ perspectives. <em>J Integr Med</em>. 2026; 24(2):140–153.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"24 2","pages":"Pages 140-153"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yin-yang dynamics in wound inflammation: Yin and yang manifestations of inflammatory substances","authors":"Yue-fei Geng ,&nbsp;Xiu-ying Ma ,&nbsp;Yan Ge ,&nbsp;Bin Liu ,&nbsp;Jin-gen Deng ,&nbsp;Shu Liu ,&nbsp;Tao-qing Wu ,&nbsp;Shun-ri Jiang ,&nbsp;Fu-neng Geng","doi":"10.1016/j.joim.2025.11.007","DOIUrl":"10.1016/j.joim.2025.11.007","url":null,"abstract":"<div><div>Over the past three decades, a growing body of research has been dedicated to the integration of traditional Chinese medicine (TCM) and modern medicine, highlighting the complementary benefits of both disciplines. However, in the context of skin wound treatment, such integration remains limited and warrants further exploration. During the wound healing process, the inflammatory response is a critical physiological event. A harmonious balance between pro-inflammatory and anti-inflammatory events is essential for the progression of inflammation and the overall wound healing process. This equilibrium reflects the dynamic and reciprocal interaction embodied in the TCM concept of yin and yang. This study analyzes the dynamic changes in wound inflammation from the perspective of TCM’s yin-yang theory and pinpoints the key cellular and molecular factors that influence the yin-yang balance in wound inflammation. The findings offer significant theoretical and practical value for future clinical and translational research. These insights will inform more effective strategies for the treatment of skin wounds and to facilitate the development of novel therapeutics.</div><div><br>Please cite this article as: Geng YF, Ma XY, Ge Y, Liu B, Deng JG, Liu S, Wu TQ, Jiang SR, Geng FN. Yin-yang dynamics in wound inflammation: yin and yang manifestations of inflammatory substances. <em>J Integr Med</em>. 2026; 24(2):154–162.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"24 2","pages":"Pages 154-162"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastroprotective activity of Talinum paniculatum (Jacq.) Gaertn. in mice: An ethnopharmacological validation","authors":"Kessy Gabrielly Pegoraro Correa ,&nbsp;Marcella do Carmo Barroso de Siqueira ,&nbsp;Mariana Zanovello ,&nbsp;Manuela Martins Belmudes ,&nbsp;Priscila de Souza ,&nbsp;Arquimedes Gasparotto Junior ,&nbsp;Thaise Boeing","doi":"10.1016/j.joim.2025.12.002","DOIUrl":"10.1016/j.joim.2025.12.002","url":null,"abstract":"<div><h3>Objective</h3><div>Gastric ulcers are a global health issue, often occurring in the stomach or duodenum and causing tissue necrosis. <em>Talinum paniculatum</em> (Jacq.) Gaertn (Erva-gorda) is used in traditional medicine for treating gastric ulcers. This study aimed to assess the gastroprotective effects of the ethanol-soluble fraction from <em>T. paniculatum</em> leaves (ESTP) in rodents.</div></div><div><h3>Methods</h3><div>The gastroprotective potential of ESTP was evaluated at 30, 100, and 300 mg/kg taken orally, or 30 mg/kg intraperitoneally against gastric lesions induced by a 60% ethanol solution containing 0.3 mol/L hydrochloric acid, in mice. Histological sections were examined after hematoxylin–eosin staining and their mucin content was determined using the periodic acid–Schiff method. Oxidative stress markers, including levels of reduced glutathione and lipid hydroperoxide, as well as inflammatory parameters such as myeloperoxidase activity and nitrite levels, were analyzed. Mechanistic studies involved pretreating the mice with <em>N</em>-ethylmaleimide (NEM), <em>N</em>-nitro-<span>l</span>-arginine methyl ester (L-NAME), and indomethacin.</div></div><div><h3>Results</h3><div>ESTP at 300 mg/kg orally and 30 mg/kg intraperitoneally significantly reduced ethanol/HCl-induced gastric injury. It decreased lipid hydroperoxide levels but did not increase levels of reduced glutathione. Myeloperoxidase activity and nitrite levels were reduced. However, ESTP did not restore mucin levels. Pretreatment with indomethacin nullified the protective effects of ESTP while NEM and L-NAME did not.</div></div><div><h3>Conclusion</h3><div>ESTP demonstrated a remarkable gastroprotective effect, as indicated by reductions in inflammatory and oxidative mediators. The observed decline in mucin activity, coupled with the absence of an effect following indomethacin pretreatment, implies a potential inhibition of the cyclooxygenase activity by the extract. These findings collectively support the traditional use of the species for gastrointestinal protection and highlight its potential as a therapeutic agent for managing gastric ulcers.