Unlocking the potential: How acupuncture reshapes the liver-centered lipid metabolism pattern to fight obesity

IF 4.2 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim Pub Date : 2024-09-01 DOI:10.1016/j.joim.2024.08.004

Shu-rui Yang , Li Chen , Dan Luo , Ya-yuan Wang , Feng-xia Liang

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引用次数: 0

Abstract

Obesity, a widespread global health issue, is frequently linked to disrupted lipid metabolism, resulting in excessive accumulation of adipose tissue and associated health complications. Acupuncture, a traditional Chinese medical modality, has exhibited potential as a viable intervention for addressing obesity. The underlying mechanism proposed involves the stimulation of specific acupoints to exert a regulatory influence on hepatic function. The liver has a central role in lipid metabolism, including processes such as lipid synthesis, storage and distribution. Acupuncture is believed to enhance the liver’s efficiency in processing lipids, thereby reducing lipid accumulation and improving metabolic functions. Research indicates that acupuncture can influence the expression of certain genes and proteins involved in lipid metabolism in the liver. This includes upregulating genes that promote lipid breakdown and oxidation, and downregulating those involved in lipid synthesis. Additionally, acupuncture has been shown to improve insulin sensitivity, which is crucial for the regulation of lipid metabolism. Furthermore, the potential anti-inflammatory effects of acupuncture may play a significant role in its efficacy for the treatment of obesity. The presence of chronic inflammation has been strongly associated with metabolic disorders such as obesity. Through its ability to mitigate inflammation, acupuncture can potentially aid in the restoration of lipid metabolism and the reduction of body weight. Moreover, the amelioration of hepatic oxidative stress represents another mechanism by which acupuncture may contribute to the reduction of lipid deposition. Notably, the liver, being the primary site of lipid metabolism, maintains communication with various organs including the brain, adipose tissue, skeletal muscle and intestines. This perspective opens new avenues for the treatment of obesity, emphasizing the importance of holistic approaches in managing complex metabolic disorders.

Please cite this article as: Yang SR, Chen L, Luo D, Wang YY, Liang FX. Unlocking the potential: How acupuncture reshapes the liver-centered lipid metabolism pattern to fight obesity. J Integr Med. 2024; 22(5): 523–532.

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释放潜能：针灸如何重塑以肝为中心的脂质代谢模式以对抗肥胖。

肥胖症是全球普遍存在的健康问题，往往与脂质代谢紊乱有关，导致脂肪组织过度堆积，并引发相关的健康并发症。针灸作为一种传统的中医疗法，已显示出作为一种可行的干预措施来解决肥胖问题的潜力。所提出的基本机制包括刺激特定穴位对肝功能产生调节作用。肝脏在脂质代谢中起着核心作用，包括脂质合成、储存和分配等过程。针灸被认为可以提高肝脏处理脂质的效率，从而减少脂质堆积，改善代谢功能。研究表明，针灸可以影响肝脏中参与脂质代谢的某些基因和蛋白质的表达。这包括上调促进脂质分解和氧化的基因，下调参与脂质合成的基因。此外，针灸还能提高胰岛素的敏感性，而胰岛素对脂质代谢的调节至关重要。此外，针灸潜在的抗炎作用也可能在其治疗肥胖症的疗效中发挥重要作用。慢性炎症的存在与肥胖等代谢性疾病密切相关。通过缓解炎症，针灸可能有助于恢复脂质代谢和减轻体重。此外，改善肝脏氧化应激也是针灸有助于减少脂质沉积的另一种机制。值得注意的是，肝脏作为脂质代谢的主要场所，与大脑、脂肪组织、骨骼肌和肠道等多个器官保持着联系。这一观点为肥胖症的治疗开辟了新途径，强调了综合方法在控制复杂代谢紊乱中的重要性。本文引用如前：Yang SR, Chen L, Luo D, Wang YY, Liang FX.释放潜能：针灸如何重塑以肝为中心的脂质代谢模式以对抗肥胖？J Integr Med.2024; Epub ahead of print.

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来源期刊

Journal of Integrative Medicine-Jim Medicine-Complementary and Alternative Medicine

CiteScore

9.20

自引率

4.20%

发文量

3319

期刊介绍： The predecessor of JIM is the Journal of Chinese Integrative Medicine (Zhong Xi Yi Jie He Xue Bao). With this new, English-language publication, we are committed to make JIM an international platform for publishing high-quality papers on complementary and alternative medicine (CAM) and an open forum in which the different professions and international scholarly communities can exchange views, share research and their clinical experience, discuss CAM education, and confer about issues and problems in our various disciplines and in CAM as a whole in order to promote integrative medicine. JIM is indexed/abstracted in: MEDLINE/PubMed, ScienceDirect, Emerging Sources Citation Index (ESCI), Scopus, Embase, Chemical Abstracts (CA), CAB Abstracts, EBSCO, WPRIM, JST China, Chinese Science Citation Database (CSCD), and China National Knowledge Infrastructure (CNKI). JIM Editorial Office uses ThomsonReuters ScholarOne Manuscripts as submitting and review system (submission link: http://mc03.manuscriptcentral.com/jcim-en). JIM is published bimonthly. Manuscripts submitted to JIM should be written in English. Article types include but are not limited to randomized controlled and pragmatic trials, translational and patient-centered effectiveness outcome studies, case series and reports, clinical trial protocols, preclinical and basic science studies, systematic reviews and meta-analyses, papers on methodology and CAM history or education, conference proceedings, editorials, commentaries, short communications, book reviews, and letters to the editor. Our purpose is to publish a prestigious international journal for studies in integrative medicine. To achieve this aim, we seek to publish high-quality papers on any aspects of integrative medicine, such as acupuncture and traditional Chinese medicine, Ayurveda medicine, herbal medicine, homeopathy, nutrition, chiropractic, mind-body medicine, taichi, qigong, meditation, and any other modalities of CAM; our commitment to international scope ensures that research and progress from all regions of the world are widely covered. These ensure that articles published in JIM have the maximum exposure to the international scholarly community. JIM can help its authors let their papers reach the widest possible range of readers, and let all those who share an interest in their research field be concerned with their study.