Journal of Integrative Medicine-Jim最新文献

{"title":"From talk to action: Developing a model to foster effective integration of traditional medicine into the Ghanaian healthcare system","authors":"Irene G. Ampomah ,&nbsp;Bunmi S. Malau-Aduli ,&nbsp;Aduli E.O. Malau-Aduli ,&nbsp;Theophilus I. Emeto","doi":"10.1016/j.joim.2023.06.007","DOIUrl":"10.1016/j.joim.2023.06.007","url":null,"abstract":"<div><p><span>This research assessed the experience of stakeholders and the efficacy of integrating traditional medicine into the Ghanaian </span>health system using the Ashanti Region as the focal point. Elements of an integrative healthcare delivery model including philosophies/values, structure, process and outcome were used to conduct a quality assessment of the integrated health system in Ghana. Each element clearly showed that Ghana is currently not running a coordinated health practice model, thus making it a tolerant, rather than an inclusive, health system. Therefore, the primary purpose of this research is to discuss the development of a new and appropriately customised model that could enhance the practice of integrated healthcare in Ghana. The model we present has flexibility and far-reaching applicability in other African countries because such countries share similar socio-cultural and economic characteristics. As such, governments and health practitioners could adapt this model to improve the practice of integrated healthcare in their specific settings. Hospital administrators and health system researchers could also adapt the model to investigate or to monitor the progress and efficacy of integrated healthcare practices within their settings. This might help to understand the relationships between the integration of traditional medicine and health outcomes for a given population.</p><p>Please cite this article as: Ampomah IG, Malau-Aduli BS, Malau-Aduli AEO, Emeto TI. From talk to action: Developing a model to foster effective integration of traditional medicine into the Ghanaian healthcare system. <em>J Integr Med</em>. 2023; 21(5): 423–429.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"21 5","pages":"Pages 423-429"},"PeriodicalIF":4.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10649359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulforaphane, an NRF2 agonist, alleviates ferroptosis in acute liver failure by regulating HDAC6 activity","authors":"Yan-qiong Zhang ,&nbsp;Chun-xia Shi ,&nbsp;Dan-mei Zhang,&nbsp;Lu-yi Zhang,&nbsp;Lu-wen Wang,&nbsp;Zuo-jiong Gong","doi":"10.1016/j.joim.2023.08.002","DOIUrl":"10.1016/j.joim.2023.08.002","url":null,"abstract":"<div><h3>Objective</h3><p><span><span>Acute liver failure (ALF) is characterized by </span>severe liver dysfunction<span>, rapid progression and high mortality and is difficult to treat. Studies have found that sulforaphane (SFN), a nuclear factor E2-related </span></span>factor 2<span> (NRF2) agonist, has anti-inflammatory, antioxidant and anticancer effects, and has certain protective effects on neurodegenerative diseases<span>, cancer and liver fibrosis. This paper aimed to explore the protective effect of SFN in ALF and it possible mechanisms of action.</span></span></p></div><div><h3>Methods</h3><p><span>Lipopolysaccharide and D-galactosamine were used to induce liver injury </span><em>in vitro</em> and <em>in vivo</em><span>. NRF2 agonist SFN and histone deacetylase 6<span> (HDAC6) inhibitor ACY1215<span><span> were used to observe the protective effect and possible mechanisms of SFN in ALF, respectively. Cell viability, </span>lactate dehydrogenase (LDH), Fe</span></span></span>²⁺<span><span>, glutathione (GSH) and </span>malondialdehyde<span><span> (MDA) were detected. The expression of HDAC6, NRF2, glutathione peroxidase 4<span> (GPX4), acyl-CoA synthetase long-chain family member 4 (ACSL4) and solute carrier family 7 member 11 (SLC7A11) were detected by </span></span>Western blotting<span> and immunofluorescence.