</div><div><br>Please cite this article as: Pegoraro Correa KG, do Carmo Barroso de Siqueira M, Zanovello M, Martins Belmudes M, de Souza P, Gasparotto Junior A, Boeing T. Gastroprotective activity of <em>Talinum paniculatum</em> (Jacq.) Gaertn. in mice: An ethnopharmacological validation. <em>J Integr Med.</em> 2026; 24(2):279–286.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"24 2","pages":"Pages 279-286"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture in depression treatment: Insights into astrocyte regulation","authors":"Ning Xu ,&nbsp;Tao Huang ,&nbsp;Long Wang","doi":"10.1016/j.joim.2025.09.003","DOIUrl":"10.1016/j.joim.2025.09.003","url":null,"abstract":"<div><div>Astrocytes are the most abundant and morphologically intricate glial cells in the central nervous system, playing diverse and crucial roles in maintaining homeostasis within this system. Increasing evidence suggests that dysfunction of astrocytes contributes to the pathophysiology of depression. As an adjunctive and integrative therapy, acupuncture presents certain advantages in alleviating the severity of depressive symptoms. In comparison to conventional pharmacotherapy, acupuncture is distinguished by its relatively rapid onset of action, minimal side effects, and compatibility with concurrent pharmacological treatments. Preclinical studies indicate that acupuncture can ameliorate both morphological and functional impairments observed in the depressed brain by targeting neurons and glia. Specifically, research has demonstrated that acupuncture reduces morphological atrophy in astrocytes while also mitigating their dysfunction in rat models of depression. This therapeutic effect may be partially mediated through the regulation of enzyme expression, cytokines, neurotrophic factors, and intracellular signaling pathways within these glial cells. This review focuses on preclinical research investigating the mechanisms through which acupuncture may aid in treating depression, with an emphasis on astrocyte modulation.</div><div>Please cite this article as: Xu N, Huang T, Wang L. Acupuncture in depression treatment: Insights into astrocyte regulation. <em>J Integr Med</em>. 2026; 24(2):163–173.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"24 2","pages":"Pages 163-173"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aconitum coreanum (H.Lév l.) Rapaics exerts neuroprotective effects on cerebral ischemic stroke by inhibiting autophagy through the AMPK/mTOR/ULK1 pathway","authors":"Yue Liu,&nbsp;Yang Qu,&nbsp;Qian Cai","doi":"10.1016/j.joim.2025.12.004","DOIUrl":"10.1016/j.joim.2025.12.004","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;Cerebral ischemic stroke (CIS) induces neuronal damage and activates neuronal autophagy through diverse mechanisms. Autophagy exerts adverse effects in acute neurological disorders, leading to neuronal apoptosis and death. The dried tuberous root of &lt;em&gt;Aconitum coreanum&lt;/em&gt; (H.Lév l.) Rapaics is a traditional herbal medicine that has been used to treat stroke. This study explores the neuroprotective effects of &lt;em&gt;A. coreanum&lt;/em&gt; through its role in autophagy and the mechanisms that underly this activity.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The middle cerebral artery occlusion/reperfusion technique was used to establish a CIS rat model. The neuroprotective effects of &lt;em&gt;A. coreanum&lt;/em&gt; were explored using a suite of techniques: behavioral injury was assessed with the Longa method; infarct size was measured using 2,3,5-triphenyltetrazolium chloride; neuronal morphology was observed using hematoxylin–eosin and Nissl staining; neuronal apoptosis was observed with terminal-deoxynucleotidyl transferase dUTP nick-end labeling staining. Then, the mechanisms behind the neuroprotective effects were explored: the oxidative stress index was detected using enzyme-linked immunosorbent assay; the ultrastructure of rat neurons was observed using transmission electron microscopy; the protein expression was detected with Western blotting and immunofluorescence analyses; the mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction analysis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;&lt;em&gt;A. coreanum&lt;/em&gt; significantly reduced the behavioral score and infarct size of CIS rats, increased the number of neurons in the cerebral cortex and hippocampus, improved the morphology and structure of neurons, and suppressed neuronal apoptosis. In addition, &lt;em&gt;A. coreanum&lt;/em&gt; downregulated levels of malondialdehyde and myeloperoxidase and upregulated those of superoxide dismutase and glutathione. It inhibited the generation of autophagosomes and modulated the indicators of autophagy, including decreasing the ratio of microtubule-associated protein 1 light chain 3-II (LC3-II)/LC3-I, and increasing the expression of sequestosome 1. &lt;em&gt;A. coreanum&lt;/em&gt; also upregulated the expression of phosphorylated mammalian target of rapamycin (mTOR) and phosphorylated unc-51-like kinase 1 (ULK1) and downregulated that of phosphorylated adenosine monophosphate-activated protein kinase (AMPK).