</span></span></span></p></div><div><h3>Results</h3><p>Our results show that NRF2 was activated by SFN. LDH, Fe²⁺, MDA and ACSL4 were downregulated, while GSH, GPX4 and SLC7A11 were upregulated by SFN <em>in vitro</em> and <em>in vivo</em><span>, indicating the inhibitory effect of SFN on ferroptosis. Additionally, HDAC6 expression was decreased in the SFN group, indicating that SFN could downregulate the expression of HDAC6 in ALF. After using the HDAC6 inhibitor, ACY1215, SFN further reduced HDAC6 expression and inhibited ferroptosis, indicating that SFN may inhibit ferroptosis by regulating HDAC6 activity.</span></p></div><div><h3>Conclusion</h3><p>SFN has a protective effect on ALF, and the mechanism may include reduction of ferroptosis through the regulation of HDAC6.</p><p>Please cite this article as: Zhang YQ, Shi CX, Zhang DM, Zhang LY, Wang LW, Gong ZJ. Sulforaphane, an NRF2 agonist, alleviates ferroptosis in acute liver failure by regulating HDAC6 activity. <em>J Integr Med</em>. 2023; 21(5): 464–473.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"21 5","pages":"Pages 464-473"},"PeriodicalIF":4.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10295879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HOW DO NURSING STUDENTS PERCEIVE HEALTHCARE TECHNOLOGY? A PSYCHOMETRIC VALIDATION STUDY OF THE USABILITY EVALUATION QUESTIONNAIRE IN VIETNAM","authors":"Le Thanh Tung, Ngo Huy Hoang, Nguyen Thi Minh Chinh, Nguyen Thi Thanh Huong, Mai Thi Thanh Thu, Truong Quang Trung, Duong Thi Thu Huyen, Nguyen Thi Thu Huong, Kazi Shafiqul Halim, Mohammad Gilam Iqbal, Israt Jahan Ummon, Masood Mohammed Abdul Aziz, F. Ferdaus, Nahida Sultana, Farhana Manzoor, Nandita Islam Pia, R. Rahman, Naheyan Bin Rahman, Essi Ylistalo, Katariina Kunnas, Annukka Huuskonen, Nina Smolander, João Manuel Garcia do Nascimento Graveto, Anabela de Sousa Salgueiro Oliveira, João Gonçalo Ribeiro Pardal, Paulo Jorge dos Santos Costa, Pedro Miguel dos Santos Dinis Parreira","doi":"10.29073/jim.v4i2.766","DOIUrl":"https://doi.org/10.29073/jim.v4i2.766","url":null,"abstract":"The rapid advancement of technology has transformed the role of nurses and nursing students in patient care, making it an integral component of healthcare delivery. The use of innovative technologies has become commonplace in healthcare settings, creating a high-tech environment that can enhance nursing care quality and patient experience. It is essential for nursing staff and students to be receptive to incorporating such tools into their practice to ensure safe and efficient use of various forms of healthcare technology. Objective: Given the absence of an existing tool in Vietnam to evaluate healthcare students’ technology acceptance, the aim of our research was to culturally adapt, translate, and validate the Usability Evaluation Questionnaire (UtEQ) among nursing students in Vietnam. Method: We conducted a methodological and cross-sectional study in two phases: translation of the UtEQ to Vietnamese (UtEQ-V) following six stages proposed by Beaton and collaborators, and assessment of its psychometric properties in a non-probability sample of 295 Vietnamese nursing students. Results: The UtEQ-V’s reliability was found to be above 0.8 for all factors (.88–.95), while confirmatory factor analysis showed adequate goodness-of-fit indicators. Conclusion: The UtEQ-V is a reliable and valid instrument that can support nursing educators and researchers to assess students’ technology acceptance during their clinical training.","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"96 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75916499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESFORÇO FÍSICO E RESTRIÇÃO DE SONO MODIFICAM MARCADORES BIOQUÍMICOS E COGNITIVOS EM MILITARES: UMA REVISÃO SISTEMÁTICA","authors":"Thiago Ramos de Barros, Verônica Salerno, Filipe Brasil e Silva, Thalita Ponce Sobral, M. Vaisman, Miriam Raquel Meira Mainenti","doi":"10.29073/jim.v4i2.702","DOIUrl":"https://doi.org/10.29073/jim.v4i2.702","url":null,"abstract":"A revisão objetivou descrever os efeitos de