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;&lt;em&gt;A. coreanum&lt;/em&gt; exerts neuroprotective effects in CIS by inhibiting autophagy through regulating the AMPK/mTOR/ULK1 signaling pathway. This finding provides a novel perspective on the treatment of CIS with &lt;em&gt;A. coreanum&lt;/em&gt;.&lt;/div&gt;&lt;div&gt;&lt;br&gt;Please cite this article as: Yue L, Yang Q, Qian C. &lt;em&gt;Aconitum coreanum&lt;/em&gt; (H.Lév l.) Rapaics exerts neuroprotective effects on cerebral ischemic stroke by inhibiting autophagy through the AMPK/mTOR/ULK1 pathway. &lt;em&gt;J Integr Med&lt;/em&gt;. 2026; 24(2):210–223.","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"24 2","pages":"Pages 210-223"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a core outcome set for clinical research on Chinese medicine dampness syndrome","authors":"Xing-ying Qiu ,&nbsp;Qi Tang ,&nbsp;Ting Cheng ,&nbsp;Wen-cong Cao ,&nbsp;Bing-qing Liu ,&nbsp;Ze-huai Wen ,&nbsp;Geng Li","doi":"10.1016/j.joim.2026.01.005","DOIUrl":"10.1016/j.joim.2026.01.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study develops a core outcome set (COS) for clinical research concerning Chinese medicine (CM) dampness syndrome (COS-CMDS) that might improve heterogeneity of outcomes, reporting, and inadequate attention to the CM characteristic outcomes in clinical research on CM dampness syndrome.</div></div><div><h3>Methods</h3><div>An initial outcome pool was constructed based on a systematic review of clinical studies related to CM dampness, registered trials, and semi-structured interviews with patients and healthcare professionals. Various stakeholders were invited to participate in a 2-round Delphi survey to scrutinize the important outcomes. A consensus meeting was held to determine the final COS-CMDS.</div></div><div><h3>Results</h3><div>We identified 1904 studies and 73 registered trials in the systematic review. Six patients and seven healthcare professionals were invited to participate in a semi-structured interview. Then, 541 outcomes were extracted, of which 397 were physicochemical. After combining certain outcomes (especially the physicochemical outcomes) and excluding those with weak relevance by discussion, 26 outcomes were included in round 1 of the Delphi survey. Round 1 was completed by 82.89% of participants, and 22 outcomes were carried on to round 2. Round 2 was completed by 92.06% of participants, and 14 outcomes achieved consensus for inclusion in the COS. Nineteen stakeholders attended the consensus meeting, voted, and discussed the final COS. It included evaluation of dampness syndrome, CM syndrome assessment, effective response, validated laboratory outcomes of CM dampness syndrome, and adverse events.</div></div><div><h3>Conclusion</h3><div>The COS-CMDS provides a reference for the selection and reporting of outcomes in clinical research concerning CM dampness syndrome, embodying the characteristics of CM.</div><div>Please cite this article as: Qiu XY, Tang Q, Cheng T, Cao WC, Liu BQ, Wen ZH, Li G. Developing a core outcome set for clinical research on Chinese medicine dampness syndrome. <em>J Integr Med</em>. 2026; 24(2):201–209.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"24 2","pages":"Pages 201-209"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the antimetastatic activity and molecular mechanism of montanine in lung cancer cells via the integration of network pharmacology approaches with in vitro and in vivo investigations","authors":"Iksen Iksen ,&nbsp;Natsaranyatron Singharajkomron ,&nbsp;Ausana Wongtayan ,&nbsp;Onsurang Wattanathamsan ,&nbsp;Amaya Choonhapan ,&nbsp;Sureeporn Wademonkolgorn ,&nbsp;Hien Minh Nguyen ,&nbsp;Trang Huyen Xuan Hoang ,&nbsp;Hoai Thi Nguyen ,&nbsp;Varisa Pongrakhananon","doi":"10.1016/j.joim.2026.01.001","DOIUrl":"10.1016/j.joim.2026.01.001","url":null,"abstract":"<div><h3>Objective</h3><div>Non-small cell lung cancer (NSCLC), a leading cause of cancer-related mortality, presents a poor prognosis due to its tendency to metastasize and its resistance to standard therapies. Montanine (MTN), a naturally occurring alkaloid, has recently shown potential as an anticancer agent. However, the specific mechanisms through which it exerts its anticancer effects are still largely unknown. This study investigates the anti-NSCLC potential of MTN by utilizing integrative network pharmacology alongside in vitro and in vivo experimental validations.