treinamentos militares que combinam atividade física intensa e privação de sono em marcadores de estresse oxidativo, lesão celular, desempenho físico e cognitivo. Foi realizada uma revisão sistemática seguindo as recomendações do PRISMA e a pesquisa foi realizada nas bases de dados Pubmed e Google Scholar. A frase de busca foi desenvolvida para identificar estudos experimentais que investigaram momentos pré e pós treinamentos militares, avaliando pelo menos uma das variáveis dependentes: dano oxidativo, capacidade antioxidante, lesão celular, alerta cognitivo e desempenho físico. Vinte e quatro estudos preencheram os critérios de inclusão. As intervenções dos estudos incluídos variaram de 1 a 63 dias, com predominância de atividade física intensa e importante privação de sono. As comparações dos dados pareados convergiram com o aumento dos níveis de lesão celular, queda dos desempenhos físico e cognitivo (p<0,05). Houve escassez das avaliações de estresse oxidativo e distinção entre os protocolos dos estudos encontrados. A revisão concluiu que a combinação de atividade física intensa e privação de sono são capazes de provocar aumento nos níveis de lesão celular e queda de performance física e cognitiva. Sugere também que há uma lacuna de informações sobre estresse oxidativo e treinamentos militares.","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"61 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87478344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTIVENESS OF THE DIGICARE EDUCATIONAL INTERVENTION IN IMPROVING NURSING AND MEDICAL STUDENTS’ CLINICAL COACHING SKILLS IN VIETNAM AND BANGLADESH: AN EXPLORATORY PRE-POST STUDY","authors":"Paulo Jorge dos Santos Costa, Anabela de Sousa Salgueiro Oliveira, João Manuel Garcia do Nascimento Graveto, João Gonçalo Ribeiro Pardal, Kazi Shafiqul Halim, Mohammad Gilam Iqbal, Israt Jahan Ummon, Truong Quang Trung, Nguyet Thi Nguyen, Le Thanh Tung, Ngo Huy Hoang, Nguyen Thi Minh Chinh, Nguyen Thi Thanh Huong, Hoang Thi Minh Thai, Masood Mohammed Abdul Aziz, F. Ferdaus, Nahida Sultana, Farhana Manzoor, Nandita Islam Pia, R. Rahman, Naheyan Bin Rahman, Essi Ylistalo, Katariina Kunnas, Annukka Huuskonen, Nina Smolander, Pedro Miguel dos Santos Dinis Parreira","doi":"10.29073/jim.v4i2.764","DOIUrl":"https://doi.org/10.29073/jim.v4i2.764","url":null,"abstract":"Coaching has become an important approach to support self-management of patients with non-communicable diseases (NCDs) in healthcare education. Studies conducted in European countries have emphasized the significance of formal coaching training in enhancing the competencies of healthcare students. However, in Southeast Asia, where NCDs pose a serious public health concern, there is a lack of such training opportunities. To address this issue, an exploratory pre and post study was conducted to evaluate the effectiveness of the DigiCare educational intervention in improving clinical coaching skills. Nursing and medical students from six universities in Vietnam and Bangladesh were invited to participate. The intervention included both theoretical and practical classes with interactive methods and home assignments, with a total duration of over 10 contact hours. Pre- and post-intervention assessments were conducted using the Self-Efficacy and Performance in Self-management Support instrument, which was translated and culturally adapted to both countries. Statistical analysis showed a significant improvement in students’ overall competence scores from before (M = 2.6, SD = .67) to after the intervention (M = 3.05, SD = .55), with a medium effect size (p < .001; d = .73). The DigiCare educational intervention appears to be a low-cost and meaningful addition to the curriculum of both nursing and medical universities across countries, with potential benefits in the development of students’ clinical coaching competencies.","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"1 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81473375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HOW DO MEDICAL AND NURSING STUDENTS VIEW HEALTHCARE TECHNOLOGY? A PSYCHOMETRIC VALIDATION STUDY OF THE USABILITY EVALUATION QUESTIONNAIRE IN BANGLADESH","authors":"Farhana Manzoor, Nandita Islam Pia, R. Rahman, Naheyan Bin Rahman, Debashish Debnath, Hasan Shahriar Rahman, Masood Mohammed Abdul Aziz, F. Ferdaus, Nahida Sultana, Kazi Shafiqul Halim, Mohammad Gilam Iqbal, Israt Jahan Ummon, Bui Vu Binh, Le Thi Tra My, Le Thi Cuc, Le Thanh Tung, Ngo Huy Hoang, Nguyen Thi Minh Chinh, Nguyen Thi Thanh Huong, Pham Thi Thuy Chinh, Mai Thi Thanh Thu, Essi Ylistalo, Katariina Kunnas, Annukka Huuskonen, Nina Smolander, Anabela de Sousa Salgueiro Oliveira, João Manuel Garcia do Nascimento Graveto, João Gonçalo Ribeiro Pardal, Paulo Jorge dos Santos Costa, Pedro Miguel dos Santos Dinis Parreira","doi":"10.29073/jim.v4i2.767","DOIUrl":"https://doi.org/10.29073/jim.v4i2.767","url":null,"abstract":"The modernization of healthcare delivery is a reality in various international settings. To ensure efficient and safe use of the diverse forms of healthcare technology available, professionals and students must be receptive to incorporating such tools into their practice. Currently, there is no instrument in Bangladesh to assess healthcare students’ technology acceptance. Objective: To translate, culturally adapt, and validate the Usability Evaluation Questionnaire (UtEQ) among Bangladeshi healthcare students. Method: A cross-sectional study with a methodological approach was conducted in two phases. The first phase involved the translation of the UtEQ questionnaire to Bengali, following the six stages proposed by Beaton et al. In the second phase, the psychometric properties of the questionnaire were evaluated using a non-probability sample of 486 undergraduate healthcare students from three higher education institutions in Bangladesh. Confirmatory factor analysis was performed, and the Cronbach’s alpha coefficient was estimated to find out the internal consistency. Results: Internal consistency was found to be excellent for all scale dimensions, ranging from 0.88 to 0.92, while confirmatory factor analysis showed adequate goodness-of-fit indicators. Conclusion: The UtEQ-B provides a reliable and valid method for healthcare educators and researchers to assess technology acceptance among healthcare students during clinical training in Bangladesh.","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"3 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88487872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 PANDEMIC’S INFLUENCE ON THE STUDY OF BURNOUT: A BIBLIOMETRIC ANALYSIS","authors":"Carla Carvalho, Ana Pinto, Soraia Oliveira, Maria Inês Matos, Paulo Santos-Costa","doi":"10.29073/jim.v4i2.733","DOIUrl":"https://doi.org/10.29073/jim.v4i2.733","url":null,"abstract":"Burnout affects physical and psychological health and is considered a major public health threat. The COVID-19 pandemic brought numerous social and economic challenges to organizations across the different work sectors, enhancing the risk of workers experiencing Burnout. However, the influence of the COVID-19 pandemic on the study of Burnout Syndrome remains unclear. To address this challenge, we analyzed pre-pandemic and post-COVID-19 outbreak research trends in this field. A comparative bibliometric analysis was conducted for the pre-pandemic period (01/2015 to 12/2019) and after the COVID-19 outbreak (01/2020 to 06/2021). Twelve thousand eighty-one publications were analyzed. Exponential growth in annual research activity on this subject was found since the COVID-19 outbreak. After 2020, the keyword “COVID-19” is often associated with “Burnout”, showing a clear international focus on this field. Research output disparities among the most affected countries have been found, with increased publications in countries such as the United States of America, China, Spain and Italy, while others have understudied this subject (e.g., India, Brazil, France). Further bibliometric analyses in this scope are