</div></div><div><h3>Methods</h3><div>Genes targeted by MTN in NSCLC were identified and subjected to functional enrichment analysis to elucidate the most enriched signaling pathways. A protein–protein interaction network was constructed to identify the interactions of potential targets. Adrenoceptor β2 (<em>ADRB2</em>) expression in lung cancer was analyzed using data from The Cancer Genome Atlas and Gene Expression Omnibus datasets. The effects of MTN on NSCLC cell lines, including migration, proliferation, viability and apoptosis, were assessed in vitro. MTN-related mechanisms were investigated using quantitative reverse transcription-polymerase chain reaction and Western blotting. Furthermore, an in vivo lung cancer metastasis experiment was performed in rats using a tail vein assay.</div></div><div><h3>Results</h3><div>MTN at nontoxic doses significantly reduced cell migration and lung colonization in an in vivo metastasis study (<em>P</em> &lt; 0.05). Network pharmacology revealed 29 targets of MTN in NSCLC, highlighting <em>ADRB2</em> as a primary target linked to poor prognosis in lung cancer. In vitro studies confirmed that MTN notably upregulated ADRB2 expression and downregulated epithelial–mesenchymal transition (EMT) signaling pathways, which was further enhanced by terbutaline sulfate, an ADRB2 activator.</div></div><div><h3>Conclusion</h3><div>MTN is a promising therapeutic agent for NSCLC by suppressing the migration via ADRB2 and EMT mechanisms.</div><div><br>Please cite this article as: Iksen I, Singharajkomron N, Wongtayan A, Wattanathamsan O, Choonhapan A, Wademonkolgorn S, Nguyen HM, Hoang THX, Nguyen HT, Pongrakhananon V. Unveiling the antimetastatic activity and molecular mechanism of montanine in lung cancer cells via the integration of network pharmacology approaches with in vitro and in vivo investigations. <em>J Integr Med</em>. 2026; 24(2):253–264.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"24 2","pages":"Pages 253-264"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic dermatitis management in the era of integrative medicine","authors":"Min Chen ,&nbsp;Wan-qing Liao","doi":"10.1016/j.joim.2026.02.003","DOIUrl":"10.1016/j.joim.2026.02.003","url":null,"abstract":"<div><div>Atopic dermatitis (AD) is the most common chronic inflammatory skin condition. It has significant socioeconomic consequences and complex pathophysiology, necessitating updated management guidelines that consider the age, sex and geographic location of patients. Despite the widespread use of Western medicine (WM), including topical corticosteroids, as the primary treatment for AD, the possible negative effects of WM therapies are inescapable. Although there is still a lack of strong evidence, the integration of traditional Chinese medicine (TCM) with WM may yield a more favorable therapeutic response for AD than WM alone, due to the synergistic effects involved. Balancing the application of diagnostic and therapeutic approaches from TCM and WM is crucial for the management of AD, enhancing treatment efficacy for patients, and averting disease recurrence. In 2025, a new clinical guideline for the diagnosis and treatment of AD was released; it emphasized the integration of TCM with WM. This guideline is crucial as it consolidates global expertise and data to provide a standardized framework for the practical integration of techniques to bridge divides among clinical disciplines. As more substantial data emerge, the development and enhancement of integrative medicine for AD management should be prioritized globally, particularly in Asian regions.</div><div><br>Please cite this article as: Chen M, Liao WQ. Atopic dermatitis management in the era of integrative medicine. <em>J Integr Med</em>. 2026; 24(2):137–139.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"24 2","pages":"Pages 137-139"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acteoside as a rising star for clinical treatment: Current fundamental research and future outlooks","authors":"Fu-kun Zhang ,&nbsp;Ke-xin Jia ,&nbsp;Hong Wang ,&nbsp;Run-ping Liu ,&nbsp;Xiao-yong Xue ,&nbsp;Zi-xuan Huo ,&nbsp;Xiao-jiao-yang Li","doi":"10.1016/j.joim.2025.08.007","DOIUrl":"10.1016/j.joim.2025.08.007","url":null,"abstract":"<div><div>Natural compounds are increasingly recognized for their therapeutic potential in disease treatment, and they make a significant contribution to modern pharmaceutical research. Among these compounds, acteoside (ACT), also known as verbascoside and kusaginin, is a phenylethanoid glycoside derived from sources like <em>Rehmannia glutinosa</em> Libosch. and <em>Cistanche deserticola</em> Ma. This natural compound exhibits a range of therapeutic properties, including neuroprotective, anti-inflammatory, anti-bacterial, and anti-tumor effects, thereby underscoring its potential value in addressing various clinical conditions. However, the unstable physicochemical properties and low bioavailability of ACT have greatly limited its clinical application. This review summarizes the latest advancements in pharmaceutical plant resources, conducts bibliometric analysis and explores the pharmacokinetics, pharmacological effects and molecular mechanisms of ACT, providing a deeper understanding of its medicinal value and current research trends. Furthermore, we utilize network pharmacology strategies and molecular docking techniques to identify additional potential therapeutic targets for ACT. We posit that ACT holds considerable promise as a treatment for atherosclerosis, diabetes with complications, hepatic and respiratory diseases as well as common malignant tumors. This review enhances our understanding of the mechanisms by which ACT treats various diseases and establishes a theoretical foundation for further drug development and research on medicinal plants.</div><div><br>Please cite this article as: Zhang FK, Jia KX, Wang H, Liu RP, Xue XY, Huo ZX, Li XJY. Acteoside as a rising star for clinical treatment: Current fundamental research and future outlooks. <em>J Integr Med</em>. 2026; 24(1):7–23.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"24 1","pages":"Pages 7-23"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The roles of traditional Chinese medicine within an interdisciplinary team in predominantly Western medical settings: A scoping review","authors":"Arkers Kwan Ching Wong,&nbsp;Nuo Shi,&nbsp;Annie Ho,&nbsp;Janice Yuen Shan Ho","doi":"10.1016/j.joim.2025.11.004","DOIUrl":"10.1016/j.joim.2025.11.004","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Traditional Chinese medicine (TCM) is increasingly recognized for its holistic approach and effectiveness. Integrated medicine, emphasizing collaboration between TCM and Western medicine (WM), is promoted globally to enhance healthcare delivery. However, the roles and responsibilities of TCM practitioners in predominantly Western medical settings are underexplored, potentially hindering their engagement in interprofessional collaboration.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;This scoping review investigated the roles and responsibilities of TCM practitioners and identified facilitators and barriers to TCM integration in Western medical contexts.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Search strategy&lt;/h3&gt;&lt;div&gt;We conducted a scoping review using data from eleven Chinese and English databases, including Cumulative Index of Nursing and Allied Health, MEDLINE, PubMed, Embase, Web of Science, Cochrane Library, PsycINFO, China National Knowledge Infrastructure. Wanfang, Chinese Scientific Journal Database, and the Chinese Science Citation Database.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Inclusion criteria&lt;/h3&gt;&lt;div&gt;Eligibility was limited to studies on TCM practitioners in interdisciplinary teams with Western professionals, published in Chinese or English, while excluding articles that lacked documentation of TCM involvement, or focused exclusively on TCM practices.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Data extraction and analysis&lt;/h3&gt;&lt;div&gt;Thematic analysis following Braun and Clarke’s six-step framework was used to summarize data on the roles of TCM and TCM practitioners, and factors that facilitate and hinder the integration of TCM and WM.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Our systematic search yielded 31 relevant papers. We identified eight key roles of TCM practitioners: mitigating WM-induced side effects, facilitating WM tapering and prevention, attenuating disease progression, improving mental health, providing pain relief, supporting stroke rehabilitation, managing symptoms, and regulating the immune system. TCM practitioners fulfill these roles through accurate diagnosis, prescription, and collaborative care while also serving as educators. Five facilitators for TCM integration were identified: safety, recognition, policy support, accessibility, and treatment guidelines. Barriers included: safety concerns, lack of research, insufficient TCM knowledge among WM practitioners, attitudinal barriers, limited access, and inconvenience.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Our review highlights the potential of TCM to enrich interdisciplinary teams in Western medical settings. Although there are successful integration models, significant barriers persist, including cost disparities and insufficient research. To achieve seamless integration, a multi-faceted approach that includes research collaboration, equitable policies, enhanced interprofessional education, and efforts to shift societal perceptions is essential.&lt;/div&gt;&lt;div&gt;&lt;br&gt;Please cite this article as: Wong AKC, Shi ","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"24 1","pages":"Pages 65-80"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}