recommended.","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"10 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87262266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CULTURAL ADAPTATION AND PSYCHOMETRIC VALIDATION OF THE SELF EFFICIENCY AND PERFORMANCE IN SELF-MANAGEMENT SUPPORT (SEPSS) QUESTIONNAIRE IN UNDERGRADUATE NURSING AND MEDICAL STUDENTS OF BANGLADESH","authors":"Masood Mohammed Abdul Aziz, F. Ferdaus, Nahida Sultana, Farhana Manzoor, Nandita Islam Pia, R. Rahman, Naheyan Bin Rahman, Kazi Shafiqul Halim, Mohammad Gilam Iqbal, Israt Jahan Ummon, Nguyen Huu Tu, Le Thi Tra My, Duong Thi Thu Huyen, Le Thanh Tung, Ngo Huy Hoang, Nguyen Thi Minh Chinh, Nguyen Thi Thanh Huong, Pham Thi Thuy Chinh, Hoang Thi Minh Thai, Essi Ylistalo, Katariina Kunnas, Annukka Huuskonen, Nina Smolander, Anabela de Sousa Salgueiro Oliveira, João Manuel Garcia do Nascimento Graveto, João Gonçalo Ribeiro Pardal, Paulo Jorge dos Santos Costa, Pedro Miguel dos Santos Dinis Parreira","doi":"10.29073/jim.v4i2.765","DOIUrl":"https://doi.org/10.29073/jim.v4i2.765","url":null,"abstract":"In an aging society, healthcare professionals and students face increasing demands to actively involve patients in the decision-making process regarding their health conditions and lifestyles. Self-management support is considered a best practice that aligns with the patient-centered care paradigm in Bangladesh. However, there is currently no instrument available to assess healthcare professionals’ competencies in this field, particularly during their early education and training period. The aim of this study was to translate the Self Efficiency and Performance in Self-management Support (SEPSS) instrument into Bangla and validate its psychometric properties in a sample of undergraduate healthcare students in Bangladeshi higher education institutions. A cross-sectional study was conducted to assess the reliability, validity, and cultural appropriateness of the Bangla version of SEPSS-36 among 486 nursing and medical students. Confirmatory factor analysis was carried out using the chi-square model fit index (CMIN), comparative fit index (CFI), and Root Mean Square Error of Approximation (RMSEA) as fit indices. The internal consistency was estimated by the Cronbach alpha coefficient. The results indicate that the CMIN (2.658) and RMSEA (.058) values suggest that the sample data and hypothetical model are an acceptable fit in the analysis, with satisfactory CFI values (.895). The reliability for all SEPSS dimensions was acceptable. The Bangla version of the SEPSS questionnaire is a valid and reliable instrument that can assist healthcare educators and researchers in determining students’ competencies within this domain.","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"64 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84989812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive overview on the role of phytocompounds in human immunodeficiency virus treatment","authors":"Chinmayee Priyadarsani Mandhata,&nbsp;Chita Ranjan Sahoo,&nbsp;Rabindra Nath Padhy","doi":"10.1016/j.joim.2023.05.001","DOIUrl":"10.1016/j.joim.2023.05.001","url":null,"abstract":"<div><p><span>Acquired immune deficiency syndrome (AIDS) is a worldwide epidemic caused by human immunodeficiency </span>virus<span> (HIV) infection. Newer medicines for eliminating the viral reservoir and eradicating the virus are urgently needed. Attempts to locate relatively safe and non-toxic medications from natural resources are ongoing now. Natural-product-based antiviral candidates have been exploited to a limited extent. However, antiviral research is inadequate to counteract for the resistant patterns. Plant-derived bioactive compounds hold promise as powerful pharmacophore scaffolds, which have shown anti-HIV potential. This review focuses on a consideration of the virus, various possible HIV-controlling methods and the recent progress in alternative natural compounds with anti-HIV activity, with a particular emphasis on recent results from natural sources of anti-HIV agents.</span></p><p><span>Please cite this article as: Mandhata CP, Sahoo CR, Padhy RN. A comprehensive overview on the role of phytocompounds in human immunodeficiency virus treatment. </span><em>J Integr Med</em>. 2023; 21(4):332–353.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"21 4","pages":"Pages 332-353"},"PeriodicalIF":4.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10170917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electro-acupuncture promotes gut motility and alleviates functional constipation by regulating gut microbiota and increasing butyric acid generation in mice","authors":"Ming-min Xu ,&nbsp;Yu Guo ,&nbsp;Ying Chen ,&nbsp;Wei Zhang ,&nbsp;Lu Wang ,&nbsp;Ying Li","doi":"10.1016/j.joim.2023.05.003","DOIUrl":"10.1016/j.joim.2023.05.003","url":null,"abstract":"<div><h3>Objective</h3><p><span>Abnormalities in the gut microbiota and intestinal short-chain fatty acid (SCFA) levels are implicated in the pathogenesis of </span>functional constipation (FC). Electro-acupuncture (EA) has been shown to improve constipation-related symptoms and rebalance the gut microbiota. However, it is currently unknown whether the gut microbiota is a key mechanistic target for EA or how EA promotes gut motility by regulating the gut microbiota and SCFAs. Therefore, we assessed the effects of EA in FC mice and pseudo-germfree (PGF) mice to address these questions.</p></div><div><h3>Methods</h3><p>Forty female Kunming mice were randomly separated into a normal control group (<em>n</em> = 8), an FC group (<em>n</em> = 8), an FC + EA group (<em>n</em> = 8), a PGF group (<em>n</em> = 8) and a PGF + EA group (<em>n</em><span><span><span> = 8). The FC group and FC + EA group were treated with diphenoxylate to establish the FC model; the PGF group and PGF + EA group were given an antibiotic cocktail to initiate the PGF model. After maintaining the model for 14 d, mice in the FC + EA and PGF + EA groups received EA stimulation at the ST25 and ST37 </span>acupoints, once a day, 5 times per week, for 2 weeks. Fecal parameters and intestinal transit rate were calculated to assess the efficacy of EA on constipation and </span>gastrointestinal motility<span><span>. Colonic contents were used to quantify gut microbial diversity using </span>16S rRNA sequencing, and measure SCFA concentrations using gas chromatography-mass spectrometry.</span></span></p></div><div><h3>Results</h3><p>EA significantly shortened the first black stool defecation time (<em>P</em> &lt; 0.05) and increased the intestinal transit rate (<em>P</em> &lt; 0.01), and fecal pellet number (<em>P</em> &lt; 0.05), wet weight (<em>P</em> &lt; 0.05) and water content (<em>P</em><span> &lt; 0.01) over 8 h, compared with the FC group, showing that EA promoted gut motility and alleviated constipation. However, EA treatment did not reverse slow-transit colonic motility in PGF mice (</span><em>P</em><span><span> &gt; 0.05), demonstrating that the gut microbiota may play a mechanistic role in the EA treatment of constipation. In addition, EA treatment restored the Firmicutes to </span>Bacteroidetes<span> ratio and significantly increased butyric acid generation in FC mice (</span></span><em>P</em><span> &lt; 0.05), most likely due to the upregulation of Staphylococcaceae microorganisms (</span><em>P</em> &lt; 0.01).</p></div><div><h3>Conclusion</h3><p>EA-mediated resolution of constipation occurs through rebalancing the gut microbiota and promoting butyric acid generation.</p><p>Please cite this article as: Xu MM, Guo Y, Chen Y, Zhang W, Wang L, Li Y. Electro-acupuncture promotes gut motility and alleviates functional constipation by regulating gut microbiota and increasing butyric acid generation in mice. <em>J Integr Med</em>. 2023; Epub ahead of print.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"21 4","pages":"Pages 397-406"},"PeriodicalIF":4.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9795656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}